Digital Commons Network^™

Past, Present, Future: The Evolution Of A Wetland Treatment System In Dutchman Canyon On Vermejo Park Ranch, Zoe Isaacson

Water Resources Professional Project Reports

The purpose of this research was to track the evolution of a constructed wetland system through time while taking into consideration anthropogenic perturbations to the system. It was accomplished by reviewing 30 years-worth of literature associated with the project site, gleaning relevant information, and then synthesizing the information to form a complete evolutionary timeline. In August 2012 a wetland was constructed using water from the evaporation ponds. The Dutchman Canyon wetland, a continuous flow, free surface wetland, was thus formed. The wetland was intended to passively treat poor-quality mine seepage and impart an improved wetland habitat for a diversity fauna …

The International War Against Doping: Limiting The Collateral Damage From Strict Liability, Thomas W. Cox

Vanderbilt Journal of Transnational Law

The World Anti-Doping Agency (WADA) and the World Anti-Doping Code are largely considered the model for an effective and well-coordinated antidoping regime. This model has allowed numerous sports and various countries to secure the same rules for domestic and international athletes. Within this regime, strict liability for prohibited substances stands as the "cornerstone." Strict liability has allowed antidoping officials to prosecute doping violations through an effective testing regime. However, this principle occasionally implicates innocent athletes with no intention of performance enhancement. This Note proposes that WADA modify its criteria for including substances on the Prohibited List and suspend strict liability …

Learning With Laz, Cynthia R. Chambers

ETSU Faculty Works

No abstract provided.

Functional Genomics Of Acclimation And Adaptation In Response To Thermal Stress In Daphnia, Lev Y. Yampolsky, Erliang Zeng, Jacqueline Lopez, Patricia J. Williams, Kenneth B. Dick, John K. Colbourne, Michael E. Pfrender

ETSU Faculty Works

Background: Gene expression regulation is one of the fundamental mechanisms of phenotypic plasticity and is expected to respond to selection in conditions favoring phenotypic response. The observation that many organisms increase their stress tolerance after acclimation to moderate levels of stress is an example of plasticity which has been long hypothesized to be based on adaptive changes in gene expression. We report genome-wide patterns of gene expression in two heat-tolerant and two heat-sensitive parthenogenetic clones of the zooplankton crustacean Daphnia pulex exposed for three generations to either optimal (18°C) or substressful (28°C) temperature. Results: A large number of genes responded …

Recognition Functions Of Pentameric C-Reactive Protein In Cardiovascular Disease, Alok Agrawal, Toh B. Gang, Antonio E. Rusiñol

ETSU Faculty Works

C-reactive protein (CRP) performs two recognition functions that are relevant to cardiovascular disease. First, in its native pentameric conformation, CRP recognizes molecules and cells with exposed phosphocholine (PCh) groups, such as microbial pathogens and damaged cells. PCh-containing ligand-bound CRP activates the complement system to destroy the ligand. Thus, the PCh-binding function of CRP is defensive if it occurs on foreign pathogens because it results in the killing of the pathogen via complement activation. On the other hand, the PCh-binding function of CRP is detrimental if it occurs on injured host cells because it causes more damage to the tissue via …

Porcine Epidemic Diarrhea Virus (Pedv) Co-Infection Induced Chlamydial Persistence/Stress Does Not Require Viral Replication, Robert V. Schoborg, Nicole Borel

ETSU Faculty Works

Chlamydiae may exist at the site of infection in an alternative replicative form, called the aberrant body (AB). ABs are produced during a viable but non-infectious developmental state termed "persistence" or "chlamydial stress." As persistent/stressed chlamydiae: (i) may contribute to chronic inflammation observed in diseases like trachoma; and (ii) are more resistant to current anti-chlamydial drugs of choice, it is critical to better understand this developmental stage. We previously demonstrated that porcine epidemic diarrhea virus (PEDV) co-infection induced Chlamydia pecorum persistence/stress in culture. One critical characteristic of persistence/stress is that the chlamydiae remain viable and can reenter the normal developmental …

The Tlr9 Ligand, Cpg-Odn, Induces Protection Against Cerebral Ischemia/Reperfusion Injury Via Activation Of Pi3k/Akt Signaling., Chen Lu, Tuanzhu Ha, Xiaohui Wang, L. Liu, Xia Zhang, Erinmarie Olson Kimbrough, Zhanxin Sha, Meijian Guan, John Schweitzer, John Kalbfleisch, David Williams, Chuanfu Li

ETSU Faculty Works

Toll-like receptors (TLRs) have been shown to be involved in cerebral ischemia/reperfusion (I/R) injury. TLR9 is located in intracellular compartments and recognizes CpG-DNA. This study examined the effect of CpG-ODN on cerebral I/R injury. C57BL/6 mice were treated with CpG-ODN by i.p. injection 1 hour before the mice were subjected to cerebral ischemia (60 minutes) followed by reperfusion (24 hours). Scrambled-ODN served as control-ODN. Untreated mice, subjected to cerebral I/R, served as I/R control. The effect of inhibitory CpG-ODN (iCpG-ODN) on cerebral I/R injury was also examined. In addition, we examined the therapeutic effect of CpG-ODN on cerebral I/R injury …

Β-Arrestin2/Mir-155/Gsk3Β Regulates Transition Of 5'-Azacytizine-Induced Sca-1-Positive Cells To Cardiomyocytes, Jing Zhao, Yimin Feng, Hui Yan, Yangchao Chen, Jinlan Wang, Balvin Chua, Charles Stuart, Deling Yin

ETSU Faculty Works

Stem-cell antigen 1-positive (Sca-1+) cardiac stem cells (CSCs), a vital kind of CSCs in humans, promote cardiac repair in vivo and can differentiate to cardiomyocytes with 5'-azacytizine treatment in vitro. However, the underlying molecular mechanisms are unknown. b-arrestin2 is an important scaffold protein and highly expressed in the heart. To explore the function of b-arrestin2 in Sca-1+ CSC differentiation, we used b-arrestin2-knockout mice and overexpression strategies. Real-time PCR revealed that b-arrestin2 promoted 5'-azacytizine-induced Sca-1+ CSC differentiation in vitro. Because the microRNA 155 (miR-155) may regulate b-arrestin2 expression, we detected its role and relationship with b-arrestin2 and glycogen synthase kinase 3 …

Do Municipal Stat Programs Improve Services And Reallocate Resources? Evidence From Louiestat, Jamie Giles

MPA/MPP/MPFM Capstone Projects

Performance metrics and municipal stat programs are becoming increasingly popular to measure performance of city departments in order to improve services and save taxpayers’ dollars. The intent of this research is to give decision makers a better understanding to what extent municipal stat programs make an impact on the departments being measured, using an analysis of Metro Louisville’s LouieStat as evidence. Understanding the effect of PerfomanceStat tools will provide insight for the Louisville Administration and for other cities considering using a similar tool.

The literature finds performance management tools to be more widely used as a management tool to influence …

Academic Asset Or Instructor’S Indulgence? The Effect Of Arts & Cultural Institutions On Academic Achievement, Hank Harned

MPA/MPP/MPFM Capstone Projects

Across the country arts and cultural institutions seek to preserve our past and use it to educate our future. As their exhibits expand these institutions have become treasures in their own rights; places like the Smithsonian Institute are landmarks that attract visitors from around the world. In addition to travelers they also attract school groups. For decades schools have been using “field trips” to museums as a way to supplement their curriculum. But do these trips actually benefit the students or are they a waste of resources? This project aims to evaluate whether these institutions are an asset to academics …

Nonprofit Organizations & Social Media Fundraising: An Analysis Of The Goodgiving Guide Challenge, Laura Whitaker

MPA/MPP/MPFM Capstone Projects

In today’s age of social media and interconnectedness, nonprofit organizations have the ability to be creative in their fundraising efforts. One method of online fundraising is a social media campaign, such as the GoodGiving Guide Challenge, an eight-week online charitable giving campaign for nonprofit organizations across Central Kentucky.

A review of related literature shows that previous studies have touched on the growing trend of social media as a nonprofit marketing tool, the role of internet in the nonprofit sector in general, the return on investment in nonprofit internet use, and the importance of accountability and trust in terms of online …

Influences On Reported Nonprofit Lobbying Efforts, Alyson Partain

MPA/MPP/MPFM Capstone Projects

The nonprofit sector holds an interesting role in democracy, as this segment balances the powers of government and business by providing a way to cultivate social justice and afford people a means of acting and promoting interests outside of the government and private sectors. Nonprofit organizations therefore allow people to join together in providing services and programs that strengthen the communities in which they act. Advocacy involves identifying, embracing, and promoting a cause, especially by educating the public about their organization, whether this is through public engagement, coalition building, or lobbying.

Lobbying is a specific but critical component of general …

Noir Westerns After World War Ii, Kenneth Estes Hall, Chritian Krug

ETSU Faculty Works

Excerpt: Towards the end of Ethan and Joel Coen's Academy-Award winning No Country for Old Men (2007), Carla Jean Moss's life depends on the toss of a coin. Heads or tails will decide whether she lives or dies.

The Kansas Cattle Towns: Where Trail Meets Rail, Kenneth Estes Hall

ETSU Faculty Works

Excerpt: That land of the West has gone now, "gone, gone with lost Atlantis," gone to the isle of ghosts and of strange dead memories. It was a land of vast silent spaces, of lonely rivers, and of plains where wild game stared at the passing horseman .

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Elevated Gene Expression Of Glutamate Receptors In Noradrenergic Neurons From The Locus Coeruleus In Major Depression, Michelle J. Chandley, Attila Szebeni, Katalin Szebeni, Jessica D. Crawford, Craig A. Stockmeier, Gustavo Turecki, Richard M. Kostrzewa, Gregory A. A. Ordway

ETSU Faculty Works

Glutamate receptors are promising drug targets for the treatment of urgent suicide ideation and chronic major depressive disorder (MDD) that may lead to suicide completion. Antagonists of glutamatergic NMDA receptors reduce depressive symptoms faster than traditional antidepressants, with beneficial effects occurring within hours. Glutamate is the prominent excitatory input to the noradrenergic locus coeruleus (LC). The LC is activated by stress in part through this glutamatergic input. Evidence has accrued demonstrating that the LC may be overactive in MDD, while treatment with traditional antidepressants reduces LC activity. Pathological alterations of both glutamatergic and noradrenergic systems have been observed in depressive …

The Possible Advantages Of Islamic Financial Jurisprudence: An Empirical Study Of The Dow Jones Islamic Market Index, Russell Powell, Arthur Delong

Faculty Articles

The Islamic financial system experienced a disproportionately smaller economic hardship in 2008 and 2009 because adherence to Shariʿa tends to encourage conservative investment approaches. Islamic mutual funds were prohibited from investing in the non-Islamic financial sector, highly leveraged companies, and various derivative instruments. Ultimately, this conservative investment approach may have been an effective strategy for mitigating downside risk. The article analyzes the fundamental classical legal requirements that pertain to modern Islamic finance, compares the modern view of Islamic equity investing and its secular capitalist counterpart, explores whether adherence to Shariʿa principles, as defined by the Dow Jones Islamic Market Index, …

Invidious Deliberation: The Problem Of Congressional Bias In Federal Hate Crime Legislation, Sara Rankin

Faculty Articles

The intersection of power and prejudice can control the shape of statutory law, and yet a dearth of legal scholarship investigates it. Invidious Deliberation addresses that deficit. It tackles the problem of prejudice in Congressional deliberations at a particularly critical point: when Congress decides which groups to protect under federal hate crime legislation. The article contends that Congress’s own bias may exclude the most vulnerable groups from hate crime protection. To illustrate the point, this article systematically reviews over two decades of Congressional decisions with respect to expansions of the Hate Crime Statistics Act, a “gateway” for groups seeking protection …

Global Spread Of Wheat Curl Mite By Its Most Polyphagous And Pestiferous Lineages, A. Skoracka, B. Rector, L. Kuczyński, W. Szydło, G. Hein, R. French

Department of Entomology: Faculty Publications

The wheat curl mite (WCM), Aceria tosichella, is an important pest of wheat and other cereal crops that transmits wheat streak mosaic virus and several other plant viruses. Wheat curl mite has long been considered a single polyphagous species, but recent studies in Poland revealed a complex of genetically distinct lineages with divergent host-acceptance traits, ranging from highly polyphagous to host-specific. This diversity of WCM genotypes and host-acceptance phenotypes in Europe, the presumed native range of WCM, raises questions about the lineage identities of invasive WCM populations on other continents and their relationships to European lineages. The goals of …

Biotic Potential, Fertility And Life Table Of Spodoptera Albula (Walker) (Lepidoptera: Noctuidae), Under Controlled Conditions, Débora G. Montezano, Alexandre Specht, Daniel Ricardo Sosa-Gómez, Vânia F. Roque-Specht, Tarciso M. Bortolin, Edegar Fronza, Patricia Pezzi, Priscila C. Luz, Neiva M. Barros

Department of Entomology: Faculty Publications

This study aimed to evaluate the biotic potential, life table parameters and fertility of Spodoptera albula (Walker, 1857) under controlled conditions (25 ± 1°C, 70 ± 10% RH and 14 hour photo phase). The longevity, pre, post and oviposition periods, fecundity and fertility of 13 couples were evaluated. The longevity of females (13.500 days) was significantly higher than those of males (11.154 days). The mean durations of the pre, post and oviposition periods were 2.615, 1.769 and 9.385 days, respectively. The mean fecundity was 1.417.69 eggs and mean fertility was 1.340.401 larvae, per female. On average, females copulated 1, 231 …

2014-2015 Risd Course Announcement, Risd Registrar's Office, Risd Archives

RISD Course Catalogs / Announcements

No abstract provided.

Feminist Women’S Health Movement Practices, Mindfulness, Sexual Body Esteem, And Genital Satisfaction, Amanda N. Carter

Scripps Senior Theses

There is a significant issue in society today regarding the lack of knowledge about and positive regard attributed to women’s bodies, but more specifically female genitalia. This is detrimental to women in that it causes us to see ourselves in a negative light, or to overly sexualize certain aspects of ourselves, which may lead to severe psychological damage (American Psychological Association Task Force on the Sexualization of Girls, 2010). The 1970’s Women’s Health Movement presented a way for women to get to know their own bodies in a way that was private from society in order to make their own …

Diplomacy & Negotiation, Liefke M. Cox

Master of Liberal Studies Theses

Over the course of history when women have been involved in the diplomatic, political, social, and economic structure of a country it has been found they are one of the key ingredients to building an effective and stable democracy. Investing in women strengthens the back bone of any society. Top CEO’s, such as Tupperware’s Rick Goings and Warren Buffett, have also publically supported this assumption. I argue that women in different societies have traits that have been instilled in them culturally which in turn translate directly to their ability to handle diplomatic situations and business negotiations. Societies, however intentionally or …

Handicraft, Hobbitcraft And The Fires Of Mordor: The Arts And Crafts Movement, Industrial Revolution And The Lord Of The Rings, Gina L. Hewitt

Master of Liberal Studies Theses

From the intimate nature of the characterization of an entirely new race of men-in-miniature and their home, where "peace and quiet and good, tilled Earth" (Tolkien 1) are held in the highest esteem, to the belching volcanoes, fires and lung-searing smoke of industry in the land of Mordor, J. R. R. Tolkien's The Lord of the Rings brings the vision of the Arts and Crafts Movement to life and delivers a cautionary tale of the highest order. This is accomplished by crafting a mirror image of the world in which the author lived, reimagining its social and industrial history. A …

The Universal Roar: Walt Whitman, John Muir, And The Song Of The Cosmos, Jason Balserait

Master of Liberal Studies Theses

The idea of an ancient harmony uniting the universe has been theorized since the ancient Pythagoreans got the idea of musica universalis, often translated as The Music of the Spheres. John Muir, founder of the Sierra Club, not only recognizes similar musical patterns in the wilderness but emphasizes how they bring a sense of balance his life. Walt Whitman, often coined America’s poet, uses the harmonies resonating throughout the natural and urban worlds to demonstrate unity throughout the cosmos. Similarly, Aldo Leopold revolutionized our understanding of ecology, as he wrote about reciprocity and the connection of all things to the …

Cutting Out Worry: Popularizing Psychosurgery In America, Antonietta Louise Iannaccone

Scripps Senior Theses

We think of the lobotomy as utterly primitive and brutal; we shudder at the idea of it. The archetypal image of creepiness, violence, and unnecessary brutality was expressed in the book and movie One Flew Over the Cuckoo’s Nest. This procedure weighs heavy on America’s conscience but in 1945 the procedure was characterized as being as gentle as ‘cutting through butter’ and the therapeutic effect was described as ‘cutting out worry’. How did the lobotomy gain such widespread acceptance? One part of the answer is that Walter Freeman advocated for it not just among his colleagues, but through the popular …

Annie Proulx's Wyoming: Subversive Storytelling From The Bunchgrass Edge Of The World, Elizabeth P. Tyson

Scripps Senior Theses

Annie Proulx’s three Wyoming short story collections, Close Range, Bad Dirt, and Fine Just the Way It Is, tell regional stories that push against the myths surrounding the American West. Elements of Naturalism in her work reverse the paradigm of man’s dominance over the frontier. The cyclical nature of time in her stories shows the unfulfilling nature of nostalgia. She uses folk storytelling techniques to take an insider’s perspective and to utilize the subversive nature of dark humor.

On Dittmer's Popular Culture, Geopolitics, And Identity As A Classroom Resource, Reecia Orzeck, James Craine, Christina E. Dando, Katrinka Somdahl-Sands

Geography and Geology Faculty Publications

In this intervention, four geographers, all of whom have used Jason Dittmer's book, Popular Culture, Geopolitics, and Identity, in their classes, assess its status as a teaching resource. All have had considerable success using Dittmer's book, alongside other resources, to cultivate critical thinking and critical knowledge production in a wide range of classes.

Crafting, Community, And Collaboration: Reflections On The Ethnographic Sala Project At The Pukara Lithic Museum, Peru, Elizabeth A. Klarich

Anthropology: Faculty Publications

The Museo Lítico Pukara (Pukara Lithic Museum) is an archaeological site museum in the small highland town of Pucará in the northwestern Lake Titicaca Basin of Peru. Recently, an ethnographic sala (exhibition space) was developed and installed within the museum that focuses on local craft production and its role within the agro-pasto- ral economy, regional exchange systems, and other house- hold-level and community activities. The sala is the culmination of a decade-long effort by national and foreign archaeologists, anthropologists from the regional univer- sity and their students, the Peruvian Ministry of Culture, and the townspeople of Pucará. This article presents …

The Spillikin (Vol. 31), Valparaiso University

The Spillikin - The Christ College Newsletter

No abstract provided.

My "Very Idea" Of Rod - And Yours, Harry Arthurs

All Papers

Text of introductory address to symposium The Unbounded Level of the Mind: Rod Macdonald's Legal Imagination, held at McGill University's Faculty of Law, February 7-8, 2014. The author expresses his admiration and affection for Prof Maconald, taking as his clue something he says frequently and in various formulations: “The very idea of law [he says] must be autobiographical”. [Roderick A. Macdonald & Martha-Marie Kleinhans, "What is a Critical Legal Pluralism?" Canadian Journal of Law and Society , 12 (1997), 25-46, 46]. Quote: "If that’s true, then the “very idea” of Rod himself must be “autobiographical”. I’m therefore going to begin …