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Modulation Of Type-I Interferon Mediated Immune Response: A Novel Innate Immune Evasion Strategy Of Equine Herpesvirus 1, Sanjay Sarkar

Theses and Dissertations--Veterinary Science

Equine herpesvirus-1 (EHV-1) is one of the major viral pathogens causing respiratory disease, abortion, perinatal mortality and neurologic disease among horses resulting in significant economic losses to the equine industry. The virus can also remain latent in the horses and recrudesce at any time. Type-I interferons (IFNs) act as a first line of defense against many viral infections.

In this study we investigated the type-I IFN response against the neuropathogenic T953 strain of EHV-1 in equine endothelial cells (EECs). The results showed that after a transient induction of IFN-β mRNA as well as protein at an early time (3h) post …

Evaluation Of The Susceptibility And Humoral Immune Response Of Foals To Rhodococcus Equi Infection, Macarena G. Sanz

Theses and Dissertations--Veterinary Science

While Rhodococcus equi (R. equi) remains the most common cause of subacute or chronic granulomatous bronchopneumonia in foals, development of a relevant model to study this bacterium has proven difficult. As a result, the reasons for the underlying foal’s susceptibility to this disease are not well understood. Furthermore, data regarding the immune response of foals to R. equi infection remains controversial. We hypothesized that foals are susceptible to R. equi early in life and that this susceptibility decreases with age. Also, we hypothesized that specific subclasses of IgG antibodies to the virulence-associated protein of R. equi, VapA, …

Anti-Müllerian Hormone In Stallions And Mares: Physiological Variations, Clinical Applications, And Molecular Aspects, Anthony N.J. Claes

Theses and Dissertations--Veterinary Science

Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein that is best known for its role in regression of the Müllerian duct in the male fetus. Accumulating evidence indicates that AMH also has an important role during different physiological processes after birth. In contrast to other species, relatively little is known about AMH in the horse. In chapter one, developmental and seasonal changes in serum AMH concentrations in male horses were determined, and the use of AMH for determination of retained cryptorchid testes was established. In chapter two, the interrelationship between plasma AMH concentrations, antral follicle counts (AFC), and age in mares …

Role Of Viral And Host Factors In Influenza Virus Mediated Inhibition Of Interleukin-23, Ashish Tiwari

Theses and Dissertations--Veterinary Science

Influenza virus is one of the major respiratory pathogens of humans as well as animals, including equines. There is an increasing evidence that bacterial infections are the most common cause of the death during influenza. In horses also, secondary bacterial pneumonia can lead to death, and surviving horses may take up to six months for the complete recovery resulting in heavy economic loss to the equine industry. Interleukin (IL)-23 mediated innate immune response has been shown to protect the host from various respiratory bacterial infections. However, studies to investigate the role of host and viral factors in the regulation of …

Examination Of The Snsag Surface Antigen Gene Family In Sarcocystis Neurona, Ablesh Gautam

Theses and Dissertations--Veterinary Science

Sarcocystis neurona is a protozoan parasite that causes the serious neurologic disease equine protozoal myeloencephalitis (EPM). The life cycle of S. neurona progresses through multiple developmental stages that differ morphologically and molecularly. The S. neurona merozoite surface is covered by multiple related proteins, which are orthologous to the surface antigen (SAG) gene family of Toxoplasma gondii. The SAG surface antigens in T. gondii and another related parasite Neospora caninum are life cycle stage-specific and seem necessary for parasite transmission and persistence of infection. The present research was conducted to explore the gene family of SnSAGs in S. …

Studies On Equine Placentitis, Igor Frederico Canisso

Theses and Dissertations--Veterinary Science

Two types of placentitis were studied: ascending and nocardioform placentitis. Although the first diagnosis of nocardioform placentitis was made three decades ago, little is known about the disease, due to the lack of an experimental model. In attempt to develop a research model, Crossiela equi was inoculated through intrauterine, intravenous, intrapharyngeal, and oral routes, but none of the routes resulted in nocardioform placentitis. This may indicate that unidentified factors may play a role in disease pathogenesis and that simple presence of bacteria is not sufficient to induce nocardioform placentitis. The second and major component of this dissertation involved the identification …

Changing Litter Resources Associated With Hemlock Woolly Adelgid Invasion Affect Benthic Communities In Headwater Streams, Christopher J. Strohm

Theses and Dissertations--Entomology

Hemlock woolly adelgid is an invasive herbivore causing extensive mortality of eastern hemlock, an important foundation species that provides stable conditions influencing biological communities. Hemlock is often found in riparian areas and following its decline, broadleaved species, including birch, beech, and rhododendron, will replace it. These plants differ from hemlock in patterns of canopy cover and leaf properties, which influence conditions and resources within streams.

My goal was to evaluate potential impacts of adelgid-induced alterations to riparian canopies and litter on benthic communities and litter breakdown in streams. I characterized benthic invertebrate communities, litter colonization and litter breakdown in streams …

Exploring The Links Between Seasonal Variation And Spider Foraging, Thomas Edward Dantas Whitney

Theses and Dissertations--Entomology

According to optimal foraging theory, generalist predators, such as spiders, are thought to feed indiscriminately on prey according to its availability, especially when food is scarce. In contrast, generalists can display selective feeding decisions under regimes of high prey abundance, but few studies have tracked changes in prey choice on a seasonal basis under open field conditions. Additionally, adaptations to surviving winter have been largely ignored in the research of foraging behavior. To elucidate this, I monitored prey availability and collected common forest-dwelling wolf spiders for molecular gut-content analysis, in parallel for 18 months, to assess the temporal changes occurring …

Exploring The Relationship Between Emotional Brain Training, Stress, Depression, Food Addiction, And Weight, Bailey Regina Adams

Theses and Dissertations--Nutrition and Food Systems

Obesity is a complex issue; stress, depression, and food addiction, are several psychological conditions that can accompany an obesity diagnosis. Emotional Brain Training (EBT) was evaluated as a new approach to these conditions. Stress, depression, food addiction, and weight were assessed at baseline, after a seven week active intervention, and after a seven week no contact period. The final sample consisted of 26 obese adults. At seven week assessments, EBT participants experienced significant weight loss (p-value = 0.05) and decreased perceived stress (p-value = 0.035). Food addiction also decreased from 50% to 8.3% (or one participant). At fourteen week assessments, …

Testing A Brief Treatment To Reduce The Frequency Of Panic Attacks In A Clinical Outpatient Population, Benjamin N. Daniels

PCOM Psychology Dissertations

Panic attacks, the key symptom of panic disorder and an associated feature of various anxiety disorders, are extremely distressing events that can negatively impact an individual’s mental health, physical health, and quality of life. This study validated a brief treatment for panic attacks, designed to reduce the frequency of panic attacks after the first session, in an outpatient clinical population. One participant was recruited to participate in this single case experimental ABA design with follow-up, where a reversal was not expected, due to the maintenance of positive effects. The treatment included both cognitive and behavioral techniques. The results were analyzed …

Digital Surveying Methodologies: A Study On And Off Campus In San Luis Obispo, Jared Sammet

City and Regional Planning

No abstract provided.

Morality In A Box, Aaron Ash

Student Works

No abstract provided.

Leads Continued Use In Avgas, Pasquale J. Storino

Student Works

No abstract provided.

Clinical Trials In Developing Countries, Michael William Jacobson

Student Works

No abstract provided.

“Ubuntu”: Market Forces And Sustainable Development In South Africa, Elizabeth A. Matecki

Student Works

No abstract provided.

The Dangerous "Waiting Game" Caused By The Failure To Recognize Animal Abuse In The Formal Definition Of Domestic Violence, Jessica Kalafut

Student Works

No abstract provided.

Environmental Regulation, Michelle C. Pautz

Political Science Faculty Publications

The terms environment and regulation are commonplace in political and policy debates about the natural environment, the role of science, and the behavior of government. Indeed, these terms reference a very contentious area of public policy and are emblematic of the growing tensions between science and politics. This chapter overviews the definition, types, and history of environmental regulation before turning to the intersection of science and politics in environmental policy and considering current and future challenges for this aspect of governmental activity.

Joseph Margolis, Aili W. Bresnahan

Philosophy Faculty Publications

Margolis’s methodology is best located in the pragmatic tradition, broadly construed. His pragmatism lies in his commitment to understanding the world as part of collective and consensual human practice and situated interaction; his embracing of the changing nature of history and science; and his approach to human knowledge as constructed.

In particular this pragmatic bent is evidenced by his affinity for Charles Sanders Peirce’s semeiotics, by which thought shows us the real world through the interpretation of signs and symbols, the existence of mind legitimated as “objective” and “real.” Margolis also uses Peirce’s theory of predicative generals (as constructed but …

Science Classics, Mark Masthay

Chemistry Faculty Publications

An essay on the impact of the works in the Imprints and Impressions: Milestones in Human Progress, an exhibition of rare books from the collection of Stuart Rose. Exhibition was held Sept. 29-Nov. 9, 2014, at the University of Dayton.

The Effects Of Narrative And Achievements On Learning In A 2d Platformer Video Game, Joseph Fanfarelli

Electronic Theses and Dissertations

Game design is a rigorous practice rife with complexity. The design of learning games is similarly complex to the design of their entertainment-based relatives. This complexity is partially due to the many interacting components that comprise games. The impacts of these individual components are not well understood. Advancing the understanding of how such component parts contribute to the formed game will inform decisions related to their inclusion and subsequent design within games. Achievements and narrative are two such components. They have been examined within gamified systems, but little research has studied them within the context of a serious game. The …

Practical Issues In Gpram Development, Yin Li

Electronic Theses and Dissertations

In this thesis, two parts of practical issues in the GPRAM system design are included. The first part is the coding part. The sum-product decoding algorithm of LDPC codes has been refined to fit for the GPRAM hardware implementation. As we all know, communication channel has noise. The noise in telecom system is different from that in GPRAM systems. So the noise should be handled well in the GPRAM design. A noise look-up table was created for FPGA and those noises in the table are quantized. The second part of the thesis is to convert perfect images in video stream …

The Effects Of Bam As An Adsorptive Media On Phosphorus Removal In Stormwater, Sultan Salamah

Electronic Theses and Dissertations

To maintain the quality of receiving water bodies, it is desirable to remove total phosphorus (TP) in stormwater runoff. Many media filtration technologies have been developed to achieve TP and soluble reactive phosphorus (SRP) removal. Efficient media adsorption is essential to insure control of stormwater phosphorus inputs to the receiving water body. This project develops and analyzes a functionalized Biosorption Media (BAM) to remove phosphorus species from stormwater runoff. One goal of this project is to find the BAM values for coefficients such as maximum adsorption capacity (QM: 4.35E-05) for the media through SRP isotherm equilibrium experiments using the Langmuir …

Dishwashing Water Recycling System And Related Water Quality Standards For Military Use, Jared Church

Electronic Theses and Dissertations

As the demand for reliable and safe water supplies increases, both water quality and available quantity are being challenged by population growth and climate change. Greywater reuse is becoming a common practice worldwide; however, in remote locations of limited water supply, such as those encountered in military installations, it is desirable to expand its classification to include dishwashing water to maximize the conservation of fresh water. Given that no standards for dishwashing greywater reuse by the military are currently available, the current study determined a specific set of water quality standards for dishwater recycling systems for U.S military field operations. …

Instructional Strategies For Scenario-Based Training Of Human Behavior Cue Analysis With Robot-Aided Intelligence, Surveillance, Reconnaissance, Julie Salcedo

Electronic Theses and Dissertations

The U.S. Army desires to improve safety during Intelligence, Surveillance, Reconnaissance (ISR) operations by removing Warfighters from direct line-of-fire by enhancing ISR operational capabilities with unmanned systems, also known as Robot-Aided ISR (RAISR) (DOD, 2013). Additionally, RAISR presents an opportunity to fulfill ISR capability requirements of modern combat environments including: detection of High-Value Individuals (HVI) from safer distances, identification of baseline behavior, and interpretation of adversarial intent (U.S. Army, 2008). Along with the demand and projected acquisition of RAISR technology, there is the added need to design training requirements for system operation and task execution instruction. While documentation identifying specific …

Automatic 3d Human Modeling: An Initial Stage Towards 2-Way Inside Interaction In Mixed Reality, Yiyan Xiong

Electronic Theses and Dissertations

3D human models play an important role in computer graphics applications from a wide range of domains, including education, entertainment, medical care simulation and military training. In many situations, we want the 3D model to have a visual appearance that matches that of a specific living person and to be able to be controlled by that person in a natural manner. Among other uses, this approach supports the notion of human surrogacy, where the virtual counterpart provides a remote presence for the human who controls the virtual character's behavior. In this dissertation, a human modeling pipeline is proposed for the …

Relationships Between Tests Of Visual Memory In Patients With Mild Cognitive Impairment And Alzheimer’S Disease, Guy Bernard Debros

Doctor of Psychology (PsyD)

Alzheimer’s disease (AD) is a degenerative neurological disorder characterized by cognitive and functional impairment (Budson & Solomon, 2011). Its prevalence is expected to rise in the upcoming decades as the world’s population ages (Alzheimer’s Association, 2014). Amnestic mild cognitive impairment (MCI) is a clinical diagnostic entity that may represent very early AD (Morris et al., 2001). Both disorders involve significant impairment in episodic memory, necessitating reliable memory measures when making diagnoses. Although verbal memory is most often impaired in the earliest stages of disease (Budson & Price, 2005), visual memory is also predictor of AD (Kawas et al., 2003). Partly …

Exploring Sparsity, Self-Similarity, And Low Rank Approximation In Action Recognition, Motion Retrieval, And Action Spotting, Chuan Sun

Electronic Theses and Dissertations

This thesis consists of 4 major parts. In the first part (Chapters 1-2), we introduce the overview, motivation, and contribution of our works, and extensively survey the current literature for 6 related topics. In the second part (Chapters 3-7), we explore the concept of "Self-Similarity" in two challenging scenarios, namely, the Action Recognition and the Motion Retrieval. We build three-dimensional volume representations for both scenarios, and devise effective techniques that can produce compact representations encoding the internal dynamics of data. In the third part (Chapter 8), we explore the challenging action spotting problem, and propose a feature-independent unsupervised framework that …

Municipal Identity As Property, Christopher J. Tyson

Dickinson Law Review (1908-2003)

Detroit is bankrupt, and very little of the theorizing and editorializing about this watershed event has contemplated municipal boundary law as a contributing factor. To the extent that it has, the analysis fails to grasp how essential municipal boundaries are to the creation of economic and social value in the modem metropolis. It has been almost 20 years since Richard Briffault, Gerald Frug, and Richard Ford released their path-breaking scholarship on the municipal boundary problem, yet metropolitan regions continue to fragment in much the same way Detroit did throughout the twentieth century.

The persistent fragmentation evident in many metropolitan areas …

The Tower Hill Collection And Other Stories, Anna Voisard

Dissertations and Theses

No abstract provided.

Does The Logic Of Collective Action Explain Federalism Doctrine?, Aziz Huq

Public Law and Legal Theory Working Papers

Recent federalism scholarship has taken a “collective action” turn. Commentators endorse or criticize the Court’s doctrinal tools for allocating regulatory authority between the states and the federal government by invoking an economic model of collective