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Town Of New London, New Hampshire Annual Reports Of The Town Officers, Boards, And Other Agencies For The Year Ending December 31, 2013., New London Town Representatives
Town Of New London, New Hampshire Annual Reports Of The Town Officers, Boards, And Other Agencies For The Year Ending December 31, 2013., New London Town Representatives
New London, NH Annual Reports
This is an annual report containing vital statistics for a town/city in the state of New Hampshire.
Annual Reports Of The Town Of Greenland, New Hampshire For The Fiscal Year Ending December 31, 2013 As Compiled By The Town Officers., Greenland Town Representatives
Annual Reports Of The Town Of Greenland, New Hampshire For The Fiscal Year Ending December 31, 2013 As Compiled By The Town Officers., Greenland Town Representatives
Greenland, NH Annual Reports
This is an annual report containing vital statistics for a town/city in the state of New Hampshire.
Annual Report Of The Town Officers Of The Town Of Jefferson, Nh For The Year Ending December 31, 2013., Jefferson Town Representatives
Annual Report Of The Town Officers Of The Town Of Jefferson, Nh For The Year Ending December 31, 2013., Jefferson Town Representatives
Jefferson, NH Annual Reports
This is an annual report containing vital statistics for a town/city in the state of New Hampshire.
Town Of Plainfield, New Hampshire Annual Reports 2013. Annual Reports Of The Officers And Selectmen And The School District., Plainfield Town Representatives
Town Of Plainfield, New Hampshire Annual Reports 2013. Annual Reports Of The Officers And Selectmen And The School District., Plainfield Town Representatives
Plainfield, NH Annual Reports
This is an annual report containing vital statistics for a town/city in the state of New Hampshire.
Annual Reports Town Of Wakefield, New Hampshire For The Fiscal Year Ending December 31, 2013 Vital Statistics For 2013., Wakefield Town Representatives
Annual Reports Town Of Wakefield, New Hampshire For The Fiscal Year Ending December 31, 2013 Vital Statistics For 2013., Wakefield Town Representatives
Wakefield, NH Annual Reports
This is an annual report containing vital statistics for a town/city in the state of New Hampshire.
A Holistic Aboriginal Framework For Individual Healing, Gus Hill
A Holistic Aboriginal Framework For Individual Healing, Gus Hill
Lyle S. Hallman Social Work Faculty Publications
This paper offers up an holistic Indigenous model of individual healing that utilizes medicine wheel teachings to break down the four aspects (spiritual, emotional, physical, and mental) of individual wellness. Teachings about each direction are presented followed by practice techniques for each aspect of the individual self. It is bookended by an introduction to the historical trauma faced by Indigenous peoples in Canada, and a conclusion that draws implications for healing.
Yemen Between Revolution And Counter-Terrorism, Sheila Carapico
Yemen Between Revolution And Counter-Terrorism, Sheila Carapico
Political Science Faculty Publications
This chapter juxtaposes these seemingly two quite different storylines - one about Yemeni aspirations for social justice and better governance and the other about American and Saudi operations undertaken in the name of combating terrorism. The so-called GCC Initiative, and in particular the National Dialogue Conference process playing out as this book goes to press, provides the link between them. From the perspective of domestic politics, the Dialogue can be read as the outcome of agitation by the new generation of 'peaceful youth', as well as an outgrowth of Yemen's tradition of dialogue - an historic effort to resolve crisis …
Bringing A World Of Light To Technology And Judicial Ethics, David Hricik
Bringing A World Of Light To Technology And Judicial Ethics, David Hricik
Articles
The Luddites thought that by smashing machines in early 19th Century England, they could eliminate the threat that those machines presented to them. Of course, they were wrong. As was the case during the Luddites’ time, technology continues to march inexorably onward in today’s society. As a result, those within the legal community—judges in particular—have no choice but to begin using technology. Although judges are currently using technology, they sometimes do so without understanding what they are doing.
Already, today’s “new-fangled” contraptions have ensnared judges. Perhaps the most widely known example is Judge Kozinski of the United States Court of …
Increasing Use Of “Negotiated” Instruments Of European Competition Law Enforcement Towards Foreign Companies, Ewelina D. Sage
Increasing Use Of “Negotiated” Instruments Of European Competition Law Enforcement Towards Foreign Companies, Ewelina D. Sage
Yearbook of Antitrust and Regulatory Studies
This paper considers the increasing use of “negotiated” instruments of European competition law (ECL) enforcement as illustrated by the European Commission’s (EC) enforcement practice directed at firms of American and East Asian origin. The paper first defines the notion of “negotiated” instruments of ECL enforcement as a non-confrontational enforcement method that centres on the existence of a public-private dialogue and mutual will to solve the contested issue, which in turn facilitate mutual benefits in enforcement outcomes (e.g. faster market improvements v. no fines). Three key “negotiated” instruments of ECL enforcement are presented next: conditional merger clearances, commitments decisions, as well …
A Paradox In Development: Exploring The Obesity Pandemic In Latin America, Laila G. Heid
A Paradox In Development: Exploring The Obesity Pandemic In Latin America, Laila G. Heid
CMC Senior Theses
The purpose of this paper is to explain the obesity pandemic in Latin America and identify the factors of development contributing to the pandemic. The paper uses the framework of the nutrition transition as presented by Barry Popkin to trace consumption patterns and changes in dietary habits in the region. The paper looks at three case studies: Mexico and Chile, two countries with high obesity rates, and Peru, the country with the lowest obesity rate in South America. This comparative framework is intended to determine which conditions are necessary for obesity, which conditions are sufficient for obesity, and any conditions …
El Sacrificio, La Perfección, Y El Aislamiento: La Imagen De La Madre Española En El Contexto Socio-Histórico Y Literario, Samantha E. Morse
El Sacrificio, La Perfección, Y El Aislamiento: La Imagen De La Madre Española En El Contexto Socio-Histórico Y Literario, Samantha E. Morse
Pitzer Senior Theses
La siguiente investigación explora las representaciones de la mujer-madre en el contexto español a través de la historia del siglo XX y XI. Usa “La niña sin alas” de Paloma Díaz-Mas, “Al colegio” de Josefina Rodríguez Aldecoa, y “Espejismos” de Josefina Rodríguez Aldecoa – tres cuentos de la antología Madres e hijas de Laura Freixas – para analizar tres temas particulares que relatan a la situación de la mujer-madre: el espíritu del sacrificio, el perfeccionismo, y el aislamiento. La investigación concluye con una evaluación de los cuentos como “obras femeninas.” Intenta de enseñar el valor de estos cuentos por sus …
Funny Pages: Comic Strips And The American Family, 1930-1960, Dahnya Nicole Hernandez
Funny Pages: Comic Strips And The American Family, 1930-1960, Dahnya Nicole Hernandez
Pitzer Senior Theses
This thesis examines a selection of American newspaper comic strips from approximately 1930 to 1960. At the height of their runs, many strips appeared in upwards of a thousand newspapers in the United States alone, and syndicates crafted and adjusted the content of these strips according to their image of the average American. This work discusses the pop cultural significance of these strips as well as the traditional American values revealed through each of them. Three strips in particular are the focal point for this thesis: Blondie, created by Chic Young in 1930, Little Orphan Annie created by …
Chronic Exposure To A Low Dose Of Ingested Petroleum Disrupts Corticosterone Receptor Signalling In A Tissue-Specific Manner In The House Sparrow (Passer Domesticus), Christine R. Lattin, L. Michael Romero
Chronic Exposure To A Low Dose Of Ingested Petroleum Disrupts Corticosterone Receptor Signalling In A Tissue-Specific Manner In The House Sparrow (Passer Domesticus), Christine R. Lattin, L. Michael Romero
Faculty Publications
© The Author 2014. Stress-induced concentrations of glucocorticoid hormones (including corticosterone, CORT) can be suppressed by chronic exposure to a low dose of ingested petroleum. However, endocrine-disrupting chemicals could interfere with CORT signalling beyond the disruption of hormone titres, including effects on receptors in different target tissues. In this study, we examined the effects of 6 weeks of exposure to a petroleum-laced diet (1% oil weight:food weight) on tissue mass and intracellular CORT receptors in liver, fat, muscle and kidney (metabolic tissues), spleen (an immune tissue) and testes (a reproductive tissue). In the laboratory, male house sparrows were fed either …
Natural Selection Canalizes Expression Variation Of Environmentally Induced Plasticity-Enabling Genes, Joseph R. Shaw, Thomas H. Hampton, Benjamin L. King, Andrew Whitehead, Fernando Galvez, Robert H. Gross, Nathan Keith, Emily Notch, Dawoon Jung, Stephen P. Glaholt, Celia Y. Chen, John K. Colbourne, Bruce A. Stanton
Natural Selection Canalizes Expression Variation Of Environmentally Induced Plasticity-Enabling Genes, Joseph R. Shaw, Thomas H. Hampton, Benjamin L. King, Andrew Whitehead, Fernando Galvez, Robert H. Gross, Nathan Keith, Emily Notch, Dawoon Jung, Stephen P. Glaholt, Celia Y. Chen, John K. Colbourne, Bruce A. Stanton
Faculty Publications
© 2014 The Author. Many organisms survive fluctuating and extreme environmental conditions by manifesting multiple distinct phenotypes during adulthood by means of developmental processes that enable phenotypic plasticity. We report on the discovery of putative plasticity-enabling genes that are involved in transforming the gill of the euryhaline teleost fish, Fundulus heteroclitus, from its freshwater to its seawater gill-type, a process that alters both morphology and function. Gene expression that normally enables osmotic plasticity is inhibited by arsenic. Gene sets defined by antagonistic interactions between arsenic and salinity show reduced transcriptional variation among individual fish, suggesting unusually accurate and precise regulatory …
Combustion By-Products And Their Health Effects - Combustion Engineering And Global Health In The 21st Century: Issues And Challenges, Slawo Lomnicki, Brian Gullett, Tobias Stöger, Ian Kennedy, Jim Diaz, Tammy R. Dugas, Kurt Varner, Danielle J. Carlin, Barry Dellinger, Stephania A. Cormier
Combustion By-Products And Their Health Effects - Combustion Engineering And Global Health In The 21st Century: Issues And Challenges, Slawo Lomnicki, Brian Gullett, Tobias Stöger, Ian Kennedy, Jim Diaz, Tammy R. Dugas, Kurt Varner, Danielle J. Carlin, Barry Dellinger, Stephania A. Cormier
Faculty Publications
The 13th International Congress on Combustion By-Products and their Health Effects was held in New Orleans, Louisiana from May 15 to 18, 2013. The congress, sponsored by the Superfund Research Program, National Institute of Environmental Health Sciences, and National Science Foundation, brought together international academic and government researchers, engineers, scientists, and policymakers. With industrial growth, increased power needs and generation and coal consumption and their concomitant emissions, pernicious health effects associated with exposures to these emissions are on the rise. This congress provides a unique platform for interdisciplinary exchange and discussion of these topics. The formation, conversion, control, and health …
Limited Type I Interferons And Plasmacytoid Dendritic Cells During Neonatal Respiratory Syncytial Virus Infection Permit Immunopathogenesis Upon Reinfection, Stephania A. Cormier, Bishwas Shrestha, Jordy Saravia, Greg I. Lee, Li Shen, John P. Devincenzo, Young In Kim, Dahui You
Limited Type I Interferons And Plasmacytoid Dendritic Cells During Neonatal Respiratory Syncytial Virus Infection Permit Immunopathogenesis Upon Reinfection, Stephania A. Cormier, Bishwas Shrestha, Jordy Saravia, Greg I. Lee, Li Shen, John P. Devincenzo, Young In Kim, Dahui You
Faculty Publications
Respiratory syncytial virus (RSV) infection is the number one cause of bronchiolitis in infants, yet no vaccines are available because of a lack of knowledge of the infant immune system. Using a neonatal mouse model, we previously revealed that mice initially infected with RSV as neonates develop Th2-biased immunopathophysiologies during reinfection, and we demonstrated a role for enhanced interleukin-4 receptor α (IL-4Rα) expression on T helper cells in these responses. Here we show that RSV infection in neonates induced limited type I interferon (IFN) and plasmacytoid dendritic cell (pDC) responses. IFN alpha (IFN-α) treatment or adoptive transfer of adult pDCs …
Deficiency Of The Two-Pore-Domain Potassium Channel Trek-1 Promotes Hyperoxia-Induced Lung Injury, Andreas Schwingshackl, Bin Teng, Patrudu Makena, Manik Ghosh, Scott E. Sinclair, Charlean Luellen, Louisa Balasz, Cynthia Rovnaghi, Robert M. Bryan, Eric E. Lloyd, Elizabeth Fitzpatrick, Jordy S. Saravia, Stephania A. Cormier, Christopher M. Waters
Deficiency Of The Two-Pore-Domain Potassium Channel Trek-1 Promotes Hyperoxia-Induced Lung Injury, Andreas Schwingshackl, Bin Teng, Patrudu Makena, Manik Ghosh, Scott E. Sinclair, Charlean Luellen, Louisa Balasz, Cynthia Rovnaghi, Robert M. Bryan, Eric E. Lloyd, Elizabeth Fitzpatrick, Jordy S. Saravia, Stephania A. Cormier, Christopher M. Waters
Faculty Publications
Copyright © 2014 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins. Objectives: We previously reported the expression of the twoporedomain K+ channel TREK-1 in lung epithelial cells and proposed a role for this channel in the regulation of alveolar epithelial cytokine secretion. In this study, we focused on investigating the role of TREK-1 in vivo in the development of hyperoxia-induced lung injury. Design: Laboratory animal experiments. Setting: University research laboratory. Subjects: Wild-type and TREK-1-deficient mice. Interventions: Mice were anesthetized and exposed to 1) room air, no mechanical ventilation, 2) 95% hyperoxia for 24 hours, and 3) …
Response Of Native Insect Communities To Invasive Plants, T. Martijn Bezemer, Jeffrey A. Harvey, James T. Cronin
Response Of Native Insect Communities To Invasive Plants, T. Martijn Bezemer, Jeffrey A. Harvey, James T. Cronin
Faculty Publications
Invasive plants can disrupt a range of trophic interactions in native communities. As a novel resource they can affect the performance of native insect herbivores and their natural enemies such as parasitoids and predators, and this can lead to host shifts of these herbivores and natural enemies. Through the release of volatile compounds, and by changing the chemical complexity of the habitat, invasive plants can also affect the behavior of native insects such as herbivores, parasitoids, and pollinators. Studies that compare insects on related native and invasive plants in invaded habitats show that the abundance of insect herbivores is often …
Relative Importance Of Host Environment, Transmission Potential And Host Phylogeny To The Structure Of Parasite Metacommunities, Tad Dallas, Steven J. Presley
Relative Importance Of Host Environment, Transmission Potential And Host Phylogeny To The Structure Of Parasite Metacommunities, Tad Dallas, Steven J. Presley
Faculty Publications
Identification of mechanisms that shape parasite community and metacommunity structures have important implications to host health, disease transmission, and the understanding of community assembly in general. Using a long-term dataset on parasites from desert rodents, we examined the relative contributions of host traits that represent important aspects of parasite environment, transmission probability between host species, and host phylogeny to the structure of a parasite metacommunity as well as for taxonomically restricted parasite metacommunities (coccidians, ectoparasites and helminths). This was done using a combination of metacommunity analysis and variance partitioning based on canonical correspondence analysis. Coccidian and ectoparasite metacommunities did not …
Nitrate Enrichment Alters A Daphnia-Microparasite Interaction Through Multiple Pathways, Tad Dallas, John M. Drake
Nitrate Enrichment Alters A Daphnia-Microparasite Interaction Through Multiple Pathways, Tad Dallas, John M. Drake
Faculty Publications
© 2013 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. Nutrient pollution has the potential to alter many ecological interactions, including host-parasite relationships. One of the largest sources of nutrient pollution comes from anthropogenic alteration of the nitrogen (N) cycle, specifically the increased rate of nitrate (NO3 -N) deposition to aquatic environments, potentially altering host-parasite relationships. This study aimed to assess the mechanisms through which nitrate may impact host-pathogen relationships using a fungal pathogen (Metschnikowia bicuspidata) parasitic to crustacean zooplankton (Daphnia dentifera) as a tractable model system. First, the influence of nitrate on host population dynamics …
Sexual Differences Of Imprinted Genes' Expression Levels, Mohammad Faisal, Hana Kim, Joomyeong Kim
Sexual Differences Of Imprinted Genes' Expression Levels, Mohammad Faisal, Hana Kim, Joomyeong Kim
Faculty Publications
In mammals, genomic imprinting has evolved as a dosage-controlling mechanism for a subset of genes that play critical roles in their unusual reproduction scheme involving viviparity and placentation. As such, many imprinted genes are highly expressed in sex-specific reproductive organs. In the current study, we sought to test whether imprinted genes are differentially expressed between the two sexes. According to the results, the expression levels of the following genes differ between the two sexes of mice: Peg3, Zim1, Igf2, H19 and Zac1. The expression levels of these imprinted genes are usually greater in males than in females. This bias is …
Urban Microbiomes And Urban Ecology: How Do Microbes In The Built Environment Affect Human Sustainability In Cities?, Gary M. King
Urban Microbiomes And Urban Ecology: How Do Microbes In The Built Environment Affect Human Sustainability In Cities?, Gary M. King
Faculty Publications
© 2014, The Microbiological Society of Korea and Springer-Verlag Berlin Heidelberg. Humans increasingly occupy cities. Globally, about 50% of the total human population lives in urban environments, and in spite of some trends for deurbanization, the transition from rural to urban life is expected to accelerate in the future, especially in developing nations and regions. The Republic of Korea, for example, has witnessed a dramatic rise in its urban population, which now accounts for nearly 90% of all residents; the increase from about 29% in 1955 has been attributed to multiple factors, but has clearly been driven by extraordinary growth …
Genetic Species Delineation Among Branching Caribbean Porites Corals, C. Prada, M. B. De Biasse, J. E. Neigel, B. Yednock, J. L. Stake, Z. H. Forsman, I. B. Baums, M. E. Hellberg
Genetic Species Delineation Among Branching Caribbean Porites Corals, C. Prada, M. B. De Biasse, J. E. Neigel, B. Yednock, J. L. Stake, Z. H. Forsman, I. B. Baums, M. E. Hellberg
Faculty Publications
© 2014, Springer-Verlag Berlin Heidelberg. Coral species are difficult to discern because of their morphological plasticity, long generation times, and slow rates of mitochondrial DNA evolution. Among Caribbean representatives of the genus Porites are three named species (P. divaricata, P. furcata, and P. porites) with branching colony morphologies whose validity as genetically isolated species has been debated. We present sequence data from the mitochondrial control region, nuclear ITS, and nine single-copy nuclear loci for the Caribbean Porites and a related eastern Pacific species. mtDNA sequences were nearly invariant among the three branching species and their crustose sister P. branneri, and …
Optimized Inhibitors Of Soluble Epoxide Hydrolase Improve In Vitro Target Residence Time And In Vivo Efficacy, Kin Sing Stephen Lee, Jun Yan Liu, Karen M. Wagner, Svetlana Pakhomova, Hua Dong, Christophe Morisseau, Samuel H. Fu, Jun Yang, Peng Wang, Arzu Ulu, Christina A. Mate, Long V. Nguyen, Sung Hee Hwang, Matthew L. Edin, Alexandria A. Mara, Heike Wulff, Marcia E. Newcomer, Darryl C. Zeldin, Bruce D. Hammock
Optimized Inhibitors Of Soluble Epoxide Hydrolase Improve In Vitro Target Residence Time And In Vivo Efficacy, Kin Sing Stephen Lee, Jun Yan Liu, Karen M. Wagner, Svetlana Pakhomova, Hua Dong, Christophe Morisseau, Samuel H. Fu, Jun Yang, Peng Wang, Arzu Ulu, Christina A. Mate, Long V. Nguyen, Sung Hee Hwang, Matthew L. Edin, Alexandria A. Mara, Heike Wulff, Marcia E. Newcomer, Darryl C. Zeldin, Bruce D. Hammock
Faculty Publications
Diabetes is affecting the life of millions of people. A large proportion of diabetic patients suffer from severe complications such as neuropathic pain, and current treatments for these complications have deleterious side effects. Thus, alternate therapeutic strategies are needed. Recently, the elevation of epoxy-fatty acids through inhibition of soluble epoxide hydrolase (sEH) was shown to reduce diabetic neuropathic pain in rodents. In this report, we describe a series of newly synthesized sEH inhibitors with at least 5-fold higher potency and doubled residence time inside both the human and rodent sEH enzyme than previously reported inhibitors. These inhibitors also have better …
Phylogeny, Classification, And Fruit Evolution Of The Species-Rich Neotropical Bellflowers (Campanulaceae: Lobelioideae), Laura P. Lagomarsino, Alexandre Antonelli, Nathan Muchhala, Allan Timmermann, Sarah Mathews, Charles C. Davis
Phylogeny, Classification, And Fruit Evolution Of The Species-Rich Neotropical Bellflowers (Campanulaceae: Lobelioideae), Laura P. Lagomarsino, Alexandre Antonelli, Nathan Muchhala, Allan Timmermann, Sarah Mathews, Charles C. Davis
Faculty Publications
© 2014 Botanical Society of America. Premise of the study: The species-rich Neotropical genera Centropogon, Burmeistera, and Siphocampylus represent more than half of the ∼1200 species in the subfamily Lobelioideae (Campanulaceae). They exhibit remarkable morphological variation in floral morphology and habit. Limited taxon sampling and phylogenetic resolution, however, obscures our understanding of relationships between and within these genera and underscores our uncertainty of the systematic value of fruit type as a major diagnostic character.Methods: We inferred a phylogeny from five plastid DNA regions (rpl32-trnL, ndhF-rpl32, rps16-trnK, trnG-trnG-trns, rbcL) using maximum-likelihood and Bayesian inference. Ancestral character reconstructions were applied to infer …
Faculty Senate Newsletter, January 2014, Louisiana State University And Agricultural & Mechanical College
Faculty Senate Newsletter, January 2014, Louisiana State University And Agricultural & Mechanical College
LSU Faculty Senate Publications
Message from President: Throughout Louisiana and across several generations of administrators, it can easily be observed that an uptick in enthusiasm for student events and interactions inevitably precedes the end of a regime. When a president or chancellor begins appearing in student forums or develops a taste for dormitory chats, seasoned observers know that the end is near. Why? The correlation of concern for the budding youth with the end of the reigning generation points up what might be called the sometimes genial, sometimes tedious “childishness” of Louisiana higher education. Rather than calling for the political equivalent of extreme unction, …
Cad’S Cradle: Untangling Copyrightability, Derivative Works, And Fair Use In 3d Printing, Kyle Dolinsky
Cad’S Cradle: Untangling Copyrightability, Derivative Works, And Fair Use In 3d Printing, Kyle Dolinsky
Washington and Lee Law Review
No abstract provided.
African Arrivals And Transformations, Andrew Sluyter
African Arrivals And Transformations, Andrew Sluyter
Faculty Publications
No abstract provided.
Biodistribution Of Plga And Plga/Chitosan Nanoparticles After Repeat-Dose Oral Delivery In F344 Rats For 7 Days, Sara M. Navarro, Caleb Darensbourg, Linda Cross, Rhett Stout, Diana Coulon, Carlos E. Astete, Timothy Morgan, Cristina M. Sabliov
Biodistribution Of Plga And Plga/Chitosan Nanoparticles After Repeat-Dose Oral Delivery In F344 Rats For 7 Days, Sara M. Navarro, Caleb Darensbourg, Linda Cross, Rhett Stout, Diana Coulon, Carlos E. Astete, Timothy Morgan, Cristina M. Sabliov
Faculty Publications
© 2014 Future Science Ltd. Aim: To quantify in vivo the biodistribution of poly(lactic-co-glycolic) acid (PLGA) and PLGA/chitosan nanoparticles (PLGA/Chi NPs) and assess if the positive charge of chitosan significantly enhances nanoparticle absorption in the GI tract.Material & methods: PLGA and PLGA/Chi NPs covalently linked to tetramethylrhodamine-5-isothiocyanate (TRITC) were orally administered to F344 rats for 7 days, and the biodistribution of fluorescent NPs was analyzed in different organs.Results: The highest amount of particles (% total dose/g) was detected for both treatments in the spleen, followed by intestine and kidney, and then by liver, lung, heart and brain, with no significant …
Biodistribution Of Plga And Plga/Chitosan Nanoparticles After Repeat-Dose Oral Delivery In F344 Rats For 7 Days, Sara M. Navarro, Caleb Darensbourg, Linda Cross, Rhett Stout, Diana Coulon, Carlos E. Astete, Timothy Morgan, Cristina M. Sabliov
Biodistribution Of Plga And Plga/Chitosan Nanoparticles After Repeat-Dose Oral Delivery In F344 Rats For 7 Days, Sara M. Navarro, Caleb Darensbourg, Linda Cross, Rhett Stout, Diana Coulon, Carlos E. Astete, Timothy Morgan, Cristina M. Sabliov
Faculty Publications
© 2014 Future Science Ltd. Aim: To quantify in vivo the biodistribution of poly(lactic-co-glycolic) acid (PLGA) and PLGA/chitosan nanoparticles (PLGA/Chi NPs) and assess if the positive charge of chitosan significantly enhances nanoparticle absorption in the GI tract.Material & methods: PLGA and PLGA/Chi NPs covalently linked to tetramethylrhodamine-5-isothiocyanate (TRITC) were orally administered to F344 rats for 7 days, and the biodistribution of fluorescent NPs was analyzed in different organs.Results: The highest amount of particles (% total dose/g) was detected for both treatments in the spleen, followed by intestine and kidney, and then by liver, lung, heart and brain, with no significant …