Digital Commons Network^™

Luis And Lucy Contreras, Csusb

South Colton Oral History Project Collection

No abstract provided.

Conceptualizing Climate Justice In Kivalina, Marissa Knodel

Seattle University Law Review

Due to climate change, indigenous communities in Alaska are forced to develop in ways that adversely affect their livelihoods and culture. For example, decreases in sea ice, increases in the frequency of sea storms, and melting permafrost have so accelerated the erosion of one barrier island that an entire village faces relocation. These indigenous communities, which have contributed little to causing climate change, are limited in their ability to adapt. After examining three broad questions about the effects of climate change on indigenous communities, this Article reaches four preliminary conclusion about relocation as a climate adaptation strategy and its relations …

United States Policy And Norwegian Commercial Whaling: A Cooperative Approach, Jamie Nystrom

Seattle University Law Review

Both the United States and Norway have a long history of commercial whaling, but the mantle of dominance in the whaling world passed from the United States to Norway in the mid-nineteenth century. As demand for whale-based products declined in the United States over the past century, and environmentalism and conservationism became more popular public ideologies, the United States shifted from a pro-whaling nation to, effectively, an anti-whaling nation. Norway, however, has continued to be the only nation that openly engages in commercial whaling for profit, albeit on a smaller scale in comparison to historical practices. The United States’ past …

Senior Recital: Thomas Kieffer, Alto Saxophone And Tyler Elvidge, Trumpet, Thomas Kieffer, Tyler Elvidge, Judy Cole, Katie Riess, Brian Reid, Brandon Boone, Matthew Richards, Brandon Austin, David Anders, Michael Desousa, Kadeem Chambers

Bailey School of Music Concert Programs

This recital is presented in partial fulfillment of requirements for the degrees Bachelor of Music in Music Education. Mr. Kieffer studies saxophone with Sam Skelton. Mr. Elvidge studies trumpet with Douglas Lindsey.

Extracting More Than Resources: Human Security And Arctic Indigenous Women, Victoria Sweet

Seattle University Law Review

The circumpolar Arctic region is at the forefront of rapid change, and with change come potential threats to human security. Numerous factors determine what makes a state, a community, or an individual feel secure. For example, extractive industry development can bring economic benefits to an area, but these development projects also bring security concerns, including potential human rights violations. While security concerns connected with development projects have been studied in southern hemisphere countries and countries classified as “developing,” concerns connected with extractive industry development projects in “developed” countries like the United States have received little attention. This Article will change …

Oil And Gas In America's Arctic Ocean: Past Problems Counsel Precaution, Michael Levine, Peter Van Tuyn, Layla Hughes

Seattle University Law Review

This Article provides context for the controversy facing government agencies charged with making decisions about the future of America’s Arctic Ocean. It then distill themes that, if addressed, could help further a lasting solution for this region that respects its natural and human values while crafting a reasonable path forward for decisions about development. First, this Article offers background about the region, the threats facing it, and some of the challenges in managing the natural resources there. Second, it provides an overview of the legal framework through which the United States government makes decisions about whether and under what conditions …

Changes In Latitudes Call For Changes In Attitudes: Towards Recognition Of A Global Imperative For Stewardship, Not Exploitation, In The Arctic, Taylor Simpson-Wood

Seattle University Law Review

For more than two centuries, the imagination of mariners has been captured by visions of a trade route across the Arctic Sea allowing vessels to travel from the Atlantic to the Pacific Ocean. Known as the Northwest Passage, this fabled route is a time- and money-saving sea lane running from the Atlantic Ocean Arctic Circle to the Pacific Ocean Arctic Circle. Now, the thinning of the ice in the Arctic may transform what was once only a dream into a reality. New shipping lanes linking the Atlantic and Pacific oceans are likely to open between 2040 and 2059. If loss …

The ​Oestrogen Receptor Alpha-Regulated Lncrna ​Neat1 Is A Critical Modulator Of Prostate Cancer, Dimple Chakravarty, Andrea Sboner, Sujit S. Nair, Eugenia Giannopoulou, Ruohan Li, +16 Additional Authors

Biochemistry and Molecular Medicine Faculty Publications

The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR status. However, the role of ERα remains elusive. Using a combination of chromatin immunoprecipitation (ChIP) and RNA-sequencing data, we identified an ERα-specific non-coding transcriptome signature. Among putatively ERα-regulated intergenic long non-coding RNAs (lncRNAs), we identified nuclear enriched abundant transcript 1 (NEAT1) as the most significantly overexpressed lncRNA in prostate cancer. Analysis of two large clinical …

The Balloonist Dreams Of Flight, Latanya Mcqueen

Booth

...As a boy Henrik is given a book full of woodcut images that tell the story of Jean-François Pilâtre de Rozier, the world’s first balloonist. The book gives brief snippets of Rozier’s life, first describing the process he went through to create his first balloon, and it ends with him flying high in the air....

Academic Freedom And Tenure Committee Minutes, November 21, 2014, Utah State University

Academic Freedom and Tenure Committee

• Old Business
• New Business
• Other Items from Committees

Phlip-Fire, A Cell Insertion-Triggered Fluorescent Probe For Imaging Tumors Demonstrates Targeted Cargo Delivery In Vivo, Alexander G. Karabadzhak, Ming An, Lan Yao, Rachel Langenbacher, Anna Moshnikova, Ramona Cosmina Adochite, Oleg A. Andreev, Yana K. Reshetnyak, Donald M. Engelman

Physics Faculty Publications

We have developed an improved tool for imaging acidic tumors by reporting the insertion of a transmembrane helix: the pHLIP-Fluorescence Insertion REporter (pHLIP-FIRE). In acidic tissues, such as tumors, peptides in the pHLIP family insert as α-helices across cell membranes. The cell-inserting end of the pHLIP-FIRE peptide has a fluorophore-fluorophore or fluorophore-quencher pair. A pair member is released by disulfide cleavage after insertion into the reducing environment inside a cell, resulting in dequenching of the probe. Thus, the fluorescence of the pHLIP-FIRE probe is enhanced upon cell-insertion in the targeted tissues but is suppressed elsewhere due to quenching. Targeting studies …

Nucleoside Reverse Transcriptase Inhibitors Possess Intrinsic Anti-Inflammatory Activity, Benjamin J. Fowler, Bradley D. Gelfand, Younghee Kim, Nagaraj Kerur, Valeria Tarallo, Yoshio Hirano, Shoba Amarnath, Daniel H. Fowler, Marta Radwan, Mark T. Young, Keir Pittman, Paul Kubes, Hitesh Agarwal, Keykavous Parang, David R. Hinton, Ana Bastos-Carvalho, Shengjian Li, Testuhiro Yasuma, Takeshi Mizutani, Reo Yasuma, Charles Wright, Jayakrishna Ambati

Pharmacy Faculty Articles and Research

Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that block retrovirus replication. Alu (an endogenous retroelement that also requires reverse transcriptase for its life cycle)–derived RNAs activate P2X7 and the NLRP3 inflammasome to cause cell death of the retinal pigment epithelium in geographic atrophy, a type of age-related macular degeneration. We found that NRTIs inhibit P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition. Multiple approved and clinically relevant NRTIs prevented caspase-1 activation, the effector of the NLRP3 inflammasome, induced by Alu RNA. NRTIs were efficacious in mouse models of geographic atrophy, choroidal neovascularization, graft-versus-host disease, and sterile …

The Oestrogen Receptor Alpha-Regulated Lncrna Neat1 Is A Critical Modulator Of Prostate Cancer, Dimple Chakravarty, Andrea Sboner, Sujit S. Nair, Eugenia Giannopoulou, Ruohan Li, Sven Hennig, Juan Miguel Mosquera, Jonathan Pauwels, Kyung Park, Myriam Kossai, Theresa Y. Macdonald, Jacqueline Fontugne, Nicholas Erho, Ismael A. Vergara, Mercedeh Ghadessi, Elai Davicioni, Robert B. Jenkins, Nallasivam Palanisamy, Zhengming Chen, Shinichi Nakagawa, Tetsuro Hirose, Neil H. Bander, Himisha Beltran, Archa H. Fox, Olivier Elemento, Mark A. Rubin

Publications and Research

The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR status. However, the role of ERα remains elusive. Using a combination of chromatin immunoprecipitation (ChIP) and RNA-sequencing data, we identified an ERα-specific non-coding transcriptome signature. Among putatively ERα-regulated intergenic long non-coding RNAs (lncRNAs), we identified nuclear enriched abundant transcript 1 (NEAT1) as the most significantly overexpressed lncRNA in prostate cancer. Analysis of two large clinical …

Using Art To Teach Students Science Outdoors: How Creative Science Instruction Influences Observation, Question Formation, And Involvement, Christina Schull Cone

Dissertations and Theses

Elementary education has become increasingly divided into subjects and focused on the demand for high math and reading scores. Consequently, teachers spend less time devoted to science and art instruction. However, teaching art and science is crucial to developing creative and rational thinking, especially for observation and questioning skills. In this study, third grade students attending an urban school in Portland, Oregon received instruction of an art strategy using observational and quantifying drawing techniques. This study examines, "Will an art strategy observing the local environment help students make observations and ask questions?" and "In what ways are student learning and …

2014-November-21-Professor Receives Grand Challenges Explorations Grant, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

The New Hampshire, Vol. 104 [105], No. 20 (Nov. 21, 2014), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 104, but it is the 105th volume in the series. This was corrected in pencil.

Developing Gifts In-Kind Support For Nonprofit Organizations: Case Study On Pretty Lake Vacation Camp, Erin Denay

Honors Theses

Nonprofit organizations often rely on in-kind donations from individuals, businesses, and organizations to help support their mission. In-kind support includes donated goods or services rather than a monetary donation. This honor’s thesis is comprised of research and applied best practices in a case study on developing gift-in-kind support for local Kalamazoo nonprofit organization, Pretty Lake Vacation Camp. In coordination with Pretty Lake Development Staff, Farm Staff, and four local businesses and organizations, $305 worth of in-kind donations were donated in time for the 2014 summer camp season for use on the camp farm. Various fundraising strategies and techniques were used …

Role Of Host Micrornas In Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis, Zhiqiang Qin, Francesca Peruzzi, Krzysztof Reiss, Lu Dai

School of Medicine Faculty Publications

MicroRNAs (miRNAs) are small non-coding RNA species that can bind to both untranslated and coding regions of target mRNAs, causing their degradation or post-transcriptional modification. Currently, over 2500 miRNAs have been identified in the human genome. Burgeoning evidence suggests that dysregulation of human miRNAs can play a role in the pathogenesis of a variety of diseases, including cancer. In contrast, only a small subset of human miRNAs has been functionally validated in the pathogenesis of oncogenic viruses, in particular, Kaposi's sarcoma-associated herpesvirus (KSHV). KSHV is the etiologic agent of several human cancers, such as primary effusion lymphoma (PEL) and Kaposi's …

Lanthorn, Vol. 49, No. 27, November 20, 2014, Grand Valley State University

Volume 49, July 7, 2014 - June 1, 2015

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Biology Class Studies Different Effects Of Ebola Outbreak, Winthrop University

Winthrop News 2014

• Biology Professor Janice Chism said the Ebola case study has been a great opportunity to help the 19 freshman honor students to see how seemingly unrelated areas of biology, such as ecology, animal behavior, viral evolution, cell physiology and function, are connected.
• The students have studied topics including how the virus works, how the disease affects people, how it enters the human population, to ecological, social and political effects.

V. 82, Issue 9, November 20, 2014 [Publication Says Issue 8]

Archway (1946-2020)

No abstract provided.

Minutes, Arts & Sciences Faculty Meeting, Thursday, November 20, 2014, Arts & Sciences Faculty

The College of Liberal Arts Faculty Minutes

No abstract provided.

Population Genetics Of Seaside Sparrow (Ammodramus Maritimus) Subspecies Along The Gulf Of Mexico., Stefan Woltmann, Phillip C. Stouffer, Christine M. Bergeon Burns, Mark S. Woodrey, Mollie F. Cashner, Sabrina S. Taylor

CREC Publications

Seaside Sparrows (Ammodramus maritimus) along the Gulf of Mexico are currently recognized as four subspecies, including taxa in Florida (A. m. juncicola and A. m. peninsulae) and southern Texas (Ammodramus m. sennetti), plus a widespread taxon between them (A. m. fisheri). We examined population genetic structure of this "Gulf Coast" clade using microsatellite and mtDNA data. Results of Bayesian analyses (Structure, GeneLand) of microsatellite data from nine locations do not entirely align with current subspecific taxonomy. Ammodramus m. sennetti from southern Texas is significantly differentiated from all other populations, but we found evidence of an admixture zone with A. m. …

The Cedar Point Experience, 40 Years Of Field Based, Experiential Learning, Jon Garbisch

Discipline-Based Education Research Group Speaker Series

The Cedar Point Experience was born in the summer of 1975. At the urging of several biology faculty UNL leased the Goodall Cedar Point Girlscout Camp and offered a broad range of field based courses exploiting the local environment as their classroom. These instructors also had a strong interest in the area as a base for their own research. Today the UNL Cedar Point Biological Station with a few additional buildings can support around 100 people with full service dining, housing, classroom and lab space.

The instructional model has remained unchanged for the past 40 years. Field based or place …

The Drivers Of Tropical Speciation, Brian Tilston Smith, John E. Mccormack, Andrés M. Cuervo, Michael J. Hickerson, Alexandre Aleixo, Carlos Daniel Cadena, Jorge Pérez-Emán, Curtis W. Burney, Xiaoou Xie, Michael G. Harvey, Brant C. Faircloth, Travis C. Glenn, Elizabeth P. Derryberry, Jesse Prejean, Samantha Fields, Robb T. Brumfield

Faculty Publications

© 2014 Macmillan Publishers Limited. All rights reserved. Since the recognition that allopatric speciation can be induced by large-scale reconfigurations of the landscape that isolate formerly continuous populations, such as the separation of continents by plate tectonics, the uplift of mountains or the formation of large rivers, landscape change has been viewed as a primary driver of biological diversification. This process is referred to in biogeography as vicariance. In the most species-rich region of the world, the Neotropics, the sundering of populations associated with the Andean uplift is ascribed this principal role in speciation. An alternative model posits that rather …

Population Genetics Of Seaside Sparrow (Ammodramus Maritimus) Subspecies Along The Gulf Of Mexico, Stefan Woltmann, Philip C. Stouffer, Christine M.Bergeon Burns, Mark S. Woodrey, Mollie F. Cashner, Sabrina S. Taylor

Faculty Publications

Seaside Sparrows (Ammodramus maritimus) along the Gulf of Mexico are currently recognized as four subspecies, including taxa in Florida (A. m. juncicola and A. m. peninsulae) and southern Texas (Ammodramus m. sennetti), plus a widespread taxon between them (A. m. fisheri). We examined population genetic structure of this ''Gulf Coast'' clade using microsatellite and mtDNA data. Results of Bayesian analyses (STRUCTURE, GENELAND) of microsatellite data from nine locations do not entirely align with current subspecific taxonomy. Ammodramus m. sennetti from southern Texas is significantly differentiated from all other populations, but we found evidence of an admixture zone with A. m. …

Presence Of Semi-Aquatic Turtles In Indianapolis Golf Course Ponds, Melissa Anne Jones

Undergraduate Honors Thesis Collection

The consequences of increasing urbanization in many areas have led to an increase in environmental awareness. Urban green spaces, such as golf courses, can increase biodiversity and serve as valuable wildlife habitats in otherwise inhospitable areas. Golf course ponds have the potential to provide suitable habitats for semi-aquatic turtles in urban areas. Previous research on semi-aquatic turtle inhabitation has been conducted on suburban golf courses. This study investigates the viability of urban Indianapolis golf courses as habitats for semi-aquatic turtles. Golf course ponds show similar turtle occupancy compared to nearby control ponds. However, when compared to a past random pond …

Review Of Thompson School Calls For A Return To Its Roots, Erika Mantz

UNH Today Archive

No abstract provided.

The Montclarion, November 20, 2014, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

Hormone-Induced Calcium Oscillations Depend On Cross-Coupling With Inositol 1,4,5-Trisphosphate Oscillations., Lawrence D Gaspers, Paula J Bartlett, Antonio Politi, Paul Burnett, Walson Metzger, Jane Johnston, Suresh K Joseph, Thomas Höfer, Andrew P Thomas

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Receptor-mediated oscillations in cytosolic Ca(2+) concentration ([Ca(2+)]i) could originate either directly from an autonomous Ca(2+) feedback oscillator at the inositol 1,4,5-trisphosphate (IP3) receptor or as a secondary consequence of IP3 oscillations driven by Ca(2+) feedback on IP3 metabolism. It is challenging to discriminate these alternatives, because IP3 fluctuations could drive Ca(2+) oscillations or could just be a secondary response to the [Ca(2+)]i spikes. To investigate this problem, we constructed a recombinant IP3 buffer using type-I IP3 receptor ligand-binding domain fused to GFP (GFP-LBD), which buffers IP3 in the physiological range. This IP3 buffer slows hormone-induced [IP3] dynamics without changing steady-state …