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New Carbohydrate-Based Anti-Cancer And Anti-Bacterial Vaccines, Zhifang Zhou

Wayne State University Dissertations

The unique carbohydrates expressed on the surface of cancer, bacterial, viral and fungal cells are excellent target antigens for the design of therapeutic or preventive vaccines. However, as antigens carbohydrates have problems. First, carbohydrates usually have low immunogenicity. Second, even if immunogenic, carbohydrates typically elicit T cell-independent immune responses. To overcome these problems and design useful vaccines based on carbohydrate antigens, they are usually coupled with carrier proteins to form conjugates to enhance the immunogenicity of the antigens. However, there are still some issues existing in glycoprotein vaccines, such as poor reproducibility of the conjugates, difficulties in quality control and …

A Novel Injectable Borate Bioactive Glass Cement As An Antibiotic Delivery Vehicle For Treating Osteomyelitis, Hao Ding, Cunju Zhao, Xu Cui, Yifei Gu, Weitao Jia, M. N. Rahaman, Yang Wang, Wenhai Huang, Changqing Zhang

Materials Science and Engineering Faculty Research & Creative Works

Background: A novel injectable cement composed of chitosan-bonded borate bioactive glass (BG) particles was evaluated as a carrier for local delivery of vancomycin in the treatment of osteomyelitis in a rabbit tibial model. Materials and Methods: The setting time, injectability, and compressive strength of the borate BG cement, and the release profile of vancomycin from the cement were measured in vitro. The capacity of the vancomycin-loaded BG cement to eradicate methicillin-resistant Staphylococcus aureus (MRSA)-induced osteomyelitis in rabbit tibiae in vivo was evaluated and compared with that for a vancomycin-loaded calcium sulfate (CS) cement and for intravenous injection of vancomycin. Results: …

Migratory Connectivity And Carry-Over Effects In Northwest Atlantic Loggerhead Turtles (Caretta Caretta, L.), Simona Ceriani

Electronic Theses and Dissertations

Migration is a widespread and complex phenomenon in nature that has fascinated humans for centuries. Connectivity among populations influences their demographics, genetic structure and response to environmental change. Here, I used the loggerhead turtle (Caretta caretta, L.) as a study organism to address questions related to migratory connectivity and carry-over effects using satellite telemetry, stable isotope analysis and GIS interpolation methods. Telemetry identified foraging areas previously overlooked for loggerheads nesting in Florida. Next, I validated and evaluated the efficacy of intrinsic markers as a complementary and low cost tool to assign loggerhead foraging regions in the Northwest Atlantic Ocean (NWA), …

Food Miles: Environmental Protection Or Veiled Protectionism?, Meredith Kolsky Lewis, Andrew D. Mitchell

Michigan Journal of International Law

Eat local. Such a small phrase yet such a loaded proposition. Buying food from nearby sources has become a popular objective. This aim is associated with helping farmers in one’s country or region; observing the seasonality of one’s location; eating fresher foods; striving for food security; and protecting the environment. One of the unmistakable messages of the “locavore” movement is that importing food—particularly food that comes from far away—causes environmental harm. The theory is that transporting food long distances results in the release of high levels of greenhouse gases (GHGs) into the atmosphere and is thus a dangerous contributor to …

Tourism At Unesco World Heritage Sites: Protecting Global Treasures And The Travelers Who Seek Them, Joann Vrabel

Case Western Reserve Journal of International Law

No abstract provided.

Tractors And Genres: Knowledge-Making And Identity Formation In An Agricultural Community, Marcy Galbreath

Electronic Theses and Dissertations

This research examines the history of a small Florida agricultural community over the course of the twentieth century from a rhetorical perspective in order to understand the technological and communicative transitions that governed the development of American agricultural production. By examining archival and oral histories, this research will add to our understandings of how written and oral communications temper the relationships and social situations of an agricultural community, including the knowledge-making and technological adaptation resulting from communications within the community and with outside institutions and entities. Agricultural villages are not isolated entities, but rather sites of multiple rhetorical situations, and …

Ord Project: Buffer Management Plan 2014, Stratagen, Landcorp

Irrigated Agricultural Development in the North

The Western Australian Minister for State Development is developing an area of land for irrigated agriculture across the Weaber Plain in the Kimberley region of Western Australia, approximately 30 km north-northeast of Kununurra and adjoining the existing Ord River Irrigation Area.

The Project requires land clearing for farms, sourcing of road building materials, construction of the main M2 channel and smaller distribution channels to service agricultural lots, roads, power supply infrastructure, and stormwater management, groundwater management, drainage and flood protection infrastructure. The Project also involves release of irrigation water from Lake Argyle, which will be conveyed via the Ord River …

Monitoring Of Livestock Grazing Effects On Bureau Of Land Management Land, Kari E. Veblen

Wildland Resources Faculty Publications

Public land management agencies, such as the Bureau of Land Management (BLM), are charged with managing rangelands throughout the Western United States for multiple uses such as livestock grazing and conservation of sensitive species and their habitats. Monitoring of condition and trends of these rangelands, particularly with respect to effects of livestock grazing, provide critical information for effective management of these multi-use landscapes. We therefore investigated the availability of livestock grazing-related quantitative monitoring data and qualitative region-specific Land Health Standards (LHS) data across BLM grazing allotments in the Western United States. We then queried university and federal rangeland science experts …

Aspects Of Human Historiographic Explanation: A View From The Philosophy Of Science, Stuart Glennan

Scholarship and Professional Work - LAS

While some philosophers of history have argued that explanations in human history are of a fundamentally different kind than explanations in the natural sciences, I shall argue that this is not the case. Human beings are part of nature, human history is part of natural history, and human historical explanation is a species of natural historical explanation. In this paper I shall use a case study from the history of the American Civil War to show the variety of close parallels between natural and human historical explanation. In both instances, I shall argue that these explanations involve narrative descriptions of …

Jesus And The Money Changers (John 2:13-16), James F. Mcgrath

Scholarship and Professional Work - LAS

Dr. James F. McGrath's Contribution to Bible Odyssey, a Society of Biblical Literature initiative.

Quantifying The Grimm Corpus: Transgressive And Transformative Bodies In The Grimms’ Fairy Tales, Jeana Jorgensen

Scholarship and Professional Work - LAS

What do bodies mean in fairy tales? Donald Haase’s engagement with the Grimms’ fairy tales has offered some hints, ranging from his attention to feminist scholarship on the Grimms to his multifaceted review of recent Grimm scholarship that addresses various meanings of bodies in the language and translation of their tales. Inspired by Haase’s work and encouragement, I created a database that lists every mention or description of a body in the Grimms’ tales and in five other European tale collections. I detailed the results of this quantitative investigation in my dissertation, generally treating all the tale collections as part …

Fields Of Individuals And Neoliberal Logics: Japanese Soccer Ideals And The 1990s Economic Crisis, Elise M. Edwards

Scholarship and Professional Work - LAS

This article explores the relationship between popular representations of soccer and the rise of neoliberal discourse celebrating a new individualism in Japan at the turn of the millennium, a time when the country experienced sharp economic decline and consequent economic restructuring. Examining dominant vocabularies and practices present in coaching discourse, on soccer fields, and in media portrayals of Japanese men’s and women’s professional leagues, the author argues that rather than a coincidental, coeval mirroring between two seemingly unrelated realms—sports and economic transformations—these relationships point to the positioning of soccer over the past 20 years in Japan as a site to …

Did Androgen-Binding Protein Paralogs Undergo Neo- And/Or Subfunctionalization As The Abp Gene Region Expanded In The Mouse Genome?, Robert C. Karn, Amanda G. Chung, Christina M. Laukaitis

Scholarship and Professional Work - LAS

The Androgen-binding protein (Abp) region of the mouse genome contains 30 Abpa genes encoding alpha subunits and 34 Abpbg genes encoding betagamma subunits, their products forming dimers composed of an alpha and a betagamma subunit. We endeavored to determine how many Abp genes are expressed as proteins in tears and saliva, and as transcripts in the exocrine glands producing them. Using standard PCR, we amplified Abp transcripts from cDNA libraries of C57BL/6 mice and found fifteen Abp gene transcripts in the lacrimal gland and five in the submandibular gland. Proteomic analyses identified proteins corresponding to eleven of the …

Who Can Afford It?: The Patient Protection And Affordable Care Act's Failure To Regulate Excessive Cost-Sharing Of Prescription Biologic Drugs , Michael Callam

Journal of Law and Health

This Note will discuss how the PPACA’s abbreviated approval pathway for biological products creates an expedited procedure to bring less expensive biologic drugs to the market, but ultimately fails to make those biologic drugs affordable because of its lack of provisions limiting insurers’ use of excessive cost-sharing requirements. Part II provides an overview of prescription drugs, compares biologics with traditional prescription drugs, and provides a brief legislative history of prescription drug laws. Part III analyzes the impact of the abbreviated approval pathway on biologic drugs’ costs to prescribed patients. It also examines the PPACA’s effects on biologics inclusion into health …

Scientific Method In Meteorology, Triberiu Popa

Scholarship and Professional Work - LAS

This article explores the main aspects of Aristotle’s scientific method in Meteorology IV. Dispositional properties such as solidifiability or combustibility play a dominant role in Meteor. IV (a) in virtue of their central place in the generic division of homoeomers, based on successive differentiation and multiple differentiae, and (b) in virtue of their role in revealing otherwise undetectable characteristics of uniform materials (composition and physical structure). While Aristotle often starts with accounts of ingredients and their ratio (e.g., solids that contain a significant amount of water are liquefiable), the natural direction of his investigation is …

2014 Otterbein Football Game Day Program, Otterbein University

Football Programs

No abstract provided.

Homing By Path Integration When A Locomotion Trajectory Crosses Itself, Naohide Yamamoto, Jayleen A. Meléndez, Derek T. Menzies

Psychology Faculty Publications

Path integration is a process with which navigators derive their current position and orientation by integrating self-motion signals along a locomotion trajectory. It has been suggested that path integration becomes disproportionately erroneous when the trajectory crosses itself. However, there is a possibility that this previous finding was confounded by effects of the length of a traveled path and the amount of turns experienced along the path, two factors that are known to affect path integration performance. The present study was designed to investigate whether the crossover of a locomotion trajectory truly increases errors of path integration. In an experiment, blindfolded …

Communing With Nature, The Ancestors And The Neighbors: Ancient Ceramic Musical Instruments From Coastal Oaxaca, Mexico, Guy David Hepp, Sarah B. Barber, Arthur A. Joyce

Anthropology Faculty Publications

The Mesoamerican Formative period (1600 BCE–CE 250) saw the establishment of sedentism, dietary transformations and the development of ceramic technologies for subsistence, artistic representation and the region’s earliest preserved musical instruments. These instruments include aerophones such as whistles, ocarinas and flutes. In this paper, we describe sixty-three ceramic aerophones from mostly Formative period contexts in coastal Oaxaca, Mexico. We situate our analysis in the broader contexts of research on music and iconography in Mesoamerican archaeology, as well as of the anthropology of sensory perception. Through a consideration of archaeological context, artifact form and technical properties, we conclude that music was …

Overwintering Biology And Tests Of Trap And Relocate As A Conservation Measure For Burying Beetles, W. Wyatt Hoback, Adrienne Conley

Nebraska Department of Transportation: Research Reports

Burying beetles are carrion beetles and utilize dead animal carcasses for feeding and reproductive efforts. They assist with decomposition, prevent the spread of disease, and reduce the number of pest species. The largest species of carrion beetle, the American burying beetle, is a federally endangered insect and its distribution has been reduced by 90%. The conservation of this species is important in maintaining a healthy ecosystem. Overwintering biology and trap and relocation were studied to determine how this beetle survives freezing temperatures and to find whether trap and relocation could be a suitable conservation management measure.

Trap and relocation is …

Wooster Magazine: Winter 2014, Karol Crosbie

Wooster Magazine: 2011-2020

The Winter 2014 edition of the Wooster Magazine highlights many different topics. Editor Karol Crosbie gives the top 10 reasons why she likes her job as an introduction in the magazine. The beloved restaurant, The Shack, has closed its doors for good. The college's radio station, WOO 91, has a new home in the basement of Lowry Center. There is a section about the plants on campus and how they are seen by different people on campus. Some students in Charles Kammer's religious study course, "Just Work" share their experience working in Lowry Dining Hall. Karol Crosbie put together a …

Synthesis And Evaluation Of Some New Aza-B-Homocholestane Derivatives As Anticancer Agents, Yanmin Huang, Jianguo Cui, Sijing Chen, Qifu Lin, Huacan Song, Chunfang Gan, Bin Su, Aimin Zhou

Chemistry Faculty Publications

Using analogues of some marine steroidal oximes as precursors, a series of aza-B-homocholestane derivatives possessing different substituted groups at the 3-position of the steroidal nucleus were synthesized. Their biological activity against cancer cell proliferation was determined with multiple cancer cell lines. Aza-B-homocholestane derivatives possessing 3-hydroxyl, 3-hydroximino and 3-thiosemicarbazone groups displayed remarkable cytotoxicity to cancer cells via apoptosis inducing mechanism. Compounds 5, 10, 12, 15 and 18 exhibited better potency to inhibit cancer cell proliferation. In addition, compound 15 was further evaluated with three dimensional (3D) multicellular spheroids assay to determine its potency against spheroid growth. The structure-activity relationship (SAR) generated …

The Effects Of Vincristine Sulfate On Expression Of Galectin-3, Bcl-2, And Carbohydrate Structures Specific For Eel, Gsl-1, And Rca-1 Lectins In Bitches With Naturally Occurring Canine Transmissible Venereal Tumor, Musa Özgür Özyi̇ği̇t, Deni̇z Nak, Hasan Akşi̇t, Sevda İnan Öztürkoğlu, Gözde Şi̇mşek, Ender Uzabaci, Yavuz Nak, Kami̇l Seyrek

Turkish Journal of Veterinary & Animal Sciences

Vincristine sulfate is one of the most effective chemical agents used in canine transmissible venereal tumor (CTVT) chemotherapy. Its therapeutic effectiveness is pronounced and significant at the beginning of treatment. The present study was designed to investigate vincristine sulfate treatment and the relationship between CTVT tumor regression and apoptosis [estimated by TdT-mediated dUTP-biotin nick end labeling (TUNEL)], galectin-3 (H-160), Bcl-2 (N-9), and lectin [EEL (B-135), GSL I (L-1100), and RCA I (BA-0084)] expression using immunohistochemical staining in 20 bitches with naturally occurring CTVTs. Evaluation was semiquantitatively performed by HSCORE values using light microscopy. All observed staining was intracytoplasmic and increased …

Legal And Economic Challenges To The Business Model Of The Television Industry, John B. Meisel

UC Law SF Communications and Entertainment Journal

Gaining access to content is critically important for entrance into the television industry; this is a necessary input to become a viable competitor against incumbent video industry players. However, incumbents have the ability and incentive to withhold programming that discourages potential competitors from entering the market. Entrants, built up over a long period of time, confront a symbiotic relationship between traditional content providers and incumbent content distributors. Access to video programming or access in the format (i.e., online) that a viewer chooses is in high demand. This demand is evident by an increasing number of legal, technological, economic, and political …

Authorship Atomized: Modeling Ownership In Participatory Media Productions, Elisabeth S. Aultman

UC Law SF Communications and Entertainment Journal

The aim of this article is to posit a solution, grounded in legal realism, for the practical issues that arise when copyright law and content monetizers encounter a work (or perhaps more accurately, a series of interdependent works) with an unprecedented number of people who could ostensibly assert authorship over some element of the content.

"Public Sentiment Is Everything": Abraham Lincoln And The Power Of Public Opinion, Allen C. Guelzo

Civil War Era Studies Faculty Publications

Book Summary: Since Abraham Lincoln’s death, generations of Americans have studied his life, presidency, and leadership, often remaking him into a figure suited to the needs and interests of their own time. This illuminating volume takes a different approach to his political thought and practice. Here, a distinguished group of contributors argue that Lincoln’s relevance today is best expressed by rendering an accurate portrait of him in his own era. They seek to understand Lincoln as he understood himself and as he attempted to make his ideas clear to his contemporaries. What emerges is a portrait of a prudent leader …

Catalonia: The New European State?, Garcia Barcia

ILSA Journal of International & Comparative Law

On September 11, 2012, a sea of Catalonians, 1.5 million according to the Urban Guard and 600,000 according to the Government Delegation, protested under the slogan: "Catalonia, new European State."'

2013 Annual Town Report Freemont, New Hampshire., Fremont Town Representatives

Fremont, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Tennessee Folklore Society Bulletin - Volume 70, No. 1 & 2, Tennessee Folklore Society

Tennessee Folklore Society Bulletin

No abstract provided.

All It Ever Does Is Rain: Bruce Springsteen And The Alienation Of Labor, David Ray Papke

Faculty Publications

The popular singer and songwriter Bruce Springsteen is a product of the working-class family, and his songs often creatively capture not only working-class life but also workers' alienation from their labor. In an unsystematic way, Springsteen's lyrics portray how modern workers are alienated from the products of their labor, the process of working, other workers, and ultimately, from themselves. Although Springsteen primarily has blue-collar, industrial workers in mind, his thoughts on the alienation of labor continue to have relevance for workers in the American consumer society and in the contemporary global economy as well.

Constitutional Disputes In Multiple Dimensions: The Washington Post, The Wall Street Journal, And Sustainable Energy Law, Steven Ferrey

Fordham Environmental Law Review

No abstract provided.