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Multi-State Models For Natural History Of Disease, Amy Laird, Rebecca A. Hubbard, Lurdes Y. T. Inoue

UW Biostatistics Working Paper Series

Longitudinal studies are a useful tool for investigating the course of chronic diseases. Many chronic diseases can be characterized by a set of health states. We can improve our understanding of the natural history of the disease by modeling the sequence of visited health states and the duration in each state. However, in most applications, subjects are observed only intermittently. This observation scheme creates a major modeling challenge: the transition times are not known exactly, and in some cases the path through the health states is not known.

In this manuscript we review existing approaches for modeling multi-state longitudinal data. …

A Mechanism Linking Id2-Tgfβ Crosstalk To Reversible Adaptive Plasticity In Neuroblastoma, Lina Chakrabarti, Bi-Dar Wang, Norman H. Lee, Anthony D. Sandler

Pharmacology and Physiology Faculty Publications

The ability of high-risk neuroblastoma to survive unfavorable growth conditions and multimodal therapy has produced an elusive childhood cancer with remarkably poor prognosis. A novel phenomenon enabling neuroblastoma to survive selection pressure is its capacity for reversible adaptive plasticity. This plasticity allows cells to transition between highly proliferative anchorage dependent (AD) and slow growing, anoikis-resistant anchorage independent (AI) phenotypes. Both phenotypes are present in established mouse and human tumors. The differential gene expression profile of the two cellular phenotypes in the mouse Neuro2a cell line delineated pathways of proliferation in AD cells or tyrosine kinase activation/ apoptosis inhibition in AI …

Correlation Of Aggregatibacter Actinomycetemcomitans Detection With Clinical/Immunoinflammatory Profile Of Localized Aggressive Periodontitis Using A 16s Rrna Microarray Method: A Cross-Sectional Study, Patricia F. Gonçalves, Vanja Klepac-Ceraj, Hong Huang, Bruce J. Paster, Ikramuddin Aukhil, Shannon M. Wallet, Luciana M. Shaddox

Faculty Research and Scholarship

Objective

The objective of this study was to determine whether the detection of Aggregatibacter actinomycetemcomitans (Aa) correlates with the clinical and immunoinflammatory profile of Localized Aggressive Periodontitis (LAP), as determined by by 16S rRNA gene-based microarray.

Subjects and Methods

Subgingival plaque samples from the deepest diseased site of 30 LAP patients [PD ≥ 5 mm, BoP and bone loss] were analyzed by 16S rRNA gene-based microarrays. Gingival crevicular fluid (GCF) samples were analyzed for 14 cyto/chemokines. Peripheral blood was obtained and stimulated in vitro with P.gingivalis and E.coli to evaluate inflammatory response profiles. Plasma lipopolysaccharide (LPS) levels were also measured. …

Shellfish Tissue Monitoring In Piscataqua Region Estuaries 2013, Matthew A. Wood, Philip R. Trowbridge

PREP Reports & Publications

Originally conducted by the Gulf of Maine Council on the Marine Environment from 1993 to 2011, the Gulfwatch Program examined trends in the water quality of the Gulf of Maine by monitoring toxic contaminant concentrations in the tissues of shellfish. Starting in 2012 the Piscataqua Region Estuaries Partnership (PREP) continued this program in the Piscataqua Region. Each year, PREP collects blue mussels at three sites: Dover Point, NH (NHDP), Clark Cove on Seavey Island, ME (MECC), and Hampton-Seabrook Harbor (NHHS). The mussel tissue is analyzed to determine the concentrations of toxic contaminantss including heavy metals, chlorinated pesticides, polychlorinated biphenyls (PCBs), …

Deafdigest: Deaf Sports News December 23, 2013, Barry Strassler

DeafDigest Sports 2013

No abstract provided.

Tinku Sharma V. Atty. Gen Usa

2013 Decisions

Agency

Medtronic V. Boston Scientific: Allocating The Burden Of Proof In Declaratory Judgment Actions For Patent Non-Infringement, Brianna Strange

Duke Journal of Constitutional Law & Public Policy Sidebar

This commentary previews an upcoming Supreme Court case, Medtronic, Inc. v. Boston Scientific Corporation, in which the Court will decide which party bears the burden of proof in a declaratory judgment action for patent non-infringement.

Lindisfarne Gospels: The Saint John's Bible Linked To Earliest Christian Communities, Michael Hemesath

Administration Publications

No abstract provided.

12/23/2013 Obituary Records, Hawaii Obituaries

Obituaries

List of Obituaries for individuals who passed away on 12/23/2013. Scroll down to see the names and obituary description.

Microfluidic Generated Egf-Gradients Induce Chemokinesis Of Transplantable Retinal Progenitor Cells Via The Jak/Stat And Pi3kinase Signaling Pathways., Uchenna J. Unachukwu, Moira Sauane, Maribel Vazquez, Stephen Redenti

Publications and Research

A growing number of studies are evaluating retinal progenitor cell (RPC) transplantation as an approach to repair retinal degeneration and restore visual function. To advance cell-replacement strategies for a practical retinal therapy, it is important to define the molecular and biochemical mechanisms guiding RPC motility. We have analyzed RPC expression of the epidermal growth factor receptor (EGFR) and evaluated whether exposure to epidermal growth factor (EGF) can coordinate motogenic activity in vitro. Using Boyden chamber analysis as an initial high-throughput screen, we determined that RPC motility was optimally stimulated by EGF concentrations in the range of 20-400 ng/ml, with decreased …

Latinas And Electoral Politics: Expanding Participation And Power In State And National Elections, Anna Sampaio

Ethnic Studies

Latina and Latino political participation in the 2012 election reached new heights, proving to be a significant factor in the electoral outcomes of several battleground states and ultimately the reelection of President Obama. Both Latinas and Latinos played pivotal roles in the 2012 election, increasing their share of the national electorate and their support for President Obama over 2008 election levels. In the end, President Obama received 71 percent of the Latina/o vote (compared with 27 percent for Mitt Romney), surpassing all previous presidential candidates with the exception of Bill Clinton, who garnered 72 percent of the Latina/o vote in …

In-Home Care Providers. Expenditures. Initiative Statute.

Initiatives

Requires businesses providing in-home care services to spend at least 75% of their total annual home care service revenue on direct patient care. Limits administrative expenses, management compensation, and profit distributions collectively to 25% of revenue. Establishes state program to administer and enforce measure, provider fees, and fines up to $10,000 per year plus mandatory license revocation for violations. Dedicates fees and fines to fund program. Requires providers to prepare annual reports showing revenue and expenditures. Requires publication of these reports and information on provider violations. Summary of estimate by Legislative Analyst and Director of Finance of fiscal impact on …

Eagle Gazette Political Science Alum Honored In Registry, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

In-Home Care Providers. Expenditures. Initiative Statute.

Initiatives

Requires businesses providing in-home care services to spend at least 75% of their total annual home care service revenue on direct patient care. Limits administrative expenses, management compensation, and profit distributions collectively to 25% of revenue. Establishes state program to administer and enforce measure, provider fees, and fines up to $10,000 per year plus mandatory license revocation for violations. Dedicates fees and fines to fund program. Requires providers to prepare annual reports showing revenue and expenditures. Requires publication of these reports and information on provider violations. Summary of estimate by Legislative Analyst and Director of Finance of fiscal impact on …

Woub Ohio Poll Supports Marriage Equality Major Shift In Opinion, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

What's Happening: December 23, 2013, Maine Medical Center

What's Happening

No abstract provided.

The Function Of Carmil1 In Migrating Cells, Marc Edwards

All Theses and Dissertations (ETDs)

This dissertation describes the physiological role of the Capping Protein- CARMIL interaction in migrating cells. I establish the CARMIL-CP complex as a key regulator of lamellipodial actin assembly and of lamellipodial dynamics. Membrane ruffling at the leading edge of motile cells and macropinocytosis were also found to be dependent on the CARMIL1-CP interaction. This is consistent with macropinocytosis and ruffling being dependent on a functional and dynamic lamellipodium.: Kerr and Teasdale, 2009).

In chapter two I demonstrate that the CBR of CARMIL1 is competent to inhibit CP in cells. I show that overexpression of the CBR in cells leads to …

Understanding Crx-Associated Retinopathies Using Animal Models, Nicholas Minh Abell Tran

All Theses and Dissertations (ETDs)

Cone-rod homeobox: CRX) protein is a "paired-like" homeodomain transcription factor that is essential for regulating rod and cone photoreceptor transcription. Mutations in human CRX are associated with the dominant retinopathies Retinitis Pigmentosa: RP), Cone-Rod Dystrophy: CoRD) and Leber Congenital Amaurosis: LCA), with variable severity. The goal of my dissertation project was to develop and characterize animal models to understand genetic mechanisms of phenotypic diversity in CRX-associated disease. Heterozygous Crx Knock-Out: KO) mice: "+/-") have normal vision as adults and fail to model the dominant human disease.

We generated two Crx Knock-IN: K-IN) mouse models: CrxE168d2: "E168d2") and CrxR90W: "R90W"), which …

Changes In Gene Explain More Of Inherited Risk For Rare Disease, Greg Williams

Browse All News

No abstract provided.

100 Hospitals With Great Women's Health Programs - 2013, Staff

Browse All News

No abstract provided.

Measurement, Monitoring, And Evaluation Of State Demonstrations To Integrate Care For Dual Eligible Individuals: Massachusetts Evaluation Design Plan., Julie T. Fralich Mba, Maureen Booth Mrp, Ma, Edith G. Walsh Phd, Angela M. Greene Ms, Mba, Melissa Morley Phd, Wayne Anderson Phd

Disability & Aging

CMS contracted with RTI International to monitor the implementation of all State demonstrations under the Financial Alignment Initiative, and to evaluate their impact on beneficiary experience, quality, utilization, and cost. The evaluation includes an aggregate evaluation and State-specific evaluations. This report describes the State-specific Evaluation Plan for the Massachusetts demonstration as of December 16, 2013. The evaluation activities may be revised if modifications are made to either the Massachusetts demonstration or to the activities described in the Aggregate Evaluation Plan (Walsh et al., 2013). Although this document will not be revised to address all changes that may occur, the annual …

Spatial Spectrograms Of Vibrating Atomic Force Microscopy Cantilevers Coupled To Sample Surfaces, Ryan Wagner, Arvind Raman, Roger Proksch

Birck and NCN Publications

Many advanced dynamic Atomic Force Microscopy (AFM) techniques such as contact resonance, force modulation, piezoresponse force microscopy, electrochemical strain microscopy, and AFM infrared spectroscopy exploit the dynamic response of a cantilever in contact with a sample to extract local material properties. Achieving quantitative results in these techniques usually requires the assumption of a certain shape of cantilever vibration. We present a technique that allows in-situ measurements of the vibrational shape of AFM cantilevers coupled to surfaces. This technique opens up unique approaches to nanoscale material property mapping, which are not possible with single point measurements alone. (C) 2013 AIP Publishing …

A Search For Enhanced Very High Energy Gamma-Ray Emission From The 2013 March Crab Nebula Flare, P. T. Reynolds, Et Al

Physical Sciences Publications

In 2013 March, a flaring episode from the Crab Nebula lasting ~2 weeks was detected by Fermi-LAT (Large Area Telescope on board the Fermi Gamma-ray Space Telescope). The Very Energetic Radiation Imaging Telescope Array System (VERITAS) provides simultaneous observations throughout this period. During the flare, Fermi-LAT detected a 20 fold increase in flux above the average synchrotron flux >100 MeV seen from the Crab Nebula. Simultaneous measurements with VERITAS are consistent with the non-variable long-term average Crab Nebula flux at TeV energies. Assuming a linear correlation between the very high energy flux change >1 TeV and the flux …

Regulation Of Pten Inhibition By The Pleckstrin Homology Domain Of P-Rex2 During Insulin Signaling And Glucose Homeostasis, Cindy Hodakoski, Benjamin D. Hopkins, Douglas Barrows, Sarah M. Mense, Megan Keniry, Karen E. Anderson, Philip A. Kern, Phillip T. Hawkins, Len R. Stephens, Ramon Parsons

Clinical and Translational Science Faculty Publications

Insulin activation of phosphoinositide 3-kinase (PI3K) signaling regulates glucose homeostasis through the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3). The dual-specificity phosphatase and tensin homolog deleted on chromosome 10 (PTEN) blocks PI3K signaling by dephosphorylating PIP3, and is inhibited through its interaction with phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 (P-REX2). The mechanism of inhibition and its physiological significance are not known. Here, we report that P-REX2 interacts with PTEN via two interfaces. The pleckstrin homology (PH) domain of P-REX2 inhibits PTEN by interacting with the catalytic region of PTEN, and the inositol polyphosphate 4-phosphatase domain of P-REX2 provides high-affinity binding to the postsynaptic …

Full-Quantum Simulation Of P-Type Junctionless Transistors With Multi-Band K · P Model, Jun Z. Huang, Weng Cho Chew, Li (Lijun) Jun Jiang, Jie Peng, Chi Yung Yam, Guan Hua Chen

Electrical and Computer Engineering Faculty Research & Creative Works

By adopting a model order reduction technique, we have successfully constructed a program for efficient simulation of nanowire transistors based on the multi-band k · p model and non-equilibrium Green's function (NEGF) approach. We then study for the first time the influences of various device parameters on the performances of p-type junctionless (JL) transistors and compare them to traditional inversion mode (IM) devices. © 2013 IEEE.

Sims V. Jacobsen Appellant's Reply Brief Dckt. 40474

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Messenger Jail Funding Analyzed By Economics Students, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Goska Named December's Employee Of The Month, Natalie Wade

Browse All News

No abstract provided.

Comparative Genomics And Functional Analysis Of Rhamnose Catabolic Pathways And Regulons In Bacteria, Irina A. Rodionova, Xiaoqing Li, Vera Thiel, Sergey Stolyar, Krista Stanton, James K. Fredrickson, Donald A. Bryant, Andrei L. Osterman, Aaron A. Best, Dmitry A. Rodionov

Faculty Publications

L-rhamnose (Rha) is a deoxy-hexose sugar commonly found in nature. L-Rha catabolic pathways were previously characterized in various bacteria including Escherichia coli. Nevertheless, homology searches failed to recognize all the genes for the complete L Rha utilization pathways in diverse microbial species involved in biomass decomposition. Moreover, the regulatory mechanisms of L-Rha catabolism have remained unclear in most species. A comparative genomics approach was used to reconstruct the L-Rha catabolic pathways and transcriptional regulons in the phyla Actinobacteria, Bacteroidetes, Chloroflexi, Firmicutes, Proteobacteria, and Thermotogae. The reconstructed pathways include multiple novel enzymes and transporters involved in the utilization of L-Rha and …

Parameters – Full Issue, Usawc Parameters

The US Army War College Quarterly: Parameters

American Power in Transition: Isaiah Wilson, James E. Goodby and Ken Weisbrode, Anna Simons. Fighting Irregular Fighters: Sibylle Scheipers, Robert J. Bunker, Robert L. Feldman and Michel Ben Arrous. Conflict by Other Means: David J. Katz, Juan Zarate, Douglas W. Winton. Preparing for Netwars: Frank J. Cilluffo and Joseph R. Clark. QDR and Landpower: Francis G. Hoffman.