Digital Commons Network^™

Microbial Genome Evolution Due To Multifaceted Symbiosis Within The Tsetse Fly (Diptera: Glossinidae), Anna Kathleen Snyder

Graduate Theses, Dissertations, and Problem Reports (ETD)

Microbes are capable of rapid genetic modification, enabling the habitation of a wide field of niches, including forming interdependent associations with macroscopic hosts. While ancient multipartite mutualisms have been shown to involve metabolic complementation, little is known concerning the early genomic adaptations leading towards co-residence within a novel host. The overall objective of this research is to gain insight on genome evolution resulting from symbiosis, particularly by examining bacteria with varying levels of host dependency and times of establishment. The tsetse fly (Diptera: Glossinidae) serves as a relatively simple model system to investigate evolutionary aspects of symbiosis, while also maintaining …

Machine-Vision-Based Pose Estimation System Using Sensor Fusion For Autonomous Satellite Grappling, Andres Felipe Velasquez Escandon

Graduate Theses, Dissertations, and Problem Reports (ETD)

When capturing a non-cooperative satellite during an on-orbit satellite servicing mission, the position and orientation (pose) of the satellite with respect to the servicing vessel is required in order to guide the robotic arm of the vessel towards the satellite. The main objective of this research is the development of a machine vision-based pose estimation system for capturing a non-cooperative satellite. The proposed system finds the satellite pose using three types of natural geometric features: circles, lines and points, and it merges data from two monocular cameras and three different algorithms (one for each type of geometric feature) to increase …

Using A Three-Dimensional Model To Understand Age Differences In The Framing Effect, Tara E. Karns

Graduate Theses, Dissertations, and Problem Reports (ETD)

The present study used a between-subjects design with three instruction conditions to investigate susceptibility to the framing effect among younger, middle-aged, and older adults. Participants were instructed to pay attention to the facts and numbers, to use their gut feelings, or to use their previous experiences to respond to two decision-making scenarios pertaining to treatment for lung cancer and a vaccination for a flu virus. Results revealed that, overall, the framing effect was present in the lung cancer scenario, but not the flu scenario. Instruction condition and age did not affect susceptibility to the framing effect; however, a frame by …

Stressors And Coping Behaviors Of Female Peer Leaders Participating In College Club Sports, Leigh A. Bryant

Graduate Theses, Dissertations, and Problem Reports (ETD)

Peer leadership positions on collegiate club sport teams can be valuable opportunities for students to develop leadership skills, maintain healthy habits, create friendships, and foster organizational and personal connections across the university setting. Nevertheless, involvement in club sports can create stress over and above the many stressors that college students may encounter during their undergraduate experience. This study focused on exploring female leaders' perceived stressors inside and outside of the sport setting, and the ways in which they coped with them. Participants ( N = 7) were interviewed based on nominations from their respective teammates. Interviews were conducted using a …

Human Action Recognition In Still Images, Biyun Lai

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recently still image-based human action recognition has become an active research topic in computer vision and pattern recognition. It focuses on identifying a person's action or behavior from a single image. Unlike the traditional action recognition approaches where videos or image sequences are used, a still image contains no temporal information for action characterization. It is more challenging to perform still image-based action recognition than the video-based, given the limited source of information as well as the cluttered background for images collected from the Internet.;Based on the emerging research in recent years, we dig into all possible cues from a …

Embedded Nanosensors For Defect Identification Using Flexible, Optically Transparent, Deformation Responsive Wrinkled Single Walled Carbon Nanotube Meshes, Pallavi Anipindi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Most structures such as buildings, pipelines carrying natural gas, nuclear plant cooling tanks and so forth are made of concrete. In vivo detection of the onset of cracks and voids in these concrete structures have many barriers and neglecting those could lead to failure of structures causing loss of properties and damage to lives. Embedded single walled carbon nanotubes (SWCNTs) with exceptional mechanical, optical, and electrical properties can be utilized in overcoming these barriers. This type of NDT technique can monitor the potential for failure in concrete structures by allowing us to monitor the cracks from the atomistic level. It …

Table Of Contents

Maryland Law Review

No abstract provided.

Molecular And Biochemical Mechanisms Of Pathogenesis In The Maize Foliar Pathogen Cercospora Zeae-Maydis, Winfred-Peck Dorleku

Graduate Theses and Dissertations

GLS is a serious foliar disease of maize, a major staple crop grown commercially in the USA for both human and animal feed production, and increasingly, for ethanol production. The disease is caused by two Cercospora species, C. zeae-maydis and C. zeina, both of which infect maize in the USA and in other parts of the world, with yield losses potentially greater than 50%, depending on local conditions. In culture, C. zeae-maydis produces a phytotoxic, host non-specific perylenequinone, cercosporin, and abscisic acid (ABA), for which there is no known pathological or physiological function in the fungus. Experimental evidence indicates …

Staphylococcus Aureus Sara Regulates Inflammation And Colonization During Central Nervous System Biofilm Formation, Jessica N. Snowden, Matthew K. Beaver, Karen Beenken, Alexander R. Horswill, Tammy L. Kielian

Journal Articles: Pediatrics

Infection is a frequent and serious complication following the treatment of hydrocephalus with CSF shunts, with limited therapeutic options because of biofilm formation along the catheter surface. Here we evaluated the possibility that the sarA regulatory locus engenders S. aureus more resistant to immune recognition in the central nervous system (CNS) based on its reported ability to regulate biofilm formation. We utilized our established model of CNS catheter-associated infection, similar to CSF shunt infections seen in humans, to compare the kinetics of bacterial titers, cytokine production and inflammatory cell influx elicited by wild type S. aureus versus an isogenic sarA …

A Novel Mechanism Of Enhanced Susceptibility To Bacterial Pneumonia In Influenza-Infected Hosts, Hazem Elsayed Ghoneim

Theses and Dissertations (ETD)

Viruses such as influenza suppress host immune function by a variety of methods. This may result in a significant morbidity through several pathways, including facilitation of secondary bacterial pneumonia from pathogens such as Streptococcus pneumoniae. Lungresident alveolar macrophages (AMs) act as the first line of innate cellular immunity against respiratory bacterial pathogens, including pneumococcus. Therefore, they represent an attractive target for study Before investigating the impact of influenza infection on resident AMs, we first characterized different subsets of lung-resident macrophages in naïve mice using a novel in vivo labeling approach in conjunction with multicolor flow cytometric analysis and confocal microscopic …

Nkg2d Ligands In Cancer, Neha Das Gupta

Theses and Dissertations (ETD)

NK cell transplantation has been increasingly used to treat cancers that are resistant to chemotherapy. However, not all cancers are susceptible to NK cell killing. The prevalence and mechanisms of NK cell resistance have not been well elucidated. Because NKG2D is a major activating receptor on NK cells, we sought to test the hypothesis that NKG2D is the primary pathway in tumor cell recognition. Herein, we comprehensively assessed 20 cancer cell lines representing a broad array of cancer types. In line with our primary hypothesis, no cancer cell lines that expressed low levels of NKG2D ligands were susceptible to NK …

Tetraspanin Cd9: Contributions To Cancer Cell And Vascular Cell Phenotypes From The Sixth Man, Michael James Herr Ii

Theses and Dissertations (ETD)

Cancer and vascular disease are the two most predominant causes of mortality in the United States. Potential regulatory mechanisms for these two diseases have consumed research interests. Tetraspanins are cell surface proteins that organize the cell membrane. Cellular membrane organization is a prerequisite for cellular signaling to occur. Deregulation of cellular signaling often precedes the formation of cancer or vascular disease phenotypes. This insinuates the necessity to understand how tetraspanins contribute to membrane organization and subsequent downstream signaling. This work examines tetraspanin CD9 contributions in a model of cancer cell invasion and vascular cell contraction. The findings presented here demonstrate …

The Relationship Between Health Literacy And Health Outcomes: A Mixed-Methods Study Of African-American Adult Patients With Asthma, Courtnee Erin Melton

Theses and Dissertations (ETD)

Introduction: Asthma affects 24.6 million people in the United States, and AfricanAmericans share a disproportionate burden of the disease. African-Americans have a higher prevalence of asthma, worse asthma control, higher hospitalization rates, and higher asthma mortality rates African-Americans are also more likely to have low health literacy. Low health literacy has been linked to increased use of emergency care, increased hospitalization, decreased use of preventive services, poorer medication adherence, poorer interpretation of prescription labels, nutrition labels, and health messages, and poorer health outcomes. Consequently, health literacy is one of the modifiable individual factors that contributes to asthma disparities among African-Americans. …

Attenuation Of Parenteral Nutritionassociated Liver Disease By Omega-3 Long-Chain Polyunsaturated Fatty Acids, Emma Monique Tillman

Theses and Dissertations (ETD)

No abstract provided.

Signal Transduction And Transcriptional Regulation Pathways Essential For Azole Resistance In Candida Albicans, Erin M. Vasicek

Theses and Dissertations (ETD)

Candida albicans is the most prevalent human fungal pathogen, found as a commensal organism in the mucosa, gastrointestinal, and urogenital tracts of humans. This pathogenic fungus causes a wide spectrum of diseases, including the mucosal infection oropharyngeal candidiasis (OPC) which frequently effects patients with human immunodeficiency virus (HIV). The azole antifungals (such as fluconazole) are the most widely used and important ergosterol biosynthesis inhibitors (EBIs) for the treatment of Candida infections, including OPC. However, the azoles are fungistatic against C. albicans and therefore have limited efficacy against this organism, especially for immunocompromised patients. In C. albicans, the transcription factor Upc2 …

Adenylyl Cyclase 2 Selectively Regulates Il-6 Expression In Human Bronchial Smooth Muscle Cells, Amy Sue Bogard

Theses and Dissertations (ETD)

Adenylyl cyclase (AC) catalyzes the formation of the ubiquitous second messenger cAMP. AC isoforms differ in their tissue distribution, cellular localization, regulation, and protein interactions, and most cells express multiple isoforms. We hypothesized that cAMP produced by different AC isoforms regulates unique cellular responses. Overexpression of individual isoforms had distinct effects on forskolin (Fsk)-induced expression of a number of known cAMP-responsive genes in human bronchial smooth muscle cells (BSMC) and human embryonic kidney cells (HEK-293). Most notable, in BSMC overexpression and activation of AC2 enhanced interleukin 6 (IL-6) expression, but overexpression of AC3 or AC6 had no effect. IL-6 production …

Erg11-Mediated Azole Resistance In Candida Albicans, Stephanie Ann Flowers

Theses and Dissertations (ETD)

Although many medically important Candida species are commensal to the gut or colonizers of the skin, these organisms have the propensity to cause disease in the event of a waning immune system. Clinical manifestations of infections with Candida species can range from superficial mucosal infections to deep organ involvement usually resulting from haematogenous spread of infection. Despite significant progress made in the management of patients with fungal infections, the emergence of antifungal resistant clinical isolates creates significant problem in regards to antifungal prophylaxis and empirical treatment strategies. Antifungal resistance is associated with high mortality rates and hefty medical costs. The …

Regulation Of Secretory Phospholipase A2 By Thyroid Hormone, Pragya Sharma

Theses and Dissertations (ETD)

Rationale: Low grade inflammation has been correlated with elevated risk of hepatic steatosis and atherosclerosis. Secretory phospholipase A2 group IIA (PLA2g2a) enhances the progression of several chronic inflammatory diseases including arthritis and atherosclerosis. The potential linkage of hypothyroidism with inflammation led us to examine the modulation of sPLA2 expression by thyroid hormone (T3) in liver.

Objective: Most of the studies of phospholipase A2 group IIA (PLA2g2a) have been conducted with macrophages and vascular smooth muscle cells with regard to atherosclerosis. The liver is one of the major contributors to the total pool of extracellular PLA2g2a. The aim of the present …

Development And Characterization Of A Recombinant Vesicular Stomatitis Virus (Rvsv) For The Treatment Of Glioblastoma, Erika A. Dillard

Theses and Dissertations (ETD)

Background: Over the past 30 years, little has changed in the treatment modalities and prognosis of patients suffering from Glioblastoma multiforme (GBM), the most common and by far the most devastating adult primary malignant brain tumor. Conventional therapies provide only a marginal increase in survival of GBM patients, post-diagnosis. Therefore, more novel means of treating GBM are needed to increase long-term survival and quality of life for those affected. Replication competent oncolytic viruses (OVs) have recently emerged as a possible option for treatment of high-grade gliomas. Particularly, recombinant vesicular stomatitis virus (rVSV), an enveloped, negative strand RNA virus, has shown …

Creating Female Space: The Feminine Sublime In The Awakening And The House Of Mirth, Emily F. Faison

Selected Honors Theses

This thesis examines the Edna Pontellier and Lily Bart, the respective protagonists of Kate Chopin’s The Awakening and Edith Wharton’s The House of Mirth, integrating the theoretical concept of the sublime, particularly engaging Barbara Freemans’s idea of a feminine sublime, as discussed in her book, The Feminine Sublime: Gender and Excess in Women’s Fiction. In three chapters, the thesis provides an overview and brief history of the theory of the sublime, contextualizing Freeman’s argument, and measures the success of both Edna’s and Lily’s attempts to engage the sublime as they each struggle to find their place as women …

Democracy In Postmodern America: Why The Postmodern Worldview Is Incompatible With America's System Of Society And Government, Peter A. Bigelow

Selected Honors Theses

No abstract provided.

A Call To Love: Campus Climate Concerning Individuals With Same-Sex Attraction, Kristan M. (Legg) Whelan

Selected Honors Theses

This study investigates the impact of campus climate concerning students with same-sex attraction at Southeastern University. The current study surveyed Southeastern undergraduate and graduate students in regards to the perceived attitudes on campus toward students with same-sex attraction (SSA). The major concern was to identify the majority attitude of administrators, faculty, staff, and students pertaining to the treatment of this sexual minority on campus by these particular groups and in major areas of the campus, such as the classroom, athletics, and chapel. This study also allotted the latter half of the survey to an anonymous questionnaire for students who identify …

Obesity And Physical Function In Rural Women Who Enroll In A Lifestyle Modification Intervention For Reducing Blood Pressure, Patricia A. Hageman, Carol H. Pullen, Paul J. Dizona, Kristin Schmidt, Linda S. Boeckner

Journal Articles: Physical Therapy

Purpose: Rural women have high prevalence of obesity and prehypertension. Obesity, if associated with poor physical function, may have implications for applying activity guidelines for women volunteering for lifestyle modification. This study examined associations of body mass index (BMI) and percent body fat with measures of 1-mile walk time, post-walk perceived exertion, and 10-repetition chair stands in rural women ages 40-69.

Methods: Cross-sectional baseline data were collected using standardized methods from 289 rural women with prehypertension who volunteered for a lifestyle clinical trial for reducing blood pressure. ANOVAs and linear regression were used for analysis.

Results: With exception of the …

Graduation As A Function Of Attendance And Discipline Of Students In The Student Success Initiative Of Texas In One South Texas Urban School District, Maria Luisa Trevino-Guerra

Theses and Dissertations - UTB/UTPA

This study examined the trends and patterns across time of grade placement committee students on the dependent variable, graduation. Longitudinal data for independent variables, attendance and discipline was collected for 173 students from 2005 to 2013. The independent variables of attendance and discipline were examined to determine whether or not high school completion is dependent on these two measures.

The Grade 5 students of 2005-2006 in one south Texas large urban school district who were retained in the fifth grade or advanced to the next higher grade by the grade placement committee in accordance with the Student Success Initiative (SSI) …

The Effect Of Perceived Parental Style On Hispanic Adults Receiving Outpatient Substance Abuse Treatment In South Texas, Elizabeth C. Palacios

Theses and Dissertations - UTB/UTPA

Hirschi's (1969) Social Control Theory proposes that parental relationships serve as a shielding factor and has positive impact in the decreasing delinquency (i.e. substance use/abuse) in young people. This theory provides a framework for understanding substance use/abuse in young adult populations. Other factors including gender, cultural influences, family composition and birth order were also examined in this study. The Drug Abuse Screening Test - 20 (Skinner, 1982), the Parental Authority Questionnaire (Buri, 1991), and a demographic scale were utilized in a population of 182 adults in outpatient substance abuse treatment centers in South Texas, Texas Gulf Coast and areas in …

Syntheses And Characterization Of Advanced Nanocomposites And Platinum Complexes, Jing Fang

Theses (Pre-2016)

The present research focuses on the following two areas: (1) to prepare advanced nanocomposites through electropolymerization, and (2) to synthesize novel platinum complexes. (1) Substrate-Enhanced Electrodeposition of Polypyrrole on Carbon Nanotubes. Silver membrane filter (SMF) was utilized as a substrate, where carbon nanotubes (CNTs) were anchored and evenly distributed in its highly porous yet interconnected microstructure through vacuum filtration. Taking advantage of SMF's superb electrical conductivity, the CNTs-loaded SMF could be engaged as a working electrode, where pyrrole was electropolymerized on the surface of CNTs. Scanning electron micrograms demonstrated that polypyrrole (PPy) grew more evenly on the H202/HCl-pretreated single-walled CNTs …

Morphological, Biochemical, Histological, And Ultrastructural Protective Effects Of Misoprostol On Cisplatin Induced-Hepatotoxicity In Adult Male Rats, Ashraf Y. Nasr

Saudi Medical Journal

OBJECTIVE: To investigate the possible protective effect of misoprostol on cisplatin-induced hepatotoxicity. METHODS: Four-equal sized groups (control, cisplatintreated, misoprostol-treated, combined misoprostol, and cisplatin-treated) adult male Wistar rats (6 each) were used in this study. Body weight, liver weight, and liver weight/body weight ratio was calculated. Blood samples were obtained from the hearts of rats to determine the levels of total serum bilirubin (TSB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and albumin. Liver specimens were prepared for both light and electron microscopes. The study was carried out between June 2012 and April 2013 at the Anatomy Department, Faculty of Medicine, Zagazig …

Appraisal Of Antimicrobial Prescribing Practices Of Governmental And Non-Governmental Dentists For Hospitals In The Western Region Of Saudi Arabia, Sameer E. Al-Harthi, Lateef M. Khan, Hassan H. Abed, Huda M. Alkreathy, Ahmed S. Ali

Saudi Medical Journal

OBJECTIVE: To scrutinize the knowledge, attitude, and antimicrobial practices in Saudi Arabian Dentistry. METHODS: In this cross-sectional survey of dentists, a self-administered questionnaire comprising of 61 questions was dispersed to the participants randomly, which included their professional profile, awareness of the current scope of antimicrobial resistance, prescribing practice, frequency of antimicrobial prescription, and sources of continuing education of antimicrobials. The study took place in the Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia between February and April 2013. RESULTS: Knowledge and awareness concerning specific antimicrobials, with specific oral cavity lesion was 78% for the students and interns, …

Bone Metastasis From Ovarian Cancer: Clinical Analysis Of 26 Cases, Min Zhang, Jimei Sun

Saudi Medical Journal

OBJECTIVE: To study the clinical characteristics of bone metastasis from ovarian cancer, and facilitate physicians to develop treatment strategies. METHODS: This retrospective study was carried out in the Provincial Hospital Affiliated to Shandong University, Shandong, China. Twenty-six cases of bone metastasis from ovarian cancer treated between January 2002 and May 2008 were reviewed, and the clinical data were collected. RESULTS: In the current study, the incidence of bone metastasis is 0.82%. Twelve cases of bone metastasis occurred in the cervical vertebra, 10 in the lumbar vertebra, 8 in the pelvis, 7 in the thoracic vertebra, 5 in the limbs, one …

Cross-Reporting Of Interpersonal Violence And Animal Cruelty: The Charlotte Project, Dennis D. Long, Shanti J. Kulkarni

The Journal of Sociology & Social Welfare

The overlapping nature of interpersonal violence and animal cruelty is well established, however historically each issue has been addressed by distinct and separate protective systems. An innovative community-based project is described that utilized crosstraining as a mechanism to foster collaboration between human services and animal control agencies. Findings are useful for professionals and community stakeholders interested in facilitating the cross-reporting of interpersonal violence and animal cruelty.