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2013

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A Pointillism Approach For Natural Language Processing Of Social Media, Piyo Song Dec 2013

A Pointillism Approach For Natural Language Processing Of Social Media, Piyo Song

Computer Science ETDs

Natural language processing tasks typically start with the basic unit of words, and then from words and their meanings a big picture is constructed about what the meanings of documents or other larger constructs are in terms of the topics discussed. Social media is very challenging for natural language processing because it challenges the notion of a word. Social media users regularly use words that are not in even the most comprehensive lexicons. These new words can be unknown named entities that have suddenly risen in prominence because of a current event, or they might be neologisms newly created to …


Community Detection In Complex Networks, Yaojia Zhu Dec 2013

Community Detection In Complex Networks, Yaojia Zhu

Computer Science ETDs

The stochastic block model is a powerful tool for inferring community structure from network topology. However, the simple block model considers community structure as the only underlying attribute for forming the relational interactions among the nodes, this makes it prefer a Poisson degree distribution within each community, while most real-world networks have a heavy-tailed degree distribution. This is essentially because the simple assumption under the traditional block model is not consistent with some real-world circumstances where factors other than the community memberships such as overall popularity also heavily affect the pattern of the relational interactions. The degree-corrected block model can …


Agewise: Fighting The New Ageism In America [Book Review], Marc A. Ouellette Dec 2013

Agewise: Fighting The New Ageism In America [Book Review], Marc A. Ouellette

English Faculty Publications

Not since an eager, combat-booted pair of massive biceps attached to a deconstructionist waterbug with a PhD buttonholed me and shoved a Cultural Studies reader into my trembling matchstick arms has a single text caused me to enact as many multiple readings and to apply as many simultaneous readings as Margaret Morganroth Gullette’s Agewise: Fight the New Ageism in America. Honestly, I cannot offer a review of this text. It does not need one. I am only able to respond to it, and even then with the timidity, awe and respect imbued in the above-cited recollection. To put it simply—if …


Locking Compression Plate In Musculoskeletal Oncology'a Nriend In Need', Masood Umer, Kashif Abbas, Shahid Khan, Haroon Ur Rashid Dec 2013

Locking Compression Plate In Musculoskeletal Oncology'a Nriend In Need', Masood Umer, Kashif Abbas, Shahid Khan, Haroon Ur Rashid

Department of Surgery Docs

Abstract

BACKGROUND:

We are presenting our experience in the use of locking compression plate (LCP) after juxta-articular oncological resections in addition to its use in pathologic fracture.

METHODS:

A retrospective audit of skeletal reconstruction using LCP in 25 cases of long bone tumors was performed from 2008 to 2010. Reconstruction following limb salvage surgery was done in 17 patients and internal fixation of pathological fracture was done in 8 patients. All patients were available for > 12 months of follow-up, and thus assessed for union at the resected ends.

RESULTS:

There were 8 males and 17 females in the study. The …


Rectal Carcinoma Under 40 Years Of Age: Seven-Year Post-Treatment Follow-Up At A Tertiary Care Hospital In Pakistan, Naveed Haroon, Salma Khan, Rehman Alvi Dec 2013

Rectal Carcinoma Under 40 Years Of Age: Seven-Year Post-Treatment Follow-Up At A Tertiary Care Hospital In Pakistan, Naveed Haroon, Salma Khan, Rehman Alvi

Department of Surgery Docs

Objectives: To determine epidemiological characteristics, clinical presentation, histopathological features, and long-term follow-up of patients below 40 years of age with carcinoma rectum.Methods: The retrospective case series comprised all patients presenting with histopathological diagnosis of carcinoma rectum with age 15-40 years at the Aga Khan University Hospital between January 1994 and December 2004. Details regarding patient demographics, pre-operative assessment, management and tumour grade and stage were obtained from a prospectively maintained database. Continuous and categorical variables in the data were analysed.Results: Of the 23 patients in the study, 14 (60.89%) were male and 9 (39.13%) were female. Mean age of the …


Hydrochemical Investigation Of A Transient Parafluvial Zone Under Drought Conditions, Platte River, Nebraska, Audrey R. Boerner Dec 2013

Hydrochemical Investigation Of A Transient Parafluvial Zone Under Drought Conditions, Platte River, Nebraska, Audrey R. Boerner

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

Shallow groundwater (0.5 m -1.2 m deep) beneath a vegetated and non-vegetated fluvial island was observed in the lower Platte River, Nebraska, USA during exceptional summer drought. Over the course of three months, sub-hourly measurements of hydraulic head, and weekly measurements of redox indicators, δ2H, δ18O, and dissolved gases were analyzed together with nitrogen and carbon species from an array of shallow piezometers in the river bed and islands. These data were compared with the same parameters collected from a 15 m-deep riparian borehole. Vertical hydraulic gradients in the island piezometers indicated the vertical component to …


The Influence Of Incomer Status: The Role Of Rural Background, Knowledge Of Mental Health Services, Stigma, And Cultural Beliefs On Help-Seeking Attitudes, Sarah E. Herzberg Dec 2013

The Influence Of Incomer Status: The Role Of Rural Background, Knowledge Of Mental Health Services, Stigma, And Cultural Beliefs On Help-Seeking Attitudes, Sarah E. Herzberg

College of Education and Human Sciences: Dissertations, Theses, and Student Research

The purpose of this study was to explore the impact of incomer status, rural background, knowledge and familiarity with mental health services, rural cultural beliefs about mental health and perceived stigma on help-seeking attitudes in a rural Southwest Iowa area. Participants were 106 rural residents over the age of 18 recruited from a rural health clinic. A multiple regression analysis was performed resulting in rural cultural beliefs about mental health being the only statistically significant predictor of help-seeking in the model. Individuals who indicated identifying with rural cultural beliefs were less likely to report positive help-seeking attitudes. Implications of the …


Impact Of Standalone Personal Health Record Use On Clinical Outcomes Of Patients With Type 2 Diabetes: An Intervention Mixed Methods Study, Kevin T. Fuji Dec 2013

Impact Of Standalone Personal Health Record Use On Clinical Outcomes Of Patients With Type 2 Diabetes: An Intervention Mixed Methods Study, Kevin T. Fuji

College of Education and Human Sciences: Dissertations, Theses, and Student Research

The purpose of this study was to assess the impact of using an online personal health record (PHR) on clinical outcomes of patients with type 2 diabetes. This study used an intervention mixed methods approach with a quantitative randomized, controlled trial combined with a qualitative exploration of how patients used the PHR. A total of 140 participants with type 2 diabetes were randomized to either receive a PHR and training to use the PHR, or to a control group who received usual care. Both clinical and social cognitive outcomes were measured and compared at baseline and follow-up, three to six …


Perceptions Of Positive Youth Development Experiences Related To Rural Hispanic Youth Academic Success, Jill A. Goedeken Dec 2013

Perceptions Of Positive Youth Development Experiences Related To Rural Hispanic Youth Academic Success, Jill A. Goedeken

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Understanding the struggles rural Hispanic youth face academically, learning more about their perceptions of positive youth development experiences relating to their academic success connects the essence of the two experiences. The purpose of this qualitative study was to explore rural Hispanic youths’ perceptions of positive youth development experiences as they relate to their academic success. The phenomenological design was chosen to explore the essence of the shared experiences of positive youth development experiences among rural Hispanic youth in the Columbus, Nebraska, community. To understand a possible perceived connection between positive youth development experiences to academic success, 28 Hispanic youth from …


Peer Victimization, Social Support, And Internalizing Symptoms: The Role Of Organized Out-Of-School Activity Participation, Scott R. Frohn Dec 2013

Peer Victimization, Social Support, And Internalizing Symptoms: The Role Of Organized Out-Of-School Activity Participation, Scott R. Frohn

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Peer victimization is associated with and predictive of internalizing symptoms, such as loneliness and depression. Social support has been found to moderate the relationship between victimization and internalizing symptoms, with increased levels of support related to lower levels of internalizing symptoms for victims of peer abuse. The current study examined if organized out-of-school activity participation was associated with lower levels of internalizing symptoms for adolescents in general and for those victimized by peers. Possible gender differences were also explored. Results indicated that participating in a broader range of activities (breadth of participation) was generally associated with higher levels of internalizing …


Juvenile Court Officers’ Perceptions Of Innovation Adoption; What Personal And Contextual Factors Make A Difference In Levels Of Adoption? An Exploratory Mixed-Method Study., Brenda Jean Moran Dec 2013

Juvenile Court Officers’ Perceptions Of Innovation Adoption; What Personal And Contextual Factors Make A Difference In Levels Of Adoption? An Exploratory Mixed-Method Study., Brenda Jean Moran

College of Education and Human Sciences: Dissertations, Theses, and Student Research

This exploratory research examined levels of innovation adoption among Juvenile Court Officers (JCOs) in a Midwestern state. The researcher applied Everett M. Rogers’ Diffusion of Innovation model as the study’s framework. According to Rogers (2003), innovation is “an idea, practice or object that is perceived as new by an individual or other unit of adoption” (p. 475). The study sought to determine the extent that demographic and work-life variables such as gender, office location, caseload, years of service, personality/temperament and employee engagement contributed to levels of innovation adoption by JCOs. This study examined the characteristics of individuals and contexts in …


Transcriptomic Analyses Of The Co2-Concentrating Mechanisms And Development Of Molecular Tools For Chlamydomonas Reinhardtii, Andrew J. Brueggeman Dec 2013

Transcriptomic Analyses Of The Co2-Concentrating Mechanisms And Development Of Molecular Tools For Chlamydomonas Reinhardtii, Andrew J. Brueggeman

Department of Biochemistry: Dissertations, Theses, and Student Research

Microalgae, such as Chlamydomonas reinhardtii, account for a large percentage of photosynthesis that occurs on the planet. Many algae possess a Carbon-Concentrating Mechanism, or CCM, that actively transports inorganic carbon (Ci) into the cell to create artificially high internal levels of CO2, enhancing their rate of carbon fixation. The production of biofuels from algal sources can serve as both a renewable and carbon-neutral energy source. This thesis details research in Chlamydomonas, in the effort to both better understand the CCM in algae and improve laboratory and industrial manipulations with algae.

In the first chapter of this …


Effects Of Time Varying Background Noise Conditions On Human Perception And Performance, Andrew H. Hathaway Dec 2013

Effects Of Time Varying Background Noise Conditions On Human Perception And Performance, Andrew H. Hathaway

Durham School of Architectural Engineering and Construction: Dissertations, Theses, and Student Research

This thesis was designed to study the effects of changing noise conditions on human perception and performance. In two phases, participants were exposed to a number of noise conditions and their performance on an arithmetic task involving short-term memory was monitored and their subjective perception of noise conditions was collected via questionnaires.

In the first phase, participants were tested while being subjected to RC-29(H) and RC-47(RV) conditions created by broadband noise fluctuating on different time intervals, resembling the changing noise conditions potentially found in modern HVAC systems. These intervals varied from two minutes to ten minutes. Results show a significant …


Population Occurrence And Pathogen Prevalence Of Lone Star Ticks (Acari: Ixodidae) Collected From Southeast Nebraska, Amanda C. Maegli Dec 2013

Population Occurrence And Pathogen Prevalence Of Lone Star Ticks (Acari: Ixodidae) Collected From Southeast Nebraska, Amanda C. Maegli

Department of Entomology: Dissertations, Theses, and Student Research

Lone star tick, Amblyomma americanum (L.), has recently become established in Nebraska; therefore, local biology, ecology, and tick-borne disease risk are not known. Research was conducted to determine monthly questing activity, establishment, and pathogenic microorganisms associated with the lone star tick in Nebraska.

Lone star tick populations were collected from May through August, 2012 in six sites in southeast Nebraska using carbon dioxide (CO2) traps. A total of 747 adults, 3,076 nymphs, and 1,289 larvae were collected. Total ticks collected and monthly activity were significantly different for each site.

A semi-randomized sample of 251 adult ticks were selected …


Toxic And Repellent Effects Of Pyrethroids Used In Orchards On The Honey Bee, Apis Mellifera L. (Hymenoptera: Apidae), Erin M. Ingram Dec 2013

Toxic And Repellent Effects Of Pyrethroids Used In Orchards On The Honey Bee, Apis Mellifera L. (Hymenoptera: Apidae), Erin M. Ingram

Department of Entomology: Dissertations, Theses, and Student Research

Managed honey bee colonies provide valuable pollination services and are rented by fruit orchards to improve fruit quality and yield. The placement of colonies in this agricultural setting increases the possibility of exposure to pyrethroids used for broad-spectrum pest control in orchards. Although highly toxic to bees, pyrethroids are believed to pose a relatively low hazard due to their low application rates in the field as well as their contact repellent properties. Previous studies have noted a decrease in foraging visits following pyrethroid application possibly preventing bees from acquiring a lethal dose in the field.

This research quantified behaviors associated …


Impact Of Wheat Streak Mosaic Virus And Triticum Mosaic Virus On Transmission By Aceria Tosichella Keifer (Eriophyidae) And Virus Epidemiology In Wheat, Camila F. De Oliveira Dec 2013

Impact Of Wheat Streak Mosaic Virus And Triticum Mosaic Virus On Transmission By Aceria Tosichella Keifer (Eriophyidae) And Virus Epidemiology In Wheat, Camila F. De Oliveira

Department of Entomology: Dissertations, Theses, and Student Research

The wheat curl mite (WCM), Aceria tosichella Keifer, transmits a complex of viruses, Wheat streak mosaic virus (WSMV), Triticum mosaic virus (TriMV) and Wheat mosaic virus (WMoV), to wheat, Triticum aestivum, in the Great Plains. Co-infection of wheat by these viruses is frequently observed, increasing disease severity and yield loss.

Current genetic work classifies WCM populations into two genotypes, Type 1 and Type 2. It has been shown that different mite genotypes are able to transmit viruses at varying rates. WCM-virus relations are very specific and can impact vector biology. In this study, the primary objective was to determine …


Defining Scavenger-Actors: Understanding A Global Menace, James Harrold Dec 2013

Defining Scavenger-Actors: Understanding A Global Menace, James Harrold

Department of Political Science: Dissertations, Theses, and Student Research

This article introduces a new international actor, the 'scavenger-actor', as a replacement for warlords and pirate gangs. The article first reviews literature on both piracy and warlordism in historical and modern contexts in order to provide a basis for its argument of a new definitional term encompassing both groups. A negative binomial regression model is then applied to data on pirate attacks and measurements of state health to show that piracy is as closely tied to state failure as is warlordism. Finally, the article presents its argument for the new term, 'scavenger-actor', as a needed reform to political science discourse, …


"Hunger Is The Best Sauce": Frontier Food Ways In Laura Ingalls Wilder's Little House Books, Erin E. Pedigo Dec 2013

"Hunger Is The Best Sauce": Frontier Food Ways In Laura Ingalls Wilder's Little House Books, Erin E. Pedigo

Department of History: Dissertations, Theses, and Student Research

This thesis examines Laura Ingalls Wilder's Little House book series for the frontier food ways described in it. Studying the series for its food ways edifies a 19th century American frontier of subsistence/companionate families practicing both old and new ways of obtaining food. The character Laura in Wilder's books is an engaging narrator who moves through childhood and adolescence, assuming the role of housewife. An overview of the century's norms about food in America, the strength of domesticity as an ideal, food and race relations, and the frontier as a physical place round out this unexplored area of Little House …


Hardy, Darwin, And The Art Of Moral Husbandry, Owen Roberts-Day Dec 2013

Hardy, Darwin, And The Art Of Moral Husbandry, Owen Roberts-Day

Department of English: Dissertations, Theses, and Student Research

This study of the influence of Charles Darwin on Thomas Hardy's tragic novels centers on two key concepts in the work of Darwin. The first is Darwin's narrative of the evolution of morality, which describes moral decisions as a struggle for survival between various instincts, habits, and customs, both within the individual and within society as a whole. Of particular importance is the role of reason and sympathy in overcoming base and selfish instincts. The second is the idea, introduced in Origin, that the work of scientific breeders represents an act of Conscious Selection, a separate form of evolution …


Investigation Of Commercial Milk Enzyme-Linked Immunosorbent Assay (Elisa) Kits: Specificity And Utility For Residues Of Foods Subjected To Proteolysis During Processing, Katherine O. Ivens Dec 2013

Investigation Of Commercial Milk Enzyme-Linked Immunosorbent Assay (Elisa) Kits: Specificity And Utility For Residues Of Foods Subjected To Proteolysis During Processing, Katherine O. Ivens

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Analytical methods, such as enzyme-linked immunosorbent assays (ELISA), are used to detect and quantify residues from allergenic sources in food products. However, ELISAs have not been validated for use in foods that have been exposed to proteolysis. This thesis explores the specificities, sensitivities, and capabilities of commercially-available milk ELISA kits for detecting milk residues in cheeses that have undergone varying degrees of proteolysis.

The specificity, accuracy, and consistency of twelve commercially-available milk ELISA kits for individual milk proteins and commonly used milk-derived ingredients, including α-,β-, and κ-casein, β-lactoglobulin, α-lactalbumin, non-fat dry milk, sodium caseinate, and whey protein concentrate were evaluated. …


The Influence Of Regulations On Duck Hunters And Harvest, Matthew T. Haugen Dec 2013

The Influence Of Regulations On Duck Hunters And Harvest, Matthew T. Haugen

School of Natural Resources: Dissertations, Theses, and Student Research

Although regulations, duck hunters, and duck harvest are interconnected, the relationships among them have not been fully explored. I used U.S. Fish and Wildlife Service’s Parts Collection Survey to examine both duck harvest and duck hunter behaviors with regard to regulations in the Central Flyway. I first examined what factors best explained the daily variation in harvest distribution across the hunting season for mallards (Anas platyrhynchos), dabbling ducks (Anas spp.), and diving ducks (Aythya spp.). Secondly, I examined how hunter behaviors were influenced by harvest regulations. Finally, I documented co-occurrence of duck species in the daily …


Improving Time Structure Patterns Of Orthogonal Markov Chains And Its Consequences In Hydraulic Simulations, Juan C. Jaimes-Correa Dec 2013

Improving Time Structure Patterns Of Orthogonal Markov Chains And Its Consequences In Hydraulic Simulations, Juan C. Jaimes-Correa

School of Natural Resources: Dissertations, Theses, and Student Research

Rainfall1 occurrences understood as rain events are relevant for agricultural practices because temporal distribution of rainfall highly affects yield production. A few stochastic models satisfactorily generate daily rainfall events while preserving temporal and spatial dependence among multiple sites. I evaluated an extension on the traditional Orthogonal Markov chain (TOMC) model in reproducing the temporal structure of rainfall events at multiple sites in Florida (FL), Nebraska (NE) and California (CA). In addition, a simulation of watershed runoff from rainfall events, reproduced by a single- and multi-site weather generator, was conducted. Results shows that (i) a temporal structure extended …


Spatial And Temporal Participation In Recreational Fishing, Dustin R. Martin Dec 2013

Spatial And Temporal Participation In Recreational Fishing, Dustin R. Martin

School of Natural Resources: Dissertations, Theses, and Student Research

Buffering inland fisheries against large-scale changes in ecosystem function, climate regimes, and societal valuations of natural resources requires progressive management approaches that incorporate fish and angler dynamics at large spatial and temporal scales. Current paradigms of inland fishery management generally utilize waterbody-specific, fish-centric frameworks designed to regulate fish populations directly, and anglers indirectly, through fish stock enhancement and harvest regulation. In reality, anglers are the most manageable component of a fishery but management of anglers requires explicit consideration of their behavior (e.g., spatial and temporal patterns of participant use), which, unlike fish populations, operates at a scale larger than a …


Anoxia Tolerance Of Forensically Important Calliphorids, Melissa M. Lein Dec 2013

Anoxia Tolerance Of Forensically Important Calliphorids, Melissa M. Lein

School of Natural Resources: Dissertations, Theses, and Student Research

Forensically important blow flies, Diptera: Calliphoridae, are among the first organisms to colonize carrion. After eggs hatch, the larvae of most blow fly species feed in an aggregation or “mass.” While in this mass larvae may experience periods of no oxygen (anoxia), little oxygen (hypoxia), or normal oxygen (normoxia), but the tolerance of blow fly larvae to severe hypoxic conditions is not known. I tested the anoxia tolerance of four species of calliphorids (Calliphora vicina, Cochliomyia macellaria, Lucilia sericata, and Phormia regina), using third stage larvae across five temperatures. Experiments were conducted by exposing larvae to pure nitrogen …


A Population Model For Walleye In Nebraska Irrigation Reservoirs, Robert A. Kill Dec 2013

A Population Model For Walleye In Nebraska Irrigation Reservoirs, Robert A. Kill

School of Natural Resources: Dissertations, Theses, and Student Research

Understanding how and why fish population size changes between years is a central theme in fisheries ecology. Fishery agencies have limited time and financial resources, thus there is a need for a quantitative way to direct the limited time and financial resources so agencies can manage fisheries more efficiently. I developed a tool for fishery managers that synthesizes common population indices and evaluated the relative importance of those indices given varying uncertainty in age-0 walleye Sander vitreus survival. Under most circumstances, I determined that resources are best utilized in reducing age-0 survival uncertainty when understanding walleye population growth. I applied …


Predicting Invasion Risk Of Non-Native Plants Using A Modified I-Rank Assessment, Justin B. Williams Dec 2013

Predicting Invasion Risk Of Non-Native Plants Using A Modified I-Rank Assessment, Justin B. Williams

School of Natural Resources: Dissertations, Theses, and Student Research

Biological invasions are a global problem responsible for native species declines worldwide. Understanding the invasion risk from non-native species is important in establishing management goals and making decisions for managing native ecosystems. Useful modeling methods for quantifying or predicting invasion risk should consider research needs, data availability, and operate at an appropriate scale. I evaluated risk assessment methods towards answering a specific research question; which plant species pose the greatest risk of becoming invasive or having the greatest negative impact in Nebraska? I selected the I-Rank assessment method, which consists of 20 questions grouped into four risk categories or Subranks: …


Determining Scaphirhynchus Sturgeon Population Demographics And Dynamics: Implications For Range-Wide Management, Recovery, And Conservation, Martin J. Hamel Dec 2013

Determining Scaphirhynchus Sturgeon Population Demographics And Dynamics: Implications For Range-Wide Management, Recovery, And Conservation, Martin J. Hamel

School of Natural Resources: Dissertations, Theses, and Student Research

Sturgeons (Acipenseridae) have experienced world-wide declines as a result of anthropogenic effects such as over-harvest, habitat degradation, altered flow regimes, and pollution. Nearly all European and Asian sturgeon species have experienced population declines and have subsequently been classified as either threatened or endangered. North American sturgeons have experienced a similar plight in that all eight native sturgeon species are listed as endangered, threatened, or of special concern. Direct linkages between North American sturgeon declines and anthropogenic effects are difficult to assess due to scale considerations, fluctuating environmental conditions, difficulty in capture, and the interaction of all these effects. To recover, …


Witnessing Inter-Parental Violence At Home: Adolescents And School Achievement, Renita Dawn Robinson-Tyrance Dec 2013

Witnessing Inter-Parental Violence At Home: Adolescents And School Achievement, Renita Dawn Robinson-Tyrance

Department of Sociology: Dissertations, Theses, and Student Research

Children’s exposure to violence is a serious social problem, but little is known about the educational implications for adolescents witnessing violence between parents. This study uses social learning theory (SLT) to examine the relationship between high school-aged adolescent students who witness parental intimate partner violence (IPV) and academic performance demonstrated by their grade point averages (GPA). A secondary analysis of data collected from the survey of 1,132 adolescent students in a medium sized, suburban/rural city was conducted. Of the respondents, 83% of the students did not witness parental IPV between parents. Students witnessing the most parental IPV had the lowest …


Development Of Food Safety Education And Pilot Study Specifically For Native Americans Audiences, Kristine M. Foley Dec 2013

Development Of Food Safety Education And Pilot Study Specifically For Native Americans Audiences, Kristine M. Foley

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

The purpose of this study was to develop and implement a culturally appropriate food safety educational program using the conceptual change teaching method while preparing a meal. The food safety educational program was based on the FightBac!™ concepts (CLEAN, SEPARATE, COOK AND CHILL). Quantitative and qualitative date were collected, compared, and analyzed. Two pilot studies were conducted with Native American participants on non-reservation sites in Omaha and Lincoln. A total of 27 participants completed a pre and post knowledge survey and were video recorded preparing a meal. The majority of the participants were female (78%), had at least a high …


The Development And Applications Of Nmr Metabolomics Analysis Of Bacterial Metabolomes, Steven M. Halouska Dec 2013

The Development And Applications Of Nmr Metabolomics Analysis Of Bacterial Metabolomes, Steven M. Halouska

Department of Chemistry: Dissertations, Theses, and Student Research

Metabolomics is a relatively new field that involves the study of metabolic responses that are occurring within a biological system. Metabolite profiles of an organism, tissue extract, and biofluids are important indicators to determine the physiological state of a biological profile. Comparison of such profiles from different phenotypes can be used to identify specific metabolic changes leading to the understanding of metabolic pathways, disease progression, drug toxicity and efficacy, and cellular responses to different intracellular and extracellular conditions. Metabolomics investigations often use sophisticated analytical techniques such as NMR spectroscopy to provide an unbiased and comprehensive approach to evaluate metabolic perturbation …