Digital Commons Network^™

Sphingosine-1-Phosphate And Fingolimod (Fty720) Regulate Icl,Swell In Hl-1 Cardiac Myocytes Via Intracellular Binding And Mitochondrial Ros Production, Pooja Desai

Theses and Dissertations

Swelling-activated Cl− current (ICl,swell) is an outwardly-rectifying current that plays an important role in cardiac electrical activity, cellular volume regulation, apoptosis, and acts as a potential effector of mechanoelectrical feedback. Persistent activation of ICl,swell has been observed in models of cardiovascular disease. We previously suggested sphingosine-1-phosphate (S1P) activates volume-sensitive Cl- current (ICl,swell) by ROS-dependent signaling. S1P and its analog, FTY720 (fingolimod), primarily act via G-protein coupled receptors (S1PR; S1PR1-3 in heart), but several intracellular S1P ligands are known. We investigated how these agents regulate ICl,swell. ICl,swell was elicited by bath S1P (500 nM), FTY720 (S1PR1,3 agonist; 10 μM), and SEW2871 …

White Trash, Heather Law

Theses

White Trash, is body of work that aims to reflect upon our personal role and contribution to the solid waste stream through routine consumption and waste disposal. From everything we eat and drink, to the refuse we flush down the drain, we all consume resources. Living in a materially saturated, mass-consumer society, we have evolved into an increasingly disposable culture. By identifying with our waste production, we then can better evaluate the pitfalls of our materialistic ways. Common consumer products stuffed inside a toilet creates a recognizable waste pattern found within the domestic household. Our trash is considered pollution. Once …

The Confessions Of A Backslider, Henry Clay Morrison

Heritage Material

No abstract provided.

Determining A New Alignment Scoring Matrix For Disordered Proteins, Adam Handen

Theses

Intrinsically disordered proteins (IDPs) are polypeptide sequences that do not form a rigid three dimensional structure when isolated in the cytosol of the cell. These sequences are very common in most genomes, and usually are involved in many protein-protein interactions. IDPs also play a key role in many diseases, including cancer and Huntington's disease. However, IDPs are difficult to study because of their amorphous shape, high mutation rate, and unique amino acid composition. These obstacles make homology studies especially difficult.

This study focused on generating a new substitution matrix designed to aid in homology studies of IDPs. The matrix was …

La Carte D’Identité De Jean-Marie Adiaffi Ou La Quête Identitaire À Travers La Symbolique De L’Initiation Allégorique, Theodore Akohoue

The Coastal Review

Since the earliest contact between Sub-Saharan Africans and Europeans, European literature tends to erase African history and civilization. Later, after an unsuccessful erasure, colonial literature denigrates it as primitive. Using the “identity card” as a motif in his novel, Jean-Marie Adiaffi exposes the defects of European colonization in its African colonies. Through an approach of allegorical initiation symbolism, Addiaffi revalorizes his culture, tradition, and identity all denied by colonial rule.

Metafilm In The Spanish Post-Civil War Period: Cinematic Self-Reflection In Berlanga’S Bienvenido, Mr. Marshall And Bardem’S Calle Mayor, Lucy F. Lee

The Coastal Review

The focus on the self-referential as a means of destabilizing reality and calling attention to the artificial nature of life may be noted in a number of films of the Spanish post-Civil War period, among them José Antonio Berlanga’s Bienvenido, Mr. Marshall and Juan Antonio Bardem’s Calle Mayor. Through their use of metacinematic devices such as distancing techniques, parody, and the incorporation of performance and cinematic models, the constructed nature of provincial life and Spanish identity is exposed, ushering in a new era of Spanish cinema.

He Healed Them: The Church’S Ministry Of Healing, Frank Bateman Stanger

Heritage Material

No abstract provided.

Halls Aflame: An Account Of The Spontaneous Revivals At Asbury College In 1950 And 1958, Robert E. Coleman, Henry C. James, Paul Rader

Heritage Material

No abstract provided.

The Follies Of Fosdick, Henry Clay Morrison

Heritage Material

No abstract provided.

"In Our Veins Flows The Blood Of Many Brave Races": The Influence Of The German Literary Vampire On Constructions Of Race And Nation In Nineteenth-Century British Vampire Fiction, Amanda L. Alexander

Cal Poly Humboldt theses and projects

The literary vampire figure, as it would be recognized today, entered English literature through translations of late eighteenth century German poetry. The purpose of this project is to explore how the relationship between German vampire ballads and British vampire narratives acts as a literary manifestation of German-British cultural and political attitudes and interactions in the roughly century and a half before World War I. This relationship will be discussed through an exploration of the constructs of blood and body within vampire narratives in direct relationship to sociocultural discourses of race in Pre-WWI England. This project seeks to explore the following …

The Evolution Of Animal Identification In Beef Cattle, Kristy E. Boehler

Nebraska Law Review

The United States’ beef cattle industry’s recent past has been plagued by a lack of a national animal identification system. The lack of a national animal identification system has made it difficult, if not impossible, to track a diseased animal back to its farm of origin or determine what other cattle have been in contact with the diseased animal. In fact, during the investigation of the December 2003 Bovine Spongiform Encephalopathy (Mad Cow Disease) outbreak, the lack of a national animal identification system meant that the United States was only able to locate twenty-eight of the eighty cows that entered …

Like A Glass Slipper On A Stepsister: How The One Ring Rules Them All At Trial, Cathren Koehlert-Page

Nebraska Law Review

This article will present the literary concept of endowed objects, provide examples of endowed objects in literature, provide examples of endowed objects in trials, and then discuss how attorneys can identify and use evidence to create an endowed object. Part II of this article explains why endowed objects are useful at trial. Part III defines endowed objects, explains the similarities and differences between endowed objects and other symbols, and illustrates the use of both in fiction and at trial. Part IV describes the process of endowing an object in both fiction narratives and legal narratives. Part V discusses how endowed …

Masthead And Table Of Contents

Nebraska Law Review

No abstract provided.

It Is Time The Law Begins To Protect Consumers From Significantly One-Sided Arbitration Clauses Within Contracts Of Adhesion, Anjanette Raymond

Nebraska Law Review

Businesses are accused of using arbitration as a private dispute resolution system that shields their transgressions from public scrutiny, uses arbitrators and institutions that are perceived as biased, and prevents any real means of justice to the consumer. Something must be done to ensure that consumers facing mandatory arbitration clauses within contracts of adhesion are protected from businesses that seek to use arbitration as an advantageous means to resolve disputes. The American public, a section of Congress, and the arbitration community are all responding, but out-of-date law and recent decisions are thwarting their efforts. It is time for Congress to …

Assessing Institutional Ability To Support Adaptive, Integrated Water Resources Management, Christina M. Hoffman, Sandra Zellmer

Nebraska Law Review

At a time when many, if not all, western states are under pressure to redefine how water resources are managed, this Article provides insight into how one state—Nebraska—has attempted to modify the water management institutions within its borders to implement more integrated management approaches that embrace flexibility and adaptability. Nebraska is a state that has extensive surface and groundwater development and different legal systems and management agencies for governing surface and groundwater resources. This late in the game, the state is unlikely to assimilate governance of surface and groundwater resources into a single, overarching legal system. Instead, Nebraska has adopted …

Hydropower: It’S A Small World After All, Gina S. Warren

Nebraska Law Review

Part I of this Article will explore the history and rise of hydroelectric power generation—from water mills to mega dams—and its regulation in the United States. The water mill was one of the first mechanisms used by mankind to harness power. It is a simple use of momentum to create energy. Water mills were used to grind grain, saw logs, create textiles, and fashion tools. As societies evolved, so did the use of water mills, and once electricity and generators arrived on the scene in the late 1800s, hydropower proved to be an efficient means of producing electricity. By the …

Latinos In Massachusetts Selected Areas: Boston, Phillip Granberry, Sarah Rustan, Faye Karp

Gastón Institute Publications

This report provides a descriptive snapshot of selected economic, social, educational, and demographic indicators pertaining to Latinos in Boston. It reflects a commitment by UMass Boston’s Mauricio Gastón Institute for Latino Community Development and Public Policy to provide periodic updates on the growing Latino population in Massachusetts.

The report on Boston is part of a larger series that covers fourteen other cities, or clusters of cities, in the Commonwealth of Massachusetts. Each report analyzes data from the 2010 American Community Survey (ACS) conducted by the U.S. Census Bureau. Data are analyzed by Public Use Microdata Area (PUMA), which consists of …

Children And Categorization: Maintaining A Standard For Recognizing Speech Categories In Brown V. Entertainment Merchants Ass’N, 131 S. Ct. 2729 (2011), Erick D. Reitz

Nebraska Law Review

The freedom to speak one’s mind free of persecution has long occupied a place of particular gravity in American culture. At its core is the idea that government cannot control our access to certain ideas by restricting some messages but not others—it prohibits government from discriminating against content. To be workable, however, this right must acknowledge exceptions, and it does so by allowing discrimination against certain types of speech to bypass this strict First Amendment protection. So while the Supreme Court prohibits discrimination of most content, there are a few types of speech, such as libel or incitement, that receive …

Law School Marketing And Legal Ethics, Ben Trachtenberg

Nebraska Law Review

This Article will show that although Paul Pless, Assistant Dean for Admissions and Financial Aid at the University of Illinois College of Law, and Mark Sargent, the Dean of Villanova University School of Law, acted with unusual mendacity, misrepresentation in law school marketing is by no means unique to a few bad actors at a handful of law schools. Part II describes many ways in which law school officials have used deceit and misrepresentation, along with misleading statistics, to market legal education. In addition to highlighting examples of particularly egregious marketing, it depicts how the common presentation of employment statistics …

Custody Of The Confined: Consideration Of The School Setting In J.D.B. V. North Carolina, 131 S. Ct. 2394 (2011), Kelli L. Ceraolo

Nebraska Law Review

The recent United States Supreme Court decision in J.D.B. v. North Carolina illustrates the Court’s continuing efforts to clarify when Miranda warnings are necessary. The Miranda framework requires courts to decide whether, under the circumstances of the interrogation, a reasonable person would have felt free to end the interrogation and leave. This usual framework cannot properly be applied to interrogations of suspects taking place in the K–12 school setting because a reasonable person in those circumstances would not feel free to leave even without the police presence. In this setting, where the suspect is already confined, a special rule is …

Forging Toward Coexistence, Laurie J. Beyranevand

Nebraska Law Review

This Article argues that because current federal policies hamper the ability of organic and non-GE farmers to ensure the safety and authenticity of their products, the AC21 needs to meet its charge and reach consensus on USDA supported mechanisms that encourage and facilitate farmers to develop long term, viable solutions that address the interests of all parties. Without USDA support, farmers have little incentive to attempt collaboration under the umbrella of existing federal policies. Part II of this Article provides a detailed history of the regulatory scheme that governs genetically engineered plants and products and demonstrates the clear preference for …

Latinos In Massachusetts Selected Areas: Brockton, Phillip Granberry, Sarah Rustan, Faye Karp

Gastón Institute Publications

This report provides a descriptive snapshot of selected economic, social, educational, and demographic indicators pertaining to Latinos in the Brockton-Abington area. It reflects a commitment by UMass Boston’s Mauricio Gastón Institute for Latino Community Development and Public Policy to provide periodic updates on the growing Latino population in Massachusetts.

The report on the Brockton-Abington area is part of a larger series that covers fourteen other cities, or clusters of cities, in the Commonwealth of Massachusetts. Each report analyzes data from the 2010 American Community Survey (ACS) conducted by the U.S. Census Bureau. Data are analyzed by Public Use Microdata Area …

Latinos In Massachusetts Selected Areas: Lynn, Nahant, And Saugus, Phillip Granberry, Sarah Rustan, Faye Karp

Gastón Institute Publications

This report provides a descriptive snapshot of selected economic, social, educational, and demographic indicators pertaining to Latinos in the cities of Lynn, Nahant, and Saugus. It reflects a commitment by UMass Boston’s Mauricio Gastón Institute for Latino Community Development and Public Policy to provide periodic updates on the growing Latino population in Massachusetts.

The report on Lynn, Nahant, and Saugus is part of a larger series that covers fourteen other cities, or clusters of cities, in the Commonwealth of Massachusetts. Each report analyzes data from the 2010 American Community Survey (ACS) conducted by the U.S. Census Bureau. Data are analyzed …

Latinos In Massachusetts Selected Areas: Worcester, Phillip Granberry, Sarah Rustan, Faye Karp

Gastón Institute Publications

This report provides a descriptive snapshot of selected economic, social, educational, and demographic indicators pertaining to Latinos in Worcester. It reflects a commitment by UMass Boston’s Mauricio Gastón Institute for Latino Community Development and Public Policy to provide periodic updates on the growing Latino population in Massachusetts.

The report on Worcester is part of a larger series that covers fourteen other cities, or clusters of cities, in the Commonwealth of Massachusetts. Each report analyzes data from the 2010 American Community Survey (ACS) conducted by the U.S. Census Bureau. Data are analyzed by Public Use Microdata Area (PUMA), which consists of …

Teaching For Tomorrow: Utilizing Technology To Implement The Reforms Of Maccrate, Carnegie, And Best Practices, Stephen Johnson

Nebraska Law Review

More than a half century ago, famed educator John Dewey predicted that, “[I]f we teach today’s students as we taught yesterday’s, we rob them of tomorrow.”1 While Dewey was not referring to legal education, the legal education community has echoed his call for reform for decades.2 Critics routinely assert that the “Socratic Method” and Christopher Columbus Langdell’s “Case Method”3 that are still employed by many law professors4 fail to provide students with a variety of important skills that are necessary to practice law.5 Further, critics argue that those traditional methods fail to adequately focus students on the important issues of …

Private Memorials On Public Space: Roadside Crosses At The Intersection Of The Free Speech Clause And The Establishment Clause, Amanda Reid

Nebraska Law Review

Private roadside memorials are part of a growing trend among the bereaved who seek to “make sense of senseless deaths” along the public roadways.2 These memorials, which often feature a Latin cross, are part of deeply meaningful bereavement practices that support the grieving process. As such, these memorials are created to satisfy a human need during a time of crisis and are, therefore, largely constructed without regard to the legality of erecting such markers.3 Courts have yet to provide clear guidance on the constitutionality of erecting and maintaining these private memorials on public spaces. This Article considers the constitutional guideposts …

The Last Rites Of Public Campaign Financing?, James Sample

Nebraska Law Review

This Article asserts the current predicament of public campaign financing is this: options that are still on the table under the Court’s First Amendment jurisprudence are, with only rare and idiosyncratic exceptions, fiscal and political non-starters. Conversely, options that would be, and indeed previously had been, fiscally and politically viable, are now, even after years of their routine practice in varied jurisdictions, no longer constitutional. It is, in short, simultaneously a legal and practical dilemma. Short of highly unlikely swings of the Supreme Court pendulum, and absent an even more unlikely constitutional amendment, cities, states, and federal government actors, who …

Give Me Your Tired, Your Poor, Your Particular And Socially Visible Masses: The Eighth Circuit’S New Standard Governing Particular Social Group Asylum Applications After Gaitan V. Holder, 671 F.3d 678 (8th Cir. 2012), Christopher J. Preston

Nebraska Law Review

For many noncitizens today, the law of asylum exists as the sole route to lawful residence in the United States. The safety and relief that the mere borderlines of our nation secure for some of the most desperate and oppressed are accessed only through this one body of law. Though it may not say so on the pedestal of the Statue of Liberty, passage through Emma Lazarus’s “golden door”1 (or, in other cases, permission to stay on this side of the door) for “the homeless, tempesttost” 2 requires, for many, navigation through the modern obstacles of asylum law. Needless to …

Experiences And Perceptions Of Mental Health Professionals Considered Effective In The Diagnosis And Treatment Of Adults With Attention Deficit Hyperactivity Disorder, Bonita H. Erb

Counseling & Human Services Theses & Dissertations

Attention Deficit Hyperactivity Disorder (ADHD) is a disorder that has been documented in medical and mental health literature for over 100 years (Still, 1902). ADHD is a neurobiological based disorder characterized by three major symptoms identified at clinical levels and validated by diagnostic criteria established for the diagnosis of children before the age of seven (Diagnostic and Statistical Manual of Mental Disorders, 4 th edition-Text Revision; DSM-IV; American Psychiatric Association, 2000). The three diagnostic criteria are inattention, impulsivity, and hyperactivity that have been observed at clinical levels.

Because many signs of the disorder were believed to discontinue …

Community College Presidents' Perspectives Of Dichotomous Events: The Consequences Of The Great Recession & Coincidental Increased Enrollment, Corey W. Carlson

Educational Leadership & Workforce Development Theses & Dissertations

The community college, like all of higher education, has been significantly impacted by the Great Recession and coincidental increased enrollment. The purpose of this qualitative study was to examine the decision making processes of community college presidents as related to resource allocation and the impact of these decisions on the comprehensive community college mission. Declining state funding and increased enrollments have greatly impacted how community college leaders make decisions with leaders incorporating shared governance and informed decision-making. Community college leaders have also been proactively seeking out alternative revenue streams in order to help offset decreased state funding. Findings of this …