Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2013

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 125761 - 125790 of 129999

Full-Text Articles in Entire DC Network

The Role Of Palmitoylation And Other Post-Translational Modifications In Cftr Biogenesis, Michelle Mcclure Jan 2013

The Role Of Palmitoylation And Other Post-Translational Modifications In Cftr Biogenesis, Michelle Mcclure

All ETDs from UAB

Post-translational modifications (PTMs) are important contributors to protein bio-genesis and function. CFTR in particular is known to be regulated by multiple PTMs, in-cluding glycosylation, phosphorylation, and ubiquitination. The functional significance and specific CFTR residues responsible for the majority of PTMs within CFTR are not known. The goal of this dissertation was to identify and characterize novel PTMs that influence wild-type and F508del CFTR. The study employed a combination of tandem and multiple reaction ion monitoring mass spectrometry to identify covalent side chain attachments. Analysis revealed the specific locations of numerous phosphorylated resi-dues, several sites of methylation, and more than twenty-five …

Go to article

Characterizing The Roles Of Il-11 And Cd68 In Breast Cancer Bone Metastasis, Erin Mills Mccoy Jan 2013

Characterizing The Roles Of Il-11 And Cd68 In Breast Cancer Bone Metastasis, Erin Mills Mccoy

All ETDs from UAB

The molecular mechanisms regulating the preferential metastasis of breast cancer to bone have not been fully elucidated, but it is hypothesized that local conditions in the bone create an environment conducive to colonization by breast cancer cells and that the breast cancer cells interact directly with cells in the bone. In this dissertation, two goals were pursued: (1) to explore breast cancer secreted interleukin (IL)-11's role on osteoclast function and (2) investigate the expression and potential role of CD68 in breast cancer adhesion to bone. Higher rates of bone metastasis occur in human breast cancer tumors expressing IL-11, a cytokine …

Go to article

Cooking With Caste Iron: Food System Modernization In Birmingham, 1910-1964, Thomas Carl Mclemore Jan 2013

Cooking With Caste Iron: Food System Modernization In Birmingham, 1910-1964, Thomas Carl Mclemore

All ETDs from UAB

This thesis aims to capture the social and political conditions that contributed to the rise of class and racial disparities in Birmingham's food system. The way in which all Birmingham residents located, grew, raised, purchased, cooked, and consumed food reinforced and furthered a caste system of social dispossession and black oppression. An overview of the poor health conditions of the pre-modern, industrial city provides a basis for understanding the reasoning of later efforts in systematic modernization. These efforts took place amid broader, national contexts of political and social Progressivism and the emerging paradigm of the New South. These trends contributed …

Go to article

Apparent Change In Obesity-Mortality Associations: Methodological Issues In Survival Analyses With Censored Outcomes, Tapan Shirish Mehta Jan 2013

Apparent Change In Obesity-Mortality Associations: Methodological Issues In Survival Analyses With Censored Outcomes, Tapan Shirish Mehta

All ETDs from UAB

Analyses of the National Health and Nutrition Examination Survey (NHANES) have suggested that the mortality rate (MR) associated with obesity has decreased over calendar time. However, there has been conflicting evidence about the apparent change in the obesity-MR over calendar time. This dissertation investigates some of the empirical and methodological issues involved in assessing the longitudinal change in the obesity-mortality associations. In the first manuscript, Obesity and Mortality: Are the Risks Declining? Evidence from Multiple Prospective Studies in the U.S., a multiple longitudinal design is proposed and implemented to evaluate whether the obesity-mortality associations have declined over calendar time after …

Go to article

An Examination Of The Molecular Mechanism Of E. Coli Clpap Catalyzed Polypeptide Translocation, Justin Mark Miller Jan 2013

An Examination Of The Molecular Mechanism Of E. Coli Clpap Catalyzed Polypeptide Translocation, Justin Mark Miller

All ETDs from UAB

ATP-dependent proteases catalyze the removal of both misfolded and properly folded proteins in cellular quality control pathways. ClpAP shares a structural homology with other ATP-dependent proteases where a hexameric ring of ClpA associates with one or both ends of the cylindrically-shaped protease ClpP, which contains serine protease active sites sequestered in its inner core. ClpA contains two nucleotide binding domains where ATP is bound and hydrolyzed, termed Domain 1 (D1) or 2 (D2). D1 has been shown to be primarily responsible for ClpA oligomerization, but both domains appear to support polypeptide translocation independently. We previously reported a molecular mechanism for …

Go to article

The Effects Of Extremes Of Ph On The Growth And Transcriptomic Profiles Of Three Haloarchaea, Aida Moran-Reyna Jan 2013

The Effects Of Extremes Of Ph On The Growth And Transcriptomic Profiles Of Three Haloarchaea, Aida Moran-Reyna

All ETDs from UAB

The Archaea represent a fascinating domain of life where each species comprises a hybrid of bacterial and eukaryal features. Unfortunately, there have been few investigations of the Archaea and many fundamental questions remain regarding their biochemistry, genetics, and genomics. One reason for this is that few archaea are amenable to detailed experimental analysis; however, a few halophilic archaea (haloarchaea) can be easily manipulated in the laboratory and contain a sequenced genome, allowing for bioinformatics studies, such as recording changes in the transcriptomes. Haloarchaea are found wherever seawater is concentrated above 2 M NaCl and contain a similarly high concentration of …

Go to article

Microevolution Of Capsule Synthesis Genes Contributes To Pneumococcal Capsule Diversity, Melissa Beth Oliver Jan 2013

Microevolution Of Capsule Synthesis Genes Contributes To Pneumococcal Capsule Diversity, Melissa Beth Oliver

All ETDs from UAB

Streptococcus pneumoniae (pneumococcus) is an important human pathogen that expresses a capsular polysaccharide (PS) to shield underlying antigenic structures from complement-mediated opsonophagocytosis. Thus, capsular PS is the major virulence factor, the target of primary immune responses to pneumococcal infections, and the antigenic component of pneumococcal vaccines. Pneumococci have diverse capsular PS synthesis (cps) loci and express over 90 different capsule types. Such diversity helps pneumococci escape immune detection and adapt to changing environments. Recombination of cps genes has been recognized as the main driver of capsule diversity. However, we show point mutations in cps genes encoding glycosyltransferases can broaden enzymes' …

Go to article

Review Of Schwam-Baird, Shira, Ed. And Trans. Valentin Et Orson: An Edition And Translation Of The Fifteenth-Century Romance Epic, Steven Millen Taylor Jan 2013

Review Of Schwam-Baird, Shira, Ed. And Trans. Valentin Et Orson: An Edition And Translation Of The Fifteenth-Century Romance Epic, Steven Millen Taylor

French and Francophone Languages and Literatures

No abstract provided.

Go to article

Academic Advising Experiences And Retention Of First-Generation Students At A Public Historically Black College And University In The Southeastern United States, Jarrod Ennis Patterson Jan 2013

Academic Advising Experiences And Retention Of First-Generation Students At A Public Historically Black College And University In The Southeastern United States, Jarrod Ennis Patterson

All ETDs from UAB

The purpose of this study was to explore the academic advising experiences of first-generation students at a public, historically black college and university (HBCU) in the southeastern United States. A qualitative analysis using a phenomenological multiple case study approach was used to explore the students' academic advising experiences. The theoretical framework for this study consisted of: the Interactionalist Theory of College Student Departure (Tinto, 1987, 2006), the Theory of Involvement (Astin, 1984, 1999), and the Psychological Model for Student Retention (Bean & Eaton, 2000). In their interviews, participants were asked questions from an approved interview protocol. The questions were open-ended …

Go to article

Understanding The Relation Between Routines And Problem Behaviors In Children With Clinical Diagnoses, Mark Ryan Pennick Jan 2013

Understanding The Relation Between Routines And Problem Behaviors In Children With Clinical Diagnoses, Mark Ryan Pennick

All ETDs from UAB

The current study investigated the impact of routines on problem behaviors in children with the clinical diagnoses of either PDD, ADHD, or depression/anxiety. Previous research has identified negative relations between externalizing behaviors and routines as well as a link between using routines and having positive parenting. The study extends these findings to children with these various diagnoses and also to internalizing symptoms. In our sample negative relations were found between routines, as measured by the Child Routines Inventory (CRI), and both internalizing and externalizing symptoms when all groups were examined together. Additionally routines were found to moderate the relation between …

Go to article

Msx1 Mutations And Their Binding Interactions, Divakar Prakash Jan 2013

Msx1 Mutations And Their Binding Interactions, Divakar Prakash

All ETDs from UAB

Orofacial clefting (OFC), also called cleft lip and/or palate, is the most common congenital birth anomaly that involve the craniofacial region in humans. The etiology of Non-Syndromic OFC (NS-OFC) is complex and multifactorial; a slew of genetic mutations, standing alone or in combinations, along with several environmental factors, play a major role in the disease process. Numerous linkage and association studies in humans, as well as expression studies and knockout mouse models, have implicated Muscle segment homeobox gene 1 (MSX1), which encodes a homeodomain/DNA binding domain (HD) containing transcription factor as a strong candidate contributing to NS-OFC and Tooth Agenesis …

Go to article

High Density Genotyping For Immunogenetic Polymorphisms Associated With Transmission And Control Of Hiv-1 Infection In Zambian Heterosexual Serodiscordant Couples, Heather Prentice Jan 2013

High Density Genotyping For Immunogenetic Polymorphisms Associated With Transmission And Control Of Hiv-1 Infection In Zambian Heterosexual Serodiscordant Couples, Heather Prentice

All ETDs from UAB

Understanding host genetic correlates of HIV-1 outcomes in sub-Saharan African populations is of continued importance due to the disproportionate disease burden in this population. We sought to identify genetic variants associated with HIV-1 acquisition in a sample of 439 initially seronegative individuals enrolled in the Zambia-Emory HIV Research Project, as well as novel variants associated with viral load (VL) in a sample of 172 seroconverters (SCs) with an estimated date of infection and 449 seroprevalent individuals (SPs). We were unable to detect any statistically significant associations in our analysis of HIV-1 acquisition, though one signal in the HLA-DOA gene associated …

Go to article

Kindergarten Goes To The Fair! How The World's Fair Of 1876 Advanced The Kindergarten Movement In The United States, Elizabeth Cornelius Pruett Jan 2013

Kindergarten Goes To The Fair! How The World's Fair Of 1876 Advanced The Kindergarten Movement In The United States, Elizabeth Cornelius Pruett

All ETDs from UAB

The purpose of this historical narrative study was to discover how the World's Fair of 1876 advanced the kindergarten movement in the United States. Historical documents, photographs, and drawings were used as data sources. The following questions guided this study: "What were the purposes of the kindergarten exhibits at the World's Fair?" "Who were the individuals that demonstrated the kindergarten at the first Centennial World's Fair and how did they influence the kindergarten exhibits at the next fair in 1893?" and "How did commercialism associated with the fair affect thekindergarten movement?" The kindergarten exhibits at the Centennial World's Fair had …

Go to article

Plant Selection, Community Dynamics, Ecophysiology, And Stormwater Mitigation On Green Roofs In The Southeastern U.S., Julie G. Price Jan 2013

Plant Selection, Community Dynamics, Ecophysiology, And Stormwater Mitigation On Green Roofs In The Southeastern U.S., Julie G. Price

All ETDs from UAB

Green roofs offer the opportunity to transform impervious surfaces into multifunctional constructed ecosystems. Plant selection for green roofs is often limited to drought-tolerant succulent species, but more diverse assemblages enhance habitat and biodiversity in urban areas and have the potential to improve green roof performance. Nineteen taxa were evaluated under irrigated and non-irrigated conditions over three growing seasons. Individual taxa were evaluated for survival and amount and mechanism of colonization, and the effect of irrigation on plant community structure and vegetation coverage was examined. Only succulent species survived under non-irrigated conditions. Irrigated plots had more taxa, higher diversity index, less …

Go to article

The Genetic Complexity Of The Human Fc-Gamma Receptor 1q23 Locus And Its Relationship To Autoimmunity, Travis Samuel Ptacek Jan 2013

The Genetic Complexity Of The Human Fc-Gamma Receptor 1q23 Locus And Its Relationship To Autoimmunity, Travis Samuel Ptacek

All ETDs from UAB

The human immune system must be able to adapt to a wide spectrum of invading pathogens in order to keep the human body alive. This variation includes directed recombination and mutation at the level of the individual and genetic variation and natural selection at the population level. A direct consequence of the adaptability of the immune system is autoimmunity: as the immune system adapts to a shifting spectrum of antigens, it can shift to self-antigens, and therefore attack the body and cause disease. Since genetic factors are part of this adaptability, they are also connected with autoimmune disease. SLE is …

Go to article

The Role Of Complement In Experimental Cerebral Malaria, Theresa N. Ramos Jan 2013

The Role Of Complement In Experimental Cerebral Malaria, Theresa N. Ramos

All ETDs from UAB

Cerebral malaria (CM) is one of the most severe clinical complications of P. falciparum malaria with a fatality rate of 15-30%, and 10% of CM survivors have permanent neurological sequelae. Since inflammation is a central pathophysiological tenet of CM, we began examining the role of the complement system in pathogenesis of experimental cerebral malaria (ECM) using Plasmodium berghei ANKA (PbA) model. Previous studies using this model indicated that mice naturally deficient in complement component C5 were protected from cerebral complications, and wild type mice treated with anti-C5aR antibody were also protected. To determine the protective mechanism of naturally-C5 deficient mice, …

Go to article

Development Of Vacuum Assisted Resin Transfer Molding (Vartm) Method For The Repair And Strengthening Of Concrete Structures, Luis Ramos Jan 2013

Development Of Vacuum Assisted Resin Transfer Molding (Vartm) Method For The Repair And Strengthening Of Concrete Structures, Luis Ramos

All ETDs from UAB

Resin infusion, a method of fabricating fiber reinforced polymer (FRP), has been shown to produce a stronger FRP of more consistent quality than other methods. It is a preferred method of fabrication in industries like automotive, aerospace, and boat build-ing. In infrastructure, however, FRP is commonly applied by the hand layup method. Hand layup is known to produce FRP of questionable quality. Vacuum Assisted Resin Transfer Molding (VARTM), a form of resin infusion, can be used to apply externally bonded FRP to infrastructure to increase structural ca-pacity. Based on experience and knowledge in other industries, VARTM is expected to produce …

Go to article

External Aid And Its Effectiveness In The Reconstruction And Development Of Afghanistan - An Analysis Of The Years 2002-2014, Muneeb Raqeebi Jan 2013

External Aid And Its Effectiveness In The Reconstruction And Development Of Afghanistan - An Analysis Of The Years 2002-2014, Muneeb Raqeebi

All ETDs from UAB

After more than twelve years of major humanitarian, security and development aid and assistance from international community, the government of the Islamic Republic of Afghanistan prepares to shift back security arrangements throughout the country from the International Security Assistance Forces (ISAF) to Afghanistan National Security Forces (ANSF). As this transition takes place, the majority of Afghan population and a large number of donor nations and international aid organizations that provided aid to Afghanistan since 2002 are concerned as whether or not this transition will also result in the transition of Afghanistan from conflict to stability, confirming success of the international …

Go to article

The Implications Of The Intelligence Reform And Terrorism Prevention Act For U.S. Bureaucracies, Brennan Anderson Reeves Jan 2013

The Implications Of The Intelligence Reform And Terrorism Prevention Act For U.S. Bureaucracies, Brennan Anderson Reeves

All ETDs from UAB

The United States faces a constantly evolving threat from terrorist organizations and individuals who wish to do harm to do harm to its assets and citizens. In 2004, as a response to the 9/11 attacks, the structural organization of the agencies that comprise the U.S. Intelligence Community was changed under the Intelligence Reform and Terrorism Prevention Act. The goal of the transformation was to enhance the ability and effectiveness of those that are supposed to maintain national security. Coordination and information sharing between the agencies in the IC is essential to ensure that the relevant actors have the knowledge and …

Go to article

Mesocorticolimbic Abnormalities In Schizophrenia: A Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging Study, Meredith A. Reid Jan 2013

Mesocorticolimbic Abnormalities In Schizophrenia: A Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging Study, Meredith A. Reid

All ETDs from UAB

Schizophrenia is a complex, often debilitating chronic mental disorder that affects approximately 1% of people worldwide. Recently, there has been growing interest in identifying non-invasive biomarkers of schizophrenia. Understanding the molecular and structural mechanisms underlying clinical features of schizophrenia and patients' drug response is an important step in identifying biomarkers and potential targets for novel medications, treatment strategies, and interventions. The primary objective of this dissertation research was to use non-invasive magnetic resonance imaging techniques, specifically magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI), to examine the neurochemical and structural correlates of symptoms, cognition, and treatment response to antipsychotic …

Go to article

Characterization Of Emergent Spatial-Temporal Orders In Transcription Regulatory Networks Using Phase Locking Analysis, Herbert Keith Roberts Jan 2013

Characterization Of Emergent Spatial-Temporal Orders In Transcription Regulatory Networks Using Phase Locking Analysis, Herbert Keith Roberts

All ETDs from UAB

The study of gene regulatory networks (GRNs) is paramount for continued breakthroughs in understanding the genetic architecture of life and how alterations thereof contribute to disease. The complex spatio-temporal orders within GRNs are studied primarily through the modeling of time-course gene expression data. Recently, gene expression profiling technology has improved greatly in regards to accuracy and resolution, enabling novel methodology development and characterization of GRNs. Many methods have been utilized to model GRNs from gene expression data (correlational measures, time-warping, coherence, and/or causality, etc). In this study, we propose a new approach based on phase locking analysis that compliments existing …

Go to article

Commensal Microbiota And Its Impact On Health And Autoimmune Diabetets, Kyle James Wolf Jan 2013

Commensal Microbiota And Its Impact On Health And Autoimmune Diabetets, Kyle James Wolf

All ETDs from UAB

Environmental exposures such as diet, use of antibiotics, and lifestyle have significant impact on the health of an individual. One mechanism that acts as a major pathway in these environmental exposures is the role intestinal commensal microbiota play in both metabolic and immunological responses. Metabolic pathways are altered through changes in metabolites provided by commensal microbiota; alterations in microbial make-up can have drastic impacts on metabolic function. Similarly, the development and maturation of the immune system is dependent on the intestinal microbes to induce tolerance and act as both an immune modulator as well as a barrier against pathogens. We …

Go to article

Executive Functions And Cardiorespiratory Fitness In Survivors Of Pediatric Posterior Fossa Tumor, Kelly Ross Wolfe Jan 2013

Executive Functions And Cardiorespiratory Fitness In Survivors Of Pediatric Posterior Fossa Tumor, Kelly Ross Wolfe

All ETDs from UAB

As survival rates for pediatric posterior fossa tumor have improved, issues related to survivorship have become increasingly important. Foremost among these are cognitive difficulties, particularly in the domain of executive functions. The first manuscript reports on a systematic, comprehensive literature review of studies examining executive deficits in survivors of pediatric posterior fossa tumor, including the intervention studies that have attempted to ameliorate these difficulties. The second manuscript establishes the safety and feasibility of peak cardiorespiratory fitness testing in a cohort of pediatric posterior fossa tumor survivors. Survivors had lower fitness than typically developing children and children with cystic fibrosis, and …

Go to article

Uniqueness Of Potential In Schrã¶Dinger's Equation With One Boundary Measurement, Mitchell Wyatt Jan 2013

Uniqueness Of Potential In Schrã¶Dinger's Equation With One Boundary Measurement, Mitchell Wyatt

All ETDs from UAB

Given an open set ­ in RN, N≥2, and a single piece of Dirichlet-Neumann data for a solution u of an equation of the form -\Delta u + \chiAu=0, uniqueness of the set A is proven under some regularity assumptions and under the assumption of a so-called "i-contact" condition.

Go to article

A Study Of Multi-Group And Multivariate Tests Of Equivalence With Application To Microarray And, Celeste Yang Jan 2013

A Study Of Multi-Group And Multivariate Tests Of Equivalence With Application To Microarray And, Celeste Yang

All ETDs from UAB

In this dissertation we have adapted two multi-group equivalence tests to be performed on high-dimensional data. The F and Range test for multi-group equivalence were applied to the public microarray dataset GSE11291 to detect equivalently expressed genes. They were also evaluated in terms of type I error and power using single gene simulation and a high-dimension simulation. The F test has higher power than the Range for the same simulated data and parameter settings, in the single gene simulations. The power of the two tests is similar in the high-dimension simulation. The multi-group equivalence tests that were applied to the …

Go to article

Characterization Of The Mumps Virus Replicase, Robert Marsden Cox Jan 2013

Characterization Of The Mumps Virus Replicase, Robert Marsden Cox

All ETDs from UAB

Negative strand RNA viruses (NSV) are unique because their nucleocapsids are used directly as the template for both transcription and replication. The viral genomic RNA is coated by the nucleoprotein (N) for the entirety of the NSV replication cycle. The viral polymerase, which is composed of the L and P proteins, can only recognize encapsidated RNA as the template for RNA synthesis. Our previous studies have solved the EM structure of the MuV N-RNA complex at 25Ņ. This structure revealed how the nucleocapsid is assembled and provides an initial model for examining how the viral polymerase may recognize the …

Go to article

Using A Mixed Methods Sequential Design To Identify Factors Associated With African American Mothers' Intention To Vaccinate Their Daughters Aged 9 To 12 For Hpv With A Purpose Of Informing A Culturally-Relevant, Theory-Based Intervention, Jennifer Cunningham Jan 2013

Using A Mixed Methods Sequential Design To Identify Factors Associated With African American Mothers' Intention To Vaccinate Their Daughters Aged 9 To 12 For Hpv With A Purpose Of Informing A Culturally-Relevant, Theory-Based Intervention, Jennifer Cunningham

All ETDs from UAB

The purpose of this sequential, explanatory mixed methods research study was to understand what factors influenced African American maternal intentions to get their daughters aged 9 years to 12 years vaccinated in Alabama. In the first, quantitative phase of the study, the research questions focused on identifying the predictive power of eleven variables, representing selected factors associated with maternal intentions to vaccinate their daughters. The data were collected via a self-developed instrument that used a mixed mode survey design that was web-based (N = 14) and paper-based (N = 228). Participant demographics were analyzed using descriptive statistics. A binary, logistic …

Go to article

Indebtedness, Debt Stress, And Health-Related Behaviors: A Study Of Alabamians' Financial Well-Being And Physical Health, Lingfei Guo Jan 2013

Indebtedness, Debt Stress, And Health-Related Behaviors: A Study Of Alabamians' Financial Well-Being And Physical Health, Lingfei Guo

All ETDs from UAB

In order to better understand the SES-health relationship and gain a more accurate estimation of SES on physical health, the primary objectives of this research are: (1) to test the relationship between Alabamians' indebtedness and their health-related behaviors; (2) to test the mediating effect of Alabamians' socioeconomic and sociodemographic status in the relationship of indebtedness and health-related behaviors; and, (3) to test the possible mediating effect of debt stress on indebtedness and health-related behaviors. The health lifestyle theory guides this research. Research has advanced two views that explain the interrelationship between socioeconomic status and physical health. The first view deals …

Go to article

Sulindac Sulfide Amide As A Novel Agent For The Prevention And Treatment Of Lung Cancer, Evrim Gurpinar Jan 2013

Sulindac Sulfide Amide As A Novel Agent For The Prevention And Treatment Of Lung Cancer, Evrim Gurpinar

All ETDs from UAB

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac sulfide (SS) have shown promising antineoplastic activity in multiple tumor types, but toxicities resulting from cyclooxygenase (COX) inhibition limit their use in cancer prevention. We recently described a N,N-dimethylethyl amine derivative of SS, sulindac sulfide amide (SSA), that does not inhibit COX-1 or -2, yet displays potent tumor cell growth inhibitory activity. Here, we studied the basis for the growth inhibitory effects of SSA on human lung adenocarcinoma cell lines and evaluated its preclinical pharmacology. SSA potently inhibited the growth of lung tumor cells with IC50 values of 2-5 μ compared with 44-52 …

Go to article

Comparison Of Low Abundance Biomarker Levels In Capillary-Collected Non-Stimulated Tears And Washout Tears Of Aqueous-Deficient And Normal Patients, Nicole Guyette Jan 2013

Comparison Of Low Abundance Biomarker Levels In Capillary-Collected Non-Stimulated Tears And Washout Tears Of Aqueous-Deficient And Normal Patients, Nicole Guyette

All ETDs from UAB

Purpose: For patients suffering from aqueous-deficient dry eye, non-stimulated (NS) tear collection can be challenging and time-consuming. Adding a small volume of sterile saline to the eye allows a "washout" (WO) tear collection that takes considerably less time. The primary goal of this project was to determine if WO tear collection is a viable alternative to NS tears for comparing the levels of common ocular surface biomarkers in patients with and without aqueous-deficient dry eye (AD). Stimulated (Stim) tears were also investigated as a second possible alternative to NS tears. Methods: Two studies were conducted, tear cytokine levels being measured …

Go to article

First Prev Next Last