Digital Commons Network^™

Regulation Of Pten Inhibition By The Pleckstrin Homology Domain Of P-Rex2 During Insulin Signaling And Glucose Homeostasis, Cindy Hodakoski, Benjamin D. Hopkins, Douglas Barrows, Sarah M. Mense, Megan Keniry, Karen E. Anderson, Philip A. Kern, Phillip T. Hawkins, Len R. Stephens, Ramon Parsons

Clinical and Translational Science Faculty Publications

Insulin activation of phosphoinositide 3-kinase (PI3K) signaling regulates glucose homeostasis through the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3). The dual-specificity phosphatase and tensin homolog deleted on chromosome 10 (PTEN) blocks PI3K signaling by dephosphorylating PIP3, and is inhibited through its interaction with phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 (P-REX2). The mechanism of inhibition and its physiological significance are not known. Here, we report that P-REX2 interacts with PTEN via two interfaces. The pleckstrin homology (PH) domain of P-REX2 inhibits PTEN by interacting with the catalytic region of PTEN, and the inositol polyphosphate 4-phosphatase domain of P-REX2 provides high-affinity binding to the postsynaptic …

Parameters – Full Issue, Usawc Parameters

The US Army War College Quarterly: Parameters

American Power in Transition: Isaiah Wilson, James E. Goodby and Ken Weisbrode, Anna Simons. Fighting Irregular Fighters: Sibylle Scheipers, Robert J. Bunker, Robert L. Feldman and Michel Ben Arrous. Conflict by Other Means: David J. Katz, Juan Zarate, Douglas W. Winton. Preparing for Netwars: Frank J. Cilluffo and Joseph R. Clark. QDR and Landpower: Francis G. Hoffman.

Reactions Of A 10 Be Beam On Proton And Deuteron Targets, K. T. Schmitt, K. L. Jones, S. Ahn, D. W. Bardayan, A. Bey, J. C. Blackmon, S. M. Brown, K. Y. Chae, K. A. Chipps, J. A. Cizewski, K. I. Hahn, J. J. Kolata, R. L. Kozub, J. F. Liang, C. Matei, M. Matos, D. Matyas, B. Moazen, C. D. Nesaraja, F. M. Nunes, P. D. O'Malley, S. D. Pain, W. A. Peters, S. T. Pittman, A. Roberts, D. Shapira, J. F. Shriner, M. S. Smith, I. Spassova, D. W. Stracener, N. J. Upadhyay, A. N. Villano, G. L. Wilson

Faculty Publications

The extraction of detailed nuclear structure information from transfer reactions requires reliable, well-normalized data, as well as optical potentials and a theoretical framework demonstrated to work well in the relevant mass and beam energy ranges. It is rare that the theoretical ingredients can be tested well for exotic nuclei owing to the paucity of data. The halo nucleus 11Be has been examined through the 10Be(d,p) reaction in inverse kinematics at equivalent deuteron energies of 12,15,18, and 21.4 MeV. Elastic scattering of 10Be on protons was used to select optical potentials for the analysis of the transfer data. Additionally, data from …

Stakeholders’ Views On The Effects Of Students’ Participation In Co-Curricular Activities In Secondary Schools In Tanzania, Rehema Japhet

Journal of Humanities and Social Sciences

This paper seeks to explore stakeholders’ views on the effects of students’ participation in co-curricular activities in secondary schools. It explores the perceptions held by heads of schools, teachers, students, chairpersons of school boards, school inspectors and parents towards academic, physical and social development of students as a result of engaging in co-curricular activities. Stakeholders’ views helped to determine the value attached to the activities in comparison to the contribution the activities have in students’ total development. A total of 218 respondents participated in the study on which this paper is based. Basically, qualitative research data collection methodology was used …

Academic Staff’S Access And Use Of Technological Tools: A Challenge To Blended Learning Implementation In Tanzania’S Tertiary Institutions, Luka Mkonongwa

Journal of Humanities and Social Sciences

This paper explores academic staff’s access to and ability to use technological tools in the course of implementing blended learning system in higher education. In a study, a survey questionnaire was used to collect data from 46 respondents. The results revealed that although academic staff had high self-efficacy towards learning and using technological tools, their access to and use of many technological tools were too limited. This affected their competence and confidence to use such technological tools to teach, and deterred the successful implementation of the blended learning approach. The study concluded that the success of blended learning will depend …

Teachers’ Attitudes Towards Sexuality Education: A Case Of Primary Schools In Morogoro Region, Tanzania, Margareth Bilinga

Journal of Humanities and Social Sciences

This paper is about teachers’ attitudes towards teaching sexuality education (SE) in Morogoro rural and urban districts. It is based on a study which employed mixed method design and used both qualitative and quantitative approaches. It involved a sample of 126 teachers residing from Morogoro rural and urban schools. Data were obtained through interviews and questionnaire. It was revealed that a majority of the teachers supported the teaching of SE in schools with more support of HIV and AIDS contents than pregnancy and contraceptives. There was no significant difference in terms of attitudes between teachers residing in rural and urban …

Understanding Social Changes In Tanzania: Independence And Loss Of Hegemonic Masculinity In Ruhumbika’S Village In Uhuru, Edith Bwana

Journal of Humanities and Social Sciences

The transition from colonialism to independence and Ujamaa had great impacts on society—politically, economically and socially. This is discussed in relation to the novel Village in Uhuru (1969) by Gabriel Ruhumbika. Within the backdrop of independence, he explores the social changes that occur in the small village of Chamambo. Through two main characters—namely Balinde and Musilanga— Ruhumbika explores the changing social values. This paper argues that masculinity is a social construct. It will explore how Musilanga serves as a representative of hegemonic masculinity, and how through the actions of his son, he is deprived of this designation, leaving a void …

Final Volcker Rule, Davis Polk & Wardwell Llp

Documents

Flowcharts: Prop Trading

Bjc Today

BJC Today

No abstract provided.

Swelling Of Elastomers In Biodiesel And The Resulting Mechanical Response Under Cyclic Loading / Chai Ai Bao, Ai Bao Chai

Student Works (2010-2019)

The environmental and economic concerns have raised the popularity of biodiesel as the replacement for the conventional fuel. However, the incompatibility of engineering rubber components with biodiesel affects significantly the performance of the components. Majority of the compatibility studies focus on evaluating the degradation of mechanical properties in the rubbers due to contamination of different types of biodiesel. Nevertheless, the resulting mechanical responses of swollen rubbers, in particular under cyclic and fatigue loading conditions, are rarely investigated. In engineering applications where elastomeric components are concurrently subjected to fluctuating mechanical loading and exposure to aggressive liquids such as biodiesel, it is …

Leave Prejudice Behind, Pei-Chen Chien

Theses

In this thesis, I strive to expose societal rules and regulations that constrict and restrict our social interactions in a way that promotes prejudice and xenophobia. Through interacting with the series of sculptures, viewers are given the opportunity to question these societal norms and start a process of self- reflection to truly understand the freedom that comes without prejudice. Interaction is the main element that ties the series of works together, to form a seamless journey of self-discovery. The following artists are discussed in relation to this series of work: Niki de Saint Phalle and Björk Guðmundsdóttir. Their art works …

A Search For Enhanced Very High Energy Gamma-Ray Emission From The 2013 March Crab Nebula Flare, P. T. Reynolds, Et Al

Physical Sciences Publications

In 2013 March, a flaring episode from the Crab Nebula lasting ~2 weeks was detected by Fermi-LAT (Large Area Telescope on board the Fermi Gamma-ray Space Telescope). The Very Energetic Radiation Imaging Telescope Array System (VERITAS) provides simultaneous observations throughout this period. During the flare, Fermi-LAT detected a 20 fold increase in flux above the average synchrotron flux >100 MeV seen from the Crab Nebula. Simultaneous measurements with VERITAS are consistent with the non-variable long-term average Crab Nebula flux at TeV energies. Assuming a linear correlation between the very high energy flux change >1 TeV and the flux …

Reece V. State Appellant's Brief Dckt. 41369

Not Reported

No abstract provided.

Bugchaser: Protective Measures, Scott Laforce

Theses

Using photographic installation and new media, Bugchaser: Protective Measures examines risk in response to perceived danger as engaged by bug chasers (or bugchasers) and suburbanites in the United States. The work explores this theme through the contrasting nature of queer social networks and the physical boundaries of the suburban landscape.

Ultimately, this work uproots conventional notions of intimacy as conscribed by the suburban middle-class and de-stigmatizes unconventional behaviors by challenging boundaries that needlessly divide. I have taken liberty with metaphor and used it in an attempt to reverse some of the damages brought forth through historical practices. If the viewer …

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Rural Women’s Exercise Self-efficacy

Students' Perceived Utility Of Precision Taught Calculus, Rebecca-Anne Dibbs, David Glassmeyer, Wafa Yacoub

Faculty Articles

The last decade of calculus research has showed students learn best when lecture is supplemented with thoughtful use of technology and group work; however, educators are given little direction of how they are to balance the already full first semester calculus class. Precision teaching is an instructional model that employs formative assessment to provide information on what topics are understood by students as well as indicate troublesome concepts. With this information, the instructor can adjust class time accordingly by incorporating supplemental activities most beneficial to students. The purpose of this interview study was to explore the perceived utility of precision …

C4a-Hydroperoxyflavin Formation In N -Hydroxylating Flavin Monooxygenases Is Mediated By The 2′-Oh Of The Nicotinamide Ribose Of Nadp⁺, Reeder Robinson, Somayesadat Badieyan, Pablo Sobrado

Chemistry Faculty Research & Creative Works

Flavin-dependent monooxygenases must stabilize a C4a-hydroperoxyflavin intermediate to hydroxylate their respective substrates. Formation and decay of the C4a-hydroperoxyflavin were monitored under rapid reaction kinetic conditions in SidA, an N-hydroxylating monooxygenase involved in siderophore biosynthesis. Solvent kinetic isotope effect studies of flavin oxidation indicate that both hydrogen peroxide elimination and water elimination occur via abstraction of hydrogen from the N5 of the flavin. Kinetic isotope effect and density functional theory results are consistent with the transfer of a proton from the 2′-OH of the nicotinamide ribose of nicotinamide adenine dinucleotide phosphate (NADP+) to the C4a-peroxyflavin to form the C4a-hydroperoxyflavin. This represents …

Students’ Perceived Utility Of Precision Taught Calculus, Rebecca- Anne Dibbs, David Glassmeyer, Wafa Yacoub

The Qualitative Report

The last decade of calculus research has showed students learn best when lecture is supplemented with thoughtful use of technology and group work; however, educators are given little direction of how they are to balance the already full first semester calculus class. Precision teaching is an instructional model that employs formative assessment to provide information on what topics are understood by students as well as indicate troublesome concepts. With this information, the instructor can adjust class time accordingly by incorporating supplemental activities most beneficial to students. The purpose of this interview study was to explore the perceived utility of precision …

Brief For The American Association On Intellectual And Developmental Disabilities, The Arc Of The United States, The National Disability Rights Network, Disability Rights Florida, And The Bazelon Center For Mental Health Law As Amicus Curiae, April Land, James W. Ellis, Ann M. Delpha, Carol M. Suzuki, Steven K. Homer

Faculty Scholarship

Question Presented: Whether the Florida scheme for identifying mentally retarded defendants in capital cases violates Atkins v. Virginia, 536 U.S. 304 (2002). Summary of Argument: In Atkins, this Court concluded that a national consensus had developed against the execution of persons with mental retardation and that such executions violated the Eighth Amendment. The Court also stated that the national consensus suggests that some characteristics of mental retardation, such as disabilities in the areas of reasoning, judgment, and control of impulses, undermine the procedural protections of our capital punishment jurisprudence and can jeopardize the reliability and fairness of capital proceedings against …

Recent Development Of Surface Integral Equation Solvers For Multiscale Interconnects And Circuits, Sheng Sun, Lijun Jiang, Weng Cho Chew

Electrical and Computer Engineering Faculty Research & Creative Works

This paper presents a brief review and recent development of surface integral equation solvers for multiscale interconnects and circuits modeling. As the future production processes down to 5 nm and the operating frequency increases, both multi-scale and large-scale natures should be taken into account in the electromagnetic simulations. Fast, efficient, stable, and broadband integral equation based solvers become indispensable when millions or ten s of millions of unknowns might be involved in the simulation of the integrated circuit. Recent progress and our latest researches in the development of broadband fast electromagnetic solvers will be demonstrated. © 2013 IEEE.

Determining The 7li(N,Gamma) Cross Section Via Coulomb Dissociation Of 8li, R. Izsak, A. Horvath, A. Kiss, Z. Seres, A. Galonsky, C. A. Bertulani, Zs Fueloep, T. Baumann, D. Bazin, K. Ieki, C. Bordeanu, N. Carlin, M. Csanád, F. Deák, Paul A. Deyoung, N. Frank, T. Fukuchi, A. Gade, D. Galaviz, C. R. Hoffman, W. A. Peters, H. Schelin, M. Thoennessen, G. I. Veres

Faculty Publications

The applicability of Coulomb dissociation reactions to determine the cross section for the inverse neutron capture reaction was explored using the reaction Li-8(gamma,n)Li-7. A 69.5 MeV/nucleon Li-8 beam was incident on a Pb target, and the outgoing neutron and Li-7 nucleus were measured in coincidence. The deduced (n,gamma) excitation function is consistent with data for the direct capture reaction Li-7(n,gamma) Li-8 and with low-energy effective field theory calculations.

Full-Quantum Simulation Of P-Type Junctionless Transistors With Multi-Band K · P Model, Jun Z. Huang, Weng Cho Chew, Li (Lijun) Jun Jiang, Jie Peng, Chi Yung Yam, Guan Hua Chen

Electrical and Computer Engineering Faculty Research & Creative Works

By adopting a model order reduction technique, we have successfully constructed a program for efficient simulation of nanowire transistors based on the multi-band k · p model and non-equilibrium Green's function (NEGF) approach. We then study for the first time the influences of various device parameters on the performances of p-type junctionless (JL) transistors and compare them to traditional inversion mode (IM) devices. © 2013 IEEE.

The Female Librarian In Film: Has The Image Changed In 60 Years?, Julia A. Wells

School of Information Student Research Journal

The stereotypical image of the female librarian as an uptight spinster has prevailed in popular culture. This paper examines the portrayal of the librarian stereotype in movies from two different eras: the 1940s/1950s and the 2000s. The historical antecedents, social and economic status of women are examined, and the influence of computers and technology in the library is considered. Common traits that typify the film librarian, along with the inclusions of computers in the library, are identified and analyzed. Approaches to combatting the stereotypes are discussed and applied to the movies in order to discover any progression of the image …

Private Flashbulb Memories: The Case Of Coming Out Memories, Gabrielle Weber

Undergraduate Honors Thesis Collection

Participants (N = 83) from Butler University and communities in Indianapolis, IN answered a three part questionnaire regarding their experience revealing their homosexual identity to their parents that included: a narrative, a set of probe questions, and a short demographic section. The narrative and probed recall data were scored in a similar fashion to flashbulb memory narratives with canonical features. The memory of revealing homosexuality to parents displayed flashbulb-like qualities. We found that those most confident in their probed recall answers were those with moderate arousal and few recounts. Also, those reporting moderate affect and fewer recounts had better memory …

The Law Of Armed Conflict's "Wicked" Problem: Levee En Masse In Cyber Warfare, David Wallace, Shane R. Reeves

International Law Studies

No abstract provided.

Keeping The Cyber Peace: International Legal Aspects Of Cyber Activities In Peace Operations, Jann K. Kleffner, Heather A. Harrison Dinniss

International Law Studies

No abstract provided.

The Cyber Road Ahead: Merging Lanes And Legal Challenges, Kenneth Watkin

International Law Studies

No abstract provided.

Cyber Warriors In The Jus In Bello, Vijay M. Padmanabhan

International Law Studies

No abstract provided.

Computer Network Operations And U.S. Domestic Law: An Overview, Robert N. Chesney

International Law Studies

No abstract provided.

The Role Of Counterterrorism Law In Shaping Ad Bellum Norms For Cyber Warfare, William Banks

International Law Studies

No abstract provided.