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Defects In Synapse Structure And Function Precede Motor Neuron Degeneration In Drosophila Models Of Fus-Related Als., Mohammad Shahidullah, Sylvain J Le Marchand, Hong Fei, Jiaming Zhang, Udai Bhan Pandey, Matthew B. Dalva, Piera Pasinelli, Irwin B. Levitan

Department of Neuroscience Faculty Papers

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease that leads invariably to fatal paralysis associated with motor neuron degeneration and muscular atrophy. One gene associated with ALS encodes the DNA/RNA-binding protein Fused in Sarcoma (FUS). There now exist two Drosophila models of ALS. In one, human FUS with ALS-causing mutations is expressed in fly motor neurons; in the other, the gene cabeza (caz), the fly homolog of FUS, is ablated. These FUS-ALS flies exhibit larval locomotor defects indicative of neuromuscular dysfunction and early death. The locus and site of initiation of this neuromuscular dysfunction remain unclear. We show here …

Sbe Notícias, Ano 8, No. 283, December 11, 2013, Natália Martins, Delci K. Ishida

SBE Notícias

SBE recebe doação do Centro de Amigos da Natureza :CAMIN; Estamos no Facebook; Biodiversidade associada a uma cavidade em Metapelito no Centro Oeste de Minas Gerais; Logística limita aumento de produção da Vale em Carajás; Homem de 61 anos salta em caverna; MPF ajuiza ação para recuperar e conservar APA Gruta dos Brejões; PARNA Peruaçu poderá receber turistas; Cientistas decodificam o mais antigo DNA de ancestral humano; Curso abordará importância dos morcegos; Neandertais foram os pioneiros da organização doméstica; Cavernas de gelo intocadas; Convite para defesa de dissertação de mestrado; Foto do leitor: Representante da Ordem Scutigeromorpha (SE_2)

Testing Pathways Linking Exposure To Community Violence And Sexual Behaviors Among African American Youth, Dexter R. Voisin

Faculty Scholarship

Exposure to community violence and HIV sexual risks are two major public health concerns among youth. This study tests various pathways linking exposure to community violence and sexual behaviors among African American adolescents. Using a sample of 563 (61 % females) African American youth attending high school we examined whether problematic psychological symptoms, low school engagement, and/or negative perceptions of peer norms about safer sex functioned as pathways linking exposure to community violence and sexual behaviors. Major findings indicated that, for boys, the relationship between exposure to community violence and sexual début and sexual risk behaviors were linked by aggression. …

Blame Me For Your Bad Grade: Autonomy In The Basic Digital Photography Classroom As A Means To Combat Poor Student Performance, Erin Collette Johnson

Theses and Dissertations

This thesis explores current research on autonomy. Autonomy is defined in three categories: freedom to pose questions and encouraging student choice, trust in students to solve problems posed by those questions, and allowing student reflection on progress. Autonomy is one solution to promote intrinsic motivation in students. Autonomy supportive classrooms feature mainly language learning atmospheres in research. However, it is also pertinent to contemporary art education as it promotes an environment for student creativity. Student performance and the modes of measurement for this research project are based on common formative and summative assessment measures. Will autonomy in the classroom combat …

The Bg News December 11, 2013, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. December 11, 2013. Volume 93-Issue 46.

Evolution And Functional Morphology Of The Cephalic Lobes In Batoids, Samantha Lynn Mulvany

USF Tampa Graduate Theses and Dissertations

Cephalic lobes are unique structures derived from the anterior pectoral fins, found in select myliobatid stingrays. Many benthic batoids utilize undulatory locomotion and use their pectoral fins for both locomotion and prey capture. Pelagic myliobatids that possess cephalic lobes utilize oscillatory locomotion, using their pectoral fins to locomote and their cephalic lobes for prey capture. Despite differences in habitat usage and locomotor modes, these batoids feed on very similar benthic organisms. The purpose of this study was to 1.) compare the morphology of the cephalic lobes and anterior pectoral fins in lobed and lobeless species, looking at skeletal elements, musculature …

Use Of Irf-3 And/Or Irf-7 Knockout Mice To Study Viral Pathogenesis: Lessons From A Murine Retrovirus-Induced Aids Model, Megan A. O'Connor, William R. Green

Dartmouth Scholarship

Interferon regulatory factor (IRF) regulation of the type I interferon response has not been extensively explored in murine retroviral infections. IRF-3(-/-) and select IRF-3/7(-/-) mice were resistant to LP-BM5-induced pathogenesis. However, further analyses strongly suggested that resistance could be attributed to strain 129-specific contamination of the known retrovirus resistance gene Fv1. Therefore, caution should be taken when interpreting phenotypes observed in these knockout mice, as strain 129-derived genetic polymorphisms may explain observed differences.

Physician Assistants: The Rise Of A Career From A Missed Opportunity In Nursing, Madeline Jary

Honors Theses

The implementation of the concept of mid-level providers in healthcare has undoubtedly contributed greatly to the solution of the physician shortage. This shortage of physicians had posed a problem in the delivery of health care for decades, particularly in rural areas. Nurse Practitioners and Physician Assistants as we know them today may not have existed without previous groundwork and inspiration. The introduction of the nurse clinician concept by Frances Reiter in 1943 led to the later development of a masters nurse clinician program at Duke University by Dr. Eugene Stead and Thelma Ingles. Despite the denial of accreditation of the …

Differences Between Healthcare Systems In Costa Rica & The United States And How Those Differences Affect The Overall Quality Of Healthcare, Carlie Decker

Honors Theses

This thesis seeks to examine the similarities and differences between the healthcare system employed in Costa Rica and the healthcare system employed in the United States through a series of interviews and web-based research. Four healthcare system components will be examined in order to determine the success of each system. These components include health insurance coverage, access to pharmaceuticals, medical licensing requirements, and medical research.

Following the completion of the interviews and research, I found that United States citizens pay nearly four times the amount Costa Rican citizens do for health insurance coverage. This dramatic increase in price can be …

The United States Holocaust Memorial Museum’S Multivalent Tower Of Faces, Grace Astrove

Theses and Dissertations

Holocaust survivor Dr. Yaffa Eliach collected over 6,000 photographs depicting residents of Eishyshok, a small Jewish settlement in Eastern Europe, taken between 1890 and 1941. Eliach survived the Nazi-led massacre in 1941 that killed nearly the entire Jewish population of Eishyshok. As a way to commemorate the destroyed town of her youth she began to collect photographs from other survivors and residents who fled Europe prior to the Holocaust. She subsequently selected 1,032 photographs from the Yaffa Eliach Shtetl Collection for display in The Tower of Faces, a permanent exhibition in The United States Holocaust Memorial Museum, located in Washington, …

Discovering Driver Somatic Mutations, Copy Number Alterations And Methylation Changes Using Markov Chain Monte Carlo, Bokhari Yahya

Theses and Dissertations

Nowadays we have tremendous amount of genetic data needing to be interpreted. Somatic mutations, copy number variations and methylation are example of the genetics data we are dealing with. Discovering driver mutations from these combined data types is challenging. Mutations are unpredictable and have broad heterogeneity, which makes our goal hard to accomplish. Many methods have been proposed to solve the mystery of genetics of cancer. In this project we manipulate those above mentioned genetics data types and choose to use and modified an existing method utilizing Markov Chain Monte Carlo (MCMC). The method introduced two properties, coverage and exclusivity. …

The Relationship Between Insecure Attachment And Premarital Sexual Timing, Carly Ostler

Theses and Dissertations

Recent studies are beginning to show evidence of marital problems for couples that have engaged in early premarital sexual activity compared to those who do not. Adult attachment theory plays an important role in explaining many kinds of distress for couples and helps explain sexual interaction, thus, in this study it is posited that attachment may influence sexual timing patterns. This study focuses on the relationship between insecure attachment styles and early premarital sexual timing. The sample consisted of 256 couples who took the Relationship Evaluation (RELATE) to measure their attachment styles and sexual timing while controlling for length of …

Exercise Intensity And Wound Healing In Diabetic Mice, Amber Wolfe

Honors Projects

Along with the increase in the incidence of type 2 diabetes (T2D) in the United States comes an increase in the health consequences of elevated blood glucose levels, including delayed wound healing. Exercise has been demonstrated to advance wound healing; however in terms of wounds in diabetics, it is not known what intensity of exercise will have the most positive effects. The purpose of this study is to examine the effects of low- and high-intensity exercise on patterns of wound healing in diabetic mice.

Imposing Duties And Original Appropriation, Bas Van Der Vossen

Philosophy Faculty Articles and Research

"To justify property rights, two things must be shown. First, the kind of exclusive rights over goods or land that property rights involve must be justified. Second, it must be possible for such property rights to come into being. These are two separate issues. It is one thing to say that it is a good idea for there to be such rights, quite another to say that some person or procedure can bring them about."

The Effect Of Varying Frequencies Of Mechanical Vibration On The Rate Of Orthodontic Tooth Movement In Mice, Thomas G. Dobie

Master's Theses

Objective: The aim of this study is to utilize the Orthodontic Tooth Movement (OTM) model in a mouse in order to study the mechanical vibrational effects in bone. Specifically, we wish to test various frequencies of vibration under an orthodontic force to determine whether or not an increase in OTM is seen. We also intend to further investigate the role of osteoclasts in OTM and how they interplay with increasing tooth movement.

Materials and Methods: Fifty-eight male CD1 mice were randomly placed into 1 of 8 groups. Three of these groups were part of the experimental subset which all received …

Optical Spectroscopic Studies Of Two Star Forming Regions, Kristen Leilani Erickson

Dissertations

The ρ Ophiuchi and Serpens molecular clouds are sites of low mass star formation. The goals of this study were to identify young stellar objects (YSOs) and estimate ages and masses in order to infer an initial mass function (IMF), investigate disk evolution, and determine the star-forming history. Optical spectroscopic surveys of an unbiased sample of candidate young stars have been completed. Optical images taken in different photometric bands were used to create color-magnitude diagrams from which sources were selected for spectroscopic observation. In combination with published data, 135 association members in ρ Ophiuchi and 63 association members plus 16 …

The Evolution Of Floral Symmetry Across The Plant Order Lamiales, Jinshun Zhong

Dissertations

Bilaterally symmetrical corollas have evolved independently numerous times from radially symmetrical ancestors and are thought to represent adaptation to specific pollinators. However, evolutionary losses of bilateral symmetry have occurred sporadically in different lineages. CYC2-like and RAD-like are genes needed for the normal development of bilateral symmetry in snapdragon corollas. However, exactly how changes in the floral symmetry patterning genes correlate with the origin and loss of floral bilateral remains poorly known. To address this question, a densely sampled phylogeny of CYC2-like genes across the order Lamiales was inferred and calibrated. The expression patterns of these genes in early diverging and …

Umsl Magazine - Fall 2013, University Of Missouri-St. Louis

UMSL Magazine and other UMSL Magazines

The University of Missouri–St. Louis publishes UMSL Magazine for alumni and friends.

Observing The Unwatchable Through Acceleration Logging Of Animal Behavior, Danielle D. Brown, Roland Kays, Martin Wikelski, Rory Wilson, A. Peter Klimley

Methodology and Animal Models in Research

Behavior is an important mechanism of evolution and it is paid for through energy expenditure. Nevertheless, field biologists can rarely observe animals for more than a fraction of their daily activities and attempts to quantify behavior for modeling ecological processes often exclude cryptic yet important behavioral events. Over the past few years, an explosion of research on remote monitoring of animal behavior using acceleration sensors has smashed the decades-old limits of observational studies. Animal-attached accelerometers measure the change in velocity of the body over time and can quantify fine-scale movements and body postures unlimited by visibility, observer bias, or the …

Trust Between Specialists And Family Physicians, J. David Spence

Department of Medicine Publications

No abstract provided.

Carbon Fluxes In Karst Aquifers: Sources, Sinks, And The Effect Of Storm Flow, William B. White

KIP Articles

An effective carbon loading can be calculated from measured alkalinity and pH of karst waters. The carbon loading is independent of the degree of saturation of the water and does not depend on the water being in equilibrium with the carbonate wall rock. A substantial data base of spring water analyses accumulated by students over the past 40 years has been used to probe the CO2 generation, transport, and storage in a variety of drainage basins that feed karst springs. Carbon loading in the water exiting karst drainage basins depends on the rate of CO2 generation in the soils of …

Cultural Competence Integration In The Nursing Curriculum, Boniface C. Stegman

Dissertations

With an increasingly diverse population, it is important to ensure that graduates of nursing programs are able to deliver culturally competent care (Krainovich-Miller et al., 2008; Allen, 2010). This study was undertaken to address this call to include cultural competence integration into nursing curriculum. The purpose of this study was to discover evidence of cultural competence integration in the nursing curriculum as perceived by faculty and students in a baccalaureate nursing program. This study addressed the following research questions: a) Does the undergraduate nursing curriculum integrate cultural competence?, b) Do the undergraduate nursing faculty perceive cultural competence content in the …

The Daily Egyptian, December 10, 2013, Daily Egyptian Staff

December 2013

No abstract provided.

A Study Of Women Through 18th-Century Literature: As Reflected By The Works Of Jane Austen, Or, A Re-Visioning, Nicole Miller

Honors Program Theses and Projects

No abstract provided.

Lgbt Homeless Youth In Boston, Massachusetts: Experiences Regarding Resources And Potential Barriers, Brittney Connery

Honors Program Theses and Projects

LGBT youth are at an escalated risk of leaving home, mental health concerns, victimization, substance abuse, and risky sexual behavior. However, research shows a lack of LGBT-specific resources. This raises concern as LGBT youth comprise 20 to 40 percent of homeless youth – disproportionate to the general youth population which is only 10 percent LGBT. The purpose of this research was to gain a deeper understanding of the experiences of LGBT homeless youth in Boston, Massachusetts regarding their use of resources and any potential barriers they may face. Furthermore, this study examined whether or not current resources are safe, welcoming …

Bowling, Richard C. Crepeau

On Sport and Society

Here it is only two days after the bowl pairings were announced and I am already approaching that semi-nauseous state of bowl fatigue. There once was a time not so long ago when that feeling didn’t set in until the second-half of the final game on January 1. Oh, for the good old days.

Evolution Of The Superconductivity Dome In The Two-Dimensional Hubbard Model, K. S. Chen, Z. Y. Meng, S. X. Yang, T. Pruschke, J. Moreno, M. Jarrell

Faculty Publications

In a recent publication, we identified a line of Lifshitz transition points separating the Fermi liquid and pseudogap regions in the hole-doped two-dimensional Hubbard model. Here, we extend the study to further determine the superconducting transition temperature in the phase diagram. By means of large-scale dynamical cluster quantum Monte Carlo simulations, we are able to identify the evolution of the d-wave superconducting dome in the hole-dope side of the phase diagram, with next-nearest-neighbor hopping (t′), chemical potential, and temperature as control parameters. To obtain the superconducting transition temperature Tc, we employ two-particle measurements of the pairing susceptibilities. As t′ goes …

2013-December-10-Sheri Hamilton, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Genetic Adjuvants For Immunotherapy, Shyam S. Mohapatra, Mukesh Kumar

USF Patents

The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of nucleic acid molecules encoding interleukin-12 (IL-12), interferon-gamma (IFN-γ), or a combination thereof, to a patient in need of such treatment. The pharmaceutical compositions of the invention contain nucleic acid molecules encoding IL-12 and/or IFN-γ and an operably-linked promoter sequence. In another aspect, the present invention concerns expression vectors containing a nucleotide sequence encoding IL-12 and IFN-γ, and an operably-linked promoter sequence. In another aspect, the present invention concerns cells genetically modified with a …

Germania-Silica-Based Sol-Gel Monolith And Uses Thereof, Abdul Malik, Erica B. Turner, Scott S. Segro

USF Patents

The present invention provides germania-silica-based sol-gel monoliths that form the solid-phase material for extraction, isolation, preconcentration, and separation of analytes. In one embodiment, the germania-silica-based sol-gel monolith can be used to coat surfaces of the inner walls of extraction and chromatographic columns. In a preferred embodiment, the sol-gel germania-silica monolith of the present invention is formed from hydrolysis and polycondensation of precursors comprising tetraethoxygermane, tetramethoxysilane, and polyethylene glycol. Also provided are methods of preparing the germania-silica-based sol-gel monolith of the present invention.