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A Hybrid Structural Approach To Analyze Ligand Binding By The Serotonin Type 4 Receptor (5-Ht4), Liwen Wang, Sayan Gupta, Tivadar Orban, Krzysztof Palczewski, Mark R. Chance

Faculty Scholarship

Hybrid structural methods have been used in recent years to understand protein-protein or protein-ligand interactions where high resolution crystallography or NMR data on the protein of interest has been limited. For G protein-coupled receptors (GPCRs), high resolution structures of native structural forms other than rhodopsin have not yet been achieved; gaps in our knowledge have been filled by creative crystallography studies that have developed stable forms of receptors by multiple means. The neurotransmitter serotonin (5-hydroxytryptamine) is a key GPCR-based signaling molecule affecting many physiological manifestations in humans ranging from mood and anxiety to bowel function. However, a high resolution structure …

The Karabus Affair Speaks To Larger Issues For American Academic And Medical Centers., Leonard A Zwelling, Md, Mba, Razelle Kurzrock, Md, Philip R Cohen, Md, Bernard Levin, Md, Ch, Lawrence Parish, Md

Department of Dermatology and Cutaneous Biology Faculty Papers

Finally, on March 12, 2013, a major American newspaper, The Wall Street Journal, reported on the plight of Dr. Cyril Karabus (1,2). Dr. Karabus is the 78 year old pediatric oncologist from Claremont, Capetown, South Africa who is well known as the retired head of the Oncology and Hematology Unit of the Red Cross Children’s Hospital, University of Cape Town, as well as for his devoted service to poor children in the apartheid era. In 2002, he cared for a three-year old Yemeni girl with acute myelogenous leukemia during a locum tenens in the United Arab Emirates (UAE).

Design And Construction Of An Experiment For The Investigation Of The Effects Of Gust On Flapping Wing Micro Air Vehicle Power Consumption, Brett Hiller

Mechanical Engineering Undergraduate Honors Theses

In recent years, the promising nature of flapping wing flight has led researchers to investigate the wing morphology and unsteady wing aerodynamics found in insects to aid in the design of modern micro air vehicles (MAVs). A high-fidelity flapping wing MAV could achieve high mobility, hovering stability, increased stealth, and efficient flight at low speeds. These characteristics offer a viable solution to the operational requirements for the typical hazardous and dynamic environments encountered during flight. While the kinematics and morphology of flapping wings are well-understood, significant research has yet to be completed with respect to the control and power requirements …

May 2013 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Influence Of Genetic Variation On Birth Defects In Caenorhabditis Elegans, Daniel Robert Kepple

Renée Crown University Honors Thesis Projects - All

In my Renee Crown Honors Capstone project, I studied how genetic variation influences birth defects that cause death in C. elegans embryos. I performed high-throughput hatching assay experiments of recombinant inbred advance intercross lines of C. elegans. These lines are genetically distinct from each other. I found significant variation in birth defects causing embryo death in these recombinant inbred advanced intercross lines. My results give evidence that gene interaction may play a significant role in causing birth defects resulting in death. My data also provides a starting point for studies making statistical arguments linking these birth defects to specific …

Transmembrane Protein Behavior In " Artificial Plasma Membranes" Reveals How Protein Binding To Lipid Rafts Is Regulated And How Lipid Asymmetry Affects Protein Structure, Qingqing Lin

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Lipid rafts are tightly packed saturated lipid and cholesterol-rich liquid-ordered (Lo) membrane domains that are believed to co-exist with loosely packed disordered domains composed mostly of unsaturated lipids. Rafts control numerous protein-protein and protein-lipid interactions at the cell surface. In this study, the sterol-dependent, pore-forming cytolysin perfringolysin O (PFO) was used to investigate how transmembrane (TM) protein association with lipid rafts is regulated and how lipid asymmetry affects transmembrane protein structure. First, to test the hypothesis that mismatch between protein TM segment length and bilayer width controls TM protein affinity for rafts, the raft affinity of PFO mutants with different …

Scottish Nephrops Survey Phase Iii: Evaluation Of Measures For Reducing Bycatch And Discards In A Nephrops Fishery, Rosanna Milligan, Amaya Albalat, Douglas Neil

Marine & Environmental Sciences Faculty Reports

No abstract provided.

Comparison Of Sugar Content For Ionic Liquid Pretreated Douglas-Fir Woodchips And Forestry Residues, Aaron M. Socha, Samuel P. Plummer, Vitalie Stavila, Blake A. Simmons, Seema Singh

Publications and Research

Background The development of affordable woody biomass feedstocks represents a significant opportunity in the development of cellulosic biofuels. Primary woodchips produced by forest mills are considered an ideal feedstock, but the prices they command on the market are currently too expensive for biorefineries. In comparison, forestry residues represent a potential low-cost input but are considered a more challenging feedstock for sugar production due to complexities in composition and potential contamination arising from soil that may be present. We compare the sugar yields, changes in composition in Douglas-fir woodchips and forestry residues after pretreatment using ionic liquids and enzymatic saccharification in …

Section Abstracts: Chemistry

Virginia Journal of Science

Abstracts of the Chemistry Section for the 91st Annual Virginia Journal of Science Meeting, May 2013

Section Abstracts: Environmental Science

Virginia Journal of Science

Abstracts of the Environmental Science Section for the 91st Annual Virginia Journal of Science Meeting, May 2013

Tremblings, May 2013, Western Aspen Alliance

Tremblings

Aspen management in Sweden — from pest to keystone species

Lars Edenius

I am honored to be the first Scandinavian scientist to author a Tremblings commentary. I will take this opportunity to briefly outline the recent history of aspen and the problems facing today’s aspen management in Sweden.

Characterization Of An Affitoid Variable Region To Be Used For Mdm-2 Detection In Elisa Microarray, Graham Reinhard

Chemical Engineering Undergraduate Honors Theses

Sandwich enzyme-linked immunosorbent assay (ELISA) microarray using peptoid-based affinity reagents, referred to as affitoids, is potentially a very powerful tool for the early detection of cancer and other complex diseases. Current detection methods for cancer are inadequate because most are imaging techniques and require that the cancer has progressed far enough for growths to be visible, which is often far too late for treatment to be effective. One possible way to overcome this issue is to use a biological detection technique that is able to detect proteins that are secreted specifically by cancerous cells (referred to as biomarkers). These biomarkers …

Developing An Optimized Light Spectrum For Plant Growth And Development, Kevin Richard Cope

Undergraduate Honors Capstone Projects

Light-emitting diodes (LEDs) are a rapidly developing technology for plant growth lighting and have become a powerful tool for understanding the spectral effects of light on plants. Several studies have shown that some blue light is necessary for normal growth and development, but the effects of blue light appear to be species dependent and may interact with other wavelengths of light as well as photosynthetic photon flux (PPF). Here we report the photobiological effects of three types of white LEDs (warm, neutral and cool) on the growth and development of radish, soybean, and wheat. All species were grown at two …

Development Of A Genetic Marker To Differentiate Between Pulex Irritans And Pulex Simulans, Colby Russell Kearl

Undergraduate Honors Capstone Projects

Pulex irritans and Pulex simulans are zoonotic flea vectors of plague and other infectious diseases. P. irritans have historically been known to use carnivores as a host, while P. simulans primarily parasitizes omnivores. To fully understand arthropod-borne infectious disease transmissibility and potential for geographical spread, it is important to differentiate between these two flea species. Traditional taxonomy uses the flea's male morphological features to distinguish species. There are no observable morphological differences between the female P. irritans and P. simulans. Molecular markers of the internal transcribed spacer regions (ITS) have been successfully used in other insect organisms to differentiate …

The Southeast In Context: An Assessment Of The Trauma Associated With Agriculture, Martin Welker

Undergraduate Honors Capstone Projects

Hunter-gatherer tradition prevailed as the dominant subsistence pattern for most of human history. Between 9,000 and 13,000 years ago peoples in the Levant, New World, and Asia began the domestication and cultivation of wild flora and fauna, creating a subsistence pattern that subsequently spread to neighboring regions (Abbo et al. 2010; Bellwood 2009; Purugganan & Fuller 2009; Richerson et al. 2001). The influence of this agricultural transition on human populations is manifested in various forms in the human skeleton, many of which have received intensive study: dental caries, degenerative joint disease, decreased stature, and increased birth rates (Bridges 1991; Larson …

The First Struggles Of The Capitalistic Peace And Its Detractors: An Analysis Of Greek Trade And Its Effects On Foreign Policy In The Athenian State, Joshua Blume

Undergraduate Honors Capstone Projects

Although, a ubiquitous number of articles has arisen recently debating the validity of the so-called "Capitalist Peace," there has been little exploration of the theory from an ancient historical perspective, primarily due to the lack of trade data between countries or city-states. As the primordial birthplace of trade and democracy, there is perhaps no better example than ancient Greece to shed insight into the possible validity of the capitalist peace theory. Utilizing new research involving trade in ancient Greece, this paper seeks to explore the relative validity of the "Capitalist Peace" in ancient Greece by conducting a qualitative analysis of …

Spectrum Noise Exposures - Analysis And Control Implementation, Kyle Lynn Naylor

Undergraduate Honors Capstone Projects

The Dee Glen Smith spectrum at Utah State University has a reputation of having one of the loudest student sections in the nation. For years, students have taken pride in creating a home court advantage by creating an extremely rowdy and loud atmosphere. Many would agree that this is what makes USU basketball so special.

Elevated noise levels, however, have the potential of creating a health hazard to both employees and spectators. Elevated noise levels can cause negative acute effects such as headache, dizziness, nausea, and tinnitus (ringing in the ears). The most likely acute affects that students, employees, and …

Modulation Of Neuronal R-Type Ca2+ Channels (Cav2.3) By G Protein-Coupled Receptors, Lauren S. Page

Undergraduate Honors Capstone Projects

Neuronal R-type Ca²⁺ channels (Ca_v2.3) are expressed at high concentrations within the cortex, hippocampus and striatal regions of the brain, where they participate in neuronal excitability and synaptic signaling. This pattern of expression may signify a connection between Ca_v2.3 channel function and neurological disorders such as Parkinson's Disease (PD) and Huntington's Disease (HD). Both of these disorders are caused by inadequate secretion of the neurotransmitter dopamine within the striatum. The first step in characterizing the potential importance of Ca_v2.3 in PD and HD is to examine its modulation by G-protein-coupled dopamine receptors. Specifically, …

Comparing Trophic Level Position Of Invertebrates In Fish And Fishless Lakes In Arctic Alaska, Katie Fisher

Undergraduate Honors Capstone Projects

Arctic lakes are likely very sensitive to the effects of climate change. Thus it is important to understand the current food web dynamics and energy flow within these lakes, to better understand how they will change in the future due to the effects of a rapidly changing climate. In order to contribute to this understanding, my project consists of an analysis of stable isotopes of carbon (delta 13 C) and nitrogen (delta 15 N) from invertebrates among fish and fishless lakes in arctic Alaska, to compare their trophic level positions and primary energetic sources. I collected pelagic invertebrates from 5 …

Thermal Microhabitat Preference Of The Common Side-Blotched Lizard, Uta Stansburiana, Maria Goller

Undergraduate Honors Capstone Projects

Ectotherms are especially susceptible to changing temperature conditions within their environment. To limit temperature fluctuations they must behaviorally regulate body temperature by moving between microhabitats of different ambient temperatures. By actively selecting specific substrate temperatures within a heterogeneous thermal environment, an individual could attain preferred body temperature and approach internal thermal homeostasis for periods of time. Ambient temperature dependence should thus force an individual to select those microhabitats that present optimal thermal conditions. Because dynamic thermal microhabitat structure is difficult to assess, the extent to which lizards employ behavioral thermoregulation is not well understood. Therefore, there is a need to …

Regulation And Expression Of Nanog, Oct4, And Sox2 In The Bovine Blastocyst Following Somatic Cell Nuclear Transfer, Justin Scott Hall

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Animal, Dairy, and Veterinary Sciences Department (ADVS) and the Center for Integrated Biosystems (CIB) at Utah State University are studying various molecular mechanisms involved in the animal cloning process. This study involves the extensive network of people, facilities, equipment, and funding already associated with the CIB and ADVS joint project.

Cloning involves many molecular challenges that for the most part have become roadblocks for the normal development of the fetus. The mechanisms necessary to transform an adult cell into a competent stem cell that can then transform and develop into a healthy organism are poorly understood. Some of these …

Attentional Factors In Temporal Distortion: The Effects Of Food Availability On Responses Within The Interval Bisection Task, Robert N. Johnson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Time estimation is a process that underlies many complex behaviors. Accurately timed performance depends upon some biological mechanism, which may be revealed by experimental methods. There have been several proposals on the subject of the function of the timing mechanism, some of which have revealed contradictory findings regarding the effect of distraction on timing. Whereas some studies have revealed underestimation (reports of time moving more slowly than it actually is) of the target interval following distracter presentation, others have revealed generalized disruption (no meaningful evidence of timing). The purpose of the present study was to determine whether food presentation for …

Predictors Of Father-Child And Mother-Child Attachment In Two-Parent Families, Jared P. Benware

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Jared Benware, M.S. and Gretchen Gimpel Peacock, Ph.D. at Utah State University examined parent-child attachment in two-parent families. Specifically, the relationship between mother-child and father-child attachment, the relationship between a child's temperament and parent-child attachment, and the relationship between the attachment and the amounts of time a parent spends away from his or her child. The researchers solicited parents as participants to complete questionnaires that measure parent-child attachment and the temperament of their child. This study focused especially on providing more information on the connection between father-child attachment and mother-child attachment rather than focusing only on mothers as the primary …

Clonal Diversity Of Quaking Aspen (Populus Tremuloides): How Multiple Clones May Add To Theresilience And Persistence Of This Forest Type, Richard Scott Gardner

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Aspen forests and woodlands are widespread across the western United States and are a primary component of many ecosystems in the west. Aspen is a clonal species, with reproduction occurring both by root sprouting (suckering) and seeding. Traditionally, western aspen forests were thought to consist almost entirely of large clones established several thousands of years ago, with seeding events being rare and ecologically negligible. Although clones in the western US can grow to be many acres, recent studies have demonstrated a far greater proportion of small clones than had been previously thought to exist. In this study I wanted to …

An Environmental History Of The Bear River Range, 1860-1910, Bradley Paul Hansen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The study of environmental history suggests that nature and culture change all the time, but that the rate and scale of such change can vary enormously. During the late 19th and early 20th centuries, Anglo settlement in the American West transformed landscapes and ecologies, creating new and complex environmental problems. This transformation was particularly impressive in Cache Valley, Utah's Bear River Range. From 1860 to 1910, Mormon settlers overused or misused the Bear River Range's lumber, grazing forage, wild game, and water resources and introduced invasive plant and animal species throughout the area.

By the turn of the 20th century, …

Enhanced Structural Support Of Metal Sites As Nodes In Metal-Organic Frameworks Compared To Metal Complexes, Sanjit Das

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Crystalline porous materials have gained long-standing interest for their application in gas storage, separation and catalysis. These materials have been useful for domestic, scientific and industrial purposes for many decades. Zeolites are a well known example of such materials.

Metal-organic frameworks are a new class of crystalline porous materials. They have many advantages over the more widely known zeolites. Though metal-organic frameworks are relatively new, their basic structure, known as the secondary building unit, very closely resembles the structure of metal complexes. Such metal complexes have been characterized in chemistry for more than a century.

Chemical catalysis is a process …

Development Of The Multiple Use Plug Hybrid For Nanosats (Muphyn) Miniature Thruster, Shannon Dean Eilers

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Multiple Use Plug Hybrid for Nanosats (MUPHyN) prototype thruster incorporates solutions to several major challenges that have traditionally limited the deployment of chemical propulsion systems on small spacecraft. The MUPHyN thruster offers several features that are uniquely suited for small satellite applications. These features include 1) a non-explosive ignition system, 2) non-mechanical thrust vectoring using secondary fluid injection on an aerospike nozzle cooled with the oxidizer flow, 3) a non-toxic, chemically-stable combination of liquid and inert solid propellants, 4) a compact form factor enabled by the direct digital manufacture of the inert solid fuel grain. Hybrid rocket motors provide …

An Evaluation Of Current Stormwater Best Management Practice Relationships Between Design And Efficiency: A Series Of Local And National Case Studies, Amanda Ann Goodwin

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Water quality continues to be threatened by human development activities such as stormwater runoff from urbanization. This study addresses the question of how stormwater Best Management Practice (BMP) system design choices affect pollutant removal efficiency, through the examination of 12 case study sites (across five states) that use three common BMP system design types (detention, retention, and wetland channel). Water quality information was obtained from the International Stormwater Database and site composite grab samples. Development conditions were inventoried by orthophotos and assessed using Geographic Information System (GIS) and AutoCAD data.

This study relates Total Suspended Solid (TSS) load removal efficiency …

Applications Of Bayesian Statistics In Fluvial Bed Load Transport, Mark L. Schmelter

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The science of fluvial sediment transport studies the processes involved in the movement of river sediments. It is commonly understood that when rivers flood they have a great capacity to move sand, gravel, and even larger cobbles and boulders. This process is not only limited to the big floods that usually attract so much attention, but also the more common river flows play a very important role in forming a river. As engineers and scientists, we like to be able to develop equations and relationships that describe some natural phenomenon—in this case, fluvial sediment transport. While we are able to …

Greater Sage-Grouse Habitat Selection And Use Patterns In Response To Vegetation Management Practices In Northwestern Utah, Stephanie E. Graham

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Greater sage-grouse (Centrocercus urophasianus; sage-grouse) are a sagebrush obligate species and an indicator of sagebrush (Artemisia spp.) habitat quality. Sage-grouse populations have declined across western North America. Fragmentation of landscapes and habitat loss have been identified as factors that negatively impact sage-grouse populations. Wildfires can increase the distribution of invasive plants and contribute to fragmentation and habitat loss across sagebrush ecosystems. Greenstripping has been identified as a technique to reduce the threat of wildfire and subsequent spread of invasive species. Forage kochia (Bassia prostrata) is a semi-shrub that contains a high moisture content year-round, high …