Digital Commons Network^™

Business Plan For Lemon Production In California, Henry Sinanta

BioResource and Agricultural Engineering

No abstract provided.

Il-4rα On Cd4+ T Cells Plays A Pathogenic Role In Respiratory Syncytial Virus Reinfection In Mice Infected Initially As Neonates, Dahui You, Nico Marr, Jordy Saravia, Bishwas Shrestha, Greg I. Lee, Stuart E. Turvey, Frank Brombacher, De'broski R. Herbert, Stephania A. Cormier

Faculty Publications

RSV is the major cause of severe bronchiolitis in infants, and severe bronchiolitis as a result of RSV is associated with subsequent asthma development. A biased Th2 immune response is thought to be responsible for neonatal RSV pathogenesis; however, molecular mechanisms remain elusive. Our data demonstrate, for the first time, that IL-4Rα is up-regulated in vitro on human CD4+ T cells from cord blood following RSV stimulation and in vivo on mouse pulmonary CD4+ T cells upon reinfection of mice, initially infected as neonates. Th cell-specific deletion of Il4ra attenuated Th2 responses and abolished the immunopathophysiology upon reinfection, including airway …

Fitness: Philosophical Problems, Grant Ramsey, Charles H. Pence

Faculty Publications

Fitness plays many roles throughout evolutionary theory, from a measure of populations in the wild to a central element in abstract theoretical presentations of natural selection. It has thus been the subject of an extensive philosophical literature, which has primarily centred on the way to understand the relationship between fitness values and reproductive outcomes. If fitness is a probabilistic or statistical quantity, how is it to be defined in general theoretical contexts? How can it be measured? Can a single conceptual model for fitness be offered that applies to all biological cases, or must fitness measures be case-specific? Philosophers have …

Reevaluating The Conceptual Framework For Applied Research On Host-Plant Resistance, Michael J. Stout

Faculty Publications

Applied research on host-plant resistance to arthropod pests has been guided over the past 60 years by a framework originally developed by Reginald Painter in his 1951 book, Insect Resistance in Crop Plants. Painter divided the "phenomena" of resistance into three "mechanisms," nonpreference (later renamed antixenosis), antibiosis, and tolerance. The weaknesses of this framework are discussed. In particular, this trichotomous framework does not encompass all known mechanisms of resistance, and the antixenosis and antibiosis categories are ambiguous and inseparable in practice. These features have perhaps led to a simplistic approach to understanding arthropod resistance in crop plants. A dichotomous scheme …

The Genomic Consequences Of Adaptive Divergence And Reproductive Isolation Between Species Of Manakins, T. L. Parchman, Z. Gompert, M. J. Braun, R. T. Brumfield, D. B. Mcdonald, J. A.C. Uy, G. Zhang, E. D. Jarvis, B. A. Schlinger, C. A. Buerkle

Faculty Publications

The processes of adaptation and speciation are expected to shape genomic variation within and between diverging species. Here we analyze genomic heterogeneity of genetic differentiation and introgression in a hybrid zone between two bird species (Manacus candei and M. vitellinus) using 59 100 SNPs, a whole genome assembly, and Bayesian models. Measures of genetic differentiation (FST) and introgression (genomic cline center [α] and rate [β]) were highly heterogeneous among loci. We identified thousands of loci with elevated parameter estimates, some of which are likely to be associated with variation in fitness in Manacus populations. To analyze the genomic organization of …

Visionary Summer 2013, College Of Optometry

Visionary

No abstract provided.

The Evolutionary Histories Of Clinical And Environmental Shv Β-Lactamases Are Intertwined, Robert L. Dorit, Christopher M. Roy, Sandra M. Robinson, Margaret A. Riley

Biological Sciences: Faculty Publications

The rise of antibiotic-resistant pathogens focuses our attention on the source of antibiotic resistance genes, on the existence of these genes in environments exposed to little or no antibiotics, and on the relationship between resistance genes found in the clinic and those encountered in non-clinical settings. Here, we address the evolutionary history of a class of resistance genes, the SHV β-lactamases. We focus on bla SHV genes isolated both from clinical and non-clinical sources and show that clinically important resistance determinants arise repeatedly from within a diverse pool of bla SHV genes present in the environment. While our results argue …

Savage Minds Interview: Kristina Killgrove, Ryan B. Anderson

Faculty Publications

Kristina Killgrove is a biological anthropologist at the University of West Florida. Her research focuses on theorizing migration in antiquity and on understanding urban development and collapse through the analysis of human skeletal remains. She works primarily in the classical world, attempting to learn about the daily lives of the lower classes in Imperial Rome through osteological and biochemical analyses, but she has also worked on questions of population interaction in the contact-period southeastern U.S.and in Medieval Germany. A strong commitment to interdisciplinary research and teaching help her bridge the sometimes large divide between classics and anthropology.For more about Killgrove's …

Polymer Fiber Arrays For Adhesion, Shing Chung Josh Wong, Johnny F. Najem, Guang Ji, Shuwen Chen

Mechanical Engineering Faculty Research

The ability of geckos to adhere to vertical solid surfaces comes from their remarkable feet with millions of projections terminating in nanometer spatulae. In this paper, we present a simple yet robust method for fabricating directionally sensitive dry adhesives. By using electrospun nylon 6 nanofiber arrays, we create gecko-inspired dry adhesives, that are electrically insulating, and that show shear adhesion strength of 27 N/cm2 on a glass slide. This measured value is 270% that reported of gecko feet and 97-fold above normal adhesion strength of the same arrays. The data indicate a strong shear binding-on and easy normal lifting-off. Size …

Measurement Of Adhesion Energy Of Electrospun Polymer Membranes Using A Shaft-Loaded Blister Test, Shing Chung Josh Wong, Haining Na, Pei Chen

Mechanical Engineering Faculty Research

This study aims to examine the adhesion work of electrospun polymer nano- and micro-fibers. The adhesion energy at the interface of electrospun membrane and a rigid substrate is characterized by a shaft-loaded blister test (SLBT). By controlling the processing parameters, polyvinylidene fluoride (PVDF) fibrous membranes are prepared with fiber diameters ranging from 201 ± 86 nm to 2,724 ± 587 nm. The adhesion energy between electrospun membrane and rigid substrate increases from 8.1 ± 0.7 mJ/m2 to 258.8 ± 43.5 mJ/m2 by use of smaller fiber diameters. Adhesion energies between electrospun PVDF membranes and SiC substrates made of different grain …

Food System Planning Benefits & Recommendations For The City Of San Luis Obispo, Ca, Tessa Salzman

City and Regional Planning

No abstract provided.

Mission, Food, And Commensality Among The Yukpa: Indigenous Creolization And Emerging Complexities In Indigenous Modernities, Ernst Halbmayer

Tipití: Journal of the Society for the Anthropology of Lowland South America

No abstract provided.

Determining The Depth Of Insertion Of Dynamically Invisible Membrane Peptides By Gel-Phase 1H Spin Diffusion Heteronuclear Correlation Nmr, T. Wang, H. Yao, M. Hong

Faculty Publications

Solid-state NMR determination of the depth of insertion of membrane peptides and proteins has so far utilized 1H spin diffusion and paramagnetic relaxation enhancement experiments, which are typically conducted in the liquid-crystalline phase of the lipid bilayer. For membrane proteins or peptide assemblies that undergo intermediate-timescale motion in the liquid-crystalline membrane, these approaches are no longer applicable because the protein signals are broadened beyond detection. Here we show that the rigid-solid HETCOR experiment, with an additional spin diffusion period, can be used to determine the depth of proteins in gel-phase lipid membranes, where the proteins are immobilized to give high-intensity …

Minimizing Human Infection From Escherichia Coli O157:H7 Using Gumbos, Marsha R. Cole, Min Li, Ravirajsinh Jadeja, Bilal El-Zahab, Daniel Hayes, Jeffery A. Hobden, Marlene E. Janes, Isiah M. Warner

Faculty Publications

Objectives: Reduction in faecal shedding of Shiga toxin-producing enterohaemorrhagic Escherichia coli (EHEC) in food-producing animals is a viable strategy to minimize human disease initiated by exposure to these microorganisms. To this end, an intervention strategy involving the electrostatic hybridization of two commonly used anti-infective agents for veterinary practice (i.e. chlorhexidine and ampicillin) was evaluated to curtail EHECtransmitted disease from ruminant sources. Chlorhexidine di-ampicillin is a novel group of uniform material based on organic salts (GUMBOS) with inherent in vitro antibacterial activity that comes from its parent antimicrobial ions, chlorhexidine and ampicillin. Methods: Antibacterial activities for chlorhexidine diacetate, sodium ampicillin, chlorhexidine …

Trade-Offs, Geography, And Limits To Thermal Adaptation In A Tide Pool Copepod, Morgan W. Kelly, Richard K. Grosberg, Eric Sanford

Faculty Publications

Antagonistic correlations among traits may slow the rate of adaptation to a changing environment. The tide pool copepod Tigriopus californicus is locally adapted to temperature, but within populations, the response to selection for increased heat tolerance plateaus rapidly, suggesting either limited variation within populations or costs of increased tolerance. To measure possible costs of thermal tolerance, we selected for increased upper lethal limits for 10 generations in 22 lines of T. californicus from six populations. Then, for each line, we measured six fitness-related traits. Selected lines showed an overall increase in male and female body sizes, fecundity, and starvation resistance, …

Efindsite: Improved Prediction Of Ligand Binding Sites In Protein Models Using Meta-Threading, Machine Learning And Auxiliary Ligands, Michal Brylinski, Wei P. Feinstein

Faculty Publications

Molecular structures and functions of the majority of proteins across different species are yet to be identified. Much needed functional annotation of these gene products often benefits from the knowledge of protein-ligand interactions. Towards this goal, we developed eFindSite, an improved version of FINDSITE, designed to more efficiently identify ligand binding sites and residues using only weakly homologous templates. It employs a collection of effective algorithms, including highly sensitive meta-threading approaches, improved clustering techniques, advanced machine learning methods and reliable confidence estimation systems. Depending on the quality of target protein structures, eFindSite outperforms geometric pocket detection algorithms by 15-40 % …

Cotton Aphid (Heteroptera: Aphididae) Susceptibility To Commercial And Experimental Insecticides In The Southern United States, J. Gore, D. Cook, A. Catchot, B. R. Leonard, S. D. Stewart, G. Lorenz, D. Kerns

Faculty Publications

Cotton aphid, Aphis gossypii Glover, has a history of developing resistance to novel insecticides. A program is needed to monitor cotton aphid susceptibility to new insecticides. Concentration-mortality bioassays were conducted from 2008 to 2011 to monitor the susceptibility of cotton aphids from fields across the midsouthern United States to thiamethoxam and sulfoxaflor. Flonicamid was included in 2010 and 2011. Bioassays followed the procedures described by the Insecticide Resistance Action Committee for testing neonicotinoids against cotton aphid. Mortality was rated at 48 and 72 h. These bioassays suggest that high levels of resistance to thiamethoxam occur in cotton aphid throughout the …

A Meta-Analysis Identifies New Loci Associated With Body Mass Index In Individuals Of African Ancestry, Keri L. Monda, Gary K. Chen, Kira C. Taylor, Cameron Palmer, Todd L. Edwards, Leslie A. Lange, Maggie C.Y. Ng, Adebowale A. Adeyemo, Matthew A. Allison, Lawrence F. Bielak, Guanjie Chen, Mariaelisa Graff, Marguerite R. Irvin, Suhn K. Rhie, Guo Li, Yongmei Liu, Youfang Liu, Yingchang Lu, Michael A. Nalls, Yan V. Sun, Mary K. Wojczynski, Lisa R. Yanek, Melinda C. Aldrich, Adeyinka Ademola, Christopher I. Amos, Elisa V. Bandera, Cathryn H. Bock, Angela Britton, Ulrich Broeckel, Quiyin Cai, Neil E. Caporaso, Chris S. Carlson, John Carpten

Faculty Publications

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a …

Summer 2013, Center For Research & Grants

Research Matters (Archival - No longer actively being published)

No abstract provided.

Linezolid Exerts Greater Bacterial Clearance But No Modification Of Host Lung Gene Expression Profiling: A Mouse Mrsa Pneumonia Model, Jiwang Chen, Gang Feng, Yang Song, Juliane B. Wardenburg, Simon Lin, Ichiro Inoshima, Michael Otto, Richard G. Wunderink

Faculty Publications – Biological Sciences

Background: Linezolid (LZD) is beneficial to patients with MRSA pneumonia, but whether and how LZD influences global host lung immune responses at the mRNA level during MRSA-mediated pneumonia is still unknown. Methods: A lethal mouse model of MRSA pneumonia mediated by USA300 was employed to study the influence of LZD on survival, while the sublethal mouse model was used to examine the effect of LZD on bacterial clearance and lung gene expression during MRSA pneumonia. LZD (100mg/kg/day, IP) was given to C57Bl6 mice for three days. On Day 1 and Day 3 post infection, bronchoalveolar lavage fluid (BALF) protein concentration …

Commencement Program 2013, Loma Linda University

Commencement Programs

CONTENTS

1 | Message from the President

3 | 2013 Events of Commencement

5 | The Academic Procession

7 | Significance of Academic Regalia

9 | The Good Samaritan

10 | University History Highlights

12 | Loma Linda University Song - "Healing Love"

13 | The Speakers

23 | The University Honorees

45 | The School Honorees

64 | The Programs

• School of Medicine, 65
• School of Pharmacy, 83
• School of Dentistry, 90
• School of Behavioral Health and School of Religion, 107
• School of Nursing, 120
• School of Pubic Health, 129
• School of Allied Health Professions - Physical Therapy, 145 …

The Case For Conscientiousness: Evidence And Implications For A Personality Trait Marker Of Health And Longevity, Tim Bogg, Brent W. Roberts

Psychology Faculty Research Publications

Purpose Recent initiatives by major funding agencies have emphasized translational and personalized approaches (e.g., genetic testing) to health research and health management. While such directives are appropriate, and will likely produce tangible health benefits, we seek to highlight a confluence of several lines of research showing relations between the personality dimension of conscientiousness and a variety of health-related outcomes.

Methods Using a modified health process model, we review the compelling evidence linking conscientiousness to health and disease processes, including longevity, diseases, morbidity-related risk factors, health-related psycho-physiological mechanisms, health-related behaviors, and social environmental factors related to health.

Conclusion We argue the …

Block Copolymer Self-Assembled And Cross-Linked Nanoassemblies For Combination Delivery Of Iron Oxide And Doxorubicin, Daniel Scott, Yihwa Beabout, Robert J. Wydra, Mo Dan, Robert A. Yokel, J. Zach Hilt, Younsoo Bae

Pharmaceutical Sciences Faculty Publications

We describe the development of nanoscale polymer drug carriers for the combinational delivery of an anticancer drug (doxorubicin: DOX) along with super paramagnetic iron oxide nanoparticles (IONPs). The drug molecules were electrostatically loaded into both block copolymer self-assembled nanoassemblies (SNAs) and cross-linked nanoassemblies (CNAs). Both nanoassemblies entrapped DOX and IONPs either individually or in tandem, maintaining sub-100 nm diameter. The IONP-loaded nanoassemblies generated heat in the presence of an alternating magnetic field (AMF). Incorporation of the drug payload, DOX, showed no adverse effects on the heating profile. Drug release from the SNAs and CNAs was accelerated as temperature increased from …

Would Women Leaders Have Prevented The Global Financial Crisis? Teaching Critical Thinking By Questioning A Question, Julie A. Nelson

Economics Faculty Publication Series

Would having more women in leadership have prevented the financial crisis? This question, raised in the popular media, can make effective fodder for teaching critical thinking within courses such as gender and economics, money and financial institutions, pluralist economics, or behavioural economics. While the question, as posed, demands an answer of 'Yes - sex differences in traits are important' or 'No - gender is irrelevant', students can be encouraged to question the question itself. The first part of this essay briefly reviews literature on the sameness-versus-difference debate, noting that the belief in exaggerated behavioural differences between men and women is …

The Nature And Predictive Validity Of A Benchmark Assessment Program In An American Indian School District, Beverly R. Payne

Department of Educational Administration: Dissertations, Theses, and Student Research

This mixed methods study explored the nature of a benchmark assessment program and how well the benchmark assessments predicted End-of-Grade (EOG) and End-of-Course (EOC) test scores in an American Indian school district. Five major themes were identified and used to develop a Dimensions of Benchmark Assessment Program Effectiveness model: Professional Development, Assessment Literacy, Data Literacy, Instructional Practice, and Program Effectiveness. The study found that Professional Development, Data Literacy, and overall Program Effectiveness were strengths of the district’s benchmark assessment program. Assessment Literacy and Instructional Practice were found to be weaker areas of the district’s program. Benchmark assessment scores correlated strongly …

Southern Alumni, Siu Alumni Association

SIU Alumni Magazine

No abstract provided.

Ranbp9 Aggravates Synaptic Damage In The Mouse Brain And Is Inversely Correlated To Spinophilin Levels In Alzheimer's Brain Synaptosomes, Juan Pablo Palavicini, Hongjie Wang, Elisabetta Bianchi, Shaohua Xu, Jagadeesh S. Rao, David E. Kang, Madepalli K. Lakshmana

Biomedical Engineering and Sciences Faculty Publications

We previously demonstrated that over expression of RanBP9 led to enhanced Ab generation in a variety of cell lines and primary neuronal cultures, and subsequently, we confirmed increased amyloid plaque burden in a mouse model of Alzheimer’s disease (AD). In the present study, we found striking reduction of spinophilin protein levels when RanBP9 is overexpressed. At 12 months of age, we found spinophilin levels reduced by 70% (Po0.001) in the cortex of APDE9/RanBP9 mice compared with that in wild-type (WT) controls. In the hippocampus, the spinophilin levels were reduced by 45% (Po0.01) in the APDE9/RanBP9 mice. Spinophilin immunoreactivity was also …

Pubh 595.50: Issues In Maternal And Child Health, Julie M. Stevens

University of Montana Course Syllabi

No abstract provided.

Pubh 580.80: Rural Issues In Global Context, Peter Koehn

University of Montana Course Syllabi

No abstract provided.

Pubh 570.50: Ethical Issues In Public Health, Ann Freeman Cook

University of Montana Course Syllabi

No abstract provided.