Digital Commons Network^™

Intratumoral Chemotherapy For Lung Cancer: Re-Challenge Current Targeted Therapies, Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Kaid Darwiche, Thomas Vogl, Eugene P. Goldberg, Haidong Huang, Michael Simoff, Qiang Li, Robert Browning, Francis J. Turner, Patrick Le Pivert, Dionysios Spyratos, Konstantinos Zarogoulidis, Seyhan I. Celikoglu, Firuz Celikoglu, Johannes Brachmann

Internal Medicine Faculty Publications

Strategies to enhance the already established doublet chemotherapy regimen for lung cancer have been investigated for more than 20 years. Initially, the concept was to administer chemotherapy drugs locally to the tumor site for efficient diffusion through passive transport within the tumor. Recent advances have enhanced the diffusion of pharmaceuticals through active transport by using pharmaceuticals designed to target the genome of tumors. In the present study, five patients with non-small cell lung cancer epidermal growth factor receptor (EGFR) negative stage IIIa–IV International Union Against Cancer 7 (UICC-7), and with Eastern Cooperative Oncology Group (ECOG) 2 scores were administered platinum-based …

What's New In Orthopaedic Trauma, William M. Ricci, Andre Spiguel, Christopher Mcandrew, Michael Gardner

Open Access Publications

No abstract provided.

Birds In Corrales, James S. Findley

Special Publications

No abstract provided.

Influence Of Porcine Dermal Fibers And Plla Fibers On Properties Of A Commercially-Available Injectable Bone Graft Substitute, Nathan Richard Thomas

Electronic Theses and Dissertations Archive

An ideal bone graft substitute (BGS) does not exist. To obtain such a material, researchers are focussing on improving its mechanical properties while not adversely affecting other properties. BGSs in current use have low toughness and low flexural strength. The focus of the present study was to determine the influence of two types of fiber (xenograft (porcine) and poly-L-lactide (PLLA)) on toughness and flexural strength as well as other mechanical properties, setting time, injectability and cytocompatibility of PRO-DENSE(R), commercially-available injectable BGS. The addition of each fiber type led to a significant increase in toughness (3X and 10X with porcine dermal …

Pathways To Aggressive Behavior: Antisocial And Borderline Personality Symptoms And The Mechanisms Of Impulsivity, Negative Affect, And Distress Tolerance, Katherine Lee Bracken-Minor

Electronic Theses and Dissertations Archive

Aggressive behaviors, including physical aggression toward others and non-suicidal self-injury, are high-risk behaviors that are prevalent in the college student population. Personality disorder symptoms, particularly those of antisocial personality disorder and borderline personality disorder, are associated with these aggressive behaviors. Some researchers have posited that ASPD and BPD are “mirror-image disorders” that have similar underlying traits but differing behavioral manifestations of those characteristics, namely differing in terms of the object of their aggression. The present study investigated these issues by examining the pathways from ASPD and BPD to aggressive behaviors via the mechanisms of impulsivity, negative affect, and distress tolerance …

Protective Factors In The Relationship Between Urgency And Bulimic Behavior, Eugenia Suzanne Hatchett

Electronic Theses and Dissertations Archive

Negative urgency, a trait marked by the tendency to react impulsively when experiencing negative affect, has recently been identified as a risk factor for bulimia. Although multiple studies have established a link between urgency and bulimia, few studies have focused on factors that might moderate this relationship. The purpose of the current study was to examine the ability of problem-focused coping, emotion-focused coping, social support, and self-efficacy for regulating negative affect (SERN) to moderate the relationship between negative urgency and bulimic behavior. Web-based assessments of negative urgency, bulimic symptoms, coping, social support, and SERN were completed by 280 female college …

Real-Time Bioacoustics Monitoring And Automated Species Identification, T. Mitchell Aide, Carlos Corrada-Bravo, Marconi Campos-Cerqueira, Carlos Milan, Giovany Vega, Rafael Alvarez

Bioacoustics Collection

Traditionally, animal species diversity and abundance is assessed using a variety of methods that are generally costly, limited in space and time, and most importantly, they rarely include a permanent record. Given the urgency of climate change and the loss of habitat, it is vital that we use new technologies to improve and expand global biodiversity monitoring to thousands of sites around the world. In this article, we describe the acoustical component of the Automated Remote Biodiversity Monitoring Network (ARBIMON), a novel combination of hardware and software for automating data acquisition, data management, and species identification based on audio recordings. …

Racial Disparities In The Use Of Cardiac Revascularization: Does Local Hospital Capacity Matter?, Suhui Li, Arnold Chen, Holly Mead

Health Policy and Management Faculty Publications

Objective

To assess the extent to which the observed racial disparities in cardiac revascularization use can be explained by the variation across counties where patients live, and how the within-county racial disparities is associated with the local hospital capacity.

Data Sources

Administrative data from Pennsylvania Health Care Cost Containment Council (PHC4) between 1995 and 2006.

Study Design

The study sample included 207,570 Medicare patients admitted to hospital for acute myocardial infarction (AMI). We identified the use of coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) procedures within three months after the patient’s initial admission for AMI. Multi-level hierarchical …

Independent - Jul.16, 2013, Jacklyn Nowotnik

The Independent (1988-present)

No abstract provided.

The Water Footprint Of Biofuel Produced From Forest Wood Residue Via A Mixed Alcohol Gasification Process, Yi-Wen Chiu, May Wu

Natural Resources Management and Environmental Sciences

Forest residue has been proposed as a feasible candidate for cellulosic biofuels. However, the number of studies assessing its water use remains limited. This work aims to analyze the impacts of forest-based biofuel on water resources and quality by using a water footprint approach. A method established here is tailored to the production system, which includes softwood, hardwood, and short-rotation woody crops. The method is then applied to selected areas in the southeastern region of the United States to quantify the county-level water footprint of the biofuel produced via a mixed alcohol gasification process, under several logistic systems, and at …

Enhanced Simulation Of Partial Gravity For Extravehicular Activity, Steven P. Chappell, David M. Klaus

Journal of Human Performance in Extreme Environments

Prior studies of human locomotion under simulated partial gravity have hypothesized that energy expenditure is increased in lunar gravity, as compared to that of Mars. This may be due to subjects having to expend excess energy for stability and posture control in the lower gravitational field. The physiological cause of this suspected ‘‘wasted energy’’ during locomotion in low gravity remains to be determined. This paper outlines factors to be considered for these analyses and enhancements to the simulation method that will enable assessment of inertial stability and associated metabolic cost. A novel simulation technique is proposed for assessing the effects …

An Mll-Dependent Network Sustains Hematopoiesis, Erika L. Artinger, Bibhu P. Mishra, Kristin M. Zaffuto, Bin E. Li, Elaine K. Y. Chung, Adrian W. Moore, Yufei Chen, Chao Cheng, Patricia Ernst

Dartmouth Scholarship

The histone methyltransferase Mixed Lineage Leukemia (MLL) is essential to maintain hematopoietic stem cells and is a leukemia protooncogene. Although clustered homeobox genes are well-characterized targets of MLL and MLL fusion oncoproteins, the range of Mll-regulated genes in normal hematopoietic cells remains unknown. Here, we identify and characterize part of the Mll-dependent transcriptional network in hematopoietic stem cells with an integrated approach by using conditional loss-of-function models, genomewide expression analyses, chromatin immunoprecipitation, and functional rescue assays. The Mll-dependent transcriptional network extends well beyond the previously appreciated Hox targets, is comprised of many characterized regulators of self-renewal, and contains target genes …

Characterization Of Hiv-1 Integrase Reactions With Viral Dna, Joanna Kettlewell

UROP Posters

HIV-1 integrase (integrase) catalyzes the insertion of viral DNA into human chromosomes and is a focus for development of anti-integrase inhibitors to combat HIV infection. Integrase catalyzes two steps, a DNA-end cleavage reaction (3’-processing), and a DNA-end joining reaction (strand transfer). Together, these steps result in viral DNA integration into the genome of the host cell, resulting in persistent infection. Better understanding of the mechanism of integration and interactions of the viral and host DNA with integrase are required for optimal inhibitor development. Recombinant integrase protein was purified and activity was evaluated in a biochemistry assay under bulk conditions to …

Don’T Be A Drag, Just Be A Queen! Assessing The Popularity Of Drag Queens As Opposed To Levels Of Anti-Transgender Prejudice In Modern American Society, Neha Jadhav

UROP Posters

Over the past few decades, drag queen shows have become a popular sensation among men and women, homosexuals and heterosexuals alike. On the other hand, transgender individuals are confronted with more prejudice than gays, lesbians, or bisexuals are. What about drag queens sets them apart from the stigma directed toward transgenders? For this study, I attended a drag brunch in a gay bar and observed how each performance compelled audience members to question perceptions of gender and sexuality. In addition, I analyzed several scholarly journal articles for research on the practices of drag queens during their performances and their appeal, …

Longitudinal Predictors Of Quality Of Life In Adolescent Survivors Of Childhood Cancer: A Report From The Childhood Cancer Survivor Study, Claire C. Russell

Theses and Dissertations

Objective: The impact of childhood cancer on future quality of life (QoL) in survivors is unclear. Current studies focus on comparing outcomes to healthy peers and identifying related treatment and demographic variables, but a shift in our approach is necessary. This study is guided by the Wilson and Cleary Model (WMC) and seeks to identify longitudinal predictors of QoL in adolescent survivors of cancer that explain variance in QoL beyond the impact of treatment and demographic variables. Methods: The Childhood Cancer Survivor Study (CCSS) is a multi-institutional longitudinal study following a cohort of childhood cancer survivors. This study focuses on …

Analysis Of Humira, Electro-Acupuncture, And Pulsatile Dry Cupping On Reducing Joint Inflammation In Patients With Rheumatoid Arthritis, Natalie Noll

UROP Posters

Humira, an anti-TNF drug aimed at decreasing inflammation in Rheumatoid Arthritis patients, can cause skin diseases from a rash to skin cancer. Humira works by blocking the chemical receptor RANKL, which therefore halts the production of osteoclasts, which attack and eat bone and cartilage, causing inflammation in arthritis patient’s joints. By analyzing Humira’s effect on the human body, it can be compared against other treatments such as electro-acupuncture and pulsatile dry cupping to see if these alternative treatments can decrease inflammation in Rheumatoid Arthritis patients through blocking RANKL, and if they are safer methods for carrying out this treatment. Under …

Contributors, Gwenyth E. Hood

The Mythic Circle

No abstract provided.

Biologists Revive Chestnut Tree At Former Coal Mine Sites, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Plant Biology Women's And Gender Studies Alum Guest Blogs For Hocking Hills, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Wisconsin State Journal Quotes Ballard On Tiny Violet Discovery, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Plant Community Structure Determines Primary Productivity In Shallow, Eutrophic Lakes, Soren Brothers, Sabine Hilt, Stephanie Meyer, Jan Kohler

Watershed Sciences Faculty Publications

Regime shifts are commonly associated with the loss of submerged macrophytes in shallow lakes; yet, the effects of this on whole-lake primary productivity remain poorly understood. This study compares the annual gross primary production (GPP) of two shallow, eutrophic lakes with different plant community structures but similar nutrient concentrations. Daily GPP rates were substantially higher in the lake containing submerged macrophytes (586 ± 23 g C m−2 year−1) than in the lake featuring only phytoplankton and periphyton (408 ± 23 g C m−2 year−1; P < 0.0001). Comparing lake-centre diel oxygen curves to compartmental estimates of GPP confirmed that single-site oxygen curves may provide unreliable estimates of whole-lake GPP. The discrepancy between approaches was greatest in the macrophyte-dominated lake during the summer, with a high proportion of GPP occurring in the littoral zone. Our empirical results were used to construct a simple conceptual model relating GPP to nutrient availability for these alternative ecological regimes. This model predicted that lakes featuring submerged macrophytes may commonly support higher rates of GPP than phytoplankton-dominated lakes, but only within a moderate range of nutrient availability (total phosphorus ranging from 30 to 100 μg L−1) and with mean lake depths shallower than 3 or 4 m. We conclude that shallow lakes with a submerged macrophyte–epiphyton complex may frequently support a higher annual primary production than comparable lakes that contain only phytoplankton and periphyton. We thus suggest that a regime shift involving the loss of submerged macrophytes may decrease the primary productivity of many lakes, with potential consequences for the entire food webs of these ecosystems.

Completions 2012-13, Southwestern Oklahoma State University

IPEDS

IPEDS Report on Completions 2012-13

Mythic Circle #35, Gwenyth E. Hood

The Mythic Circle

No abstract provided.

Synthetic, Spectroscopic And Dft Studies Of Iron Complexes With Iminobenzo(Semi)Quinone Ligands: Implications For O-Aminophenol Dioxygenases, Michael M. Bittner, David S. Krause, Sergey V. Lindeman, Cordina V. Popescu, Adam T. Fiedler

Chemistry Faculty Research and Publications

The oxidative CC bond cleavage of o-aminophenols by nonheme Fe dioxygenases is a critical step in both human metabolism (the kynurenine pathway) and the microbial degradation of nitroaromatic pollutants. The catalytic cycle of o-aminophenol dioxygenases (APDOs) has been proposed to involve formation of an Fe^II/O₂/iminobenzosemiquinone complex, although the presence of a substrate radical has been called into question by studies of related ring-cleaving dioxygenases. Recently, we reported the first synthesis of an iron(II) complex coordinated to an iminobenzosemiquinone (ISQ) ligand, namely, [Fe(Tp)(^tBuISQ)] (2 a; where Tp=hydrotris(3,5-diphenylpyrazol-1-yl)borate and ^{tBu …}

Population Cancer Risks Associated With Coal Mining: A Systematic Review, Wiley D. Jenkins, W. Jay Christian, Georgia Mueller, K. Thomas Robbins

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: Coal is produced across 25 states and provides 42% of US energy. With production expected to increase 7.6% by 2035, proximate populations remain at risk of exposure to carcinogenic coal products such as silica dust and organic compounds. It is unclear if population exposure is associated with increased risk, or even which cancers have been studied in this regard.

METHODS: We performed a systematic review of English-language manuscripts published since 1980 to determine if coal mining exposure was associated with increased cancer risk (incidence and mortality).

RESULTS: Of 34 studies identified, 27 studied coal mining as an occupational exposure …

Effect Of Variable Dose Rate On Biologically Effective Dose, Vadim Y. Kuperman, Gregory S. Spradlin

Publications

Purpose: to investigate the effect of variable dose rate on biologically effective dose ( BED ).

Materials and methods: by using the linear-quadratic (LQ) model with bi-exponential repair, we analytically determine the time-dependent dose rate R ~ which minimizes the effective protraction factor ( eff G ) and BEDunder the condition of fixed fraction time and dose per fraction.  Because normal tissue complication probability ( NTCP) monotonically decreases with decreasingBED , the dose rate R ~ also minimizes NTCP.

Results: the dependences of Geff, BED, and NTCP on fraction time were determined for different radiobiological parameters and two different …

Analysis Of Compressive Sensing For Hyperspectral Remote Sensing Applications, Maria Busuioceanu

Theses

Compressive Sensing (CS) systems capture data with fewer measurements than traditional sensors assuming that imagery is redundant and compressible in the spectral and spatial dimensions. This thesis utilizes a model of the Coded Aperture Snapshot Spectral Imager-Dual Disperser (CASSI-DD) to simulate CS measurements from traditionally sensed HyMap images. A novel reconstruction algorithm that combines spectral smoothing and spatial total variation (TV) is used to create high resolution hyperspectral imagery from the simulated CS measurements. This research examines the effect of the number of measurements, which corresponds to the percentage of physical data sampled, on the quality of simulated CS data …

Use Of Support Vector Machines And Fabry-Perot Interferometry To Classify States Of A Laser, John Motley Mckinnon

Master's Theses and Doctoral Dissertations

This thesis develops an algorithm that can determine if a laser is functioning correctly over a long period of time. A Fourier fit is created to model fringe profiles from a Fabry-Perot interferometer, and singular value decomposition is used to reduce noise in each signal. Levenberg-Marquardt gradient descent is performed to correctly locate the center of each image and to optimize each fit with respect to the spatial frequency. The Fourier fit is used to extract important information from each image to be used for separating the image types from one another. Principal component analysis is used to reduce the …

Quantity And Composition Of Stream Dissolved Organic Matter In The Watershed Of Conesus Lake, New York, Morgan R. Bida

Theses

The watershed of Conesus Lake, New York is drained by more than 18 unique streams and several smaller tributaries and has multiple land uses, varying from highly agricultural to primarily wooded, making the lake an ideal study site for analysis of the effects of land use on various water quality parameters. Previous water quality and watershed-health studies at Conesus Lake have focused on the delivery of inorganic nutrients to the lake. We know much less, however, about the effects of watershed land use on the quantity and composition of dissolved organic matter (DOM) exported to the lake. We sought to …

Interview With Jane West - Oh 274, Martha Jane Cato West

Winthrop University Oral History Program

In her July 15, 2013 interview with Martha Manning, Jane Cato West (Class of 1968) details her time at Winthrop as a Biology major in the 1960s. Briefly, West discusses student life and Winthrop traditions, but she provides insight into her life student teaching at Florence High School. Additionally, West includes her experience in required courses like English and Math, as well as experiments conducted in her Biology courses. West concludes the interview with her overall perceptions of Winthrop.