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Annotated Legal Bibliography On Gender

Cardozo Journal of Equal Rights & Social Justice

No abstract provided.

Unlikely Partners: Tort Law As A Tool For Trans Activism, Courtney Sirwatka

Cardozo Journal of Equal Rights & Social Justice

The note argues that tort law reform and trans activism can mutually benefit each other by addressing systemic discrimination and advancing equality for trans individuals. It critiques the legal system for perpetuating discrimination through its emphasis on physical injury over emotional or sexual harm and its refusal to validate trans identities. The analysis proposes that recognizing sexual autonomy and reproduction as protected interests in tort law, along with legal education reforms, could legitimize trans narratives and lead to meaningful change.

Annotated Legal Bibliography On Gender

Cardozo Journal of Equal Rights & Social Justice

No abstract provided.

Ethical Implications Of Intellectual Property In Africa, Dick Kawooya

Faculty Publications

No abstract provided.

Melungeon Portraits: Lived Experience And Identity, Tamara L. Stachowicz

Antioch University Dissertations & Theses

The desire to claim an ethnicity may be in response to an institutional and systemic political movement towards multiculturalism where ethnic difference is something to be recognized and celebrated (Jimenez, 2010; Tatum, 1997). Those who were a member of a dominant or advantaged group took that element of their identity for granted (Tatum, 1997). Identity work has included reflections and congruence between how individuals see themselves and how they perceive others to see them, including Optimal Distinctiveness Theory where one determines the optimal amount of individual distinctiveness needed to feel a healthy group and personal identity (Brewer, 2012). When most …

Histology And Ultrastructure Of Transitional Changes In Skin Morphology In The Juvenile And Adult Four-Striped Mouse (Rhabdomys Pumilio), Eranée Stewart, Moyosore Salihu Ajao, Amadi O. Ihunwo

Brain and Mind Institute

The four-striped mouse has a grey to brown coloured coat with four characteristic dark stripes interspersed with three lighter stripes running along its back. The histological differences in the skin of the juvenile and adult mouse were investigated by Haematoxylin and Eosin and Masson Trichrome staining, while melanocytes in the skin were studied through melanin-specific Ferro-ferricyanide staining. The ultrastructure of the juvenile skin, hair follicles, and melanocytes was also explored. In both the juvenile and adult four-striped mouse, pigment-containing cells were observed in the dermis and were homogeneously dispersed throughout this layer. Apart from these cells, the histology of the …

Slavery, Free Blacks And Citizenship, Henry L. Chambers, Jr.

Law Faculty Publications

Reconstruction Amendments says about the nature of American citizenship. The essay is organized as follows. Part I of the essay explores citizenship and membership by discussing belonging-based citizenship and rights-based citizenship. Part II describes how American and African American citizenship were constructed prior to the passage of the Reconstruction Amendments. Part III notes a few cases to explain how the Reconstruction Amendment's jurisprudence has developed in the wake of Dred Scott v. Sandford' and possibly led to a tilt toward a rights-based citizenship rather than a somewhat more robust belonging-based citizenship.

Catalog 2013-2014, University Of North Florida

UNF Course Catalogs

No abstract provided.

Horseshoe Crab Eggs: A Rare Resource For Predators In Long Island Sound, Mark Beekey, Jennifer Mattei, Barbara J. Pierce

Biology Faculty Publications

In Delaware Bay, the spawning of several million horseshoe crabs (Limulus polyphemus) coincides with the arrival of migratory shorebirds that feed on their eggs. High horseshoe crab spawning densities and resulting high egg densities drive egg availability and predation rates. At high spawning densities, female horseshoe crabs perturb previously deposited clutches causing eggs to rise to the sediment surface (surface egg densities average 100,000 eggs m^{− 2}). At the surface (0–5 cm), the eggs are quickly depleted by shorebirds and other predators. This interaction between egg density and egg predation has not been explicitly explored on …

A Historical Geography Of Sand Island 1870–1944, Lucas P. Johnson

Department of Geography: Dissertations, Theses, and Student Research

This thesis examines the settlement of Sand Island, one of two permanent colonies included within Lake Superior’s Apostle Islands archipelago. Following the introduction and literature review, a summary of Sand Island’s geology, climate and biological features is presented, serving to construct a baseline upon which to build a discussion of the island’s communal life. This foundation gives context to the seventy-four year struggle faced by the predominantly Norwegian immigrants adapting to that environment. It also serves to assist future scholars in studying wilderness recovery after what today is nearly an eighty year absence of the farmer’s plow. Chapter Four includes …

The Incidence And Aetiology Of Hospitalised Community-Acquired Pneumonia Among Vietnamese Adults: A Prospective Surveillance In Central Vietnam, Kensuke Takahashi, Motoi Suzuki, Le Minh, Nguyen Anh, Luu Thi Huong, Tran Vo Son, Phan Long, Nguyen Thi Ai, Le Tho, Konosuke Morimoto, Paul E. Kilgore, Dang Anh, Koya Ariyoshi, Lay Yoshida

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Lower respiratory tract infection (LRTI) including Community-acquired pneumonia (CAP) is a common infectious disease that is associated with significant morbidity and mortality. The patterns of aetiological pathogens differ by region and country. Special attention must be paid to CAP in Southeast Asia (SEA), a region facing rapid demographic transition. Estimates burden and aetiological patterns of CAP are essential for the clinical and public health management. The purposes of the study are to determine the incidence, aetiological pathogens, clinical pictures and risk factors of community-acquired pneumonia (CAP) in the Vietnamese adult population.

Methods

A prospective surveillance for hospitalised adult …

Formulation Devlopment Of Mesoporous Silica Nanoparticles As An Injectable Delivery System, Amit S. Wani

Wayne State University Dissertations

Our long term goal is to develop a versatile and robust injectable carrier based on Mesoporous Silica Nanoparticles (MSN) for drug/drug combination therapies. The objective of my dissertation was to optimize surface functionality, particle shape and methods of colloidal stabilization of mesoporous silica by PEG for delivery of drug/drug combinations. This was achieved by pursuing the following three aims:

1. Optimize surface functionality of MSN for high drug loading and controlled release

2. Investigate the effect of particle shape and PEGylation on drug delivery in hypoxic tumor cells

3. Develop MSN capable of delivering drug/drug combinations

To investigate the effect …

Intronic Non-Cg Dna Hydroxymethylation And Alternative Mrna Splicing In Honey Bees, Pablo Cingolani, Xiaoyi Cao, Radhika S. Khetani, Chieh-Chun Chen, Melissa Coon, Alya'a Sammak, Aliccia Bollig-Fischer, Susan Land, Yun Huang, Matthew E. Hudson, Mark D. Garfinkel, Sheng Zhong, Gene E. Robinson, Douglas M. Ruden

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Previous whole-genome shotgun bisulfite sequencing experiments showed that DNA cytosine methylation in the honey bee (Apis mellifera) is almost exclusively at CG dinucleotides in exons. However, the most commonly used method, bisulfite sequencing, cannot distinguish 5-methylcytosine from 5-hydroxymethylcytosine, an oxidized form of 5-methylcytosine that is catalyzed by the TET family of dioxygenases. Furthermore, some analysis software programs under-represent non-CG DNA methylation and hydryoxymethylation for a variety of reasons. Therefore, we used an unbiased analysis of bisulfite sequencing data combined with molecular and bioinformatics approaches to distinguish 5-methylcytosine from 5-hydroxymethylcytosine. By doing this, we have performed the first whole …

Quantitative Measures Of Estrogen Receptor Expression In Relation To Breast Cancer-Specific Mortality Risk Among White Women And Black Women, Huiyan Ma, Yani Lu, Polly A. Marchbanks, Suzanne G. Folger, Brian L. Strom, Jill A. Mcdonald, Michael S. Simon, Linda K. Weiss, Kathleen E. Malone, Ronald T. Burkman, Jane Sullivan-Halley, Dennis M. Deapen, Michael F. Press, Leslie Bernstein

Wayne State University Associated BioMed Central Scholarship

Abstract

Introduction

The association of breast cancer patients’ mortality with estrogen receptor (ER) status (ER + versus ER-) has been well studied. However, little attention has been paid to the relationship between the quantitative measures of ER expression and mortality.

Methods

We evaluated the association between semi-quantitative, immunohistochemical staining of ER in formalin-fixed paraffin-embedded breast carcinomas and breast cancer-specific mortality risk in an observational cohort of invasive breast cancer in 681 white women and 523 black women ages 35-64 years at first diagnosis of invasive breast cancer, who were followed for a median of 10 years. The quantitative measures of …

Residential Proximity To Industrial Combustion Facilities And Risk Of Non-Hodgkin Lymphoma: A Case–Control Study, Anjoeka Pronk, John R. Nuckols, Anneclaire J. De Roos, Matthew Airola, Joanne S. Colt, James R. Cerhan, Lindsay Morton, Wendy Cozen, Richard Severson, Aaron Blair, David Cleverly, Mary H. Ward

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Residence near municipal solid waste incinerators, a major historical source of dioxin emissions, has been associated with increased risk of non-Hodgkin lymphoma (NHL) in European studies. The aim of our study was to evaluate residence near industrial combustion facilities and estimates of dioxin emissions in relation to NHL risk in the United States.

Methods

We conducted a population-based case–control study of NHL (1998–2000) in four National Cancer Institute-Surveillance Epidemiology and End Results centers (Detroit, Iowa, Los Angeles, Seattle). Residential histories 15 years before diagnosis (similar date for controls) were linked to an Environmental Protection Agency database of dioxin-emitting …

The Bca2 And Ampk Paradigm: Unraveling The Cancer Connection, Daniela (Buac) Ventro

Wayne State University Dissertations

THE BCA2 & AMPK PARADIGM: UNRAVELING THE CANCER CONNECTION

By

DANIELA (BUAC) VENTRO

December 2013

Advisor: Dr. Q Ping Dou and Angelika M. Burger (deceased)

Major: Cancer Biology

Degree: Doctor of Philosophy

Adenosine monophosphate-activated kinase (AMPK), a master regulator of cellular energy homeostasis, has emerged as a promising molecular target in the prevention of breast cancer, and phase II and III clinical trials using the FDA-approved, AMPK activating, anti-diabetic drug metformin are promising in this regard, but the question of why metformin is protective for some women but not others still remains. Breast Cancer Associated Gene 2 (BCA2/Rabring7/RNF115), a novel …

Biochemical, Structural, And Drug Design Studies Of Multi-Drug Resistant Hiv-1 Therapeutic Targets, Tamaria Grace Dewdney

Wayne State University Dissertations

Protein point mutations acquired as a mechanism of survival against therapeutics cause structural changes that effect protein function and inhibitor binding. This work investigates the structural mechanisms that lead to multi-drug resistance to HIV-1 protease and integrase inhibitors.

Proper proteolytic processing of the HIV-1 Gag/Pol polyprotein is required for HIV infection and viral replication. This feature has made HIV-1 protease an attractive target for antiretroviral drug design for the treatment of HIV-1 infected patients, thus the development of drug resistance has arisen as a major therapeutic and drug design challenge. To understand the molecular mechanisms leading to drug resistance we …

Further Reflections On Extinguishing The Fountainhead Of Knowledge: A Call To Transition To The "Innovation Policy" Narrative In Patent Law, Simone Rose

SMU Law Review

Economists are unable to provide a clear answer to how effective the patent system is in encouraging innovation. At best, they point to certain sectors, such as pharmaceutical and biotechnology, which benefit from a robust patent scheme. Conversely, sectors such as software and, ironically at the same time, biotechnology may be harmed by an overly broad patent scheme. The question emerges: Why do the various stakeholders in all industrial sectors, Congress, the Patent and Trademark Office ("PTO"), and the courts (in particular, the Federal Circuit) continue to center the development of patent law around the "innovation presumption" despite the lack …

Four Questions About Fracking, Thomas W. Merrill

Case Western Reserve Law Review

No abstract provided.

Diets Of Two Species Of Horned Lizards (Phrynosoma Modestum And P. Solare) From Mexico, J. A. Lemos-Espinal, Christopher J. Dibble, Geoffrey R. Smith

Faculty Publications

No abstract provided.

Uintah Basin Revisited - 2012-2013 Bioregional Planning Studio Project, Richard E. Toth, Matthew Coombs, C Michael Gottfredson, Tyler Allen

Environment and Society Faculty Publications

Since the Uintah Basin Research Conference in 2007, residents of the area have witnessed a consistent level of land-use development throughout the region. Portions of that growth and development have precipitated the need to develop a landscape-level plan in order to maintain the context of their region and community identity in the coming years. The purpose of this study is to research and develop a process that identifies current and future land-use issues throughout the Uintah Basin. The identification of these issues by various stakeholders will help to provide a framework for future policy decisions.

Contributions Of Ocular Surface Components To Matrix-Metalloproteinases (Mmp)-2 And Mmp-9 In Feline Tears Following Corneal Epithelial Wounding, A Petznick, M Madigan, Q Garrett, D Sweeney, M Evans

Medical Papers and Journal Articles

Purpose: This study investigated ocular surface components that contribute to matrix-metalloproteinase (MMP)-2 and MMP-9 found in tears following corneal epithelial wounding.

Methods: Laboratory short-haired cats underwent corneal epithelial debridement in one randomly chosen eye (n = 18). Eyeflush tears were collected at baseline and during various healing stages. Procedural control eyes (identical experimental protocol as wounded eyes except for wounding, n = 5) served as controls for tear analysis. MMP activity was analyzed in tears using gelatin zymography. MMP staining patterns were evaluated in ocular tissues using immunohistochemistry and used to determine MMP expression sites responsible for tear-derived MMPs.

Results: …

Efficacy Of Osmoprotectants On Prevention And Treatment Of Murine Dry Eye, W Chen, X Zhang, J Li, Y Wang, Q Chen, C Hou, Q Garrett

Medical Papers and Journal Articles

Purpose: To evaluate the efficacy of osmoprotectants on prevention and treatment of dry eye in a murine model.

Methods: Dry eye was induced in mice by using an intelligently controlled environmental system (ICES). Osmoprotectants betaine, L-carnitine, erythritol, or vehicle (PBS) were topically administered to eyes four times daily following two schedules: schedule 1 (modeling prevention): dosing started at the beginning of housing in ICES and lasted for 21 or 35 days; schedule 2 (modeling treatment): dosing started after ICES-housed mice developed dry eye (day 21), continuing until day 35. Treatment efficacy was evaluated for corneal fluorescein staining; corneal epithelial apoptosis …

Decrease In Hyperosmotic Stress-Induced Corneal Epithelial Cell Apoptosis By L-Carnitine, N Khandekar, M Willcox, S Shih, P Simmons, J Vehige, Q Garrett

Medical Papers and Journal Articles

Purpose: To characterize the osmoprotective properties of L-carnitine on human corneal epithelial cell volume and apoptosis during hyperosmotic stress.

Methods: Human corneal limbal epithelial (HCLE) cells were exposed to culture medium at 300 mOsm (isotonic) or 500 mOsm (hyperosmotic) with or without L-carnitine (10 mM). Induction of apoptosis was detected by quantifying the proteolytic activity of caspase-8, caspase-9, and caspase-3/7 using caspase activity assays, the expression of tumor necrosis factor (TNF)-α with enzyme-linked immunosorbent assay, and annexin V/propidium iodide staining of HCLE cells evaluated with confocal microscopy and flow cytometry. Cell volume changes in response to hyperosmotic stress were analyzed …

Assessment Of Potential Anti-Cancer Stem Cell Activity Of Marine Algal Compounds Using An In Vitro Mammosphere Assay, J De La Mare, J Sterrenberg, M Sukhthankar, M Chiwakata, D Beukes, G Blatch, A Edkins

Medical Papers and Journal Articles

Background: The cancer stem cell (CSC) theory proposes that tumours arise from and are sustained by a subpopulation of cells with both cancer and stem cell properties. One of the key hallmarks of CSCs is the ability to grow anchorage-independently under serum-free culture conditions resulting in the formation of tumourspheres. It has further been reported that these cells are resistant to traditional chemotherapeutic agents.

Methods: In this study, the tumoursphere assay was validated in MCF-7 cells and used to screen novel marine algal compounds for potential anti-cancer stem cell (CSC) activity in vitro.

Results: MCF-7 breast cancer cells were observed …

Embodied Conflict Resolution: Resurrecting Roleplay-Based Curricula Through Dance, Nadja Alexander, Michelle Lebaron

Research Collection Yong Pung How School Of Law

Moving on from the authors’ seminal 2009 critique of the overuse of role-plays in negotiation teaching, "Death of the Role-Play" (chapter 13 in Rethinking Negotiation Teaching), Alexander and LeBaron have taken the rapidly increasing enthusiasm for experiential learning in a new direction: multiple intelligences. Their particular interest is in a use of experiential learning that focuses on kinesthetic intelligence, employing actual physical movement, particularly dance, to unlock creativity in other mental domains, as well as to encourage authentic participation by people whose skills are not primarily verbal or mathematical. Those who may be inclined to be skeptical should note that …

Maternal And Infant Infections Stimulate A Rapid Leukocyte Response In Breastmilk, F Hassiotou, A Hepworth, P Metzger, C Lai, N Trengove, P Hartmann, L Filgueira

Health Sciences Papers and Journal Articles

Breastmilk protects infants against infections; however, specific responses of breastmilk immune factors to different infections of either the mother or the infant are not well understood. Here, we examined the baseline range of breastmilk leukocytes and immunomodulatory biomolecules in healthy mother/infant dyads and how they are influenced by infections of the dyad. Consistent with a greater immunological need in the early postpartum period, colostrum contained considerable numbers of leukocytes (13–70% out of total cells) and high levels of immunoglobulins and lactoferrin. Within the first 1–2 weeks postpartum, leukocyte numbers decreased significantly to a low baseline level in mature breastmilk (0–2%) …

Development Of A Gravid Trap For Collecting Live Malaria Vectors Anopheles Gambiae S.L, Sisay Dugassa, Jenny M. Lindh, Florence Oyieke, Wolfgang R. Mukabana, Steven W. Lindsay, Ulrike Fillinger

All Peer-Reviewed Publications

BACKGROUND: Effective malaria vector control targeting indoor host-seeking mosquitoes has resulted in fewer vectors entering houses in many areas of sub-Saharan Africa, with the proportion of vectors outdoors becoming more important in the transmission of this disease. This study aimed to develop a gravid trap for the outdoor collection of the malaria vector Anopheles gambiae s.l. based on evaluation and modification of commercially available gravid traps. METHODS: Experiments were implemented in an 80 m(2) semi-field system where 200 gravid Anopheles gambiae s.s. were released nightly. The efficacy of the Box, CDC and Frommer updraft gravid traps was compared. The Box …

Identification Of A Histidine Metal Ligand In The Arge-Encoded N-Acetyl-L-Ornithine Deacetylase From Escherichia Coli, Wade C. Mcgregor, Danuta Gillner, Sabina I. Swierczek, Dali Liu, Richard C. Holz

Chemistry Faculty Research and Publications

The H355A, H355K, H80A, and H80K mutant enzymes of the argE-encoded N-acetyl-L-ornithine deacetylase (ArgE) from Escherichia coli were prepared, however, only the H355A enzyme was found to be soluble. Kinetic analysis of the Co(II)-loaded H355A exhibited activity levels that were 380-fold less than Co(II)-loaded WT ArgE. Electronic absorption spectra of Co(II)-loaded H355A-ArgE indicate that the bound Co(II) ion resides in a distorted, five-coordinate environment and Isothermal Titration Calorimetry (ITC) data for Zn(II) binding to the H355A enzyme provided a dissociation constant (K_d) of 39 μM. A three-dimensional homology model of ArgE was generated using the …

Molecular Docking And Nmr Binding Studies To Identify Novel Inhibitors Of Human Phosphomevalonate Kinase, Pornthip Boonsri, Terrence S. Neumann, Andrew Lawrence Olson, Sheng Cai, Timothy J. Herdendorf, Henry M. Miziorko, Supa Hannongbua, Daniel S. Sem

Chemistry Faculty Research and Publications

Phosphomevalonate kinase (PMK) phosphorylates mevalonate-5-phosphate (M5P) in the mevalonate pathway, which is the sole source of isoprenoids and steroids in humans. We have identified new PMK inhibitors with virtual screening, using autodock. Promising hits were verified and their affinity measured using NMR-based ¹H–¹⁵N heteronuclear single quantum coherence (HSQC) chemical shift perturbation and fluorescence titrations. Chemical shift changes were monitored, plotted, and fitted to obtain dissociation constants (K_d). Tight binding compounds with K_d’s ranging from 6–60 μM were identified. These compounds tended to have significant polarity and negative charge, similar to the natural …