Digital Commons Network^™

Sotomayor's Empathy Moves The Court A Step Closer To Equitable Adjudication, Veronica Couzo

Notre Dame Law Review

On August 6, 2009, then-Judge, now-Justice, Sonia Sotomayor was confirmed as the nation’s first Latina Supreme Court Justice. While many Latinos embraced the idea of having “Sonia from the Bronx” on the bench, others were fearful that her jurisprudence, combined with her background, would result in “reverse racism.” These fears, while arguably unfounded at the time, have been completely dispelled. Just as Justice Thurgood Marshall transformed the adjudications of the Supreme Court through experiential discourse, so too, to a lesser extent, has Justice Sotomayor. In both oral arguments and written opinions, Justice Sonia Sotomayor has demonstrated educative leadership—enlightening her colleagues …

The Evolutionary History Of Cetacean Brain And Body Size, Stephen H. Montgomery, Jonathan H. Geisler, Michael R. Mcgowen, Charlotte Fox, Lori Marino, John Gatesy

Veterinary Science and Medicine Collection

Cetaceans rival primates in brain size relative to body size and include species with the largest brains and biggest bodies to have ever evolved. Cetaceans are remarkably diverse, varying in both phenotypes by several orders of magnitude, with notable differences between the two extant suborders, Mysticeti and Odontoceti.We analyzed the evolutionary history of brain and body mass, and relative brain size measured by the encephalization quotient (EQ), using a data set of extinct and extant taxa to capture temporal variation in the mode and direction of evolution. Our results suggest that cetacean brain and body mass evolved under strong directional …

The Need To Include Animal Protection In Public Health Policies, Aysha Akhtar

Animal Welfare Collection

Many critical public health issues require non-traditional approaches. Although many novel strategies are used, one approach not widely applied involves improving the treatment of animals. Emerging infectious diseases are pressing public health challenges that could benefit from improving the treatment of animals. Other human health issues, that overlap with animal treatment issues, and that warrant further exploration, are medical research and domestic violence. The diverse nature of these health issues and their connection with animal treatment suggest that there may be other similar intersections. Public health would benefit by including the treatment of animals as a topic of study and …

An Analysis Of The Use Of Dogs In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls

Laboratory Experiments Collection

Dogs remain the main non-rodent species in preclinical drug development. Despite the current dearth of new drug approvals and meagre pipelines, this continues, with little supportive evidence of its value or necessity. To estimate the evidential weight provided by canine data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive dataset of 2,366 drugs with both animal and human data, including tissue-level effects and Medical Dictionary for Regulatory Activities (MedDRA) Level 1–4 biomedical observations. The resulting LRs show that the absence of toxicity in dogs provides virtually no …

Your Pet

Serial - All Animals 2009-15

Inside the Rat Pack

Forget everything you thought you knew about rats: They’re clean, they’re smart, and they want to be your best friend.

Incorporating New Technologies Into Toxicity Testing And Risk Assessment: Moving From 21st Century Vision To A Data-Driven Framework, Russell S. Thomas, Martin A. Philbert, Scott Auerbach, Barbara A. Wetmore, Michael J. Devito, Ila Cote, J. Craig Rowlands, Maurice Whelan, Sean M. Hays, Melvin E. Andersen, M.E. (Bette) Meek, Lawrence W. Reiter, Jason C. Lambert, Harvey J. Clewell Iii, Martin L. Stephens, Q. Jay Zhao, Scott C. Wesselkamper, Lynn Flowers, Edward W. Carney, Tim P. Pastoor, Dan D. Petersen, Carole L. Yauk, Andy Nong

in Vitro Research Models Collection

Based on existing data and previous work, a series of studies is proposed as a basis toward a pragmatic early step in transforming toxicity testing. These studies were assembled into a data-driven framework that invokes successive tiers of testing with margin of exposure (MOE) as the primary metric. The first tier of the framework integrates data from high-throughput in vitro assays, in vitro-to-in vivo extrapolation (IVIVE) pharmacokinetic modeling, and exposure modeling. The in vitro assays are used to separate chemicals based on their relative selectivity in interacting with biological targets and identify the concentration at which these interactions …

Discrimination Of Familiar Human Faces In Dogs (Canis Familiaris), Ludwig Huber, Anaïs Racca, Billy Scaf, Zsófia Virányi, Friederike Range

Recognition Collection

Faces are an important visual category for many taxa, and the human face is no exception to this. Because faces differ in subtle ways and possess many idiosyncratic features, they provide a rich source of perceptual cues. A fair amount of those cues are learned through social interactions and are used for future identification of individual humans. These effects of individual experience can be studied particularly well in hetero-specific face perception. Domestic dogs represent a perfect model in this respect, due to their proved ability to extract important information from the human face in socio-communicative interactions. There is also …

The Impact Of Reducing Nitrogen Fertilizer In Iceberg Head Lettuce, Jason Acquistapace

Agricultural Education and Communication

The impact of Nitrogen use in Iceberg lettuce was studied by measuring the weight and size of lettuce heads. A standard nitrogen application based on traditional commercial production was determined and portions of commercial fields (401 and 406) were designated for testing. Based on the standard, three fertilizer treatments (40%, 60%, and 80% of the control) were tested against the control in fields 401 and 406. The results indicated there was no difference in the weight of lettuce heads when treated with the relative fertilizer percentages. However, the size of lettuce heads decreased as the relative fertilizer percentages decreased. This …

Phylogeography Of The California Sheephead, Semicossyphus Pulcher: The Role Of Deep Reefs As Stepping Stones And Pathways To Antitropicality, Marloes Poortvliet, Gary C. Longo, Kimberly Selkoe, Paul H. Berber, Crow White, Jennifer E. Caselle, Alejandro Perez-Matus, Steven D. Gaines, Giacomo Bernardi

Biological Sciences

In the past decade, the study of dispersal of marine organisms has shifted from focusing predominantly on the larval stage to a recent interest in adult movement. Antitropical distributions provide a unique system to assess vagility and dispersal. In this study, we have focused on an antitropical wrasse genus, Semicossyphus, which includes the California sheephead, S. pulcher, and Darwin's sheephead, S. darwini. Using a phylogenetic approach based on mitochondrial and nuclear markers, and a population genetic approach based on mitochondrial control region sequences and 10 microsatellite loci, we compared the phylogenetic relationships of these two species, as well …

Uni Grad Student News, V9n2, November/December 2013, University Of Northern Iowa. Graduate College.

UNI Grad Student News

Inside this issue:

-- Message from the Dean
-- Seventh Annual UNI Graduate Student Symposium
-- Graduate Student Profile: Katherine Beane
-- Graduate Student Profile: Hayley Thomas
-- Graduate Alumni Profile: Nathan Green
-- Graduate Alumni Profile: Darius Robinson
-- Graduate Faculty Profile: Dr. Eric Hiris
-- Graduate Faculty Profile: Leisl Carr Childers
-- Tips to Prepare for the 2014 Spring Semester
-- Update Your Resume and CV
-- Communication Studies Student Attends and Presents at the 36th Annual Global Studies Conference
-- Elementary Education Graduate Presents at the 2013 Iowa Council for Social Studies Conference
-- Graduate Student Advisory …

Stem Literacy For Ells Through Service Learning, Sandra Rodriguez-Arroyo, Barbara Brimmerman, Olga Zeisler

Teacher Education Faculty Proceedings & Presentations

This presentation features: Rationale, Model of Academic Language Proficiency/ Jim Cummins’s Quadrant, STEM Literacy for ELLs, ELLS-OPS, Tall grasses and Wildflowers of Nebraska: A Service Learning Experience, UNO Students, Objectives, First Year: 2011-2012, Second Year: 2012-2013, Community Partner: Allwine Prairie, Support from Service Learning Academy, Research Presentations, Literacy Strategies, Service Learning Project Outcomes, Visit to the Prairie, and Future Research.

Student Success And Perceptions Of Course Satisfaction In Face-To-Face, Hybrid, And Online Sections Of Introductory Biology Classes At Three, Open Enrollment, Two-Year Colleges In Southern Missouri, Joyce Diane Hill

Dissertations

Introductory biology courses at two-year, open enrollment colleges in America are presented in a variety of different course delivery formats. Traditionally, most students have enrolled in seated or face-to-face (F2F) lectures and laboratories. There is increased demand for courses presented online or in a hybrid format, although some studies report higher attrition rates, and lower grades for these course delivery formats. The purpose of this study was to examine if there were academic differences among F2F, hybrid, or online introductory biology courses by analyzing pre-course and post-course assessment scores, final grades, attrition rates, and students’ perceptions of course satisfaction. This …

November 1, 2013, Ohio University Board Of Trustees Meeting Minutes, Ohio University Board Of Trustees

Board of Trustees Meeting Minutes

Meeting minutes document the activities of Ohio University's Board of Trustees.

Bioinformatics Journal Club Views Gattaca, Nov 12, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Bioinformatics: What Is A Support Vector Machine? Nov. 19, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Environmental And Plant Biology Dissertation Presentation, Nov 13, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Plant Bio Colloquium Long-Term Flowering And Fruiting Patterns In Dioecious Tropical Forest Trees, Nov 8, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Research Seminar: Stevens On Cenozoic Faunal Dynamics On Afro Arabia, Nov 18, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Psychological Impact Of Historical Trauma On The Native American People, Tammy R. Barker

Regis University Student Publications (comprehensive collection)

Native American historical trauma is similar to other massive generational group traumas. Past examples include the Jewish holocaust, slavery of the African people in the United States, and treatment of the Japanese Americans in the U.S. during World War II. Understanding the history of Native Americans allows for the design of culturally specific preventative and therapeutic interventions. Contrary to what is taught in modern history books, Native Americans were an advanced culture deeply immersed in their environments. From the invasion by the Spanish in the 1400s to the scorched earth extermination policies of the United States in the 1800s, Native …

Key Findings Of The 2013 West Coast Demersal Scalefish Resource Stock Assessment, Department Of Fisheries Western Australia

Fisheries Management Papers

Now, six years since the first stock assessment, and with the completion of a comprehensive boat-based survey of recreational fishing, ongoing annual monitoring of commercial and charter catches and a third stock assessment completed in 2013, the effectiveness of current management measures is able to be assessed.

This paper also provides an overview of the determination in regard to the sectoral allocations of the demersal scalefish resource in the WCB.

Keeping Tabs On Financial Innovation: Product Identifiers In Consumer Financial Regulation, Daniel Carpenter, Patricia A. Mccoy

North Carolina Banking Institute

No abstract provided.

Molecular Detection Of Culture-Confirmed Bacterial Bloodstream Infections With Limited Enrichment Time, Miranda S. Moore, Chase D. Mccann, Jeanne Jordan

Epidemiology Faculty Publications

Conventional blood culturing using automated instrumentation with phenotypic identification requires a significant amount of time to generate results. This study investigated the speed and accuracy of results generated using PCR and pyrosequencing compared to the time required to obtain Gram stain results and final culture identification for cases of culture-confirmed bloodstream infections. Research and physician-ordered blood cultures were drawn concurrently. Aliquots of the incubating research blood culture fluid were removed hourly between 5 and 8 h, at 24 h, and again at 5 days. DNA was extracted from these 6 time point aliquots and analyzed by PCR and pyrosequencing for …

Global Carbon-And-Conservation Models, Global Eco-States? Ecuador’S Yasuní-Itt Initiative And Governance Implications, Conny Davidsen Ph.D., Laura Kiff

Journal of International and Global Studies

The “global carbon age” marks a structural change far beyond the economic realms of implementing carbon trade, affecting the fabric of global environmental governance and its actors. Carbon trade and conservation in the Global South have taken on various forms, and climate change mitigation efforts in light of continued rainforest deforestation are scrambling to establish effective approaches. Ecuador’s Yasuní-ITT Initiative proposes a new global carbon-and-conservation model in the Ecuadorian Amazon that leaves oil reserves of the Yasuní Ishpingo Tambococha Tiputini (ITT) oil fields underground, in exchange for international compensation payments that would be based on voluntary contributions of governments and …

Filtering Of Ms/Ms Data For Peptide Identification, Jason Gallia, Katelyn Lavrich, Anna Tan-Wilson, Patrick H. Madden

Biological Sciences Faculty Scholarship

Background: The identification of proteins based on analysis of tandem mass spectrometry (MS/MS) data is a valuable tool that is not fully realized because of the difficulty in carrying out automated analysis of large numbers of spectra. MS/MS spectra consist of peaks that represent each peptide fragment, usually b and y ions, with experimentally determined mass to charge ratios. Whether the strategy employed is database matching or De Novo sequencing, a major obstacle is distinguishing signal from noise. Improved ability to distinguish signal peaks of low intensity from background noise increases the likelihood of correctly identifying the peptide, as valuable …

College Of Arts And Sciences E-News Issue 7: November 2013, College Of Arts And Sciences

College of Arts and Sciences news

No abstract provided.

No-Boundary Thinking In Bioinformatics Research, Xiuzhen Huang, Barry Bruce, Alison Buchan, Clare Bates Congdon, Carole L. Cramer, Steven F. Jennings, Hongmei Jiang, Zenglu Li, Gail Mcclure, Rick Mcmullen, Jason H. Moore, Bindu Nanduri, Joan Peckham, Andy Perkins, Shawn W. Polson, Bhanu Rekepalli, Saeed Salem, Jennifer Specker, Donald Wunsch, Donghai Xiong, Shuzhong Zhang, Zhongming Zhao

Computer Science and Statistics Faculty Publications

Currently there are definitions from many agencies and research societies defining “bioinformatics” as deriving knowledge from computational analysis of large volumes of biological and biomedical data. Should this be the bioinformatics research focus? We will discuss this issue in this review article. We would like to promote the idea of supporting human-infrastructure (HI) with no-boundary thinking (NT) in bioinformatics (HINT).

The Genome Of Polymorphonuclear Neutrophils Maintains Normal Coding Sequences, Fengxia Xiao, Yeong C. Kim, Hongxiu Wen, Jiangtao Luo, Pei Xian Chen, Kenneth Cowan, San Ming Wang

Journal Articles: Genetics, Cell Biology & Anatomy

Genetic studies often use genomic DNA from whole blood cells, of which the majority are the polymorphonuclear myeloid cells. Those cells undergo dramatic change of nuclear morphology following cellular differentiation. It remains elusive if the nuclear morphological change accompanies sequence alternations from the intact genome. If such event exists, it will cause a serious problem in using such type of genomic DNA for genetic study as the sequences will not represent the intact genome in the host individuals. Using exome sequencing, we compared the coding regions between neutrophil, which is the major type of polymorphonuclear cells, and CD4+ T cell, …

Regulation Of Stress-Inducible Phosphoprotein 1 Nuclear Retention By Protein Inhibitor Of Activated Stat Pias1, Iaci N. Soares, Fabiana A. Caetano, Jordan Pinder, Bruna Roz Rodrigues, Flavio H. Beraldo, Valeriy G. Ostapchenko, Chantal Durette, Grace Schenatto Pereira, Marilene H. Lopes, Nicolle Queiroz-Hazarbassanov, Isabela W. Cunha, Paulo I. Sanematsu, Sergio Suzuki, Luiz F. Bleggi-Torres, Caroline Schild-Poulter, Pierre Thibault, Graham Dellaire, Vilma R. Martins, Vania F. Prado, Marco A. M. Prado

Anatomy and Cell Biology Publications

Stress-inducible phosphoprotein 1 (STI1), a cochaperone for Hsp90, has been shown to regulate multiple pathways in astrocytes, but its contributions to cellular stress responses are not fully understood. We show that in response to irradiation-mediated DNA damage stress STI1 accumulates in the nucleus of astrocytes. Also, STI1 haploinsufficiency decreases astrocyte survival after irradiation. Using yeast two-hybrid screenings we identified several nuclear proteins as STI1 interactors. Overexpression of one of these interactors, PIAS1, seems to be specifically involved in STI1 nuclear retention and in directing STI1 and Hsp90 to specific sub-nuclear regions. PIAS1 and STI1 co-immunoprecipitate and PIAS1 can function as …

An Interface-Capturing Regularization Method For Solving The Equations For Two-Fluid Mixtures, Jian Du, Robert D. Guy, Aaron L. Fogelson, Grady B. Wright, James P. Keener

Mathematics Faculty Publications and Presentations

Many problems in biology involve gels which are mixtures composed of a polymer network permeated by a fluid solvent (water). The two-fluid model is a widely used approach to described gel mechanics, in which both network and solvent coexist at each point of space and their relative abundance is described by their volume fractions. Each phase is modeled as a continuum with its own velocity and constitutive law. In some biological applications, free boundaries separate regions of gel and regions of pure solvent, resulting in a degenerate network momentum equation where the network volume fraction vanishes. To overcome this difficulty, …

Zebrafish: Modeling For Herpes Simplex Virus Infections, Kevin Jones

Department of Biology Faculty Publications

Abstract For many years, zebrafish have been the prototypical model for studies in developmental biology. In recent years, zebrafish has emerged as a powerful model system to study infectious diseases, including viral infections. Experiments conducted with herpes simplex virus type-1 in adult zebrafish or in embryo models are encouraging as they establish proof of concept with viral-host tropism and possible screening of antiviral compounds. In addition, the presence of human homologs of viral entry receptors in zebrafish such as 3-O sulfated heparan sulfate, nectins, and tumor necrosis factor receptor superfamily member 14-like receptor bring strong rationale for virologists to test …