Digital Commons Network^™

Babies Without Borders: Human Rights, Human Dignity, And The Regulation Of International Commercial Surrogacy, Yasmine Ergas

Emory International Law Review

In recent decades, a robust international market in commercial reproductive surrogacy has emerged. But, as German citizens Jan Balaz and Susan Lohle discovered when they struggled to engineer the last-minute diplomatic compromise that saved their commissioned twins from becoming wards of the Indian state, conflicts among legal frameworks have placed the children born at risk of being "marooned stateless and parentless."

Identification Of A Histidine Metal Ligand In The Arge-Encoded N-Acetyl-L-Ornithine Deacetylase From Escherichia Coli, Wade C. Mcgregor, Danuta M. Gillner, Sabina I. Swierczek, Dali Liu, Richard C. Holz

Chemistry: Faculty Publications and Other Works

The H355A, H355K, H80A, and H80K mutant enzymes of the argE-encoded N-acetyl-L-ornithine deacetylase (ArgE) from Escherichia coli were prepared, however, only the H355A enzyme was found to be soluble. Kinetic analysis of the Co(II)-loaded H355A exhibited activity levels that were 380-fold less than Co(II)-loaded WT ArgE. Electronic absorption spectra of Co(II)-loaded H355A-ArgE indicate that the bound Co(II) ion resides in a distorted, five-coordinate environment and Isothermal Titration Calorimetry (ITC) data for Zn(II) binding to the H355A enzyme provided a dissociation constant (K_d) of 39 μM. A three-dimensional homology model of ArgE was generated using the …

Candida Albicans Induces Arginine Biosynthetic Genes In Response To Host-Derived Reactive Oxygen Species, Claudia Jimenez-Lopez, John R. Collette, Kimberly M. Brothers, Kelly M. Shepardson, Robert A. Kramer

Dartmouth Scholarship

The interaction of Candida albicans with phagocytes of the host's innate immune system is highly dynamic, and its outcome directly impacts the progression of infection. While the switch to hyphal growth within the macrophage is the most obvious physiological response, much of the genetic response reflects nutrient starvation: translational repression and induction of alternative carbon metabolism. Changes in amino acid metabolism are not seen, with the striking exception of arginine biosynthesis, which is upregulated in its entirety during coculture with macrophages. Using single-cell reporters, we showed here that arginine biosynthetic genes are induced specifically in phagocytosed cells. This induction is …

The Teacher As Servant-Leader, David W. Anderson

International Christian Community of Teacher Educators Journal

Any Christian philosophy of education must begin with acknowledging God to be the Creator of all that is, and as the source of all Truth. All knowledge is derived from, or in some way related to, the Creator God. Three elements that inform our understanding of education are:

• our having been created in the image of God;
• the creation mandate; and
• the principle of stewardship.

The fact that humans are created in the image of God (Ge 1:26-27) sets the stage for our educability. Essential to our understanding of that image are such attributes as language (communication), reasoning, imaginative and …

Doing Impacting Being: A Case Study Of Service Learning As A Method Of Faith And Learning Integration, Calvin G. Roso

International Christian Community of Teacher Educators Journal

C. S. Lewis argues that Christians become more like Christ by practicing to be something they are not: “Pretense leads up to the real thing . . . very often the only way to get a quality in reality is to start behaving as if you had it already” (Lewis, 1952, p. 160). Likewise, educators indicate that when students practice and apply their learning “true understanding is demonstrated” (Tomlinson & McTighe, 2006, p. 67). Even Jesus, the Master Teacher, modeled experiential integration in training His disciples (Matthew 10:1-15; Luke 9:1-6; Mark 6:7-13). Doing impacts being—what we do and experience shapes …

Design And Optimization Of A Thermal Capacitor, Karen Nielson, Jordan Tracy Cox

Undergraduate Honors Capstone Projects

Team Hot Stuff designed a thermal capacitor for Senior Design I at Utah State University. This thermal capacitor is intended for use in the food service industry as a low-cost alternative to chafers. Chafers are platters which use oil burners to keep food warm. The client for this thermal capacitor is Thermal Management Technologies (TMT), a company specializing in thermal science solutions whose mission is “to provide simple, practical thermal science solutions to a wide range of platforms including: Industry, Defense, and Space”¹. The founder and president of TMT, Dr. J. Clair Batty, serves as a mentor for …

System Analysis Of Spatial Frequency Domain Imaging For Quantitative Mapping Of Surgically Resected Breast Tissues, Ashley M. Laughney, Venkataramanan Krishnaswamy, Tyler B. Rice, David J. Cuccia

Dartmouth Scholarship

No abstract provided.

R.A. Fisher And The Foundations Of Statistical Biology, Michael Dietrich

Dartmouth Scholarship

Chapter eight, addressing the topic of statistical biology and statistical methods in genetics.

Aqueous Red-Emitting Silicon Nanoparticles For Cellular Imaging: Consequences Of Protecting Against Surface Passivation By Hydroxide And Water For Stable Red Emission, Sheng-Kuei Chiu, Beth Ann Manhat, William J.I. Debenedetti, Anna L. Brown, Katye Fichter, Tania Vu, Micah Eastman, Jun Jiao, Andrea Mitchell Goforth

Chemistry Faculty Publications and Presentations

Stable, aqueous, red-to-near infrared emission is critical for the use of silicon nanoparticles (Si NPs) in biological fluorescence assays, but such Si NPs have been difficult to attain. We report a synthesis and surface modification strategy that protects Si NPs and preserves red photoluminescence (PL) in water for more than 6 mo. The Si NPs were synthesized via high temperature reaction, liberated from an oxide matrix, and functionalized via hydrosilylation to yield hydrophobic particles. The hydrophobic Si NPs were phase transferred to water using the surfactant cetyltrimethylammonium bromide (CTAB) with retention of red PL. CTAB apparently serves a double role …

Robust Visible Light Photoswitching With Ortho-Thiol Substituted Azobenzenes, Subhas Samanta, Theresa M. Mccormick, Simone K. Schmidt, Dwight S. Seferos, G. Andrew Woolley

Chemistry Faculty Publications and Presentations

Introduction of S-ethyl groups in all four ortho positions of azobenzene prevents reduction of the azo group by intracellular glutathione, while enhancing the absorptivity to ∼10000 M⁻¹ cm⁻¹ in the blue and green regions of the visible spectrum. cis-to-trans isomerization occurs thermally on the minutes timescale. Further, this substitution pattern permits switching with red light, a color that is more penetrating through biological tissues than other parts of the visible spectrum.

Assessing Institutional Ability To Support Adaptive, Integrated Water Resources Management, Sandra B. Zellmer, Christina Hoffman

Faculty Law Review Articles

No abstract provided.

Physical Activity, Physical Fitness Or Physical Education: Are We Betting On The Wrong Horse?, Beth P. Hands

Health Sciences Papers and Journal Articles

If you read the daily newspaper, it is highly likely there will an article on the importance of physical activity. A recent survey I undertook showed that on some weeks up to 25 articles with physical activity as a key word were published in mainstream Australian papers. A key word search of peer reviewed journals in Academic Search Premier reveals a similar pattern-with up to 30,000 articles having the word physical activity in the abstract. This is a relatively recent phenomenon. The number of published articles about physical activity related studies has grown astronomically compared to two other important terms, …

The Contribution Of Visceral Fat To Positive Insulin Signaling In Ames Dwarf Mice, Vinal Menon

Electronic Theses and Dissertations

Ames dwarf (df/df) mice are homozygous for a spontaneous mutation in the prop1 gene due to which there is no development of anterior pituitary cells – somatotrophs, lactotrophs and thyrotrophs, leading to a deficiency of growth hormone (GH), prolactin (PRL) and thyrotropin (TSH). They tend to become obese as they age, but still live longer and healthier lives compared to their wild-type littermates, being very insulin sensitive, showing no signs of diabetes and cancer. These mutant mice also have high circulating levels of anti-inflammatory and antidiabetic adiponectin. Plasma levels of this adipokine usually decrease with an increase in accumulation of …

The Impact Of Voluntary Pre-Kindergarten On The Academic Achievement And Kindergarten Readiness Of Students In A Large Suburban School District, Jordan Rodriguez

Electronic Theses and Dissertations

Throughout the United States, state governments are allocating millions of dollars to support Voluntary Pre-Kindergarten (VPK) programs. Recent research has indicated that students that participate in VPK demonstrate higher academic achievement scores across a number of subject areas. Moreover, VPK participants are more likely to enter primary school on grade level, which in turn leads to a reduction in grade retention. Studies have indicated that although all students that participate in VPK programs benefit from such programs, minority students and students that come from low-socioeconomic backgrounds benefit at an even higher level. The intent of this study was to determine …

An Examination Of Inclusive Education In Schools Operated By The Jordan Field Of The United Nations Relief And Works Agency For Palestine Refugees In The Near East, Jacqueline Rodriguez

Electronic Theses and Dissertations

For refugee children with disabilities, international agencies largely provide humanitarian assistance, including education. However, the obstacles associated with refugee existence can impede progress in the movement towards educating children with disabilities in inclusive settings. Perceptions of inclusive education in schools operated by the Jordan field of the United Nations Relief and Works Agency for Palestine Refugees in the Near East were explored through multiple embedded case studies. Each of the three schools examined included a student with a special educational need. The researcher also investigated strategies and supports provided by education stakeholders to students with special educational needs in inclusive …

Fetal-Pelvic Disproportion And Pelvic Asymmetry As A Potential Cause For High Maternal Mortality In Archaeological Populations, Sarah Stansfield

Electronic Theses and Dissertations

Females of childbearing age are overrepresented in the population of the Kellis 2 cemetery (100-450 AD) in the Dakhleh Oasis, Egypt (Wheeler 2009). The demographic overrepresentation found here may be the result of complications related to childbirth. Clinical literature demonstrates that fetal size is rarely an explanation for failed labor (Cunningham et al. 2001) and the fetuses buried in the Kellis 2 Cemetery at the Dakhleh Oasis were not larger than average (Tocheri et al. 2005), directing the focus to dimensions of the maternal pelvis for evidence of obstetrical issues, such as abnormally compressed pelvises. To formulate a test for …

Wavelength Scale Resonant Structures For Integrated Photonic Applications, Matthew Weed

Electronic Theses and Dissertations

An approach to integrated frequency-comb filtering is presented, building from a background in photonic crystal cavity design and fabrication. Previous work in the development of quantum information processing devices through integrated photonic crystals consists of photonic band gap engineering and methods of on-chip photon transfer. This work leads directly to research into coupled-resonator optical waveguides which stands as a basis for the primary line of investigation. These coupled cavity systems offer the designer slow light propagation which increases photon lifetime, reduces size limitations toward on-chip integration, and offers enhanced light-matter interaction. A unique resonant structure explained by various numerical models …

Investigation Of A Novel Magnesium And Acidified Ethanol System For The Degradation Of Persistent Organic Pollutants, Phillip Maloney

Electronic Theses and Dissertations

For centuries chemists have sought to improve humankind’s quality of life and address many of society’s most pressing needs through the development of chemical processes and synthesis of new compounds, often with phenomenal results. Unfortunately, there also are many examples where these chemicals have had unintended, detrimental consequences that are not apparent until years or decades after their initial use. There are numerous halogenated molecules in this category that are globally dispersed, resistant to natural degradation processes, bioaccumulative, and toxic to living organisms. Chemicals such as these are classified as persistent organic pollutants (POPs), and due to their negative environmental …

Prediction Of Optical Properties Of Pi-Conjugated Organic Materials For Technological Innovations, Iffat Nayyar

Electronic Theses and Dissertations

Organic π-conjugated solids are promising candidates for new optoelectronic materials. The large body of evidence points at their advantageous properties such as high charge-carrier mobility, large nonlinear polarizability, mechanical flexibility, simple and low cost fabrication and superior luminescence. They can be used as nonlinear optical (NLO) materials with large two-photon absorption (2PA) and as electronic components capable of generating nonlinear neutral (excitonic) and charged (polaronic) excitations. In this work, we investigate the appropriate theoretical methods used for the (a) prediction of 2PA properties for rational design of organic materials with improved NLO properties, and (b) understanding of the essential electronic …

Cerium Oxide Nanoparticles Sensitize Pancreatic Cancer Cells To Radiation By Promoting Acidic Ph, Ros, And Jnk Dependent Apoptosis, Melissa Wason

Electronic Theses and Dissertations

Side effects of radiation therapy (RT) remain the most challenging issue for pancreatic cancer treatment. In this report we determined whether and how cerium oxide nanoparticles (CONPs) sensitize pancreatic cancer cells to RT. CONP pretreatment enhanced radiation-induced reactive oxygen species (ROS) production preferentially in acidic cell-free solutions as well as acidic human pancreatic cancer cells. In acidic environments, CONPs favor the scavenging of superoxide radical over the hydroxyl peroxide resulting in accumulation of the latter whereas in neutral pH CONPs scavenge both. CONP treatment prior to RT markedly potentiated the cancer cell apoptosis both in culture and in tumors and …

Hidden In Plain Sight: Development And Testing Of A Model To Evaluate Political Leadership Tactics, Albert Citron

Electronic Theses and Dissertations

This thesis analyzes the kinds of verbal and nonverbal signals elites manifest to show leadership qualities. Launching from Max Weber’s conceptual framework of charisma as a power term and Harold Lasswell’s study of propaganda, this study takes a multidisciplinary approach to studying political leadership with elements of communication methodology and an ontological basis in evolutionary psychology. The study’s goal is to offer a framework for defining and evaluating the diverse signal patterns employed by political elites in three real-life situations. These are the Malta Summit, the 1992 Virginia Presidential Debate, and the 2012 South Carolina Republican Presidential Primary. The cases …

Interpreting Diet And Nutritional Stress In Napoleon's Grand Army Using Stable Carbon And Nitrogen Isotope Analysis, Sammantha Holder

Electronic Theses and Dissertations

A mass grave containing the remains of at least 3269 Napoleonic soldiers from 1812 was discovered in Vilnius, Lithuania in 2001. Stable carbon and nitrogen isotopic analyses were performed on collagen from 78 femoral samples to explore dietary variation within the sample. Starvation and nutritional distress were also evaluated through the examination of nitrogen enrichment in bone collagen. Clinical studies have demonstrated that enriched nitrogen isotope values can indicate periods of nutritional stress and starvation; however, this is the first study to examine its use as a diagnostic indicator of starvation in a historical population using bone tissue. According to …

Inverse Intuition: Repurposing As A Method To Create New Artifacts, To Invent New Practices, And To Produce New Knowledge, Warren Jones

Electronic Theses and Dissertations

This dissertation argues that Digital Natives, rather than employing novel ways of thinking (such as those suggested by Walter Ong's concept of Second Orality), are in fact employing a way of thinking that has always existed: repurposing. Ruth Oldenziel discusses how, historically, women used "a kind of mental quality" enabling them to re-use objects in novel ways to accomplish more of life's tasks. My research led me to investigate how a wide variety of people, especially historically marginalized people, used this kind of mental quality. This dissertation explores repurposing's real world uses as well as its uses in narratives, specifically …

Wetland Diversity In A Disturbance-Maintained Landscape: Effects Of Fire And A Fire Surrogate On Aquatic Amphibian Survival And Species Depauperateness., Joyce Klaus

Electronic Theses and Dissertations

Disturbance is one of the central concepts explaining how diversity arises and is perpetuated in ecological time. A good model system for testing hypotheses related to disturbance is the longleaf pine ecosystem in the southeastern U.S. because in this ecosystem frequent, low-severity fires acts as a disturbance that maintains a unique vegetation structure and high species richness. Vegetation structure influences animal distributions; in fire-dependent ecosystems many animals rely on open-structured, fire-maintained vegetation but shrubs and trees encroach into fire-dependent ecosystems where fire has been excluded. Prescribed burning and mechanical removal are commonly used as restoration tools to control encroachment. To …

Gender Differences And Fast Food Preferences Among U.S. College Students, Donald Persaud

Electronic Theses and Dissertations

The intent of this research is to examine the relationship of corporate fast food and health within the context of gender. It tests the hypothesis that Western perceptions of masculinity and femininity inform a differentiated pattern of food preference, which will correlate with health as measured by Body Mass Index (BMI). The targeted sample population for the study is the undergraduate community of the University of Central Florida, and fast food is a chosen dietary medium because it is an increasingly ubiquitous source of caloric energy in the American foodscape, representative of the mass production model applied to cuisine in …

Road Networks, Social Disorganization And Lethality, An Exploration Of Theory And An Examination Of Covariates, Aaron Poole

Electronic Theses and Dissertations

Utilizing a Criminal Event Perspective, the analyses of this dissertation test a variety of relationships to the dependent variable: the Criminal Lethality Index. Data from the National Incident-Based Reporting System, the Census and American Community Survey, the American Trauma Society, and data derived from the Census’s mapping TIGER files are combined to create a database of 190 cities. This database is used to test road network connectivity (Gama Index), medical resources, criminal covariates and Social Disorganization variables in relation to a city’s Criminal Lethality Index. OLS regression demonstrates a significant and negative relationship between a city’s Gama Index and its …

Inverse Problems In Multiple Light Scattering, John Broky

Electronic Theses and Dissertations

The interaction between coherent waves and material systems with complex optical properties is a complicated, deterministic process. Light that scatters from such media gives rise to random fields with intricate properties. It is common perception that the randomness of these complex fields is undesired and therefore is to be removed, usually through a process of ensemble averaging. However, random fields emerging from light matter interaction contain information about the properties of the medium and a thorough analysis of the scattered light allows solving specific inverse problems. Traditional attempts to solve these kinds of inverse problems tend to rely on statistical …

Reduced Susceptibility Of Deformation Due To Vibrational And Gravitational Effects On A Focus Variable Adaptive Lens, Victoriya Relina

Electronic Theses and Dissertations

Orthodox optical devices, such as lenses, mirrors, and prisms, are composed of solidstate materials, which although well studied and implemented ubiquitously are severely limited in their adaptable properties. An arguably new field of adaptive optics has emerged to further expand photonic manipulation competences of optical components. Fluid-based adaptive optical components were introduced as early as 1968 [1]; such components have the ability to change the shape of their interface surface, thus allowing for a variable curvature profile. The method of manipulation varies greatly, as does the range of surface deformations. A solid-state optical component is affected by system vibration variation …

Biogeography And Systematics Of The Nerodia Clarkii/Nerodia Fasciata Clade In Florida, Gregory Territo

Electronic Theses and Dissertations

Biogeography provides a window into the evolutionary history of populations, and helps explain the diversity and distribution of life through time. Viewed from a systematic perspective, biogeographic studies generate convincing arguments to explain the relationships among organisms and categorize them into useful taxonomies. When taxonomies do not reflect evolutionary histories, inaccurate representations of biodiversity confound future studies and conservation efforts. Two thamnophiine snakes, Nerodia clarkii and Nerodia fasciata, harbor unique morphological and ecological adaptations that obscured natural groupings, leading to controversial taxonomic delimitations. Additionally, population declines documented in N. clarkii compressicauda and N. clarkii taeniata led managers to list N. …

An Event-Related Potential Investigation Of Error Monitoring In Adults With A History Of Psychosis, Chi Chan

Electronic Theses and Dissertations

Metacognition, which involves monitoring and controlling of one’s thoughts and actions, is essential for guiding behavior and organization of information. Deficits in self-monitoring have been suggested to lead to psychosis and poor functional outcome. Abnormalities in eventrelated potentials originating from the anterior cingulate cortex (ACC), a brain region associated with error detection, have been consistently reported in individuals with schizophrenia during error monitoring tasks. This study sought to examine whether these abnormalities are present in individuals with a history of psychosis across diagnostic categories and whether they are associated with subjective appraisal of self-performance and personality traits related to psychosis. …