Digital Commons Network^™

Identification Of A Pan-Cancer Oncogenic Microrna Superfamily Anchored By A Central Core Seed Motif, Mark P. Hamilton, Kimal Rajapakshe, Sean M. Hartig, Boris Reva, Michael D. Mclellan, Cyriac Kandoth, Li Ding, Travis I. Zack, Preethi H. Gunaratne, David A. Wheeler, Cristian Coarfa, Sean E. Mcguire

Open Access Publications

No abstract provided.

Rapid-Selex For Rna Aptamers, Kylan Szeto, David R. Latulippe, Abdullah Ozer, John M. Pagano, Brian S. White, David Shalloway, John T. Lis, Harold G. Craighead

Open Access Publications

No abstract provided.

Exploration Of Hinge Residues Among Gfp-Like Proteins, Binsen Li

Biology Honors Papers

Before the maturation of the chromophore, a fluorescent protein, just like any other three-dimensional protein structure, has to fold into the correct tertiary structure to function. We proposed that the evolutionarily conserved hinge residues, believed to be located on or near the lids of the fluorescent protein, are involved in the folding mechanism and rotation of the β-sheets and lids into the correct geometry. Acting like door hinges, these residues are translationally immobilized but rotationally active. Interference of the hinge sites may lead to allosteric effects and disruption of the protein’s functional motions. In the study, significant sequential and …

Arboretum Annual Report 2012-2013, Connecticut College

Annual Reports

No abstract provided.

2013-2014 Hccp Year-End Summary, Darby Ray

Year-end Summaries

No abstract provided.

The Future Of Hipaa In The Cloud, Frank Pasquale, Tara Adams Ragone

Faculty Scholarship

This white paper examines how cloud computing generates new privacy challenges for both healthcare providers and patients, and how American health privacy laws may be interpreted or amended to address these challenges. Given the current implementation of Meaningful Use rules for health information technology and the Omnibus HIPAA Rule in health care generally, the stage is now set for a distinctive law of “health information” to emerge. HIPAA has come of age of late, with more aggressive enforcement efforts targeting wayward healthcare providers and entities. Nevertheless, more needs to be done to assure that health privacy and all the values …

The Legacy Of Jane Larson: The Politics Of Practicality And Surprise, Martha M. Ertman

Faculty Scholarship

Jane Larson's work and life enriched my own and others. Her intellectual framework - applying legal economic ideas of consent to feminist theory, backed up by legal history - suggest surprising practical solutions to problems ranging from the injuries of adultery and prostitution to housing in border towns.

Transgender People, Intimate Partner Abuse, And The Legal System, Leigh S. Goodmark

Faculty Scholarship

The unique experiences of transgender persons subjected to abuse have not been the focus of legal scholarship; instead, the experiences of transgender people are often subsumed in the broader discourse around domestic violence in the lesbian, gay, bisexual, and transgender (LGBT) community. This dearth of legal scholarship is not surprising given how little research of any kind exists on how transgender people experience intimate partner abuse. This is the first law review article to concentrate specifically on intimate partner abuse and the transgender community. The Article begins by discussing the difficulties of engaging in scholarship around this topic, noting the …

Models Of Somatic Hypermutation Targeting And Substitution Based On Synonymous Mutations From High-Throughput Immunoglobulin Sequencing Data, G. Yaari, J. A. Vander Heiden, D. Gadala-Maria, N. Gupta, J. N. Stern, K. C. O'Connor, D. A. Hafler, U. Laserson, F. Vigneault, S. H. Kleinstein, +1 Additional Author

Journal Articles

Analyses of somatic hypermutation (SHM) patterns in B cell immunoglobulin (Ig) sequences contribute to our basic understanding of adaptive immunity, and have broad applications not only for understanding the immune response to pathogens, but also to determining the role of SHM in autoimmunity and B cell cancers. Although stochastic, SHM displays intrinsic biases that can confound statistical analysis, especially when combined with the particular codon usage and base composition in Ig sequences. Analysis of B cell clonal expansion, diversification, and selection processes thus critically depends on an accurate background model for SHM micro-sequence targeting (i.e., hot/cold-spots) and nucleotide substitution. Existing …

University Imprimaturs On Student Speech: The Certification Cases, Emily Gold Waldman

First Amendment Law Review

No abstract provided.

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Scholarworks Statistics - January 2013, Scholarworks

ScholarWorks Reports

For the month of January 2013, ScholarWorks recorded a total of 26,686 full-text downloads and 11,356 page views.

2013-2014 Boise State University Graduate Catalog, Boise State University Office Of The Registrar

University Catalogs

No abstract provided.

2013-2014 Boise State University Undergraduate Catalog, Boise State University Office Of The Registrar

University Catalogs

No abstract provided.

Insect Communities In Soybeans Of Eastern South Dakota: The Effects Of Vegetation Management And Pesticides On Soybean Aphids, Bean Leaf Beetles, And Their Natural Enemies, Jonathan G. Lundgren, Louis S. Hesler, Sharon A. Clay, Scott F. Fausti

Agronomy, Horticulture and Plant Science Faculty Publications

Although most pests of soybeans, Gycine max (L.), in the Northern Great Plains are managed using pesticides, farm management practices that encourage biodiversity offer promising long-term, sustainable solutions for controlling insect and weed pests profitably. The recent invasion of the Northern Great Plains by the soybean aphid (Aphis glycinesMatsumura; Hemiptera: Aphididae) has had potentially important implications for insect communities in soybeans of this region, although recent descriptions of this regional community are scarce. We describe how three pest management systems that vary in the intensity with which they rely on herbicides and insecticides (chemically intensive, reduced chemical, and …

Using Foursquare: Check‐Ins Are Not Just For Books!, Chee Hsien Aaron (Zheng Zhixian) Tay, Georgiana Glass, Shu Wen Chew

Research Collection Library

Purpose – This paper aims to provide an overview of how the National University of Singapore (NUS) Libraries has been using FourSquare Specials to engage users and to promote library activities and events. This paper will describe the implementation of various FourSquare “Specials” in the different library branches and the reactions of the users. Design/methodology/approach – The paper provides an analysis of the check‐ins at the different NUS Libraries. Firstly, there is a comparison of the historical total number of check‐ins at the main Central Library versus other popular venues on campus, as well as a benchmark against other academic …

Epigenetics: A Novel Therapeutic Approach For The Treatment Of Alzheimer's Disease, Lina Adwan, Nasser H. Zawia

Biomedical and Pharmaceutical Sciences Faculty Publications

Alzheimer's disease (AD) is the most common type of dementia in the elderly. It is characterized by the deposition of two forms of aggregates within the brain, the amyloid β plaques and tau neurofibrillary tangles. Currently, no disease-modifying agent is approved for the treatment of AD. Approved pharmacotherapies target the peripheral symptoms but they do not prevent or slow down the progression of the disease. Although several disease-modifying immunotherapeutic agents are in clinical development, many have failed due to the lack of efficacy or serious adverse events. Epigenetic changes including DNA methylation and histone modifications are involved in learning and …

Surfo Technical Report No. 13-03, Surfo

SURFO Technical Reports

The 2013 technical reports written by undergraduate students participating in the SURFO (Summer Undergraduate Research Fellowships in Oceanography) Program while at the University of Rhode Island.

The Motherhood Penalty: How Gender And Parental Status Influence Judgements Of Job-Related Competence And Organizational Commitment, Noël Burgess

Seminar Research Paper Series

The Motherhood Penalty is an ongoing problem in the United States as many women find themselves working full-time after becoming mothers. Women who become mothers are perceived as less competent, less committed, and thus less employable and/or promotable in the workplace. Unfortunately the status of “mother” has certain perceptions associated with it that are incompatible with the image of an “ideal worker.” Given this reality, the purpose of this research, which uses a literature review, is to examine the reasons for the Motherhood Penalty, the theory behind the negative perceptions of mothers, and how women and organizations can confront these …

Division Of Research And Economic Development Annual Report For Fy2013, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

Annual report for the Division of Research and Economic Development of the University of Rhode Island for the year 2012-2013.

Includes statistics of project proposals, expenditures, URI Foundation Awards, previous annual report summaries and awards received by individual academic and administrative departments.

Division Of Research And Economic Development Monthly Report For January 2013, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For May 2013, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For December 2013, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Epitope Recognition In Hla-Dr3 Transgenic Mice Immunized To Tsh-R Protein Or Peptides, Hidefumi Inaba, Leonard Moise, William Martin, Anne S. De Groot, Joe Desrosiers, Ryan Tassone, George Buchman, Takashi Akamizu, Leslie J. De Groot

Institute for Immunology and Informatics Faculty Publications

Development of Graves' disease is related to HLA-DR3. The extracellular domain (ECD) of human TSH receptor (hTSH-R) is a crucial antigen in Graves' disease. hTSH-R peptide 37 (amino acids 78–94) is an important immunogenic peptide in DR3 transgenic mice immunized to hTSH-R. This study examined the epitope recognition in DR3 transgenic mice immunized to hTSH-R protein and evaluated the ability of a mutant hTSH-R peptide to attenuate the immunogenicity of hTSH-R peptide 37. DR3 transgenic mice were immunized to recombinant hTSH-R-ECD protein or peptides. A mutant hTSH-R 37 peptide (ISRIYVSIDATLSQLES: 37m), in which DR3 binding motif position 5 was mutated …

The Two-Faced T Cell Epitope: Examining The Host-Microbe Interface With Janusmatrix, Leonard Moise, Andres H. Gutierrez, Chris Bailey-Kellogg, Frances Terry, Qibin Leng, Karim M. Abdel Hady, Nathan C. Verberkmoes, Marcelo B. Sztein, Phyllis T. Losikoff, William D. Martin, Alan L. Rotham, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

Advances in the field of T cell immunology have contributed to the understanding that cross-reactivity is an intrinsic characteristic of the T cell receptor (TCR), and that each TCR can potentially interact with many different T cell epitopes. To better define the potential for TCR cross-reactivity between epitopes derived from the human genome, the human microbiome, and human pathogens, we developed a new immunoinformatics tool, JanusMatrix, that represents an extension of the validated T cell epitope mapping tool, EpiMatrix. Initial explorations, summarized in this synopsis, have uncovered what appear to be important differences in the TCR cross-reactivity of selected regulatory …

Laboratory Assessment Of Beauveria Bassiana (Hypocreales: Clavicipitaceae) Strain Gha For Control Of Listronotus Maculicollis (Coleoptera: Curculionidae) Adults, Christopher Clavet, Emily Hampton, Matthew Requintina, Steven R. Alm

Plant Sciences and Entomology Faculty Publications

Bioassays were designed to evaluate Beauveria bassiana (Balsamo) Vuillemin strain GHA against Listronotus maculicollis (Kirby) adults. B. bassiana and its “inert” carrier oil in the product BotaniGard and the inert carrier oil alone provided 99 and 96% mortality, respectively, in petri dish assays 1 d after treatment when applied in 1 ml water. When the same treatments were applied in 0.5 ml of carrier water, mortality was only 1.4 and 0.7%, respectively, 1 d after treatment. After 10 d in petri dishes, B. bassiana and its inert carrier oil and the inert carrier oil alone applied in 0.5 ml water …

Identification Of Borrelia Burgdorferi Ospc Genotypes In Canine Tissue Following Tick Infestation: Implications For Lyme Disease Vaccine And Diagnostic Assay Design, D. V.L. Rhodes, C. G. Earnhart, Thomas N. Mather, P. F.M. Meeus, R. T. Marconi

Plant Sciences and Entomology Faculty Publications

In endemic regions, Lyme disease is a potential health threat to dogs. Canine Lyme disease manifests with arthritis-induced lameness, anorexia, fever, lethargy, lymphadenopathy and, in some cases, fatal glomerulonephritis. A recent study revealed that the regional mean for the percentage of seropositive dogs in the north-east of the USA is 11.6%. The outer surface protein C (OspC) of Lyme disease spirochetes is an important virulence factor required for the establishment of infection in mammals. It is a leading candidate in human and canine Lyme disease vaccine development efforts. Over 30 distinct ospC phyletic types have been defined. It has been …

The Influence Of Cytokines On Obesity-Associated Pain, Stacy Stolzman

Maria Dittman Library Research Competition: Student Award Winners

No abstract provided.

Final Report: Randomized Comparison Of Two Internet-Supported Methods Of Natural Family Planning, Richard J. Fehring, Mary Schneider

Randomized Comparison of Two Internet-Supported Methods of Natural Family Planning

Studies consistently show that women want safe, effective, easy to use, and convenient methods of family planning (Arévalo,1997; Severy 2001). Although Natural Family Planning (NFP) methods are free of side effects, they are often ineffective and complex to learn and use (Grimes et al. 2005). Efforts have occurred over the past 10 years to simplify the teaching and use of NFP methods and increase their efficacy. These efforts include the development of low tech calendar-based methods (Arévalo et al. 2004), simplifying instructions (Frank-Herrmann et al. 2005), and developing accurate biological markers of fertility (Guida et al. 1999).

A new high-tech …

Transdisciplinary Case Studies As A Framework For Working In Global Project Teams (2013), Mark W. Rectanus

Online Journal for Global Engineering Education

This article will examine how transdisciplinary case studies can be used to introduce students to critical skills for global project management and intercultural competency. The combination of case study formats, global project management tools, and intercultural communication activities provides frameworks for developing multiple competencies that span professional disciplines and support global internships, service learning projects, or international research assignments. Case studies that draw upon diverse resources and experiential “reports from the field” enable students to successfully prepare for global internships or study abroad and transition from the world of academic study to the complex challenges of everyday life in a …