Digital Commons Network^™

Gambogic Acid Is A Tissue-Specific Proteasome Inhibitor In Vitro And In Vivo, Xiaofen Li, Shouting Liu, Hongbiao Huang, Ningning Liu, Chong Zhao, Siyan Liao, Changshan Yang, Yurong Liu, Canguo Zhao, Shujue Li, Xiaoyu Lu, Chunjiao Liu, Lixia Guan, Kai Zhao, Xiaoqing Shi, Wenbin Song, Ping Zhou, Xiaoxian Dong, Haiping Guo, Guanmei Wen, Change Zhang, Lili Jiang, Ningfang Ma, Bing Li, Shunqing Wang, Huo Tan, Xuejun Wang, Q. Ping Dou, Jinbao Lin

Oncology Faculty Publications

Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied. Here, we report that GA inhibits tumor proteasome activity, with potency comparable to bortezomib but much less toxicity. First, GA acts as a prodrug and only gains proteasome-inhibitory function after being metabolized by intracellular CYP2E1. Second, GA-induced proteasome inhibition is a prerequisite for its cytotoxicity and anticancer effect without off-targets. Finally, because expression of the CYP2E1 gene is very high in tumor tissues …

The Eastern Echo, January 21, 2013, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Indicators Of Family Care For Development For Use In Multicountry Surveys, Patricia Kariger, Edward A. Frongillo Jr., Patrice Engle, Pia M. Rebello Britto, Sara M. Sywulka, Purnima Menon

Faculty Publications

Indicators of family care for development are essential for ascertaining whether families are providing their children with an environment that leads to positive developmental outcomes. This project aimed to develop indicators from a set of items, measuring family care practices and resources important for caregiving, for use in epidemiologic surveys in developing countries. A mixed method (quantitative and qualitative) design was used for item selection and evaluation. Qualitative and quantitative analyses were conducted to examine the validity of candidate items in several country samples. Qualitative methods included the use of global expert panels to identify and evaluate the performance of …

Phi X 174, David J. Hall

Infectious Pathogens

Phi X 174 database number # 1CD3. Phi X 174 is a virus that infects bacteria and was the first DNA-based genome to be sequenced in 1977. This bacteriophage has a [+] circular single-stranded DNA genome. The assembly of the capsid has been successfully done in vitro and is the focus of many studies on self-assembly, drug delivery and nanotechnology.

Acidic Nucleoplasmic Dna-Binding Protein (And-1) Controls Chromosome Congression By Regulating The Assembly Of Centromere Protein A (Cenp-A) At Centromeres, Aimee Jaramillo-Lambert, Jing Hao, Haijie Xiao, Yongming Li, Zhiyong Han, Wenge Zhu

Biochemistry and Molecular Medicine Faculty Publications

Background: The incorporation of CENP-A at centromeres is important for chromosome segregation during mitosis.

Results: And-1 together with HJURP regulates the assembly of new CENP-A onto centromeres.

Conclusion: And-1 facilitates the recruitment of CENP-A to centromeres.

Significance: These studies reveal a novel role of And-1 in the regulation of chromosome congression during mitosis.

The Tiger Vol. 107 Issue 1 2013-01-18, Clemson University

Tiger Newspapers

No abstract provided.

Huntington's Disease And The Perils Of Adoption, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

The Lesson Of Grace In Teaching, Francis Su

All HMC Faculty Publications and Research

I want to talk about the biggest life lesson that I have learned, and that I continue to learn over and over again. It is deep and profound. It has changed the way I relate with people. It has reshaped my academic life. And it continually renovates the way I approach my students.

Daily Eastern News: January 18, 2013, Eastern Illinois University

January

No abstract provided.

Effects Of Rare And Common Blood Pressure Gene Variants On Essential Hypertension: Results From The Family Blood Pressure Program, Clue, And Atherosclerosis Risk In Communities Studies, Khanh Dung H. Nguyen, Vasyl Pihur, Santhi K. Ganesh, Ankit Rakha, Richard S. Cooper, Steven C. Hunt, Barry I. Freedman, Joe Coresh, W. H.Linda Kao, Alanna C. Morrison, Eric Boerwinkle, Georg B. Ehret, Aravinda Chakravarti

Faculty Publications

Rationale: Hypertension affects ≈30% of adults in industrialized countries and is the major risk factor for cardiovascular disease. Objective: We sought to study the genetic effect of coding and conserved noncoding variants in syndromic hypertension genes on systolic blood pressure (BP) and diastolic BP to assess their overall impact on essential hypertension. Methods and Results: We resequenced 11 genes (AGT, CYP11B1, CYP17A1, HSD11B2, NR3C1, NR3C2, SCNN1A, SCNN1B, SCNN1G, WNK1, and WNK4) in 560 European American (EA) and African American ancestry GenNet participants with extreme systolic BP. We investigated genetic associations of 2535 variants with BP in 19997 EAs and in …

2013 Keya Paha Biological Unique Landscape Ecological Evaluation, Robert F. Steinauer

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

The Nebraska Natural Legacy Project (Schneider et al, 2005), a statewide comprehensive wildlife conservation strategy developed by the Nebraska Game and Parks Commission (NGPC), identified the Keya Paha River drainage as a “Biologically Unique Landscape” (BUL). To facilitate conservation efforts, ecological evaluations of mesic prairie, wetlands, and bur oak woodland plant communities and surveys for Tier 1 and Tier 2 at-risk-plant species were conducted within the Keya Paha BUL.

Nebraska Natural Heritage Program (NNHP) Ecological Community Survey Forms were completed to document native plant communities and NNHP Rare Plant Survey Forms were completed to document rare plant occurrences (S1-S2 species) …

Emu Today, January 18, 2013, Eastern Michigan University

EMU Today

No abstract provided.

Dengue Virus, David J. Hall

Infectious Pathogens

Dengue virus, database # 1THD Dengue fever, is an infectious tropical disease caused by the dengue virus and transmitted by mosquito. Symptoms include fever, headache, muscle and joint pains, and a characteristic skin rash that is similar to measles. In a small proportion of cases the disease develops into the life-threatening dengue hemorrhagic fever. Dengue is a positive strand RNA virus that is part of the flavivirus family. Dengue is an enveloped virus meaning it has a nucleocapsid protecting the RNA and the nucleocapsid is surrounded by lipids (hence the name enveloped).

Human Papilloma Virus 16, David J. Hall

Infectious Pathogens

Human Papilloma virus 16, database# 1DZL Infection by most papillomaviruses is either asymptomatic or causes small benign tumors, known as papillomas or warts (e.g. human papillomavirus HPV6 or HPV11). Papillomas caused by some types, however, such as human papillomaviruses 16 and 18, carry a risk of becoming cancerous. Human papilloma virus is a non-enveloped, double stranded, circular DNA virus.

Hepatitis B, David J. Hall

Infectious Pathogens

Hepatitis B, database # 2g33. Hepatitis B is an infectious inflammatory illness of the liver caused by the hepatitis B virus (HBV). Hepatitis B virus (HBV) is a member of the Hepadnavirus family.The virus particle, (virion) consists of an outer lipid envelope and an icosahedral nucleocapsid core composed of protein. These virions are 42 nM in diameter. The nucleocapsid encloses the viral DNA and a DNA polymerase that has reverse transcriptase activity.

The Bg News January 18, 2013, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 18, 2013. Volume 92-Issue 56.

Bats Of The Wildcat Hills And Surrounding Areas In Western Nebraska, Keith Geluso, Jeffrey J. Huebschman, Kenneth N. Geluso

Monographs of the Western North American Naturalist

During the last few decades, detailed studies of bats have been conducted in many parts of Nebraska, but comprehensive surveys were lacking in the Wildcat Hills and other western regions of the state. The Wildcat Hills represent a unique and isolated area of rugged buttes, ridges, and canyons dominated by ponderosa pine forests (Pinus ponderosa) in central parts of Nebraska’s panhandle. This area also contains landscapes with some of the highest wind speeds in the state, making it conducive for future wind-energy development. To better understand the natural history of bats and to promote conservation efforts in the …

Climate Change Or Urbanization? Impacts On A Traditional Coffee Production System In East Africa Over The Last 80 Years, Juliana Jaramillo, Mamoudou Setamou, Eric Muchugu, Adenirin Chabi-Olaye, Alvaro Jaramillo, Joseph Mukabana, Johnson Maina, Simon Gathara, Christian Borgemeister

All Peer-Reviewed Publications

Global environmental changes (GEC) such as climate change (CC) and climate variability have serious impacts in the tropics, particularly in Africa. These are compounded by changes in land use/land cover, which in turn are driven mainly by economic and population growth, and urbanization. These factors create a feedback loop, which affects ecosystems and particularly ecosystem services, for example plant-insect interactions, and by consequence agricultural productivity. We studied effects of GEC at a local level, using a traditional coffee production area in greater Nairobi, Kenya. We chose coffee, the most valuable agricultural commodity worldwide, as it generates income for 100 million …

Saint Francis College V. Al-Khazraji: Cosmetic Surgery Or A Fresh Breadth For Section 1981? , Barbara A. Bayliss

Pepperdine Law Review

No abstract provided.

Commonwealth Times 2013-01-17

Commonwealth Times, 1969-

No abstract provided.

Nutritional Basis For Colonization Resistance By Human Commensal Escherichia Coli Strains Hs And Nissle 1917 Against E. Coli O157:H7 In The Mouse Intestine, Rosalie Maltby, Mary P. Leatham-Jensen, Terri Gibson, Paul S. Cohen, Tyrrell Conway

Cell and Molecular Biology Faculty Publications

Escherichia coli is a single species consisting of many biotypes, some of which are commensal colonizers of mammals and others that cause disease. Humans are colonized on average with five commensal biotypes, and it is widely thought that the commensals serve as a barrier to infection by pathogens. Previous studies showed that a combination of three pre-colonized commensal E. coli strains prevents colonization of E. coli O157:H7 in a mouse model (Leatham, et al., 2010, Infect Immun 77: 2876–7886). The commensal biotypes included E. coli HS, which is known to successfully colonize humans at high doses with no adverse effects, …

Minutes, Arts And Sciences Executive Committee Meeting, Thursday, January 17, 2013, Arts And Sciences Executive Committee

Executive Committee Minutes

No abstract provided.

Activation Of Thromboxane A2 Receptor (Tp) Increases The Expression Of Monocyte Chemoattractant Protein -1 (Mcp-1)/Chemokine (C-C Motif) Ligand 2 (Ccl2) And Recruits Macrophages To Promote Invasion Of Lung Cancer Cells, Xiuling Li, Hsin-Hsiung Tai

Pharmaceutical Sciences Faculty Publications

Thromboxane synthase (TXAS) and thromboxane A₂ receptor (TP), two critical components for thromboxane A₂ (TXA₂) signaling, have been suggested to be involved in cancer invasion and metastasis. However, the mechanisms by which TXA₂ promotes these processes are still unclear. Here we show that TXA₂ mimetic, I-BOP, induced monocyte chemoattractant protein -1(MCP-1)/chemokine (C-C motif) ligand 2 (CCL2) expression at both mRNA and protein levels in human lung adenocarcinoma A549 cells stably over-expressing TP receptor α isoform (A549-TPα). The induction of MCP-1 was also found in other lung cancer cells H157 and H460 that express relatively …

Motivational Interviewing Targeting Risk Behaviors For Youth Living With Hiv In Thailand, Chokechai Rongkavilit, Sylvie Naar-King, Bo Wang, Apirudee Panthong, Torsak Bunupuradah, Jeffrey T. Parsons, Supalak Phonphithak, Juline A. Koken, Pichai Saengcharnchai, Praphan Phanuphak

Publications and Research

Healthy Choices, a four-session motivational interviewing-based intervention, reduces risk behaviors among US youth living with HIV (YLWH). We randomized 110 Thai YLWH (16–25 years) to receive either Healthy Choices or time-matched health education (Control) over 12 weeks. Risk behaviors were assessed at baseline, 1, and 6 months post-session. The pilot study was not powered for between-group differences; there were no statistical differences in sexual risks, alcohol use, and antiretroviral adherence between the two groups at any visit. In within-group analyses, Healthy Choices group demonstrated decreases in the proportion of HIV-negative partners (20 vs 8.2 %, P = 0.03) and HIV …

Daily Eastern News: January 17, 2013, Eastern Illinois University

January

No abstract provided.

Emu Today, January 17, 2013, Eastern Michigan University

EMU Today

No abstract provided.

Development Of Plant Lectin Rtb For Delivery Of Therapeutic Proteins, Walter Acosta Gamboa

Student Theses and Dissertations

One of the main challenges for successful drug development is the creation of molecules that are able to cross the cell membrane to deliver therapeutics into specific subcellular compartments where they can serve their purpose. Among the therapeutic applications burdened with cell uptake limitations are enzyme replacement therapeutics (ERTs) for both lysosomal storage disorders (LSD) and endoplasmic reticulum storage diseases (ERSD). LSD and ERSD are rare disorders caused by defects in specific proteins within these cellular compartments, and current treatments rely on the regular provision of active enzyme to replace the missing/defective protein in patients. Plant lectin RTB, naturally present …

Mult Ensemble Drought Forecasts For Arkansas Applying Available Resampling Techniques, Yan Liu

Student Theses and Dissertations

Drought forecast is substantial in water management and agriculture planning. The historical climate records, including drought indices, temperature, and precipitation, provide useful information for drought forecasts. Arkansas has suffered severe droughts in recent years and study has been rarely done for this area. In this study, a local nonparametric autoregressive model and stochastic approaches are applied to produce ensemble drought forecasts with associated confidence. Various resampling techniques are tested for monthly forecasts of Palmer drought severity index (PDSI) and standardized precipitation index of both three- and twelve-month (SPI03 & SPI12) in Arkansas climate divisions. Normalized Root Mean Square Error (NRMSE), …

Graduate Teaching Assistants' Perceptions Of Their Preparation For Teaching In Departments Of Communication Studies At Selected Universities, Brenda Atkins-Randle

Student Theses and Dissertations

The study examined the adequacy of preparation that graduate teaching assistants receive before or during the pursuit of their graduate degree. Specifically, this study looked at graduate teaching assistants' perceptions of their particular programs. Additionally, this study explored how prevalent or non-prevalent TA training was before and/or during services as a Teaching Assistant, the strengths and weaknesses of training program components, the intensity of training programs, the role faculty mentoring played in TA training and the differences in perceptions based on gender and degree status (Master's versus Doctoral). The researcher was interested in identifying and assessing the adequacy of graduate …

Serum Amyloid P Inhibits Granulocyte Adhesion, Anu S. Maharjan, David Roife, Derrick Brazill, Richard H. Gomer

Publications and Research

Background The extravasation of granulocytes (such as neutrophils) at a site of inflammation is a key aspect of the innate immune system. Signals from the site of inflammation upregulate granulocyte adhesion to the endothelium to initiate extravasation, and also enhance granulocyte adhesion to extracellular matrix proteins to facilitate granulocyte movement through the inflamed tissue. During the resolution of inflammation, other signals inhibit granulocyte adhesion to slow and ultimately stop granulocyte influx into the tissue. In a variety of inflammatory diseases such as acute respiratory distress syndrome, an excess infiltration of granulocytes into a tissue causes undesired collateral damage, and being …