Digital Commons Network^™

Emu Today, March 28, 2013, Eastern Michigan University

EMU Today

No abstract provided.

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.

Derivation Of Multivariate Syndromic Outcome Metrics For Consistent Testing Across Multiple Models Of Cervical Spinal Cord Injury In Rats, Adam R. Ferguson, Karen-Amanda Irvine, John C. Gensel, Jessica L. Nielson, Amity Lin, Johnathan Ly, Mark R. Segal, Rajiv R. Ratan, Jacqueline C. Bresnahan, Michael S. Beattie

Physiology Faculty Publications

Spinal cord injury (SCI) and other neurological disorders involve complex biological and functional changes. Well-characterized preclinical models provide a powerful tool for understanding mechanisms of disease; however managing information produced by experimental models represents a significant challenge for translating findings across research projects and presents a substantial hurdle for translation of novel therapies to humans. In the present work we demonstrate a novel 'syndromic' information-processing approach for capitalizing on heterogeneous data from diverse preclinical models of SCI to discover translational outcomes for therapeutic testing. We first built a large, detailed repository of preclinical outcome data from 10 years of basic …

Science For The Half-Century To Come, Lisa Strandberg

St. Norbert College Magazine 2013-2018

Transformation takes effort. St. Norbert science faculty and administrators can testify to that. As ground is broken this spring for the construction of the Gehl-Mulva Science Center, they see unleashed the 15 years of energy they’ve invested in envisioning the transformation of John R. Minahan Science Hall into a state-of-the-art research and learning facility – a facility for the next five decades.

Liberal Knowledge, St. Norbert College

St. Norbert College Magazine 2013-2018

In a scientific society transformed by the internet, the liberal arts are essential in forming effective, responsible scientists. Michael Foley ’84, chemical biology platform director for the Broad Institute of MIT and Harvard University, explains why.

Population Structure And The Colonization Route Of One Of The Oldest North American Invasive Insects: Stories From The Worn Road Of The Hessian Fly, Mayetiola Destructor (Say)., Philip K. Morton, Brandon J. Schemerhorn

Department of Entomology Faculty Publications

An integral part to understanding the biology of an invasive species is determining its origin, particularly in pest species. As one of the oldest known invasive species, the goals of this study were to evaluate the evidence of a westward expansion of Hessian fly into North America, from a potential singular introduction event, and the population genetic structure of current populations. Levels of genetic diversity and population structure in the Hessian fly were compared across North America, Europe, North Africa, Western Asia, and New Zealand. Furthermore, Old World populations were evaluated as possible sources of introduction. We tested diversity and …

Sipb-Sipc Complex Is Essential For Translocon Formation., Sebenzile K. Myeni, Lu Wang, Daoguo Zhou

Department of Biological Sciences Faculty Publications

The delivery of effector proteins by Salmonella across the host cell membrane requires a subset of effectors secreted by the type III secretion system (TTSS) known as translocators. SipC and SipB are translocator proteins that are inserted into host membranes and presumably form a channel that translocates type III effectors into the host cell. The molecular events of how these translocators insert into the host cell membrane remain unknown. We have previously shown that the SipC C-terminal amino acid region (321–409) is required for the translocation of effectors into host cells. In this study, we demonstrate that the ability to …

Batf Regulates The Development And Function Of Il-17 Producing Inkt Cells., Kimberly L. Jordan-Williams, Stacie Poston, Elizabeth J. Taparowsky

Department of Biological Sciences Faculty Publications

Background

BATF plays important roles in the function of the immune system. Batf null mice are deficient in both CD4⁺ Th17 cells and T follicular helper cells and possess an intrinsic B cell defect that leads to the complete absence of class switched Ig. In this study, Tg mice overexpressing BATF in T cells were used together with Batf null mice to investigate how altering levels of BATF expression in T cells impacts the development and function of a recently characterized population of iNKT cells expressing IL-17 (iNKT-17).

Results

BATF has a direct impact on IL-17 expression by iNKT …

Volume 50, Number 32: March 27, 2013, University Of North Dakota

University Letter Archive

No abstract provided.

The Impact Of A Theater Service Learning Course For Underserved Children Through A Mixed Methodology, Fanny Chouinard

Theses and Dissertations

In general, the community partnerships found in service learning programs can be conduits between underserved populations and populations that have greater access to resources (Burbank & Hunter, 2008). A typical community partnership would be among a local institution of learning, the parents of underserved children, and their children. Although service learning programs cannot be expected to solve all problems of the individuals, the community, and the University, they can have a positive impact on the complex relationships between its stakeholders. The intention of this action research project was to determine the effect of a theater service learning course with children. …

An Informational Algorithm As The Basis For Perception-Action Control Of The Instantaneous Axes Of The Knee, Wangdo Kim, Margarida M. Espanha, António P. Veloso, Duarte Araújo, Filipa João, Luis Carrão, Sean S. Kohles

Mechanical and Materials Engineering Faculty Publications and Presentations

Traditional locomotion studies emphasize an optimization of the desired movement trajectories while ignoring sensory feedback. We propose an information based theory that locomotion is neither triggered nor commanded but controlled. The basis for this control is the information derived from perceiving oneself in the world. Control therefore lies in the human-environment system. In order to test this hypothesis, we derived a mathematical foundation characterizing the energy that is required to perform a rotational twist, with small amplitude, of the instantaneous axes of the knee (IAK). We have found that the joint’s perception of the ground reaction force may be replaced …

Etudes On Iurids, V. Further Revision Of Iurus Thorell, 1876 (Scorpiones: Iuridae), With A Description Of A New Genus And Two New Species, Michael E. Soleglad, Victor Fet, František Kovařík, Ersen Aydın Yağmur

Euscorpius

Iurus populations from the Aegean area are studied, including the Greek islands of Crete, Karpathos, Kythira, Rhodes, and Samos. A new genus, Protoiurus gen. nov., and two new species, Protoiurus rhodiensis sp. nov. and P. stathiae sp. nov., are described. The two genera, Iurus and Protoiurus, are diagnosed by their hemispermatophore structure; a cladistic analysis based on this structure is presented. Genus Iurus Thorell, 1876 includes three species: I. dekanum, I. dufoureius, and I. kinzelbachi; genus Protoiurus includes five species: P. asiaticus comb. nov., P. kadleci comb. nov., P. kraepelini comb. nov., P. rhodiensis sp. nov., and P. …

Euscorpiops Neradi Sp. N. From Thailand (Scorpiones: Euscorpiidae: Scorpiopinae), František Kovařík, Jana Plíšková, František Šťáhlavský

Euscorpius

Euscorpiops neradi sp. n. from Thailand is described and compared with other species of the genus Euscorpiops Vachon, 1980. It is the smallest species of the genus, with total length about 25 mm in both sexes. In E. neradi sp. n. external trichobothria on the patella number 16 (5 eb, 2 esb, 2 em, 3 est, 4 et) and ventral trichobothria on the patella number 6. Pedipalp fingers are flexed in males and straight in females.

Alloscorpiops Citadelle Sp. N. From Thailand (Scorpiones: Euscorpiidae: Scorpiopinae)., František Kovařík

Euscorpius

Alloscorpiops citadelle sp. n. from Thailand is described and compared with A. anthracinus (Simon, 1887). A. citadelle sp. n. is characterized mainly by a higher number of trichobothria on the patella, which has 29–34 external (23–24 in A. anthracinus) and 19–21 ventral (15–19 in A. anthracinus) trichobothria.

Evolution Of Scorpion Orthobothriotaxy: A Cladistic Approach, Michael E. Soleglad, Victor Fet

Euscorpius

This study presents a cladistic analysis of the derivation of orthobothriotaxic patterns in scorpions. Included in this analysis are the original three orthobothriotaxic patterns defined by Vachon (1972, 1974), the pattern of the unique scorpion Pseudochactas ovchinnikovi Gromov, 1998, and two trichobothrial patterns of fossil scorpions, the Upper Carboniferous palaeopisthacanthids and the Lower Cretaceous archaeobuthids. An overview of all fossil scorpion material where trichobothria are reported is presented in detail. The approach used in this analysis is to model the existence of an individual trichobothrium, adopting the ‘absence of’, ‘petite size’ and ‘full size’ as incremental stages of a trichobothrium’s …

Contributions To Scorpion Systematics. I. On Recent Changes In High-Level Taxonomy, Victor Fet, Michael E. Soleglad

Euscorpius

Prendini & Wheeler (2005) criticized the methods of phylogenetic analyses by Soleglad, Fet, and their coauthors, and executed an unprecedented taxonomic action: without analyzing any of these taxa, they performed a wholesale synonymization of four parvorders, eight superfamilies, one family, 11 subfamilies, eight tribes, two subtribes, and three genera (in total, 37 taxa) of scorpions, and made other taxonomic changes. No alternative new classification has been proposed (instead, they revert to a previous classification), and no results of original work on this subject by Prendini & Wheeler (2005) have been presented. Here, we reverse all taxonomic changes performed by Prendini …

Trinity As Trope: The Relational Turn In Communication Studies, Dennis Cali

Claritas: Journal of Dialogue and Culture

Previous “systems” of rhetoric, which have arisen as responses to felt needs, emphasize an individualist paradigm whereas the contemporary system, responding to current impulses, tends toward a relational paradigm. The “Trinity” is proposed here as a trope that both prefigures this relational and dialogical turn in communication studies and suggests the ethical ends toward which communication praxis should aim. In particular, the Trinitarian thought of Chiara Lubich offers a unique perspective on the relational current in communication studies, especially its links of ontology with praxis, relational being with communication, and kenosis with perichoresis.

Magnetotactic Bacteria From Extreme Environments, Dennis A. Bazylinski, Christopher T. Lefèvre

Life Sciences Faculty Research

Magnetotactic bacteria (MTB) represent a diverse collection of motile prokaryotes that biomineralize intracellular, membrane-bounded, tens-of-nanometer-sized crystals of a magnetic mineral called magnetosomes. Magnetosome minerals consist of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and cause cells to align along the Earth’s geomagnetic field lines as they swim, a trait called magnetotaxis. MTB are known to mainly inhabit the oxic–anoxic interface (OAI) in water columns or sediments of aquatic habitats and it is currently thought that magnetosomes function as a means of making chemotaxis more efficient in locating and maintaining an optimal position for …

Ua12/2/1 College Heights Herald, Vol. 88, No. 42, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

• Harrison, Taylor. Gary Ransdell to Push WKU’s Need for Tuition Increase with Council on Postsecondary Education
• Aulbach, Lucas. Seeing Double – Basketball
• Grogg, Mitchell. Shamrock Shootout Raises Money for Family & Children’s Charities – Kappa Delta
• Stukenborg, Sarah. Student Government Association Prepares for Upcoming Election Debate
• Matchen, Quiche. International Justice Mission Stands for 27 Hours Against Sex Trafficking – Human Trafficking
• Vogt, Darren. Editorial Cartoon Voting
• Students Should Vote for Those Who Represent Them – Student Government Association, Elections
• People Poll: Do You Think the Student Government Association Makes …

Ocean Current Measurements: Challenges And Opportunities In The Florida Current, William E. Baxley

HCNSO Student Capstones

The water velocities offshore south Florida are dominated by the Florida Current, and these effects result not only from the tremendous flow of water between Florida and the Bahamas, but also from the eddies and other rotational components imparted by the change in flow direction from eastward to northward along the Florida Keys and the end of the peninsula. These currents have been measured for decades, with methods ranging from subsurface floats to acoustic Doppler current profilers (ADCPs) and surface current measuring radars. Data suggests that there is a large degree of variability in the mean flow, including significant vorticity …

The Variables Related To Public Acceptance Of Evolution In The United States, Benjamin C. Heddy, Louis S. Nadelson

Curriculum, Instruction, and Foundational Studies Faculty Publications and Presentations

Background: The current study explores variables related to public acceptance of evolution in the United States by state. Data on acceptance of evolution, religiosity, science, technology, engineering, and mathematics (STEM) degree attainment, educational attainment, high school dropout rate, average teacher salary, and gross domestic product (GDP) per capita were analyzed for the 50 states.

Methods: Employing secondary data analysis, bivariate correlations were used to investigate the relationship between US acceptance of evolution and each variable.

Results: As predicted, there was a strong negative correlation between acceptance of evolution and religiosity and a strong positive relationship between acceptance and science degrees …

The Advocate, March 26, 2013, Minnesota State University Moorhead

The Advocate

No abstract provided.

Expansion Of Breast Cancer Stem Cells With Fibrous Scaffolds, Sheng Feng, Pang-Kuo Lo, Shou Liu, Xinfeng Liu, Hexin Chen, Qian Wang

Faculty Publications

Cancer stem cells (CSCs) are hypothesized as tumor-initiating cells within tumors and main contributors of tumor growth, metastasis and recurrence. Mammary cancer cells, MCF-7 cells, were cultured on 3D polycaprolactone (PCL) fibrous scaffolds, showing an increased proportion of CSCs. The expression of stem cell markers, including OCT3/4 and SOX2, and breast CSC-specific markers, SOX4 and CD49f, was significantly upregulated, and the mammosphere-forming capability in cells cultured on PCL fibrous scaffolds increased. The fibrous scaffolds also induced the elongation of MCF-7 cells and extended cell proliferation. The increase of CSC properties after being cultured on fibrous scaffolds was further confirmed with …

Emu Today, March 26, 2013, Eastern Michigan University

EMU Today

No abstract provided.

Heterosubstituted N-Thiolated Beta-Lactam Compounds And Methods Of Use, Edward Turos, Praveen Ramaraju

USF Patents

The invention relates to heterosubstituted N-thiolated beta-lactams, compositions comprising these compounds, methods for their production, and methods of use as antibiotics to inhibit the growth of bacteria. In one embodiment, the compounds have the structure shown in formula (A) or formula (B) or formula (C):

wherein the R groups are as defined in the specification. The antibacterial agents of the invention can be administered to a human or animal to treat or inhibit bacterial infection, such as that of Staphylococcus species, including methicillin-resistant Staphylococcus aureus (MRSA).

Synthesis Of Nanocrystalline Diamond Fibers, Ashok Kumar, Manoj Kumar Singh

USF Patents

Provided herein is a method for the synthesis of nanocrystalline diamond (NCD) wires by depositing nanocrystalline diamond on Si nanowires using chemical vapor deposition methods. Seeding the nanowires in solutions containing nanodiamond powers, NCD wires are fabricated in typical CVD growth conditions within a very short time. NCD wires were 0.5-5 μm in diameter, depending on the growth time, with lengths in the range of 20-100 μm. The average elastic modulus determined by nanoindentation is 474.16±13.48 GPa. The unique mechanical properties of the NCD wire make it a potential material for active components of both electronic and electromechanical devices.

Robust Detection Of Rare Species Using Environmental Dna: The Importance Of Primer Specificity, Taylor M. Wilcox, Kevin S. Mckelvey, Michael K. Young, Stephen F. Jane, Winsor H. Lowe, Andrew R. Whiteley, Michael K. Schwartz

Biological Sciences Faculty Publications

Environmental DNA (eDNA) is being rapidly adopted as a tool to detect rare animals. Quantitative PCR (qPCR) using probe-based chemistries may represent a particularly powerful tool because of the method's sensitivity, specificity, and potential to quantify target DNA. However, there has been little work understanding the performance of these assays in the presence of closely related, sympatric taxa. If related species cause any cross-amplification or interference, false positives and negatives may be generated. These errors can be disastrous if false positives lead to overestimate the abundance of an endangered species or if false negatives prevent detection of an invasive species. …

Melanin Concentration Gradients In Modern And Fossil Feathers, Daniel J. Field, Liliana D’Alba, Jakob Vinther, Samuel M. Webb, William Gearty, Matthew D. Shawkey

School of Biological Sciences: Faculty Publications

In birds and feathered non-avian dinosaurs, within-feather pigmentation patterns range from discrete spots and stripes to more subtle patterns, but the latter remain largely unstudied. A ,55 million year old fossil contour feather with a dark distal tip grading into a lighter base was recovered from the Fur Formation in Denmark. SEM and synchrotron-based trace metal mapping confirmed that this gradient was caused by differential concentration of melanin. To assess the potential ecological and phylogenetic prevalence of this pattern, we evaluated 321 modern samples from 18 orders within Aves. We observed that the pattern was found most frequently in distantly …

The Current Volume 23 : Issue 25, Nova Southeastern University

Student Newspapers

No abstract provided.

Drug Delivery Microdevice: Design, Simulation, And Experiments, Jae Hwan Lee

Theses and Dissertations

Ocular diseases such as glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa require drug management in order to prevent blindness and affecting millions of adults in US and worldwide. There is an increasing need to develop devices for drug delivery to address ocular diseases. This research focused on an implantable ocular drug delivery device design, simulation and experiments with design requirements including constant diffusion rate, extended period of time operation, the smallest possible volume of device and reservoir. The drug delivery device concept uses micro-/nano-channels module embedded between top and bottom covers with a drug reservoir. Several microchannel …