Digital Commons Network^™

Stat3 Inhibitor Having Anti-Cancer Activity And Methods (Us), James Turkson, Andrew Hamilton, Richard Jove, Said Sebti

UCF Patents

A small-molecule Stat3 dimerization inhibitor, S3I-M2001, is described and the dynamics of intracellular processing of activated Stat3 within the context of the biochemical and biological effects of the Stat3 chemical probe inhibitor are elucidated. S3I-M2001 is a newly-identified oxazole-based peptidomimetic of the Stat3 Src Homology (SH) 2 domain-binding phosphotyrosine peptide that selectively disrupts active Stat3:Stat3 dimers. Stat3-dependent malignant transformation, survival, and migration and invasion of mouse and human cancer cells harboring persistently-activated Stat3 were inhibited by S3I-M2001. S3I-M2001 inhibited Stat3-dependent transcriptional regulation of tumor survival genes, such as Bcl-xL. The disclosed compound is useful as a new potential treatment for …

The Governance Of Wolves In Transboundary Regions: A Triquetrous Study Of Ephemeral Agreements Transcending Sub-National And National Boundaries, Brett M. Parks

Natural Resources

Contradictory management objectives in adjacent jurisdictions can affect transboundary wolves and their associated socio-ecological systems. Elite interviews and case study methodology were used in this thesis to explore three transboundary wolf management agreements, their effectiveness, and their impacts on wolves, ecosystems and stakeholders. Separate agreements between the State of Alaska and: Yukon-Charley Rivers National Preserve, and Denali National Park and Preserve, and an agreement between Italy and Switzerland show that despite a diversity of socio-ecological contexts, approaches, and hierarchical level of actors, transboundary wolf agreements are prone to ephemerality. The ephemerality of these agreements appears to be due primarily to …

Chancellor's Report 2013-12, John Pugh

Chancellor's Report

No abstract provided.

Chancellor's Philanthropy Report 2013 Winter, John Pugh

Chancellor's Report

No abstract provided.

Soundings 2013-12-17, N/A N/A

Soundings

No abstract provided.

Jakobshavn Isbr�_: Velocity Variations From Hourly To Decadal Time Scales At Greenland's Fastest Tidewater Glacier, David Bryan Podrasky

Geosciences

Outlet glaciers in Greenland, and elsewhere, have recently shown large variations in terminus position and ice flux. One example is the tidewater retreat of Jakobshavn Isbr�_, which began in the late 1990s with high thinning rates, acceleration and collapse of the floating glacier tongue. The retreat has continued to the present, with glacier speeds more than doubling in two decades' time. A campaign of in-situ measurements was initiated in 2006 with the aim of determining the importance of short-term forcing as a control on the continuing evolution of the glacier. Three years of continuous GPS measurements along the centerline of …

The Relationships Between Licensed Vocational Nurses' Care, Documentation, And Perceptions Of Dementia-Compromised Behaviors In The Nursing Home, Jennifer J. Yeager

Nursing Theses and Dissertations

Behavioral and psychological symptoms of dementia increase as Alzheimer's disease and related dementias progress; these symptoms occur in as many as 80% of persons with dementia living in nursing homes. Behavioral and psychological symptoms of dementia, also known as dementia-compromised behaviors, are a source of stress for nursing home staff, family members, and other residents and adversely affect the quality of life and safety of residents. Ethnonursing, a qualitative research method, was used to examine the relationship between licensed vocational nurses' responses to dementia-compromised behaviors, documentation, and perceptions of dementia care. Data analysis resulted in three overarching themes related to …

Dean Logan's Blog: Celebrating The Holidays, Rwu Style, Roger Williams University School Of Law

Law School Blogs

No abstract provided.

Remarks In Remembrance Of Fred Meijer, Delivered At The University Club Luncheon On December 17, 2013, Arend D. Lubbers

Presidential Speeches

Remarks in Remembrance of Fred Meijer, delivered at the University Club Luncheon on December 17, 2013 by Arend D. Lubbers, who served as President of Grand Valley from 1969-2001.

Alaska Energy Statistics 1960-2011 Final Report, Ginny Fay, Alejandra Villalobos Meléndez, Corinna West

ISER Reports

This twenty-sixth edition of the Alaska Energy Statistics reconciles energy data from public sources and makes that data more easily available to the public and stakeholders. It primarily presents 2011 data on electricity produced by certified utilities in Alaska. It includes a brief introduction, highlights, and summary data tables. The first major section describes basic statistical indicators for Alaska utilities, and the second discusses renewable energy in Alaska. After that we look more broadly at the big picture of energy in Alaska, describing production and consumption of various energy sources. A series of appendixes defines terms, lists references, and describes …

Interpolation Of Rainfall For The Albuquerque Area : A Comparison To The Primary Local Climatological Data Site, Christopher N. Wolff

Water Resources Professional Project Reports

The main objective of this project was to assess the ability of the Primary Local Climatological Data Site (LCD) to estimate precipitation around the City of Albuquerque. In other words, this study determined how representative LCD precipitation data is as a point source station for characterizing precipitation within the Albuquerque metro area and nearby sites. Because the LCD is located in a permanent position near the Albuquerque International Airport, precipitation associated with rainfall localized away from the LCD, but within the Albuquerque metro area, is not accounted for in the LCD precipitation data record. This study quantified regional variability in …

Regulating The Ngo Sector, Ishrat Husain Dr.

Faculty Research - Newspaper and Magazine Articles

The Millennium Development Goal of poverty reduction has been achieved ahead of the 2015 deadline. Human development indicators have improved significantly in almost all countries with very few exceptions.

Developing countries now account for almost half the world’s income, and most of the growth in the global economy in the post-2007 period has been contributed by them. Technological revolution particularly in information and communications technology has been a major driver of economic growth.

Strategies of the past, however successful in boosting growth and alleviating poverty, have given rise to second-generation problems that have surfaced in the last decade or so. …

The Bg News December 17, 2013, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. December 17, 2013. Volume 93-Issue 49.

Foxes And Food Subsidies: Anthropogenic Food Use By Red And Arctic Foxes, And Effects On Arctic Fox Survival, On The Arctic Coastal Plain Of Alaska, Garrett Savory

Biological Sciences

Food subsidies have the potential to impact wildlife on the Arctic Coastal Plain of Alaska. Red foxes (Vulpes vulpes (L., 1758)) expanded their range into Arctic regions during the 20th century, and the availability of anthropogenic foods may have contributed to their success and persistence in the Arctic. Arctic foxes (Vulpes lagopus (L., 1758)) are also known to forage on anthropogenic foods in Prudhoe Bay and to forage on marine mammals on the sea ice, but it is unknown whether these strategies benefit survival of Arctic foxes. This thesis examined: 1) the importance of anthropogenic foods to the diets of …

Habitat Associations, Distribution, And Abundance Of Smith's Longspur (Calcarius Pictus), An Uncommon Species Of Concern In The Brooks Range, Alaska, Teri Corvus Wild

Biological Sciences

Smith's Longspur (Calcarius pictus) is a species of conservation concern in the U.S. and Canada, yet few studies have been conducted on their breeding grounds in the Arctic, which are expected to undergo dramatic changes due to climate change. For effective conservation, we need information on breeding distribution and abundance; thus I conducted surveys for Smith's Longspur and habitat characteristics across a broad geographic range that included twelve sites within Alaska's Brooks Range, June 2003-2009. My main objectives were to (1) locate breeding populations (2) describe habitats at local and broader geographic scales, (3) develop a predictive distribution map based …

Phylogeny Of Fomitopsis Pinicola: A Species Complex, John-Erich Haight

Biological Sciences

Fomitopsis pinicola sensu lato is a common, saprotrophic fungal species occurring over the large circumpolar region covering Eurasia and North America, and extending south along areas of high elevation. It colonizes hardwood and softwood substrates, causing brown rot decay of wood, and exhibits a wide variety of morphological types and colors. Since the late nineteenth century, attempts have been made to determine how many species were in the genus Fomitopsis. Early attempts described two to three species based on host specificity and morphology. By the mid twentieth century, extensive mating studies among single spore isolates had been completed revealing three …

Engaging Local Perspectives For Improved Conservation And Climate Change Adaptation, Corrine Noel Knapp

Biological Sciences

Climate change is a global process that will impact local places in heterogeneous and unpredictable manners. This dissertation considers whose knowledge and observations could contribute to conservation and climate adaptation planning, how perceptions influence social-ecological feedbacks, and how science could be more relevant to decision-makers and local residents. In Chapter 2, I report on interviews (n=36) conducted with ranchers and recreation-based business owners in Colorado to understand their self-perceptions of resilience and vulnerability. I find that ranchers perceive more exposure and sensitivity to climate change and they also demonstrate more adaptive capacity than recreation businesses. In Chapter 3, I convey …

Peeking Through A Frosty Window: Molecular Insights Into The Communities Of Arctic Soil Fungi, Ina Timling

Biological Sciences

Fungi are thought to be one of the most diverse groups of organisms in the Arctic. They drive mineral and energy cycles and influence the occurrence of other organisms as mutualists (mycorrhizae, endophytes, lichens), decomposers and pathogens. Nevertheless, information on fungal biodiversity and distribution patterns in relation to environments across the Arctic is still sparse. Molecular methods were used to examine the diversity and community structures of ectomycorrhizal fungi (EMF) associated with two principal arctic host plants, Salix aretica and Dryas integrifolia, as well as total soil fungal communities of adjacent disturbed and undisturbed areas of patterned-ground features across the …

State V. Caudill Respondent's Brief Dckt. 40782

Not Reported

No abstract provided.

A Departmental Focus On High Impact Undergraduate Research Experiences, Robin Kinnel, Adam W. Van Wynsberghe, Ian J. Rosenstein, Karen S. Brewer, Myriam Cotten, George C. Shields, Charles J. Borton, Sueann Z. Senior, Gregory S. Rahn, Timothy E. Elgren

Faculty Journal Articles

Undergraduate research experiences have become an integral part of the Hamilton College chemistry experience. The major premise of the chemistry department’s curriculum is that research is a powerful teaching tool. Curricular offerings have been developed and implemented to better prepare students for the independence required for successful undergraduate research experiences offered during the academic year and the summer. Administrative support has played a critical role in our ability to initiate and sustain scholarly research programs for all faculty members in the department. The research-rich curriculum is built directly upon or derived from the scholarly research agendas of our faculty members. …

A Kinetic Study Of Aqueous Calcium Carbonate, Derek Daniel Harris

Theses and Dissertations

Amorphous calcium carbonate (ACC) precipitation is modeled using particle nucleation, growth, and aggregation. The particles are tracked in terms of their radial size and particle density using direct quadrature method of moments (DQMOM). Four separate nucleation models are implemented and are compared to experimental data. In discord with a recent study, it is shown that classical nucleation, coupled with equilibrium chemistry, is in good agreement with experimental data. Novel nucleation mechanisms are presented which fit the experimental data with slightly greater accuracy. Using equilibrium chemistry it is shown that the equilibrium value of ACC is pKeq = 7.74 at 24C, …

Ataam Taikina: Traditional Knowledge And Conservation Ethics In The Yukon River Delta, Alaska, Chad M. Cook

Arctic and Northern Studies

This research was conducted in collaboration with rural Yup'ik residents of the Yukon River delta region of Alaska. The thesis explores traditional knowledge and conservation ethics among rural Yup'ik residents who continue to maintain active subsistence lifestyles. From the end of July through August of 2012, ethnographic field research was conducted primarily through participant observation and semi-structured interviews, documenting Yup'ik subsistence hunting and fishing practices. Research participants invited me beluga whale hunting, seal hunting, moose hunting, commercial and subsistence fishing, gathering berries, and a variety of other activities that highlights local Yup'ik environmental knowledge, practices, and ethics. Through firsthand examples …

Improving The Renovation, Repair And Painting Training Course To Eliminate Childhood Lead Poisonings: Wisconsin Observations, Anke M. Hildebrandt

Arctic and Northern Studies

In 2011, I worked briefly with the Asbestos and Lead Program for the State of Wisconsin. It was my job to conduct audits of our training providers as well as on-site inspections of work sites. During my time there I discovered a real disconnect between what I saw in the field and what is taught in class. Wisconsin has its own lead rules that are more stringent than the EPA's. After taking a critical look at the EPA's Renovation, Repair and Painting Rule (RRP) curriculum, I saw where the problems lay. The required hands-on training does not present the skills …

Observation And Analysis On The Characteristics Of Strain Induced By Frost Heave For A Full-Scale Buried, Chilled Gas Pipeline, Kun Yang

Engineering

This thesis examines the strain characteristics of a large-scale, buried chilled gas pipeline in the discontinuous permafrost region. A full-scale chilled pipeline gas experiment was conducted in Fairbanks, Alaska. The test pipeline had a length of 105 m and a diameter of 0.9 m. One-third of the pipeline was located in permafrost and the rest was in non-permafrost. The monitoring data were collected from December 1999 to January 2005 including both freezing and thawing phases. In the transition zone between frozen and unfrozen soil, the foundation experienced a vertical movement caused by differential frost heave. The test results indicated that …

Modeling And Analysis Of Masonry Electro-Thermal Heating And Storage For Optimal Integration With Remote Stand-Alone Wind-Diesel Systems, Maura Eileen Sateriale

Engineering

Due to their remote locations and small populations, many remote villages in Alaska generate electricity with microgrids that employ diesel-electric generators for their primary source of power, and supplement this production with wind turbines. In such communities, it is economically advantageous to minimize fuel consumption by shifting as much of the village's energy demands to the wind system as is feasible. When wind turbines produce in excess of the demand, it is possible to use the excess electricity to power resistance heaters to heat water in tanks or masonry. The heat is then stored so that it can be used …

The Dynamics Of Creating Strong Democracy In Portland, Oregon : 1974 To 2013, Paul Roland Leistner

Dissertations and Theses

Communities across the United States are experiencing a "civic revival" that is reconnecting community members with local decision-making and civic life in their communities. Since the 1980s, academic researchers and local governance reformers have advocated for a shift away from the traditional top-down, expert-driven approach to governance and toward a governance model in which government leaders and staff and community members work as partners to shape the community and make local decisions. Portland, Oregon, since the 1970s, has been known nationally and internationally as a city with a tradition of strong community involvement. Portland's successes and failures offer a valuable …

The Phylogeography And Population Genetic Structure Of Least Cisco (Coregonus Sardinella) In Alaska, Veronica M. Padula

Fisheries

The least cisco (Coregonus sardinella) is a whitefish species broadly distributed across the Arctic regions of Russia, Alaska, and Canada, and little is known about the genetic relationships among groups within this species. We investigated the genetic relationships among least cisco on two landscape scales. On a broader landscape scale, we investigated the relationships among populations across the state of Alaska by comparing mitochondria) DNA (mtDNA) sequences. On a finer landscape scale, we investigated the relationships among least cisco populations in closely located lakes on the Arctic Coastal Plain by comparing microsatellite DNA haplotypes. Data from mtDNA suggest that least …

Creating A Christmas Memory For A Huntington’S Family, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Study Of The Crafting Industry In Croatia: Insight Into Individual, Sara Milic

Theses

This research explores several elements of the Croatian crafting scene; individual motivations of crafters, how the community functions and common business practices. The study is qualitative and part phenomenological, part ethnographic in nature. The main goal was to collect information and data that can act as a foundation for further research. The key methods were in-depth interviews with several Croatian crafters, observation at crafting events and content analysis of online sources and promotional material. The main findings showed that many crafters obtain artistic fulfilment from their art, some turned to crafting out of financial necessity and others were seeking independence. …

Three Dimensional Volcano-Acoustic Source Localization At Karymsky Volcano, Kamchatka, Russia, Colin Rowell

Geosciences

We test two methods of 3-D acoustic source localization on volcanic explosions and small-scale jetting events at Karymsky Volcano, Kamchatka, Russia. Recent infrasound studies have provided evidence that volcanic jets produce low-frequency aerodynamic sound (jet noise) similar to that from man-made jet engines. Man-made jets are known to produce sound through turbulence along the jet axis, but discrimination of sources along the axis of a volcanic jet requires a network of sufficient topographic relief to attain resolution in the vertical dimension. At Karymsky Volcano, the topography of an eroded edifice adjacent to the active cone provided a platform for the …