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2013

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Inhibitory Effect Of Matrine On Blood-Brain Barrier Disruption For The Treatment Of Experimental Autoimmune Encephalomyelitis., Su Zhang, Quan-Cheng Kan, Yuming Xu, Guang-Xian Zhang, Lin Zhu Jan 2013

Inhibitory Effect Of Matrine On Blood-Brain Barrier Disruption For The Treatment Of Experimental Autoimmune Encephalomyelitis., Su Zhang, Quan-Cheng Kan, Yuming Xu, Guang-Xian Zhang, Lin Zhu

Department of Neurology Faculty Papers

Dysfunction of the blood-brain barrier (BBB) is a primary characteristic of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been recently found to suppress clinical EAE and CNS inflammation. However, whether this effect of MAT is through protecting the integrity and function of the BBB is not known. In the present study, we show that MAT treatment had a therapeutic effect comparable to dexamethasone (DEX) in EAE rats, with reduced Evans Blue extravasation, increased expression of collagen IV, the major component of the basement …


An Economic Model To Value Companion Diagnostics In Non-Small-Cell Lung Cancer, Robert D. Lieberthal, Kellie Dudash, Rita S. Axelrod, Neil I. Goldfarb Jan 2013

An Economic Model To Value Companion Diagnostics In Non-Small-Cell Lung Cancer, Robert D. Lieberthal, Kellie Dudash, Rita S. Axelrod, Neil I. Goldfarb

College of Population Health Faculty Papers

Aim: An economic model was used to evaluate the potential economic impact and cost–effectiveness of companion diagnostic testing for patients with non-small-cell lung cancer (NSCLC). Materials & methods: A decision analysis model examined alternative patient management strategies for patients with advanced NSCLC who were not amenable to surgical treatment. A review of the literature provided the variables used to develop a timely base case and sensitivity analysis. A potential future scenario was also modeled. The model includes three options: conventional treatment (CT), new treatment (NT) and companion diagnostic (CD) strategy. Results: In the base case analysis based upon current data, …


What Are The Characteristics That Explain Hospital Quality? A Longitudinal Pridit Approach, Robert D. Lieberthal, Dominique M. Comer Jan 2013

What Are The Characteristics That Explain Hospital Quality? A Longitudinal Pridit Approach, Robert D. Lieberthal, Dominique M. Comer

College of Population Health Faculty Papers

Health outcomes vary substantially between high and low quality institutions, meaning the difference between life and death in some cases. Prior literature has identified a number of variables that can be used to determine hospital quality, but methodologies for combining variables into an overall measure of hospital quality are not well developed. This analysis builds on the prior investigation of hospital quality by evaluating a method originally developed for the detection of healthcare fraud, Pridit, in the context of determining hospital quality. We developed a theoretical model to justify the application of Pridit to the hospital quality setting and then …


Identifying (With) Disability: Using Film To Teach Employment Discrimination, Elizabeth Pendo Jan 2013

Identifying (With) Disability: Using Film To Teach Employment Discrimination, Elizabeth Pendo

All Faculty Scholarship

Building on a prior article about using film to teach health law, this Essay is intended to share my experience using the film Philadelphia as a method of enhancing coverage and discussion of the employment provisions of the Americans with Disabilities Act (ADA), and to provide an opportunity for recognition of, and identification with, the experiences of people with disabilities.


Micro-Symposium On Orin Kerr's 'A Theory Of Law', Laura Appleman, Shawn Bayern, Adam D. Chandler, Robert Cheren, Miriam A. Cherry, Ross E. Davies, Lee Anne Fennell, Paul A. Gowder, Caitlin Hartsell, Kieran Healy, Robert A. James, Jeffrey H. Kahn, Orin S. Kerr, Jacob T. Levy, Jeffrey M. Lipshaw, Orly Lobel, Geoffrey A. Manne, Chad M. Oldfather, Ronak Patel, Jeffrey A. Pojanowski, Alexandra J. Roberts, Kent Scheidegger, Arthur Stock, Anders Walker Jan 2013

Micro-Symposium On Orin Kerr's 'A Theory Of Law', Laura Appleman, Shawn Bayern, Adam D. Chandler, Robert Cheren, Miriam A. Cherry, Ross E. Davies, Lee Anne Fennell, Paul A. Gowder, Caitlin Hartsell, Kieran Healy, Robert A. James, Jeffrey H. Kahn, Orin S. Kerr, Jacob T. Levy, Jeffrey M. Lipshaw, Orly Lobel, Geoffrey A. Manne, Chad M. Oldfather, Ronak Patel, Jeffrey A. Pojanowski, Alexandra J. Roberts, Kent Scheidegger, Arthur Stock, Anders Walker

All Faculty Scholarship

For more than a century, careful readers of the Green Bag have known that “[t]here is nothing sacred in a theory of law...which has outlived its usefulness or which was radically wrong from the beginning...The question is What is the law and what is the true public policy?” Professor Orin Kerr bravely, creatively, and eloquently answered that question in his article, “A Theory of Law,” in the Autumn 2012 issue of the Green Bag. Uniquely among all theories of law that I know of, Kerr’s answer to the fundamental question of law and true public policy enables all scholars to …


Ethical Issues In Faith-Based Ngos: A Cross Cultural Perspective, Annetta M. Gibson, Charles H. Tidwell Jr. Jan 2013

Ethical Issues In Faith-Based Ngos: A Cross Cultural Perspective, Annetta M. Gibson, Charles H. Tidwell Jr.

Andrews University Seminary Studies (AUSS)

No abstract provided.


Martin Luther: Marriage And The Family As A Remedy For Sin, Trevor O'Reggio Jan 2013

Martin Luther: Marriage And The Family As A Remedy For Sin, Trevor O'Reggio

Andrews University Seminary Studies (AUSS)

No abstract provided.


Review Of John H. Walton's Genesis 1 As Ancient Cosmology, Jacques B. Doukhan Jan 2013

Review Of John H. Walton's Genesis 1 As Ancient Cosmology, Jacques B. Doukhan

Andrews University Seminary Studies (AUSS)

No abstract provided.


Celebrating A Century Of Ecumenism: Exploring The Achievements Of International Dialogue [Review] / John A. Radano, Ed., Denis Fortin Jan 2013

Celebrating A Century Of Ecumenism: Exploring The Achievements Of International Dialogue [Review] / John A. Radano, Ed., Denis Fortin

Andrews University Seminary Studies (AUSS)

No abstract provided.


Victorian Religious Revivals: Culture And Piety In Local And Global Contexts. [Review] / David Bebbington, Michael W. Campbell Jan 2013

Victorian Religious Revivals: Culture And Piety In Local And Global Contexts. [Review] / David Bebbington, Michael W. Campbell

Andrews University Seminary Studies (AUSS)

No abstract provided.


Building Below The Waterline [Review] / Gordon Macdonald, Skip Bell Jan 2013

Building Below The Waterline [Review] / Gordon Macdonald, Skip Bell

Andrews University Seminary Studies (AUSS)

No abstract provided.


John Wesley’S Teachings (Vols 1-4) [Review] / Thomas C. Oden, Russell L. Staples Jan 2013

John Wesley’S Teachings (Vols 1-4) [Review] / Thomas C. Oden, Russell L. Staples

Andrews University Seminary Studies (AUSS)

No abstract provided.


Seventh-Day Adventist, Semi-Pelagiansim, And Overlooked Topics In Adventist Soteriology: Moving Beyond Missing Links And Toward A More Explicit Understanding, George R. Knight Jan 2013

Seventh-Day Adventist, Semi-Pelagiansim, And Overlooked Topics In Adventist Soteriology: Moving Beyond Missing Links And Toward A More Explicit Understanding, George R. Knight

Andrews University Seminary Studies (AUSS)

No abstract provided.


And Man Created God: Is God A Human Invention? [Review] / Robert Banks, Ray W. Mcallister Jan 2013

And Man Created God: Is God A Human Invention? [Review] / Robert Banks, Ray W. Mcallister

Andrews University Seminary Studies (AUSS)

No abstract provided.


The Nuts And Bolts Of Church Planting [Review] / Aubrey Malphurs, Tom L. Evans Jan 2013

The Nuts And Bolts Of Church Planting [Review] / Aubrey Malphurs, Tom L. Evans

Andrews University Seminary Studies (AUSS)

No abstract provided.


Women's Ordination, Gender Identity, And The Sabbath, Mathilde Frey Jan 2013

Women's Ordination, Gender Identity, And The Sabbath, Mathilde Frey

Andrews University Seminary Studies (AUSS)

No abstract provided.


Flying Bishops, Women Clergy, And The Processes Of Change In The Anglican Communion, Gilbert M. Valentine Jan 2013

Flying Bishops, Women Clergy, And The Processes Of Change In The Anglican Communion, Gilbert M. Valentine

Andrews University Seminary Studies (AUSS)

No abstract provided.


The Remnant Concept In Early Adventism: From Apocalyptic Antisectarianism To An Eschatological Denominational Ecclesiology, Stefan Höschele Jan 2013

The Remnant Concept In Early Adventism: From Apocalyptic Antisectarianism To An Eschatological Denominational Ecclesiology, Stefan Höschele

Andrews University Seminary Studies (AUSS)

No abstract provided.


Denomination: Assessing An Ecclesiological Category [Review] / Paul M. Collins And Barry Ensign-George, Eds., Stefan Höschele Jan 2013

Denomination: Assessing An Ecclesiological Category [Review] / Paul M. Collins And Barry Ensign-George, Eds., Stefan Höschele

Andrews University Seminary Studies (AUSS)

No abstract provided.


Preaching Christ From Daniel [Review] / Sidney Greidanus, Zdravko Stefanovic Jan 2013

Preaching Christ From Daniel [Review] / Sidney Greidanus, Zdravko Stefanovic

Andrews University Seminary Studies (AUSS)

No abstract provided.


Half The Sky: Turning Oppression Into Opportunity For Women Worldwide [Review] / Nicholas D. Kristof, Leanne M. Sigvartsen Jan 2013

Half The Sky: Turning Oppression Into Opportunity For Women Worldwide [Review] / Nicholas D. Kristof, Leanne M. Sigvartsen

Andrews University Seminary Studies (AUSS)

No abstract provided.


Logos Bible Software Version 5: Platinum Collection [Review] / Logos Bible Software, Eike Müller Jan 2013

Logos Bible Software Version 5: Platinum Collection [Review] / Logos Bible Software, Eike Müller

Andrews University Seminary Studies (AUSS)

No abstract provided.


Contextualization In World Missions: Mapping And Assessing Evangelical Models [Review] / A. Scott Moreau, Bruce Campbell Moyer Jan 2013

Contextualization In World Missions: Mapping And Assessing Evangelical Models [Review] / A. Scott Moreau, Bruce Campbell Moyer

Andrews University Seminary Studies (AUSS)

No abstract provided.