Digital Commons Network^™

A Realist Review Of Interventions And Strategies To Promote Evidence-Informed Healthcare: A Focus On Change Agency, Brendan Mccormack, Joanne Rycroft-Malone, Kara Decorby, Alison M. Hutchinson, Tracey Bucknall, Bridie Kent, Alyce Schultz, Erna Snelgrove-Clarke, Cheyl Stetler, Marita Titler, Lars Wallin, Valerie Wilson

School of Nursing and Midwifery

No abstract provided.

Unbreakable Vows: Same-Sex Marriage And The Fundamental Right To Divorce, Meg Penrose

Faculty Scholarship

This Article considers whether there is a fundamental constitutional right, through the liberty component of substantive due process, to divorce. This right to divorce becomes particularly important for same-sex couples whose marital rights are incomplete, at best. Surely, if divorce were outlawed by any state, the masses would rise up against such tyranny with cries that divorce must be constitutionally protected. But place divorce in the context of same-sex marriage and the response is predictably more tepid. “Those” marriages are not legal anyway, so what harm is there in excluding them from divorce? States that refuse to recognize same-sex marriage, …

Judicial Roles In Nonjudicial Functions, Nuno Garoupa, Tom Ginsburg

Faculty Scholarship

Judges perform nonjudicial functions in many contexts. Most jurisdictions regulate these functions in multiple ways, by statute and by custom. We provide a theory of judicial demand and judicial supply for nonjudicial functions. By teasing out the determinants of judicial involvement in nonjudicial functions, we show the potential market failures and the need for regulation. We suggest that some limitations on the judicial exercise of nonjudicial functions seem justified. However, these limits might vary across jurisdictions depending on institutional and contextual factors.

The Future Of Energy: The European And American Approaches -- The American Approach, Gina S. Warren

Faculty Scholarship

Presentation by Professor Gina S. Warren in which she provides an idea of the energy mix in the United States, where energy comes from, and what it is used for. Professor Warren then discusses U.S. energy policy and climate change proposals. She also covers numbers and indicators from an April 17, 2013 U.S. Department of Energy (“DOE”) report outlining projections in energy through 2040.

Gender Differences In Attitudes Impeding Colorectal Cancer Screening., Paul Ritvo, Ronald E. Myers, Lawrence Paszat, Mardie Serenity, Daniel F Perez, Linda Rabeneck

Department of Medical Oncology Faculty Papers

BACKGROUND: Colorectal cancer screening (CRCS) is the only type of cancer screening where both genders reduce risks by similar proportions with identical procedures. It is an important context for examining gender differences in disease-prevention, as CRCS significantly reduces mortality via early detection and prevention. In efforts to increase screening adherence, there is increasing acknowledgment that obstructive attitudes prevent CRCS uptake. Precise identification of the gender differences in obstructive attitudes is necessary to improve uptake promotion. This study randomly sampled unscreened, screening - eligible individuals in Ontario, employing semi-structured interviews to elicit key differences in attitudinal obstructions towards colorectal cancer screening …

Presence Of Anaplastic Lymphoma Kinase In Inflammatory Breast Cancer., Fredika M Robertson, Emanuel F Petricoin Iii, Steven J Van Laere, Francois Bertucci, Khoi Chu, Sandra V Fernandez, Zhaomei Mu, Katherine Alpaugh, Jianming Pei, Rita Circo, Julia Wulfkuhle, Zaiming Ye, Kimberly M Boley, Hui Liu, Ricardo Moraes, Xuejun Zhang, Ruggero Demaria, Sanford H Barsky, Guoxian Sun, Massimo Cristofanilli

Department of Medical Oncology Faculty Papers

Although Inflammatory Breast Cancer (IBC) is recognized as the most metastatic variant of locally advanced breast cancer, the molecular basis for the distinct clinical presentation and accelerated program of metastasis of IBC is unknown. Reverse phase protein arrays revealed activation of the receptor tyrosine kinase, anaplastic lymphoma kinase (ALK) and biochemically-linked downstream signaling molecules including JAK1/STAT3, AKT, mTor, PDK1, and AMPKβ in pre-clinical models of IBC. To evaluate the clinical relevance of ALK in IBC, analysis of 25 IBC patient tumors using the FDA approved diagnostic test for ALK genetic abnormalities was performed. These studies revealed that 20/25 (80%) had …

Dysregulated Methylation At Imprinted Genes In Prostate Tumor Tissue Detected By Methylation Microarray., Daniel I Jacobs, Yingying Mao, Alan Fu, William Kevin Kelly, Yong Zhu

Department of Medical Oncology Faculty Papers

BACKGROUND: Imprinting is an important epigenetic regulator of gene expression that is often disrupted in cancer. While loss of imprinting (LOI) has been reported for two genes in prostate cancer (IGF2 and TFPI2), disease-related changes in methylation across all imprinted gene regions has not been investigated.

METHODS: Using an Illumina Infinium Methylation Assay, we analyzed methylation of 396 CpG sites in the promoter regions of 56 genes in a pooled sample of 12 pairs of prostate tumor and adjacent normal tissue. Selected LOI identified from the array was validated using the Sequenom EpiTYPER assay for individual samples and further confirmed …

Ezh2 Knockdown Suppresses The Growth And Invasion Of Human Inflammatory Breast Cancer Cells., Zhaomei Mu, Hua Li, Sandra V Fernandez, Katherine R Alpaugh, Rugang Zhang, Massimo Cristofanilli

Department of Medical Oncology Faculty Papers

INTRODUCTION: Inflammatory breast cancer (IBC) is the most metastatic variant of breast cancer with the poorest survival in all types of breast cancer patients and presently therapeutic targets for IBC are very limited. Enhancer of zeste homolog 2 (EZH2) is frequently expressed in human IBC and its expression positively correlates with worse clinical outcome. However, the molecular basis for EZH2 promoting IBC has not been explored. Here, we investigated the functional role of EZH2 in IBC cells by examining the effects of its knockdown on the formation of tumor spheroids and invasion of these cells in vitro and in vivo …

Infective Endocarditis Epidemiology Over Five Decades: A Systematic Review., Leandro Slipczuk, J Nicolas Codolosa, Carlos D Davila, Abel Romero-Corral, Jeong Yun, Gregg S. Pressman, Vincent M. Figueredo

Division of Cardiology Faculty Papers

AIMS: To Assess changes in infective endocarditis (IE) epidemiology over the last 5 decades.

METHODS AND RESULTS: We searched the published literature using PubMed, MEDLINE, and EMBASE from inception until December 2011.

DATA FROM: Einstein Medical Center, Philadelphia, PA were also included. Criteria for inclusion in this systematic review included studies with reported IE microbiology, IE definition, description of population studied, and time frame. Two authors independently extracted data and assessed manuscript quality. One hundred sixty studies (27,083 patients) met inclusion criteria. Among hospital-based studies (n=142; 23,606 patients) staphylococcal IE percentage increased over time, with coagulase-negative staphylococcus (CNS) increasing over …

Using A Soc 1sm Report In A Financial Statement Audit; Practice Aid Series, American Institute Of Certified Public Accountants (Aicpa)

Guides, Handbooks and Manuals

No abstract provided.

Assessing And Responding To Audit Risk : International Auditing Standards, American Institute Of Certified Public Accountants (Aicpa)

Guides, Handbooks and Manuals

No abstract provided.

Cpa’S Guide To Social Security Planning, American Institute Of Certified Public Accountants. Personal Financial Planning Section

Guides, Handbooks and Manuals

No abstract provided.

Communications : Methods And Applications For Financial Managers, James Carberry

Guides, Handbooks and Manuals

No abstract provided.

Related-Party Audit Considerations : A Case Study Approach; Aicpa Practice Aid Series, American Institute Of Certified Public Accountants (Aicpa)

Guides, Handbooks and Manuals

No abstract provided.

Using A Soc 1sm Report In Audits Of Employee Benefit Plans; Aicpa Practice Aid Series, American Institute Of Certified Public Accountants (Aicpa)

Guides, Handbooks and Manuals

No abstract provided.

Overachiever's Guide To Getting Unstuck : Replan, Reprioritize, Reaffirm, William L. Reeb

Guides, Handbooks and Manuals

No abstract provided.

Cpa’S Guide To Technology In A Pfp Practice, Joel Bruckenstein

Guides, Handbooks and Manuals

No abstract provided.

Accounting Changes : Chronicles Of Convergence, Crisis, And Complexity In Financial Reporting, Robert H. Herz

Guides, Handbooks and Manuals

No abstract provided.

Icipe’S Results Based Management Framework 2011–2013, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Results Based Management Framework

No abstract provided.

Aicpa Annual Report 2012-13: Looking Forward. Reaching Out. Giving Back, American Institute Of Certified Public Accountants (Aicpa)

AICPA Annual Reports

No abstract provided.

Role Of Ultrasound In Characterization Of Ovarian Masses, Saima Hafeez, Saira Sufian, Quratulain Merchant, Yasir Jamil, Imrana Masroor

Department of Radiology

Background: Ovarian cancer is the second most common malignancy in Pakistani women, accounting for 4% of all cancers in the female population. The aim of this study was to determine sensitivity, specificity, positive and negative predictive values and 95% confidence intervals for ultrasound in characterization of ovarian masses in patients presenting at public and private tertiary care hospitals in Karachi, Pakistan.MATERIALS AND Methods: We adopted a cross-sectional analytical study design to retrospectively collect data from January 2009-11 from medical records of two tertiary care hospitals. Using a non-probability purposive sampling technique, we recruited a sample of 86 women aged between …

Quadricuspid Aortic Valve With Aortic Regurgitation: A Rare Echocardiographic Finding., Javed Tai, Abid Laghari, Cyrus Tariq Gill

Department of Medicine

We report on a middle-aged woman treated for chronic hepatitis C virus infection with pegylated interferon. Auscultation revealed a diastolic murmur and the peripheral signs of aortic regurgitation. She had shortness of breath on moderate exertion for the past 4 months, which she attributed to her liver disease. Echocardiogram showed a quadricuspid aortic valve with severe aortic regurgitation. She was referred to a cardiothoracic surgeon for aortic valve replacement (AVR). However, she decided against AVR despite detailed counselling, and opted for medical treatment.

Full Issue, Neutrosophic Sets And Systems

Neutrosophic Sets and Systems

No abstract provided.

Communication Vs. Information: An Axiomatic Neutrosophic Solution, Florentin Smarandache, Stefan Vladutescu

Neutrosophic Sets and Systems

No abstract provided.

Part 5: Asian Indians In Hampton Roads, Regional Studies Institute, Old Dominion University

State of the Region Reports: Hampton Roads

This “model” minority group in our region has attained significant economic success and civic influence.

Part 6: Virtual Education At The K-12 Level In Hampton Roads, Regional Studies Institute, Old Dominion University

State of the Region Reports: Hampton Roads

Online education in our region is growing rapidly in a laissez-faire manner that exhibits little accountability.

Foreword: The State Of The Republican Form Of Government In Montana, Anthony Johnstone

Faculty Law Review Articles

This foreword to the 2012 Browning Symposium contributes to the discussion of republican forms of government in the states by situating Montana's experience in broader themes of federal intervention in state republicanism. It serves as an epilogue to match Jeff Wiltse's prologue, which reexamines the election in 1912 that gave birth to the Corrupt Practices Act by examining the aftermath of the U.S. Supreme Court's burial of that law 100 years later.

Part I of the foreword considers the recent federal constitutional challenges that dismantled elements of the republican form of government that prevailed in Montana for the past century. …

Hitching Our Wagon To A Dim Star: Why Outmoded Water Codes And "Public Interest" Review Cannot Protect The Public Trust In Western Water Law, Michelle Bryan Mudd

Faculty Law Review Articles

This article examines the interrelationship between the public trust and water rights as it is emerging in western states.

Part I of this article describes the traditional public trust principles that apply to waters, as well as the modern judicial trend of extending those principles to water use permitting in the West.

Focusing on an area of particular concern in water codes, Part II analyzes the risky implications of supplanting the public trust doctrine with existing public interest review provisions.

Finally, Part III advances a water use permitting framework that better fulfills the states' public trust responsibilities. Drawing on the …

Foreword To When A Woman Campaigns: Emily Sloan's Races To Become Montana's First Female County Attorney, Bari R. Burke

Faculty Law Review Articles

This essay introduces Emily Sloan and her races to become Montana's first female county attorney.

Family Mediation After Hendershott: The Case For Uniform Domestic Violence Screening And Opt-In Provision In Montana, Eduardo R.C. Capulong

Faculty Law Review Articles

In Hendershott v. Westphal, the Montana Supreme Court held that § 40-4-301(2) of the Montana Code Annotated absolutely bars mediation in family law cases involving domestic violence. Yet neither the Court nor the statute prescribes a method by which to screen for such cases. In this article, the author argues that a uniform, statewide screening method is the only way by which to implement this policy. The author also argues that Hendershott should be interpreted narrowly and Montana should allow parties to opt in to mediation and other forms of alternative dispute resolution. The Court's understanding of domestic violence …