Digital Commons Network^™

Novel Therapeutic Targets Identified By High-Throughput Technologies For Triple-Negative Breast Cancer, Christine Shiang

Dissertations and Theses (Open Access)

Triple-negative breast cancers (TNBC) are characterized by the lack of or reduced expression of the estrogen and progesterone receptors, and normal expression of the human epidermal growth factor receptor 2. The lack of a well-characterized target for treatment leaves only systemic chemotherapy as the mainstay of treatment. Approximately 60-70% of patients are chemosensitive, while the remaining majority does not respond. Targeted therapies that take advantage of the unique molecular perturbations found in triple-negative breast cancer are needed. The genes that are frequently amplified or overexpressed represent potential therapeutic targets for triple-negative breast cancer. The purpose of this study was to …

Interaction Between Brk And Her2 In Breast Cancer, Midan Ai

Dissertations and Theses (Open Access)

INTERACTION BETWEEN BRK AND HER2 IN BREAST CANCER

Midan Ai, Ph.D.

Supervisory Professor: Zhen Fan, M.D.

Breast tumor kinase (Brk) is a nonreceptor protein-tyrosine kinase that is highly expressed in approximately two thirds of breast cancers but is not detectable or is expressed at very low levels in normal mammary epithelium. Brk plays important roles in promoting proliferation, survival, invasion, and metastasis of breast cancer cells, but the mechanism(s) of which remain largely unknown. Recent studies showed that Brk is frequently co-overexpressed with human epidermal growth factor receptor-2 (HER2) and is physically associated with HER2 in breast cancer. The mechanism …

Acceleration Of The Panin Development In Mice Expressing Oncogenic K-Ras Due To A High Fat Diet, Bincy Philip

Dissertations and Theses (Open Access)

Obesity is postulated to be one of the major risk factors for pancreatic cancer, and recently it was indicated that an elevated body mass index (BMI correlates strongly with a decrease in patient survival. Despite the evident relationship, the molecular mechanisms involved are unclear. Oncogenic mutation of K-Ras is found early and is universal in pancreatic cancer. Extensive evidence indicates oncogenic K-Ras is not entirely active and it requires a triggering event to surpass the activity of Ras beyond the threshold necessary for a Ras-inflammation feed-forward loop. We hypothesize that high fat intake induces a persistent low level inflammatory response …

The Fungal Pathogen Aspergillus Fumigatus Regulates Growth, Metabolism, And Stress Resistance In Response To Light, Kevin K. Fuller, Carol S. Ringelberg, Jennifer J. Loros, Jay C. Dunlap

Dartmouth Scholarship

Light is a pervasive environmental factor that regulates development, stress resistance, and even virulence in numerous fungal species. Though much research has focused on signaling pathways in Aspergillus fumigatus, an understanding of how this pathogen responds to light is lacking. In this report, we demonstrate that the fungus does indeed respond to both blue and red portions of the visible spectrum. Included in the A. fumigatus light response is a reduction in conidial germination rates, increased hyphal pigmentation, enhanced resistance to acute ultraviolet and oxidative stresses, and an increased susceptibility to cell wall perturbation. By performing gene deletion analyses, we …

Food Handling, Hygiene, And Sanitation Practices In The Child-Care Environment In North Carolina And South Carolina, Xi Chen

All Theses

Introduction: Children between the ages of 37 and 54 months enrolled in child-care facilities (CCFs) are reported to be 2.3 to 3.5 times more likely to experience an acute gastrointestinal illness (AGI) than are children cared for in their own home. Identifying potential risk factors for the transmission of enteric pathogens in CCFs is essential to the prevention of AGI.
Methods: A convenience sample of CCFs in North Carolina and South Carolina was recruited to participate in this study. A survey was administered to all CCF directors to collect information about facility characteristics, meal preparation, staff training, hygiene policies and …

A New Clinical Model For Primary Care: A Critical Component Of Healthcare Innovation Zones, Judith Crews

All Theses

The overall aim of this research and design project is to develop a primary care setting that responds to the current changes in the healthcare system and accommodates predicted developments in the future. It takes advantage of opportunities created by the Affordable Care Act and initiatives started under the new Center for Medicare and Medicaid Innovation. One of these includes the creation of Healthcare Innovation Zones as a way to bring integrative, comprehensive health services to a wider population through the network of a teaching hospital, physicians, and other clinical entities. The proposed ambulatory care setting is a model for …

Cultivating America's Working Lands: A Study Of The Sociocultural Value Of Family Farms, Katherine Lloyd

All Theses

Our ability to produce food in a sustainable, healthy and humane manner is threatened, both in the United States and on the global scale. This difficulty is exacerbated by expected population growth, creating a need for 60% more food worldwide by 2050 to feed a population of 9.3 billion (United Nations Chronicle, 2012). How we produce food affects local economies, the cultural vitality of communities, and the health of regional ecosystems. Industrial or conventional agriculture is damaging all three of these systems, by draining local economies through corporate business practices, isolating farmers and attributing to rural population losses, while depleting …

Exploring Doctoral Student Experiences From The Perspectives Of Mid-Career Professionals In Educational Leadership Using Photo-Elicitation, Kenyae L. Reese

All Dissertations

Recent literature cites a growing population of students who wait several years post-baccalaureate and into their careers before entering a PhD program. Such population includes doctoral students in education. Despite repeated calls from scholars of higher education, few empirical studies investigate mid-career students’ experiences in doctoral programs. Existing literature consists of anecdotal reports, demographic accounts in which mid-career is a data point among many variables, or empirical studies of international students. Theoretical models describing student experiences of mid-career professionals in doctoral programs are particularly absent. A handful of studies have explored doctoral student experiences of mid-career professionals through traditional interviewing …

Analysis Of The Interaction Of Francisella Tularensis Lvs And Legionella Pneumophila Biofilms With Components Of The Aquatic Environment, Uma Mahajan

All Dissertations

Biofilms are complex communities of organisms enclosed in a matrix (EPS) composed of polysaccharides, proteins and DNA. Biofilms are the base of the aquatic ecosystem and interact with the biotic as well as the abiotic components in the environment. Biofilms interact with biotic components of the environment such as protozoa and aquatic invertebrates. In this project, the biotic interactions of Francisella tularensis LVS biofilms are studied in relation to the mosquito larvae of Culex quinquefasciatus. F. tularensis is the causative agent of tularemia and is transmitted by ticks, deer flies, and mosquitoes. Mosquitoes are believed to play a role in …

Small Interfering Rna-Mediated Translation Repression Alters Ribosome Sensitivity To Inhibition By Cycloheximide In Chlamydomonas Reinhardtii, Xinrong Ma

School of Biological Sciences: Dissertations, Theses, and Student Research

RNA interference (RNAi) is an evolutionarily conserved gene silencing mechanism in eukaryotes, with regulatory roles in a variety of biological processes, including cell cycle, cell differentiation, physiological and metabolic pathways, and stress responses. RNAi can function by transcriptional silencing, mRNA target cleavage, translation repression and/or DNA elimination. In this study, we used the unicellular green alga Chlamydomonas reinhardtii as a model system to study RNAi-mediated translation repression. We demonstrated that small RNAs (sRNAs) generated from exogenously introduced inverted repeat transgenes, with perfect complementarity to the 3’UTR of a target transcript, can inhibit protein synthesis, without or with only minimal mRNA …

Nebraska Chapter Gamma Sigma Delta Newsletter Issue #46 Spring 2013

Gamma Sigma Delta, Nebraska Chapter: Newsletters

• President's message
• Upcoming events
• Welcome new members
• Gamma Sigma Delta award recipients: Elizabeth Birnstihl, Galen Erickson, Madhavan Soundararajan, Jennifer Rees, Rachel Coburn, Josiah Dallmann, Aruna Gangaplara
• In memoriam: Oliver Davies Grace, C. Dean Yonts
• Committees 2013
• Outstanding graduate student award fund
• Renewal of membership dues for 2013

May 2013 Commencement Program, Bowling Green State University

Commencement Programs

No abstract provided.

An Exploratory Study Of College Students’ Dietary Choices Relative To Independence, Emily Raines

Theses, Dissertations and Culminating Projects

The college years have been acknowledged as a time of emerging adulthood, during which students develop habits and make choices that endure long into their future (Arnett, 2000). To date, limited research exists that examines the college population, particularly in relation to diet. The purpose of this study is to explore the dietary choices college students make as they transition from the home and develop autonomy and to help fill the gap in literature. Four focus groups were organized (n=24) to reveal themes intrinsic to the development of dietary habits during the on-campus experience. The focus groups were recorded with …

Public Health Aspects Of The Daugherty Water For Food Institute Strategic Plan, Eleanor G. Rogan, Bruce Grogan, Terry Huang, Alan Kolok, Risto Rautiainen, Oscar Araz, Christopher Fisher, Andrew Jameton, Ashish Joshi, Sharon Meaker-Medcalf, Jim P. Stimpson, Melissa Tibbits

Reports: College of Public Health

The University of Nebraska College of Public Health is committed to contributing to the research, service and education programs of the Daugherty Water for Food Institute. The College can offer a wide variety of expertise that can contribute to programs related to water, food and health. This document has been written to highlight the areas in which College faculty have particular interests, knowledge and experience to contribute.

Getting Help When Needed: Food Insecurity Among College Students And The Impact Of Food Pantry Availability, Jasmine Loftin

HIM 1990-2015

Although studies on food insecurity among low-income families and children are prevalent, it's rare to come upon a study specifically measuring food insecurities among college students. There are limited accesses for students to government assistance such as food stamps because of their "dependency" on their parents. Although, on paper, the student may still be a dependent, there are a myriad of instances where they are unable to receive monetary help from their parents for different circumstances. My current study is examining an understudied population of college students who use the Knights Helping Knights pantry. The Knights Helping Knights pantry is …

Journal Of Sociology & Social Welfare Vol. 40, No. 2 (June 2013)

The Journal of Sociology & Social Welfare

TABLE OF CONTENTS

• A HALF-CENTURY OF CALIFORNIA POVERTY - Robert G. Mogull
• THE POTENTIAL OF YOUTH SAVINGS ACCOUNTS IN THREE EAST AFRICAN COUNTRIES: KENYA, TANZANIA, AND UGANDA - Njeri Kagotho, Proscovia Nabunya, Fred Ssewamala, and Vilma Ilic
• THE MASARYKS OF CZECHOSLOVAKIA: CONTRIBUTIONS IN SOCIOLOGY, SOCIAL WELFARE AND POLITICS - Rebecca L. Hegar
• SWEDEN'S PARENTAL LEAVE INSURANCE: A POLICY ANALYSIS OF STRATEGIES TO INCREASE GENDER EQUALITY - Juliana Carlson
• REMARITAL CHANCES, CHOICES, AND ECONOMIC CONSEQUENCES: ISSUES OF SOCIAL AND PERSONAL WELFARE - Kevin Shafer and Todd M. Jensen
• BLACK WOMEN IN THE "BLACK METROPOLIS" OF THE EARLY TWENTIETH CENTURY: THE CASE …

Recombination And Screening Of Putative Grapefruit Glucosyltransferase 4 Expressed In Pichia Pastoris., Peri Loftis

Undergraduate Honors Theses

Flavonoids are a group of plant secondary metabolites that are vital to the cell systems of plants. The intake of these chemicals is advantageous to animals for their antioxidant properties that affect the function of immune and inflammatory cells. The bitter taste of grapefruit (Citrus paradisi) and other citrus species is caused by the accumulation of glycosylated flavonoids. Glucosyltransferases (GTs) are enzymes that add glucose moieties to a carbon or hydroxyl group of natural products. The function of a putative secondary product GT clone was tested. In previous research, putative GT 4 was cloned into a pCD1 modified …

The Study Of The Effect Of Two Flavone Isomers Derived From Gnaphalium Elegans And Achyrocline Bogotensis In Breast Cancer., Jessica J. Walker

Undergraduate Honors Theses

Flavonoids are ubiquitous to all terrestrial plants and many are known to have anti-tumor activities. In this research project we studied the differential cytotoxic effects of two flavone isomers on human breast cancer cells (BT-474, SKBR-3, and MCF-7) and normal breast cells as a control (MCF-10A). The basis of the relationships between chemical structures, type and position of substituent groups and the effects these compounds exert specifically on cancer cells are not completely elucidated. These flavones are derived from plants native of Colombia, South America. These plants of the family Asteraceae, genera Gnaphalium and Achyrocline are reputed to have anti-cancer …

Cinemeducation: Teaching Family Assessment Skills Using Full-Length Movies, Astrid H. Wilson, Barbara J. Blake, Gloria A. Taylor, Glenda Hannings

Faculty Articles

A thorough family assessment provides a foundation for the nursing process when working with families. Therefore, nurses, along with other health care providers must develop expertise in conducting family assessments to provide the best possible care within the community. This article describes an innovative educational strategy using movies to teach family assessment skills and puts forth recommendations for future research to provide evidence to support this teaching modality.

Body Condition Score Description Of Cattle, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

Spectrum, Volume 30, Issue 20, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Sacred Heart Relays to Help Fight Cancer -- Mr. SHU participants ready to take the stage -- Seniors prepare for life post-graduation -- Students hit the gym to create the perfect summer bod -- Editorials -- National Volunteer Week -- Sacred Heart introduces new dance company

Novel Method For Sequential Batch Recovery Of Biomass From A Helical Photobioreactor, Matthew Hurst

Chemical Engineering Undergraduate Honors Theses

This study developed and evaluated a novel method to recover the microalgae species Arthrospira platensis from a closed helical photo bioreactor system. A recovery apparatus was designed and shown to increase recovery by 40% via periodic online recovery runs during exponential growth phase of biomass. Considerations for the apparatus design included the low shear tolerance of the algae and the necessity for a closed system in order to monitor CO2 consumption. The recovery method draws on methods used for large scale recovery as reported in literature by Vonshak and Shimmatsu [1], [2]. This work seeks to improve reactor biomass yield …

Behavioral Feeding Intervention In Children, Richard Liou

Research Papers

No abstract provided.

Pink And Dude Chefs: A Nutrition And Culinary Intervention For Middle School Students, Tianna R. Sheehan

Master's Theses

Pink and Dude Chefs: A nutrition and culinary intervention for middle school students

Tianna Sheehan

The prevalence of obesity in US adolescents has more than tripled in the past 35 years, and the greatest impact has been among low-income and minority racial/ethnic populations. Adolescents report inadequate fruit and vegetable intake, an overconsumption of sweetened beverages, and a high reliance on fast food locations for meals or snacks; increasing the risk of adolescent obesity. Building knowledge and skills through culinary interventions may empower middle school students to create and also choose healthful foods.

Pink and Dude Chefs, a six-week nutrition and …

Determinants Of Food Insecurity Among Vulnerable White And Latino Households: Contextualizing The Impact Of Sociodemographic And Household-Level Factors, Alexandra Lund

Master's Theses

Household-level characteristics have been shown to be associated with food insecurity but studies among vulnerable populations are sparse. A food security assessment was developed to determine food security and collect sociodemographic and household level data across San Luis Obispo County. The assessments were administered to vulnerable groups through interviews at multiple sites across the County. Three household characteristics (marital status, number of children in the household and number of workers in the household) were examined in this analysis. A total of 808 surveys were collected, 69% in English and 31% in Spanish. Through ethnicity-stratified sequentially adjusted logistic regression models, the …

Parenting Nutrition Skills Workshop: An Evaluation Of Facilitated Group Discussions To Enhance Parenting Nutrition Self Efficacy, Lisa A. Dawes

Master's Theses

Abstract

Parenting Nutrition Skills Workshops: An Evaluation of Facilitated Group Discussions to Enhance Parenting Nutrition Self-Efficacy

By: Lisa Dawes, RD, CDE

This research study was conducted to determine the effectiveness of using facilitated group discussion (FGD), a less traditional method of nutrition education, for increasing parents’ feelings of self-efficacy in their ability to make nutrition-related decisions, and to set and enforce nutrition-related boundaries with their children.

Childhood obesity is on the rise; poor food choices, portion control, and inactivity are identified as contributing causes. Parents play a major role in creating healthy habits and providing a well-balanced diet for their …

Variations In Phenotypic Plasticity And Fluctuating Asymmetry Of Leaf Morphology Of Three Quercus (Oak) Species In Response To Environmental Factors, Joseph Kusi

Electronic Theses and Dissertations

Leaf morphology of Quercus (oak) species is highly variable and complicated confounded with phenotypic plasticity and fluctuating asymmetry (FA). However, the study of variation is mostly limited to leaf morphology. This study was extended to plasticity and FA variations in Q. alba (white oak), Q. palustris (pin oak), and Q. velutina (black oak). It was hypothesized that light exposure, individual trees, leaf position, and other leaf traits will influence variation in these species. Leaves were sampled from trees of these species and their morphological traits were measured. Absolute asymmetry of leaf width and area were determined and plasticity of each …

Genetic Diversity Of Seed Dormancy And Molecular Evolution Of Weedy Red Rice, Te Ming Tseng

Graduate Theses and Dissertations

Rice is the grain with the third-highest global production. In the US, Arkansas is the largest rice producing state; however, an estimated 62% of the rice fields in the state are infested with red rice, and can cause up to 80% yield reduction in rice. Among its weedy traits, seed dormancy plays an important role in its persistence, and helps red rice escape weed management techniques thereby increasing the red rice soil seedbank. Red rice also has the potential to hybridize among themselves and with cultivated rice, thus resulting in diverse phenotypes and genotypes. In this study we measured variation …

(Wp 2013-05) Future Implications Of Debt And Deleveraging In The United States Economy, Abdur Chowdhury, Patrick Brown

Economics Working Papers

This paper will take a broad based approach in analyzing the structure of the U.S. economy with a particular emphasis on the disruptive U.S. recession and financial crisis which began circa 2008. The role of the U.S. government and the implications high levels of fiscal debt have on the projected growth path of the U.S. economy will be the primary focus of the paper. The discussion will show that the U.S. has likely entered a new, much more difficult stage in its history of economic growth. The short to medium term growth potential of the U.S. economy has fallen below …

Fatty Acid Induced Insulin Resistance In The Brain, Hyoung Il Oh

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The prevalence of obesity is rapidly increasing; it is now one of the most serious public health problems worldwide. Obesity is thought to reflect the interaction between genetics and modern life style. In particular, high fat diets (HFD) are considered as a major contributing factor to the development of obesity and type 2 diabetes as well as other metabolic disorders such as cardiovascular disease, Alzheimer’s disease and some types of cancer. Recently, it has been suggested that insulin actions in the brain are important in the regulation of energy homeostasis and peripheral metabolism.

With the support of USTAR (The Utah …