Digital Commons Network^™

Formulation Devlopment Of Mesoporous Silica Nanoparticles As An Injectable Delivery System, Amit S. Wani

Wayne State University Dissertations

Our long term goal is to develop a versatile and robust injectable carrier based on Mesoporous Silica Nanoparticles (MSN) for drug/drug combination therapies. The objective of my dissertation was to optimize surface functionality, particle shape and methods of colloidal stabilization of mesoporous silica by PEG for delivery of drug/drug combinations. This was achieved by pursuing the following three aims:

1. Optimize surface functionality of MSN for high drug loading and controlled release

2. Investigate the effect of particle shape and PEGylation on drug delivery in hypoxic tumor cells

3. Develop MSN capable of delivering drug/drug combinations

To investigate the effect …

"I Can't Just Turn Over My Daughter And Let It Be": Black Mothers And The Racial Socialization Of Their Daughters Attending White Schools, Chasity Bailey-Fakhoury

Wayne State University Dissertations

"I CAN'T JUST TURN OVER MY DAUGHTER AND LET IT BE":

BLACK MOTHERS AND THE RACIAL SOCIALIZATION OF THEIR DAUGHTERS ATTENDING WHITE SCHOOLS

by

CHASITY YASHICA BAILEY-FAKHOURY

August 2013

Advisor: Dr. Heather E. Dillaway

Major: Sociology

Degree: Doctor of Philosophy

Studies of parental racial socialization and racial identity development have tended to focus on urban, lower-income African American parents and their adolescent or early adulthood children. Findings emanating from these studies are then extrapolated to all African Americans. Disregarding within group differences produces gaps in our knowledge. This mixed-methods study pushes the research further by investigating the approaches suburban, middle-class …

Pulsed Line Source Response Of A Thin Sheet With High-Contrast Dielectric And Conductive Properties - A Time-Domain Analysis, Adrianus T. De Hoop, Ling Ling Meng, Li (Lijun) Jun Jiang

Electrical and Computer Engineering Faculty Research & Creative Works

A methodology is presented for analytically modeling the reflection and transmission of line-source excited pulsed electromagnetic fields at a thin, planar layer with high-contrast dielectric and conductive properties. Closed-form analytic time-domain expressions are derived for the field components in a 2-D setting via an extension of the Cagniard-DeHoop method. The response to the power exponential source and the power exponential monocycle pulse were studied using the newly proposed method. © 2013 IEEE.

Finite-Width Feed And Load Models, Yat Hei Lo, Li (Lijun) Jun Jiang, Weng Cho Chew

Electrical and Computer Engineering Faculty Research & Creative Works

We demonstrate a new method of applying the feed model for the method of moments (MoM) formulation for the electric field integral equation (EFIE). The model is based around a previously reported magnetic ribbon current model which is accurate and allows for a finite width of the feed port. However, with proper approximations, one can reduce the formulation such that the magnetic field operator can be removed in order to simplify computations arising from the curl of the dyadic Green's function and its singularities. We show here that the new feed model can also be used to model a lumped …

Discussion Of Christine C. Shepard, Vera N. Agostini, Ben Gilmer, Tashya Allen, Jeff Stone, William Brooks And Michael W. Beck. Reply: Evaluating Alternative Future Sea-Level Rise Scenarios, Natural Hazards, 2012 Doi:10.1007/S11069-012-0160-2, A. Boretti

Mechanical and Aerospace Engineering Faculty Research & Creative Works

No abstract provided.

Energy And Spectral Efficient Transmissions Of Coded Arq Systems, Jingxian Wu, Gang Wang, Yahong Rosa Zheng

Electrical and Computer Engineering Faculty Research & Creative Works

Energy efficiency (EE) and spectral efficiency (SE) feature one of the most fundamental tradeoffs in communication systems. In this paper, we propose an optimum transmission scheme for coded Type-I automatic repeat request (ARQ) systems to balance the EE-SE tradeoff. The optimization is performed with respect to a new design metric, the normalized EE (NEE), which is defined as the energy per bit normalized by the SE. Minimizing NEE means either reducing the energy per bit or increasing the SE, it thus yields a balanced tradeoff between the two. The system design incorporates a wide range of practical system parameters, such …

Single-Stranded Dna Scanning And Deamination With Single-Molecule Resolution, Padhuk Gamarala Senavirathne

Wayne State University Dissertations

SINGLE-STRANDED DNA SCANNING AND DEAMINATION WITH SINGLE-MOLECULE RESOLUTION

by

GAYAN SENAVIRATHNE

December 2013

Advisor: Dr. David Rueda & Dr.Ashok Bhagwat

Major: Chemistry (Analytical)

Degree: Doctor of Philosophy

APOBEC3G (Apo3G) and Activation-Induced cytidine Deaminase (AID) are the most notable members of APOBEC enzymes, a family of cytidine (C) deaminases with crucial functions in the immune system. In T cells, Apo3G deaminates C in viral cDNA to halt the replication of HIV 1 strains lacking viral infectivity factor (vif). In B cells, AID is required for the diversification of antibodies through initiation of somatic hypermutation (SHM), and class switch recombination (CSR), by …

The Accessibility Of Birth Control Methods: Assessing The Household Demographics & Socioeconomic Factors On The Demand For Contraceptives In The Philippines, Darlene Angelini R. Co, Charlyn Janna H. Francisco, Maria Theresa M. Nogoy, Wilhelm Matthew R. Ong

Angelo King Institute for Economic and Business Studies (AKI)

The Reproductive Health Bill No. 5043 (RH Bill) is a controversial issue in the Philippines. It has been a topic of debates by public and private groups. The RH Bill will allow citizens universal access to medically safe, affordable, and effective reproductive health care services and information. It encourages the use of contraceptives, like condoms, birth-control pills. It aims to reduce the rapid increase in the Philippine population. Hence, preventing it from reaching a hundred million in five years as estimated by the Department of Health.

This study highlights the most controversial issue of the bill: Making contraceptives readily available …

Bundo Kanduang: (Hanya) Pemimpin Di Rumah (Gadang), Zainal Arifin

Antropologi Indonesia

Minangkabau ethnic group known is very strictly implement custom of matrilineal. One of these values is male position (sumando) that marginal, because according to matrilineal custom, a man is urang asing (outsiders) in the group of women (wife families). This is expressed through the proverb bak abu diateh tunggua (like ashes on the stump). This position of course is not profitable, so that they have to negotiate with the women to strengthen “the identity of maleness" of them. It shows the politics movement of Minangkaba’s men in an effort to show and strengthen their identity. This political identity of Minangkabau’s …

A Master's Recital In Piano, Katrina Ann Benjegerdes

Dissertations and Theses @ UNI

Katrina Benjegerdes presented a full graduate piano recital on Monday, October 28, 2013. The recital was performed at 6 p.m. in Davis Hall in the Gallagher-Bluedorn Performing Arts Center at the University of Northern Iowa. This recital was given in partial fulfillment of the Master of Music degree in Piano Performance and Pedagogy. The program consisted of works by Scarlatti, Mendelssohn, Rachmaninoff, and Mozart. This abstract contains further discussion of the performed works.

Method And Apparatus For Adaptive Scatter Correction, Xin Liu, J. Hsieh, X. Wu

Nuclear Engineering and Radiation Science Faculty Research & Creative Works

A CT system includes a rotatable gantry having an opening to receive an object to be scanned, an x-ray source configured to project an x-ray beam toward the object having a primary intensity, a detector configured to detect high frequency electromagnetic energy passing through the object and output imaging data, and a data acquisition system (DAS) connected to the detector and configured to receive the imaging data. The system also includes a computer programmed to obtain image projection data of the object from the DAS, correct the projection data using a scatter function that is based at least on a …

Desulfotomaculum Dissimilatory Reduction Of Iron (Iii), Jim Elric

Dissertations and Theses @ UNI

Excess plant nutrient, often from agricultural runoff, can cause uncontrolled algal growth that leads to eutrophic conditions in a water body. Desulfotomaculum sp. reduction of ferric ions to ferrous ions can aid in reduction of excess phosphate in a water body. This bacterium may use iron mine tailings as an inexpensive source of iron ions that can aid in elimination of excess nutrient load such as phosphates. As part of a remediation plan Desulfotomaculum sp. reduction of ferric ions can help restore and maintain a healthy aquatic ecosystem. The biochemical pathway of iron reduction by Desulfotomaculum sp. is unclear and …

Asia Pacific Perspectives Vol. 11 No. 1, August 2013, University Of San Francisco

Asia Pacific Perspectives

Contents:

Editor's Note by John Nelson and Dayna Barnes

Languages of Human Rights in Timor-Leste by David Webster

This paper examines the historical process by which Timorese embraced the language of human rights, and their transnational support networks as diffusion belts for “rights talk.” It argues for a two-way understanding of rights diffusion, suggesting that Timorese framing of rights have contributed to a global shift towards a wider understanding of human rights as more than simply civil liberties in the Western tradition. Human rights, in other words, is a language that has served the Timorese independence cause, and in turn …

Beyond Fear And Loathing: Tea Party Organizers' Continuum Of Knowledge In A Racialized Social System, Meghan Burke

Scholarship

Making use of fieldwork and 25 open-ended interviews with Tea Party organizers in the state of Illinois, I argue that Tea Party organizers draw from a continuum of knowledge, combining personal knowledge and experience with a conservative corporate media and Tea Party network frame. I draw upon the work of Weber to show how this continuum connects to various types of rational social action. Widening this scope of analysis allows not only for a more complex analysis of how corporate interests are connected to the grass roots movement, but also how the core frames of the movement are located throughout …

Visual-Textual Joint Relevance Learning For Tag-Based Social Image Search, Yue Gao, Meng Wang, Zheng-Jun Zha, Jialie Shen, Xuelong Li, Xindong Wu

Research Collection School Of Computing and Information Systems

With the popularity of social media websites, extensive research efforts have been dedicated to tag-based social image search. Both visual information and tags have been investigated in the research field. However, most existing methods use tags and visual characteristics either separately or sequentially in order to estimate the relevance of images. In this paper, we propose an approach that simultaneously utilizes both visual and textual information to estimate the relevance of user tagged images. The relevance estimation is determined with a hypergraph learning approach. In this method, a social image hypergraph is constructed, where vertices represent images and hyperedges represent …

Valuation Of Participation In Social Gaming, Kwansoo Kim, Byungjoon Yoo, Robert J. Kauffman

Research Collection School Of Computing and Information Systems

This study examines the value of the time that a user spends to participate in a social game. We focus on how a massive multiplayer online role-playing game (MMORPG) vendor can establish prices to encourage participation and retain its players. We estimate value through an application of the hedonic pricing model and analyze a data set for an MMORPG in Korea. The results permit us to estimate the value of game-playing time in monetary terms. Based on our empirical results, we propose an economic model and conduct numerical simulation to show how a game vendor can apply differential pricing in …

Organized Music Instruction As A Predictor Of Nursing Student Success, Sandra K. Cesario, Robert Cesario, Anthony R. Cesario

Arts, Languages and Philosophy Faculty Research & Creative Works

Stringent admission criteria exist for nursing programs in the United States, but better predictors of success are needed to reduce student attrition. Research indicates that organized music experiences are associated with greater academic success. This exploratory study examined the association between early music experiences and undergraduate nursing student success. Findings suggest that students with a music background were more likely to graduate, have higher grade point averages, and pass the licensure examination. Previous music education might be considered as an additional predictor of nursing student success. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Faculty Guidebook, January 2013, Lindenwood University

Employee Handbooks

Information and guidelines for Lindenwood University faculty.

Nutritional Intervention Restores Muscle But Not Kidney Phenotypes In Adult Calcineurin Aα Null Mice, K. Madsen, R. N. Reddy, S. R. Price, C. R. Williams, Jennifer L. Gooch

PCOM Scholarly Works

Mice lacking the α isoform of the catalytic subunit of calcineurin (CnAα) were first reported in 1996 and have been an important model to understand the role of calcineurin in the brain, immune system, bones, muscle, and kidney. Research using the mice has been limited, however, by failure to thrive and early lethality of most null pups. Work in our laboratory led to the rescue of CnAα-/- mice by supplemental feeding to compensate for a defect in salivary enzyme secretion. The data revealed that, without intervention, knockout mice suffer from severe caloric restriction. Since nutritional deprivation is known to significantly …

The Charter's Influence Around The World, Mark Tushnet

Osgoode Hall Law Journal

Over the past several decades, the influence of the United States Constitution and Supreme Court around the world has waned while that of the Canadian Charter and Supreme Court has increased. This article examines several reasons for these changes, including: the relative ages of the constitutions; the US Supreme Court’s recent conservatism; the Canadian Supreme Court’s role in developing the doctrine of proportionality; the US Supreme Court’s interest in originalism; differing structures of constitutional review and judicial supremacy; and the two Courts’ relative openness to transnational influences.

Using Twitter To Facilitate Case-Based Instruction In A Nursing Classroom, Sherleena Ann Buchman, Patricia Burke Snider, Tian Luo, Kaboni Gondwe

STEMPS Faculty Publications

This paper is a report on the use of Twitter within a sophomore level course in the baccalaureate nursing program at a rural Appalachian university. Students enrolled in the Foundations of Nursing course were in their second year of a traditional nursing program. Meeting the challenge of providing students with a ubiquitous learning environment that extends beyond their rural environment is important in the education of many students in the Appalachian region. The preliminary study looks at the usability of Twitter as the medium that will assist nursing students to build the confidence that comes from completing a case study …

Translated Literature In Your Library: The Mildred L Batchelder Award, Kasey L. Garrison, Danielle E. Forest, Sue C. Kimmel

STEMPS Faculty Publications

Translated books represent a unique bridge between cultures for young readers. This article discusses recent trends and practical applications for award-winning literature that has been translated into English and published in the United States. Winner and honour titles earning the Mildred L Batchelder Award for their publishers often include European languages of origins and settings. Despite this homogeneity, the books represent a quality option as a way to diversify a library collection for English-speaking patrons, particularly young adults, and to enhance teaching lessons with the integration of this global literature.

Designing Microblogging-Based Class Activities With Twiducate, Tian Luo, Fei Gao

STEMPS Faculty Publications

[First paragraph] Microblogging tools such as Twitter have been frequently adopted in educational setting to facilitate learning in recent years. Although the original purpose of microblogging tools is to connect with others in a wide network and instantly share what is happening to them with the rest of the world, educators have vigorously attempted to repurpose the utilization of the tool and integrate it into various educational settings to promote student learning.

Management Options For Patients With Chronic Back Pain Without An Etiology, Lenny D. Salzberg, Eron G. Manusov

School of Medicine Publications

The treatment and management of low back pain is complex when there is no specific etiology such as cancer, fracture, or herniated disc. An organized approach to management that follows evidence based guidelines will facilitate care in a problem that reflects a lifetime prevalence of over 70 percent. The purpose of this review is to present a guideline to care for a common disabling process with a very heterogeneous etiology.

Collaborating To Nowhere: The Imperative Of Government Accountability For Restoring The Chesapeake Bay, Rena I. Steinzor, Shana Jones

Faculty Scholarship

This Article opens with an analysis of why the Chesapeake Bay Program will repeat its past failures unless a reliable mechanism for ensuring accountability is created. It then explains how the independent evaluator should be constructed to make possible the overall success of Bay restoration. Finally, it closes with a rebuttal of the arguments in favor of self--auditing and against independent review.

In Ignatian Footsteps: Translational Learning For Educating And Training Adults In The 21st Century, Janna L. Oakes

Jesuit Higher Education: A Journal

Each fall, countless people of various ages, ethnicities, and intentions begin a college education at a variety of American institutions of higher education. Higher education has long been viewed as the doorway to the American dream; a ‘social good,’ in economic terms, that promises benefit to the American masses. Studying under higher minds in traditional and non-traditional college and university settings is an opportunity afforded to nearly any person of ability in the United States. Indeed, higher education touches nearly every aspect of American society, from research and biomedicine to technology and the arts.

Augmented Resistance: The Possibilities For Ar And Data Driven Art, Conor Mcgarrigle

Articles

This article discusses the possibilities for Augmented Reality (AR) as a driver of data based art. The combination of AR and Open Data (in the broadest post-Wikileaks sense) is seen to provide a powerful tool-set for the artist/activist to augment specific sites with a critical, context-specific data layer. Such situated interventions offer powerful new methods for the political activation of sites which enhance and strengthen traditional non- virtual approaches and should be thought of as complementary to, rather than replacing, physical intervention.

I offer as a case study this author’s “NAMAland” project, a mobile artwork which uses Open Data and …

How It Came To Be…Integrating Ignatian Philosophy And Pedagogical Paradigm Into Marquette University’S Pre-Licensure Nursing Curriculum, Kerry Kosmoski-Goepfert, Margaret Callahan, Stephanie Russell

College of Nursing Faculty Research and Publications

This article describes the process that Marquette University’s College of Nursing used to revise its prelicensure nursing curriculum. More specifically, it explains how faculty discussions, with the Vice President of Mission & Ministry and a faculty member from the Department of Theology, which is centered on the philosophy of St. Ignatius of Loyola, and faculty participation in the Marquette Colleagues Program helped ameliorate the curricular change. The article also addresses how faculty selected the Ignatian Pedagogical Model as the framework for the revised curriculum; and the development of faculty and students for an enhanced understanding and application of Ignatian philosophy, …

Diversifying Clearinghouse Ownership In Order To Safeguard Free And Open Access To The Derivatives Clearing Market, Michael Greenberger

Faculty Scholarship

Implementing the rigorous governance and ownership standards established in the Dodd-Frank Wall Street Reform and Consumer Protection Act3 for derivatives clearing organizations (DCOs) will promote free and open access to clearing and reduce systemic risk within what is now the $700 trillion notional value derivatives market. Such standards are central to and advance the key regulatory tenants of Dodd-Frank: i.e., to restore transparency, capital adequacy, and accountability to what was the unregulated over-the-counter (OTC) derivatives market by ensuring that swaps are cleared through financially sound DCOs. Also, these rules will promote competition by curtailing large swap dealers‘ (SDs) control …

What's On First?: Organizing The Casebook And Molding The Mind, Donald G. Gifford, Joseph L. Kroart Iii, Brian Jones, Cheryl Cortemeglia

Faculty Scholarship

This study empirically tests the proposition that law students adopt different conceptions of the judge’s role in adjudication based on whether they first study intentional torts, negligence, or strict liability. The authors conducted an anonymous survey of more than 450 students enrolled in eight law schools at the beginning, mid-point, and end of the first semester of law school. The students were prompted to indicate to what extent they believed the judge’s role to be one of rule application and, conversely, to what extent it was one of considering social, economic, and ideological factors. The survey found that while all …