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Investigating Apoptosis Pathway In Chronic Lymphocytic Leukemia: Stromal Influence And Therapeutic Activation, Viralkumar M. Patel

Dissertations and Theses (Open Access)

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy. High levels of Bcl-2 and IAP family proteins are responsible for apoptotic-resistance and accumulation of mature CLL lymphocytes in bone-marrow, lymph nodes and peripheral blood. Besides pro-survival proteins, supporting stromal cells as well as soluble factors in the microenvironment of bone-marrow and lymph nodes provide survival advantage to CLL leukemic cells.

Though the stromal – leukemia cell interactions has been studied extensively, in-depth-knowledge on the regulation of apoptotic pathway proteins in the context of microenvironment is still limited. To address this, the first part of our study focused on comprehensive analysis of …

Ventral Tegmental Area Neuronal Responses To Methylphenidate Correlated To Behavioral Responses Of Adolescent And Adult Rats, Zachary Jones

Dissertations and Theses (Open Access)

Methylphenidate (MPD) is a psychostimulant used in the treat treatment of attention deficit hyperactivity disorder and more recently is being used as a cognitive enhancement and recreational drug. Its therapeutic effects are not fully understood, nor are the long term effects of the drug on brain development. The ventral tegmental area (VTA) is a site of psychostimulant action thought to be involved in behavioral sensitization. The aim of the this study was to first determine if there are differences in neuronal responses between individuals, with respect to neuronal firing patterns in the ventral tegmental area (VTA), and whether these differences …

C-Jun N-Terminal Kinases Regulate Adenovirus-Mediated Autophagy And Antigen Presentation, Sarah R. Klein

Dissertations and Theses (Open Access)

Targeted immunotherapy with recombinant, oncolytic adenoviruses is under investigation for the treatment of cancer. Evidence indicates adenoviruses induce autophagy that is required for oncolysis, but the molecular regulation of autophagy in infected cells remains under investigation. Our data suggested the canonical pathway regulating starvation-induced autophagy was not implemented in adenovirus-induced autophagy; however, adenovirus infection triggered phosphorylation of c-Jun N-terminal kinases (JNK) that was essential for autophagy. Adenoviral replication within the host cell elicited JNK pathway activation leading to B cell lymphoma-2 (Bcl-2) phosphorylation. JNK-dependent Bcl-2 phosphorylation stimulated the dissociation of Bcl-2/beclin 1 heterodimers, enabling beclin 1 to initiate autophagy. Moreover, …

Characterization Of The Rna Binding And Rna Degrading Subunits Of The Eukaryotic Exosome, Borislava Tsanova

Dissertations and Theses (Open Access)

The exosome is an essential complex of ten proteins involved in the processing and degradation of many RNAs in the cell. These include various stable RNAs, mRNAs, and aberrant transcripts both in the nucleus and in the cytoplasm.

In this work I characterize the three members of the exosome “cap”, the RNA binding proteins Rrp4, Rrp40, and Csl4. I determine that in spite of their structural similarity, they each have a unique essential role. Second, I determine that two of the cap proteins Rrp4 and Rrp40 have a role in bridging subunits of the PH ring of the exosome. The …

Regulation Of The Myostatin Protein In Overload-Induced Hypertrophied Rat Skeletal Muscle, Paige Abriel Affleck

Theses and Dissertations

Myostatin (GDF-8) is the chief chalone in skeletal muscle and negatively controls adult skeletal muscle growth. The role of myostatin during overload-induced hypertrophy of adult muscle is unclear. We tested the hypothesis that overloaded adult rodent skeletal muscle would result in reduced myostatin protein levels. Overload-induced hypertrophy was accomplished by unilateral tenotomy of the gastrocnemius tendon in male adult Sprague-Dawley rats followed by a two-week period of compensatory overload of the plantaris and soleus muscles. Western blot analysis was performed to evaluate changes in active, latent and precursor myostatin protein levels. Significant hypertrophy was noted in the plantaris (494 ± …

Shaping Swarms Through Coordinated Mediation, Shin-Young Jung

Theses and Dissertations

A swarm is a group of uninformed individuals that exhibit collective behaviors. Without any information about the external world, a swarm has limited ability to achieve complex goals. Prior work on human-swarm interaction methods allow a human to influence these uninformed individuals through either leadership or predation as informed agents that directly interact with humans. These methods of influence have two main limitations: (1) although leaders sustain influence over nominal agents for a long period of time, they tend to cause all collective structures to turn in to flocks (negating the benefit of other swarm formations) and (2) predators tend …

Studies Of Molecular Mechanisms Of Cranberry Mediated Healthspan Promotion In Caenorhabditis Elegans, Sujay Guha

All Dissertations

Extensive studies have demonstrated the potent ability of many nutraceuticals to alleviate the symptoms of aging and stress. We found that cranberry extract (CBE) supplementation at an optimum concentration could prolong Caenorhabditis elegans (C. elegans) lifespan in a manner of daf-16 and osr-1 dependence. Considering that aging is a progressive degeneration of physiological functions, it is intriguing to know whether CBE consumption may delay the age-related degenerative changes in animals. Thus, we examined the effect of CBE consumption on healthspan in C. elegans populations with different ages and age-related disorders. Our results suggest that long-term CBE supplementation leads to a …

Neutron Study Of Structured Polymers At Interfaces, Thusitha Etampawala

All Dissertations

This work focuses on interfacial structure and dynamics of structured polymers in thin films and in solutions using neutron techniques accompanied by atomic force microscopy. We probed polymers with a common theme that were highly segregated either because of presence of ionic groups or topological constraints. In these polymers the interfacial regions often define their function in different applications such as clean energy, printing adhesions and drug delivery systems. Thin film studies include systems of polystyrene/sulfonated polystyrene, a rigid sulfonated polyphenylene and polystyrene three-arm stars/linear polystyrene. The first two systems include ionic components and the last exhibits topological constraints. Polystyrene …

Vascular Nanomedicine: Site Specific Delivery Of Elastin Stabilizing Therapeutics To Damaged Arteries, Aditi Sinha

All Dissertations

Elastin, a structural protein in the extra-cellular matrix, plays a critical role in the normal functioning of blood vessels. Apart from performing its primary function of providing resilience to arteries, it also plays major role in regulating cell-cell and cell-matrix interactions, response to injury, and morphogenesis. Medial arterial calcification (MAC) and abdominal aortic aneurysm (AAA) are two diseases where the structural and functional integrity of elastin is severely compromised. Although the clinical presentation of MAC and AAA differ, they have one common underlying causative mechanism--pathological degradation of elastin. Hence prevention of elastin degradation in the early stages of MAC and …

Arachidonic Acid Reverses The Pyriproxyfen And Ibuprofen Induced Toxicity In Daphnia Magna, Gautam Kumar Ginjupalli

All Dissertations

Healthy reproduction and neonatal sex ratios of Daphnia are crucial to the health of the aquatic ecosystems in which Daphnia play principal roles in trophic transfer of nutrients. Combinations of environmental factors such as availability and quality of diet, overcrowding, hypoxia, reduced photoperiods and fall in ambient temperatures perturb normal parthenogeneic reproduction and induce sexual reproduction through male production. Male production provides a mechanism for overcoming specific stressors such as overcrowding and overwinter pond desiccation. However, it also induces a decrease in the Daphnia population that could have adverse implications on the pond ecosystem that depend on Daphnia . Interestingly, …

Biological Scaffolds For Peripheral Vascular Surgery, George Fercana

All Dissertations

The gold standards for small diameter peripheral vascular graft replacement are autologous arteries or veins; however, one-third of patients lack such vessels due to previous vessel harvesting or advanced vascular disease. A promising approach for patients in this category is tissue engineering with off-the-shelf biological vascular grafts. Three small diameter acellular scaffolds were developed and evaluated as vascular grafts. Porcine renal arteries (2-3 mm diameter, 20 mm length) were decellularized by immersion and stabilized with penta-galloyl glucose (PGG) with and without subsequent heparinization via carbodiimide chemistry. Bovine mammary (4-6 mm ID, 250 mm length) and femoral arteries (6-8 mm ID, …

Encapsulated And Monolithic Resonant Structures For Laser Applications, Aaron Pung

All Dissertations

Typically, the composition of a laser system includes a gain medium, a pump illumination source, and an external feedback cavity. This cavity consists of a highly reflective mirror and an outcoupler component. The geometry of the outcoupler can be engineered to tailor the reflected or transmitted beam's spatial and spectral distribution. Functionally, the transmitted beam profile is dependent on the laser application. Broadband reflection profiles can be obtained by utilizing a distributed Bragg reflector (DBR). A DBR device consists of multiple layers of alternating materials. Constructive interference of the reflected light off each interface between different materials produces the spectrally …

Design And Synthesis Of Polymer - Magnetic Nanoparticle Composites For Use In Biomedical Applications, Roland Stone

All Dissertations

The future of diagnostics and therapeutic drugs in biomedicine is nanoparticles. These nanoparticles come in many different shapes, sizes, and combination of materials. Magnetic nanoparticles have been studied for many years for use in biomedicine, not only for their high surface area, but also because of its unique magnetic properties. They can magnetically interact with their environment, be guided to a specific location, and manipulated to release energy in the form of heat. To ensure that these magnetic nanoparticles survive in the circulatory system, they must be modified with materials to make them colloidally stable in water and shield them …

Investigation Of The Life History And Lipid Content Consequences Of Reduced Abundance Of Delta-9 Desaturases In Drosophila Melanogaster, Li Ko

School of Biological Sciences: Dissertations, Theses, and Student Research

Monounsaturated fatty acids (MUFAs) are essential components in all organisms, and the key enzymes that catalyze the production of MUFA are delta-9 desaturases. These enzymes are ER bound and introduce the first double bonds in saturated fatty acids. To investigate the role that delta-9 desaturases play in Drosophila life history and development we performed a series of studies using the RNAi method. Longevity results showed die-off peaks of the knocked-down (KD) flies at day 45. Fecundity study showed decreases in both egg productions and viability of these eggs. Development difficulties were observed in both regular diet and low fat diet. …

Trade-Offs In Male Lek Behavior, Sarah A. Cowles

School of Biological Sciences: Dissertations, Theses, and Student Research

In lek mating systems, males aggregate together and perform courtship displays to visiting females. However, display may be energetically expensive and reduce the time available for foraging. These costs in turn could lower energy reserves, which could decrease survival. I examined trade-offs in male lek behavior using two methods: 1) I conducted an empirical study of how sharp-tailed grouse (Tympanuchus phasianellus) males allocate time between courtship display (“dancing”), agonism, foraging, and inactivity in relation to female numbers both within and across days. I also measured head turning rates during these same behaviors as a proxy for visual attentiveness …

Matched; Crossed; Reached. The Matched Trilogy, William Morris, Ally Condie

BYU Studies

Ally Condie, a Latter-day Saint and graduate of Brigham Young University, is best known as the author of the Matched trilogy. These three books contain all the ingredients for a successful YA (young adult fiction) series: a plucky heroine, a love triangle, a dystopian setting. And a success it is: each volume has spent numerous weeks on various best-seller lists, Disney has optioned the film rights to the trilogy, and numerous fan sites and social media groups are active online. If it were just those ingredients alone, the trilogy would not be worth noting amid the outpouring of YA novels …

Full Issue, Byu Studies

BYU Studies

No abstract provided.

The Viper On The Hearth, Updated Edition, Mickell J. Summerhays, Terryl L. Givens

BYU Studies

Terryl L. Givens, the well-known Mormon author, is a professor of literature and religion and is the James A. Bostwick Professor of English at the University of Richmond, Virginia. He has authored books such as By the Hand of Mormon: The American Scripture that Launched a New World Religion and The God Who Weeps: How Mormonism Makes Sense of Life.

Many may be familiar with Givens's classic study on Mormon literature entitled The Viper on the Hearth. It is known as one of the most in-depth studies of anti-Mormon literary texts. Givens himself calls this a look at "the long …

Shifting Borders And A Tattered Passport: Intellectual Journeys Of A Mormon Academic, Roger Terry, Armand L. Mauss

BYU Studies

"When the intellectual history of late-twentieth-century Mormonism is written," begins Richard Bushman in the foreword to this memoir, "Armand Mauss will occupy a preeminent position." For this reason alone, Mauss's reminiscences should be of interest to any serious student of Mormonism.

Mauss takes his title from the following quote by Neal A. Maxwell: "The LDS scholar has his citizenship in the Kingdom, but carries his passport into the professional world--not the other way around." But Mauss's observation that the borders have shifted over time and his passport is tattered reminds us that travel between the Church and the world is …

Teacher Effectiveness And Experience Comparing Evaluation Ratings And Student Achievement, Janice Marie Garnett

Student Work

The purpose of this quantitative study was to discover and describe the relationship of teacher experience and evaluation ratings aligned with student achievement results in a public school setting. The research question guiding this study: Is there a significant relationship between teacher effect data in elementary school mathematics and reading and a teacher’s years of experience and performance ratings?

Competition Law Enforcement In Times Of Crisis: The Case Of Serbia, Dusan Popovic

Yearbook of Antitrust and Regulatory Studies

The development of Serbian competition law started in 2005 with the adoption of its first modern Competition Act. National competition rules are generally harmonized with European Union law, especially following the adoption of the current Competition Act of 2009. However, several problems in competition law enforcement can be identified still, the importance of which increases as the effects of the current economic crisis spread. The paper focuses mainly on three problems specific to competition law enforcement in Serbia, a country with a weak economy. The first problem identified is that of a possibly privileged treatment of state-owned companies. The Competition …

Private Enforcement Of Competition Law In Slovenia: A New Field To Be Developed By Slovenian Courts, Maja Brkan, Tanja Bratina

Yearbook of Antitrust and Regulatory Studies

This contribution aims to demonstrate the legal framework that can shape and influence private enforcement in Slovenia. This includes, in particular, conditions for damage claims, collective redress mechanisms, legal costs and fees as well as discovery and burden of proof. It is shown which legislative changes may be needed in order to improve the effectiveness of private enforcement and the practical obstacles that will have to be overcome in the future. Furthermore, the article analyses the jurisprudence of Slovenian courts concerning private enforcement. Although there was practically no jurisprudence in this area only a few years ago, Slovenian courts have …

Recent Competition Policy Developments In Hungary – Merger Control, Aranka Nagy

Yearbook of Antitrust and Regulatory Studies

No abstract provided.

Recent Judgements Of The General Court And The Supreme Court Of The Slovak Republic In Inspection Matters – Landmark Decisions Or Wasted Opportunities To Solve Problem?, Ondrej Blažo

Yearbook of Antitrust and Regulatory Studies

No abstract provided.

Detecting Well-Being Via Computerized Content Analysis Of Brief Diary Entries, William Tov, Kok Leong Ng, Han Lin, Lin Qiu

Research Collection School of Social Sciences

Two studies evaluated the correspondence between self-reported well-being and codings of emotion and life content by the Linguistic Inquiry and Word Count (LIWC; Pennebaker, Booth, & Francis, 2011). Open-ended diary responses were collected from 206 participants daily for 3 weeks (Study 1) and from 139 participants twice a week for 8 weeks (Study 2). LIWC negative emotion consistently correlated with self-reported negative emotion. LIWC positive emotion correlated with self-reported positive emotion in Study 1 but not in Study 2. No correlations were observed with global life satisfaction. Using a co-occurrence coding method to combine LIWC emotion codings with life-content codings, …

Between Evangelism And Multiculturalism: The Dynamics Of Christianity In Indonesia, Chang Yau Hoon

Research Collection School of Social Sciences

Christianity has experienced rapid growth in Indonesia, particularly the Evangelical and Pentecostal/Charismatic movements, which find fertile ground among the urban middle class. This phenomenon has given rise to fears of Christianisation among the Muslim majority, who perceive the Christian growth as a moral threat. Tensions between Christians and Muslims have been part and parcel of religious developments in Indonesia. The author addresses the ways in which Protestant churches in Indonesia negotiate between evangelism (to fulfil the ‘Great Commission’) on the one hand, and multiculturalism (peaceful coexistence with difference) on the other. The article will examine how Christians in Indonesia navigate …

Recruiting The All-Female Rani Of Jhansi Regiment: Subhas Chandra Bose And Dr Lakshmi Swaminadhan, Tobias Frederik Rettig

Research Collection School of Social Sciences

The recruitment of the all-female Rani of Jhansi Regiment of the Indian National Army in Japanese-controlled Singapore and Malaya, with a particular focus on the period between the first female guard of honour on 12 July 1943 through to the opening of the regiment's main camp in Singapore on 22 October 1943, has to date been insufficiently studied. Starting with the conception of the Regiment in an Axis submarine by the Indian nationalist leader Subhas CHANdra Bose (1897–1945), this paper examines the ideas and figures that inspired the regiment and the role of Bose and Dr Lakshmi Swaminadhan (1914–2012) in …

Decd2013, Robert Kelly

Robert Kelly Manuscripts

From December 2013 Robert Kelly Archives

Evaluation Of Alternate Mouthpiece Material Types To Minimize Vibrations And Heat Loss - The Research And Execution Of Prototypes, Kristen Bobuk

Theses, Dissertations and Capstones

This paper is based on the idea of current horn mouthpieces being made solely out of brass with a limited market of stainless steel and titanium with plating being silver or gold. This is an opportunity to explore alternate materials; specifically steel, cast iron and aluminum for the base material and chrome, copper and nickel for plating materials. Readers will learn about metal properties such as hardness, thermal conductivity and specific heat and learn why certain materials are more beneficial than others.

Biafra And The Discourse On The Igbo Genocide, Chima J. Korieh

History Faculty Research and Publications

There has been a reluctance or indifference to a systematic study and documentation of the Igbo Genocide in Nigeria. In the main, the reason has been due to official and non-official attempts to subvert a focus on an event in which more than one million Igbo were slaughtered through a process that was fomented, orchestrated, executed, and supervised by the Nigerian state.