Digital Commons Network^™

C-Rel Is A Transcriptional Target Of Mesoderm Inducer In Xenopus Like 1 (Mixl1), Aaron C. Raymond

Dissertations and Theses (Open Access)

MIXL1, an evolutionarily conserved, paired-type homeobox transcription factor induced by BMP4/TGFb signaling, is a critical regulator of embryonic and adult hematopoiesis. Several lines of evidence implicate MIXL1 in hematopoietic transformation: (i) Aberrant MIXL1 expression is seen in human CML ( Chronic Myelogenous Leukemia) in blast crisis, AML (Acute myelogenous leukemia), B cell lymphomas and pediatric ALL (Acute lymphocytic leukemia). (ii) Retroviral transduction of Mixl1 induces AML in murine models. Nonetheless, mechanisms underlying MIXL1 mediated proliferative, survival advantages are unknown.

The goal of my studies is to understand if and how aberrant MIXL1 expression contributes to leukemogenesis. As a first step, …

Measuring Performance Excellence: Key Performance Indicators For Institutions Accepted Into The Academic Quality Improvement Program (Aqip), Paul J. Ballard

Dissertations

Given growing interest in accountability and outcomes, the North Central Association's Higher Learning Commission developed a new path for accreditation, the Academic Quality Improvement Program (AQIP). The goal is to infuse continuous improvement and quality in the culture of higher education, and to blend traditional accreditation with the philosophy and techniques of the Baldrige Performance Excellence Program. Yet, little is known about the key performance indicators (KPI) that colleges and universities are using to improve their quality and continuous improvement processes.

To this end, my research involved a content analysis of the Systems Portfolios submitted for accreditation by 34 purposefully …

The Impact Of Institutional Culture On Student Activism: A Multi-Case Study In Christian Higher Education, Brian E. Cole

Dissertations

This study contributes to the description and meaning of student activism within the context of Christian college environments and cultures, and is interpreted through the sociological concept of symbolic interactionism. The purpose of this study is to help fill the void in the literature on student activism at Christian colleges and universities, positioning it within literature of broader Christian culture and activism, Christian higher education, generational history of college student activism, and student development theories and leadership models. The goal of the study is to help create an understanding of how students at Christian institutions understand and engage in activism …

After The Final Rose: Effects Of The Bachelor On Viewers’ Perceived Realism, Relationship Satisfaction, And Expectation Of Sexual Timing, Macy Boschee

Communication Studies

The purpose of this study was to determine the effect of ABC’s The Bachelor on viewers’ ideology of dating and relationships. Ninety-eight participants voluntarily took part in a survey, posted to Facebook. The survey measured whether increased exposure to The Bachelor affects viewers’ perceived realism of television, relationship satisfaction, or expectations of sexual timing. The role of viewing habits on each of these factors was also examined. The effects of exposure to The Bachelor on the dependent variables, perceived realism and relationship satisfaction, were measured using an analysis of variance (ANOVA). Effects of exposure on expectations of sexual timing were …

The Nature Of Distributed Research: Narratives Of Shifting Experience, Jingjing Zhang

Journal of Educational Technology Development and Exchange (JETDE)

Distributed work over geographical distance is not new, but this century has witnessed a rapid extension of this kind of work (Juan, Daradoumis, Roca, Grasman, & Faulin, 2012). In academia, it seems that the use of many technologies has inevitably led to an increasing trend of distributed research. In an attempt to explore this phenomenon, a qualitative study involving 24 senior researchers was conducted, and their lived and told stories illustrated that they worked together privately and publicly, informally and formally, with a high degree of reciprocity and with written records of their discourse. All forms of research activities, mediated …

Why Run: A Website For New Runners, Irene C. Meyer

Theses

Running is one of the simplest forms of physical activity that a person can take part in, but can still seem daunting to someone who has never done it before. whyRun is a website that guides interested beginners, through a simple and easy user interface design, in the basics of the sport: Why they should get started, how to take those first steps, the different types of running, equipment needed, and how to stay safe and motivated.

I believe that running can genuinely change not only how a person

appears physically by getting a sedentary body into motion, but also …

Augmented Sound, Berio Molina

Theses

A Computer Vision System for doing Interactive Installations

This thesis is a computer vision system for doing interactive-creative musical installations: A portable computer vision system based on video projection and a green laser, that allows the interaction with the projection itself, with the physical space where it is projected and with multiple users.

By using a green laser as a physical user interface, people create projections of sound balls that are projected on top of objects. These balls interact with the physical characteristics of the object where they are projected, as well as with other balls that where previously created …

Parody As Brand, Stacey Dogan, Mark Lemley

Faculty Scholarship

Courts have struggled with the evaluation of parody under trademark law. While many trademark courts have protected parodies, there are a surprising number of cases that hold obvious parodies illegal. The problem is particularly severe with respect to parodies that are used to brand products, a growing category. The doctrinal tools that generally protect expressive parodies often don't apply to brand parodies. Our goal in this paper is to think about what circumstances (if any) should lead courts to find parody illegal. We conclude that, despite courts’ increasing attention to speech interests in recent years, the law’s treatment of parody …

The Antitrust Implications Of Filing “Sham” Citizen Petitions With The Fda, Matthew Avery, William Newsom, Brian Hahn

UC Law Journal

The First Amendment protects the right of all citizens to petition the government. The Food and Drug Administration (the “FDA”) has provided a means by which citizens or interested entities can voice their concerns to the FDA by filing a so-called “citizen petition.” However, some brand-name pharmaceutical companies have abused this process by filing baseless petitions with the FDA in an effort to delay generic competition. Such anticompetitive activity is generally protected by the Noerr- Pennington doctrine, which grants antitrust immunity to activity that involves petitioning the government for redress. However, the immunity does not apply to “sham” petitions, the …

From Sex For Pleasure To Sex For Parenthood: How The Law Manufactures Mothers, Beth A. Burkstrand-Reid

UC Law Journal

In Sargon Enterprises, Inc. v. University of Southern California, the California Supreme Court decided arguably the most important expert testimony decision that it has rendered in at least two decades. Prior to Sargon, California appeared steadfastly committed to the classic “general acceptance” test, which required judges to assess whether an expert’s theory or technique had gained general acceptance in the relevant fields. In 1993, in Daubert v. Merrell Dow Pharmaceuticals, Inc., the United States Supreme Court announced a new empirical validation test. In the years since 1993, most state courts adopted some version of Daubert, but until Sargon the California …

Note – Internalizing The External Costs Of Medical Device Preemption, David Chang

UC Law Journal

Medical device preemption is highly controversial because it provides medical device companies with immunity from state tort claims. Congress provided medical device companies with preemption in 1976 because it was concerned that medical device companies were being overwhelmed by the costs of litigation. Congress feared that this was destroying the incentive for medical device companies to develop risky but innovative life-saving devices.Today, the dark side of medical device preemption has come to light. Medical device preemption fails to require medical device companies to account for harms that their products create for society. Medical device companies have been able to externalize …

Trust Management For Mobile Media Distribution, Raimund K. Ege

Faculty Articles, Papers, and Other Scholarship

Multimedia content delivery to capable smart phones with high-speed next-generation Internet connectivity is becoming commonplace. However, the openness of delivery demands adaptive and robust management of intellectual property rights. The purpose of this article is to describe a framework to address the central issues in content delivery: a scalable peer-to-peer-based content delivery model. Our method pairs the delivery with a secure access control model that enables data providers to secure a return from making their original content available. Our work resulted in a prototype implementation written in Java that includes a client for the Android mobile platform. Adding robust trust …

Analysis Of Polarimetric Synthetic Aperture Radar And Passive Visible Light Polarimetric Imaging Data Fusion For Remote Sensing Applications, Sanjit Maitra

Theses

The recent launch of spaceborne (TerraSAR-X, RADARSAT-2, ALOS-PALSAR, RISAT) and airborne (SIRC, AIRSAR, UAVSAR, PISAR) polarimetric radar sensors, with capability of imaging through day and night in almost all weather conditions, has made polarimetric synthetic aperture radar (PolSAR) image interpretation and analysis an active area of research. PolSAR image classification is sensitive to object orientation and scattering properties. In recent years, significant work has been done in many areas including agriculture, forestry, oceanography, geology, terrain analysis. Visible light passive polarimetric imaging has also emerged as a powerful tool in remote sensing for enhanced information extraction. The intensity image provides information …

Approachi Significans, Luke Shaw

Theses

Approachi Significans is a demonstration of the interference patterns created by scientific and artistic logics. It promotes immersion in the everyday world through experimentation and a search for novel experience, as such efforts prime the mind for novel thought. It is loosely based in a search for constellations of experiences that prompt Eureka moments and an effort to illustrate the organic nature of the scientific process. The title is derived from the phrase `approaching significance,' which is used to indicate that experimental data is moving towards the confirmation of a hypothesis.

Us Medical Specialty Global Health Training And The Global Burden Of Disease, Vanessa B. Kerry, Rochelle P. Walensky, Alexander C. Tsai, Regan W. Bergmark, Brian A. Bergmark, Chaturia Rouse, David R. Bangsberg

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: Rapid growth in global health activity among US medical specialty education programs has lead to heterogeneity in types of activities and global health training models. The breadth and scope of this activity is not well chronicled.

Methods: Using a standardized search protocol, we examined the characteristics of US medical residency global health programs by number of programs, clinical specialty, nature of activity (elective, research, extended curriculum based field training), and geographic location across seven different clinical medical residency education specialties. We tabulated programmatic activity by clinical discipline, region and country. We calculated the Spearman's rank correlation coefficient to estimate …

Securing Information Technology In Healthcare, Denise Anthony, Andrew T. Campbell, Thomas Candon, Andrew Gettinger, David Kotz, Lisa A. Marsch, Andrés Molina-Markham, Karen M. Page, Sean W. Smith, Carl A. Gunter, M. Eric Johnson

Dartmouth Scholarship

Information technology (IT) has great potential to improve healthcare quality while also improving efficiency, and thus has been a major focus of recent healthcare reform efforts. However, developing, deploying and using IT that is both secure and genuinely effective in the complex clinical, organizational and economic environment of healthcare is a significant challenge. Further, it is imperative that we better understand the privacy concerns of patients and providers, as well as the ability of current technologies, policies, and laws to adequately protect privacy. The Securing Information Technology in Healthcare (SITH) workshops were created to provide a forum to discuss security …

Designing The Tangible Experience Of Interactive Memories, Miguel Angel Cardona Jr

Theses

The process for memory keeping in the digital age has become easier, immediate, and more efficient thanks to the advent of sophisticated pocket-sized toolsets that can capture everyday experiences.

Consumer-level photo and video recording products are introduced regularly and boast more fidelity, faster speeds, and greater control than their predecessors. More often than not, these expanding feature sets do not properly serve all of their users' needs.

While the technology exists to allow for a near-complete record of one's life to be made through the use of sensors and storage media, problems involve how best to meaningfully learn from and …

Campaign In A Box: Creating A Universal Public Relations Plan For Community Success For Any Small Business, Emily Branson

Journalism

No abstract provided.

2013 Performance Horse Sale At The Cal Poly Equine Center, Jennifer Rauch

Animal Science

No abstract provided.

Wonderment : Chinese Ink Paintings / Video / Projection / Installation / Soundscape, Anna Glynn

Artists-in-Residence Programme : Exhibition Catalogues

A major component of Wonderment is the first showing of work done as part of my multimedia MEOAW Project: My Extraordinary Onomatopoeic Animal World. Onomatopoeic words mimic the sounds they represent; the sound of the word imitates the sound the object makes. The words are creations of our human minds and in different cultures and languages the words for the same sounds differ. The Lingnan University community responded enthusiastically to my call for volunteers to participate in the MEAOW project. I have spent many happy hours collecting and recording sound and video from members of this wonderful, culturally-diverse population.

Characterizations Of Concretes With Alkali-Activated Binder And Correlating Their Properties From Micro- To Specimen Level, Arkamitra Kar

Graduate Theses, Dissertations, and Problem Reports (ETD)

The manufacturing of portland cement (PC), the main binder of concrete, generates large amount of CO2 (a greenhouse gas), cement kiln dust (solid waste), and consumes significant amount of heat energy. Alkali-activated binder (AAB) is increasingly being considered as an environmentally friendly or green alternative to PC. The AAB is produced by alkali activation of aluminosilicate compounds as precursors with or without calcium ions in them in the temperature range of 60° C to 90° C. Since most of the precursors are waste or by-products, the AAB is regarded as sustainable and green construction material with great potential for its …

Winter 2013

Conversations

Notes from the dean; Renowned journalist Chris Bury joins the faculty; Public relations students shine on national stage; Alumna finds success bringing bands and brands together; Student organization spotlight: SPJ DePaul; All for DePaul campaign; Around the college; Accolades

Many Roads To Social Satisfaction? Social Anxiety, Social Interaction Format, And Social Belonging, Mohamed Mi Ismail

Honors Theses

This study explored how different social interaction formats (face-to-face versus virtual) influence individuals’ belongingness need satisfaction and interaction enjoyment. Furthermore, it also explored how personality variables related to social anxiety (i.e., Interaction Anxiousness, Fear of Negative Evaluation) interact with social interaction format to influence belongingness needs satisfaction and enjoyment. Participants engaged in a conventional face-to-face interaction or a virtual interaction (via Instant Messenger) with a same-sex confederate on a between-subjects basis. Participants then indicated the extent to which the interaction satisfied fundamental social needs (e.g., self-esteem, belonging), their positive and negative mood, as well as how much they enjoyed the …

Liquid Chromatography -- Tandem Mass Spectrometry Techniques For Drugs Of Abuse As Applied To Bacterial And Forensic Toxicology, Stephanie Marie Martindale

Graduate Theses, Dissertations, and Problem Reports (ETD)

The ability of bacterial species to transform complex chemical substances has been well documented. Some of these species are native to the human gastrointestinal tract and play an active role in the postmortem decomposition process. These species have potential to cause biotransformations that affect compound-to-metabolite ratios within the human body, especially after death. Postmortem changes such as these have rarely been evaluated or taken into consideration but they have potential to supply valuable information, especially concerning compound identification and confirmation.;The purpose of this research was to investigate the effects of Escherichia coli, Bacteroides fragilis, and Clostridium perfringens on drugs of …

Altered Hemodynamic Control In The Skeletal Muscle Microcirculation In The Metabolic Syndrome: The Emergence Of A New Attractor, Joshua Thomas Butcher

Graduate Theses, Dissertations, and Problem Reports (ETD)

Peripheral vascular disease is a pathological disease state whereby the peripheral vascular system becomes progressively limited in its ability to adequately perfuse extremities despite increases in metabolic demand. One of the primary risk factors for development of peripheral disease is the Metabolic Syndrome. It is the presentation of three simultaneous comorbidities, with obesity being the most common denominator in most metabolic syndrome patients, but also including a pro-inflammatory state, pro-oxidant state, pro-thrombotic state, increased blood pressure, atherogenic dyslipidemia, or insulin resistance. Currently, the population of the United States is approximately 75% overweight, obese, or extremely obese and the prevalence of …

Development Of A 16s Rrna Gene Sequence As A Biomarker Specific To The Gastrointestinal Tract And Feces Of Swine Based On Suppressive Subtractive Hybridization, Autumn Sayre

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fecal contamination of water bodies causes environmental issues and human health risks. Swine are a major contributor of fecal inputs to environmental waters due to their importance in American agriculture. Water quality currently is regulated using fecal coliforms, which have natural reservoirs in the environment and may not correlate with pathogens. In recent years there has been a shift towards microbial source tracking (MST). MST employs microbiological, genotypic, phenotypic and chemical methods to determine the source of fecal pollution in water bodies. Previous studies aimed at developing swine fecal biomarkers have had limited success. The overall objective of this research …

The Impact Of Service Learning On Leadership Skills Of Students Who Are Gifted And Talented In The Middle School, Patricia Anne Coon

Graduate Theses, Dissertations, and Problem Reports (ETD)

This investigation relates to the impact of service learning on leadership skills of students who are gifted in the middle school while the students plan the project in-school and execute their goals out-of-school for their yearlong service learning project called Community Problem-Solving, or CmPS. Based on surveys, observations, and interviews from 25 students identified as gifted in the middle school, this study describes the student responses and observations from the researcher and teacher of the gifted. Findings show that most of the students in the study felt that their yearlong service learning project positively impacted their leadership skills. The data …

American Grail: Contemporary Federal Budget Reform, Velda Frisco

Graduate Theses, Dissertations, and Problem Reports (ETD)

Federal budget reforms initiated by the executive branch of government have been unsustainable. A commonality of these failed reforms is that they lack the support of Congress. The objective of this research is to determine whether the Program Assessment Rating Tool (PART), the most recent executive-initiated budget reform, was supported by Congress. The scope of this research includes an exploration of historic budget reforms, initiated from 1921 through 2008, to provide insight into previous reform sustainability.;Budget reforms provide context from which to view the power struggle between the executive and legislative branches of government; the tension of separate institutions sharing …

Influence Of Weight Loss On Metabolic And Mitochondrial Function In The Mature Horse, Jennie L. Zambito

Graduate Theses, Dissertations, and Problem Reports (ETD)

Obesity causes a multitude of metabolic issues in the horse, yet stepwise alterations in glucose and lipid metabolism, mitochondrial capacity and oxidant status during weight loss have yet to be analyzed. Skeletal muscle contains subsarcolemmal (SSM) and interfibrillar (IFM) mitochondria, which respond differently to physiological stimuli, impacting tissue and whole body oxidant status. We hypothesized that 8 light-type horses would display improvements in skeletal muscle mitochondrial subpopulation function and decreases in circulating oxidant status markers during weight loss from an obese (7 to 8) to moderate (5) body condition score (BCS). Additionally, we hypothesized improvements in morphometric measurements, circulating metabolic …

American Indian Adolescents Access To And Involvement In In-School Extracurricular Activities In Relation To Substance Use Frequency And Risk Behaviors, Elizabeth A. Jones

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis looks at the protective benefits that involvement in adult-led in-school extracurricular activities had on the use of drugs and alcohol by 8th, 10th, and 12th grade American Indian adolescents in Arizona. This population has been chosen because they have a history of oppression, substance abuse, and prejudice. These adolescents represent an extremely at-risk population due to historical trauma and the present-day responses to this trauma. The researcher used data previously collected by the Arizona Youth Survey in 2010 and looked at it through the lens of Hirschi's Social Control Theory and the protective model of resilience. Hirschi's theory …