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2013

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Cyclic Block Copolypeptoids : Synthesis, Self-Assembly And Macroscopic Properties, Chang-Uk Lee Jan 2013

Cyclic Block Copolypeptoids : Synthesis, Self-Assembly And Macroscopic Properties, Chang-Uk Lee

LSU Doctoral Dissertations

This dissertation presents the first experimental efforts for synthesizing a new class of peptidomimetic polymers, cyclic block copolypeptoids, studying their self-assembly in dilute solution, and examining their macroscopic properties. Cyclic poly(N-methyl-glycine)-b-poly(N-decyl-glycine) (PNMG-b-PNDG) diblock copolymers were synthesized via sequential, N-heterocyclic carbene (NHC)-mediated ring-opening polymerization of NCA monomers with controlled chain length and compositions. Cryo-TEM shows that PNMG105-b-PNDG10 copolymers in methanol (1 mg/mL) form spherical micelles that organize to form cylindrical micelles over time. The formation of cylindrical micelles is attributed to the crystallization of PNDG chains, as revealed by SAED and microDSC analyses. Cyclic PNMG100-b-PNDG10 copolymers form thermo-reversible, free-standing gels at …

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The Ring Theory And The Representation Theory Of Quantum Schubert Cells, Joel Benjamin Geiger Jan 2013

The Ring Theory And The Representation Theory Of Quantum Schubert Cells, Joel Benjamin Geiger

LSU Doctoral Dissertations

In recent years the quantum Schubert cell algebras, introduced by Lusztig and De Concini--Kac, and Procesi, have garnered much interest as this versatile class of objects are furtive testing grounds for noncommutative algebraic geometry. We unify the two main approaches to analyzing the structure of the torus-invariant prime spectra of quantum Schubert cell algebras, a ring theoretic one via Cauchon's deleting derivations and a representation theoretic characterization of Yakimov via Demazure modules. As a result one can combine the strengths of the two approaches. In unifying the theories, we resolve two questions of Cauchon and Mériaux, one of which involves …

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Mathematical And Computer-Based Models For Optimizing Microwave Heating Processes Of Frozen Oysters, Jie Zhang Jan 2013

Mathematical And Computer-Based Models For Optimizing Microwave Heating Processes Of Frozen Oysters, Jie Zhang

LSU Doctoral Dissertations

Consumers with full-time jobs prefer microwavable-frozen-meals for convenience when lack time to cook. Microwaves do not require a medium for heat transfer and provide quick heating even in low thermal conductivity foods, which does not occur in conventional heating. The main problem in utilizing microwave-heating for cooking is the non-uniform temperature distribution in foods which may result in insufficient lethality of microorganisms in some part. This non-uniformity can be due to a number of factors including composition and geometry of food. The objectives of this study were to develop a mathematical-model based on Maxwell¡¯s equations for predicting the temperature distribution …

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A Study Of The Temporal And Spatial Distribution Of Ichthyoplankton And Post-Larval Penaeids Recruiting Into A Louisiana Tidal Pass, Matthew John Kupchik Jan 2013

A Study Of The Temporal And Spatial Distribution Of Ichthyoplankton And Post-Larval Penaeids Recruiting Into A Louisiana Tidal Pass, Matthew John Kupchik

LSU Doctoral Dissertations

This dissertation attempts to better understand astronomical, meteorological, and oceanographic forcing of offshore-spawned, estuarine-dependent species from continental shelf to estuarine waters through tidal passes. The vertical distribution of zoo-/ichthyoplankton within the inner continental shelf from the Louisiana Offshore Oil Platform monitoring project (1978-1995) provided an important offshore end member for the estuarine recruitment study, and is potentially useful in predicting vulnerabilities to past and future oil spills. The role that atmospheric cold front passages may have on densities and movement of zoo-/ichthyoplankton recruiting through the Bayou Tartellan tidal pass, Louisiana, were analyzed using a Generalized Additive Model. The pre-frontal phase, …

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Fluorescent Materials For Chemical Sensing, Brian Gerard Imsick Jan 2013

Fluorescent Materials For Chemical Sensing, Brian Gerard Imsick

LSU Doctoral Dissertations

Materials incorporating fluorescent π-electron conjugated molecular species for sensing and imaging are advantageous over other detection or identification methods such as colorimetric reporters. Fluorescent materials offer easy recognition of binding events due to the highly sensitive nature of fluorescence techniques down to the single molecule level. The properties of fluorescent molecules allow for rapid attenuation of observable readout due to the facile transport of excited state energy via both inter- and intramolecular pathways. This dissertation primarily focused on the development and study of a general platform for ratiometric fluorescent chemosensing using surface-immobilized oligomers, as well as in depth explorations of …

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Bear With Me : Signs Are Tricksters, And Reality Is Invisible To The Naked Eye: A One-Person Play, Chia-Wen Hsu Jan 2013

Bear With Me : Signs Are Tricksters, And Reality Is Invisible To The Naked Eye: A One-Person Play, Chia-Wen Hsu

LSU Master's Theses

The creation of a one-person play is required in order to complete the Master of Fine Arts degree in acting. There are no official guidelines, only twenty to forty minutes in length is required. Although I was very excited about receiving the challenge, I did not breathe a sigh of relief until I found the topic I wanted to explore－Signs and Reality, and the one-person play that followed: Bear With Me. Since I am not a native English speaker, I have been frustrated by miscommunication through words in the English-speaking world, which gave me the eagerness to talk about the …

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Spatial Variations In Salinity And Temperature Around The Bay Marchand Salt Dome, Offshore Louisiana, Laurie Richards Jan 2013

Spatial Variations In Salinity And Temperature Around The Bay Marchand Salt Dome, Offshore Louisiana, Laurie Richards

LSU Master's Theses

The Bay Marchand field is located about 60 miles south of New Orleans, Louisiana on the continental shelf. The structurally complex field has produced over 960 MMBOE as of 2012 (http://www.eplweb.com), with many of these hydrocarbons being trapped against the massive salt dome and associated faulting present in the area. A study by Bruno and Hanor (2003) documented the presence of a high salinity plume off the southeast flank of the dome that had less saline and less dense pore water below it. The purpose of this study was to investigate the spatial variations in pore water salinity and temperature …

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Hydraulic Fracturing And Water Use In Dallas, Texas, Sarah Yates Jan 2013

Hydraulic Fracturing And Water Use In Dallas, Texas, Sarah Yates

LSU Master's Theses

Dallas, Texas is located in North Texas and sits above the eastern portion of the Barnett Shale natural gas formation. Hydraulic fracturing, or “fracking”, was introduced to the region as a means to access previously inaccessible natural gas within the formation. This fracking concerns many because it requires large amounts of fresh water, an average of over 4 million gallons per well within Dallas Water Utilities’ service area. This thesis examines whether water use for fracking will have a negative effect on the water supply for the city of Dallas and its wholesale water customer cities. The water is typically …

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Treatment Integrity Failures Matched To Behavioral Function, Joanna Elizabeth Lomas Mevers Jan 2013

Treatment Integrity Failures Matched To Behavioral Function, Joanna Elizabeth Lomas Mevers

LSU Doctoral Dissertations

Prior research on treatment integrity has focused on either the lack of measurement of the independent variable (Peterson, Homer & Wonderlich, 1982; Gresham, Gansle & Noel, 1993; Wheeler, Baggett, Fox & Blevins, 2006; McIntyre, Gresham, DiGennaro & Reed, 2007; Sanetti, Gritter & Dobey, 2011) or on methods to increase overall levels of treatment integrity(Witt, Noell, LaFleur & Mortenson, 1997; Noell, Witt, Gilbertson, Ranier & Freeland,1997; Noell et al., 2005). Yet little research has been devoted to understanding the effectiveness of common interventions when those interventions are implemented with less than perfect integrity. The current investigation evaluated the effectiveness of using …

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Reciprocal Peer Mentoring : Increasing The Prosocial Behavior Of Socially Neglected Students, Tai A. Collins Jan 2013

Reciprocal Peer Mentoring : Increasing The Prosocial Behavior Of Socially Neglected Students, Tai A. Collins

LSU Doctoral Dissertations

Two studies investigated the effectiveness of the Reciprocal Peer Mentoring intervention in improving the prosocial behavior of socially neglected elementary school students as measured by a Direct Behavior Rating filled out by their teachers. Reciprocal Peer Mentoring uses the methodological framework of the Check-In/Check-Out intervention (e.g. Hawken & Horner, 2003), but expands on it by using peers as mentors, adding a reciprocity component, focusing on prosocial behavior, and targeting socially neglected students. In Study 1, the effectiveness of Nonreciprocal Peer Mentoring was examined, as popular peers served as mentors for neglected peers. In Study 2, neglected or rejected students mentored …

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Quantification Of Total And Oil-Degrading Bacteria In Louisiana Marsh Sediment Following The Deepwater Horizon Oil Spill Using Cultivation And Real-Time Pcr Assays, Kristopher Nolan Ackoury Jan 2013

Quantification Of Total And Oil-Degrading Bacteria In Louisiana Marsh Sediment Following The Deepwater Horizon Oil Spill Using Cultivation And Real-Time Pcr Assays, Kristopher Nolan Ackoury

LSU Master's Theses

Although the impacts of the Deepwater Horizon (DWH) oil spill on the bacterial communities in several Gulf of Mexico habitats have been described, little if any research has been published evaluating the impacts of the spill on bacterial populations in the most severely oiled salt marsh soils of Barataria Bay, Louisiana. The aim of this study was to define the effects of the spill on the total and oil-degrading bacterial communities in these marshes. Using quantitative real-time PCR (qPCR) and traditional cultivation methods bacterial communities from contaminated marsh soils were examined thirteen, twenty-two, and twenty-nine months after the initial oiling …

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Evaluation Of An Automated Delivery Verification System For Volumetric Modulated Arc Therapy Treatments, John-Paul Grenier Jan 2013

Evaluation Of An Automated Delivery Verification System For Volumetric Modulated Arc Therapy Treatments, John-Paul Grenier

LSU Master's Theses

Purpose: The purpose of this work was to evaluate the ability of a treatment delivery verification system to detect clinically significant mechanical errors in VMAT delivery utilizing data contained within a commercial record and verify (RV) system, and to test whether the system can be used to reconstruct dose distributions that agree more closely with measured dose distributions than do the original treatment plans. Methods: VMAT treatment plans from five prostate patients, five head and neck patients, and five post-mastectomy chest wall patients treated at our clinic were selected for this study. Known mechanical errors were introduced into each plan, …

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Evaluation Of Thermal Insulation By Coal Beds In The Western Arkoma Basin, Ok And Implications For Large Scale Geothermal Resources, Matthew Freeman Jan 2013

Evaluation Of Thermal Insulation By Coal Beds In The Western Arkoma Basin, Ok And Implications For Large Scale Geothermal Resources, Matthew Freeman

LSU Master's Theses

Weighted average geothermal gradients in the Western Arkoma Basin, Oklahoma are estimated from bottom hole temperatures (BHT) from 158 oil and gas wells. The regional geothermal gradient is 28.8 °C/km. The central and north central portions of the basin have higher gradients than southern and northern portions, especially in large areas of Pittsburg and Haskell counties where geothermal gradients in excess of 36 °C/km exist. These gradients suggest that temperatures suitable for low temperature geothermal power exist at depths of 2-3 km. Coals have very low thermal conductivity (0.15 – 0.5 W/m°K) acting as thermal insulators. This study examines the …

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The Development Of An Ac Magneto- Optic Kerr Effect System For The Characterization Of Pulsed Laser Deposited Co₂Mnsi-Xal1-X Heusler Alloy Thin Films, Matthew Stephen Champagne Jan 2013

The Development Of An Ac Magneto- Optic Kerr Effect System For The Characterization Of Pulsed Laser Deposited Co₂Mnsi-Xal1-X Heusler Alloy Thin Films, Matthew Stephen Champagne

LSU Master's Theses

The Kerr rotation and Kerr ellipticity of thin films can be measured using an AC magneto-optic Kerr effect (AC-MOKE) system. The longitudinal MOKE measurements were taken for a series of Co2MnSixAl1-x thin films with values of x= 0.00, 0.25, 0.50, 0.75, 1.00. The films were fabricated using ultra high vacuum, pulsed laser deposition (PLD) techniques. The PLD targets were made using conventional arc-melting techniques. Using a Jones matrix analysis, it was shown that the Kerr rotation and Kerr ellipticity can be measured separately using two optical setups by taking advantage of a photoelastic modulator and lock-in techniques. Co2MnAl and Co2MnSi …

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Adaptive Stochastic Conjugate Gradient Optimization For Temporal Medical Image Registration, Huanhuan Xu Jan 2013

Adaptive Stochastic Conjugate Gradient Optimization For Temporal Medical Image Registration, Huanhuan Xu

LSU Master's Theses

We propose an Adaptive Stochastic Conjugate Gradient (ASCG) optimization algorithm for temporal medical image registration. This method combines the advantages of Conjugate Gradient (CG) method and Adaptive Stochastic Gradient Descent (ASGD) method. The main idea is that the search direction of ASGD is replaced by stochastic approximations of the conjugate gradient of the cost function. In addition, the step size of ASCG is based on the approximation of the Lipschitz constant of the stochastic gradient function. Thus, this algorithm could maintain the good properties of the conjugate gradient method, meanwhile it uses less gradient computation time per iteration and adjusts …

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Surface Studies Of Organic Thin Films Using Scanning Probe Microscopy And Nanofabrication, Venetia Denae Lyles Jan 2013

Surface Studies Of Organic Thin Films Using Scanning Probe Microscopy And Nanofabrication, Venetia Denae Lyles

LSU Doctoral Dissertations

Porphyrins and metalloporphyrins have unique chemical and electronic properties and thus provide useful model structures for nanoscale studies of the role of chemical structure for electronic properties. Porphyrins have been proposed as viable materials for molecular-based information-storage devices, gas sensors, photovoltaic cells, organic light-emitting diodes and molecular wires. The function and efficiency of porphyrins in devices is largely attributable to molecular architecture and how the molecules are self-organized. Modifications of the porphyrin macrocycle, peripheral groups or bound metal ions can generate a range of electrical, photoelectrical or magnetic properties. The conductive properties are greatly influenced at the molecular level by …

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Super-Aptamer Bio-Imprinted Hydrogels : An Investigation Into The Optimization And Characterization Of Cross-Linked Polymeric Materials Displaying Macromolecular Amplified Responses, Nicholas Alexander Gariano Jan 2013

Super-Aptamer Bio-Imprinted Hydrogels : An Investigation Into The Optimization And Characterization Of Cross-Linked Polymeric Materials Displaying Macromolecular Amplified Responses, Nicholas Alexander Gariano

LSU Doctoral Dissertations

It is becoming more important to detect ultra-low concentrations of analytes for biomedical, environmental, and national security applications. Equally important is that new methods should be easy to use, inexpensive, portable, and if possible allow detection using the naked eye. Detection of low concentrations of analytes generally cannot be achieved directly, but requires signal amplification by catalysts, macromolecules, metal surfaces or supramolecular aggregates. The rapidly progressing field of macromolecular signal amplification has been advanced using conjugated polymers, chirality in polymers, solvating polymers and polymerization/depolymerization strategies. The use of molecularly imprinted polymers is ideal for creation of novel sensors to meet …

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Molecular-Level Investigations Combining Nanoscale Lithography And Atomic Force Microscopy, Chamarra Karmelia Saner Jan 2013

Molecular-Level Investigations Combining Nanoscale Lithography And Atomic Force Microscopy, Chamarra Karmelia Saner

LSU Doctoral Dissertations

In this dissertation, nanostructures of octadecyltrichlorosilane (OTS) and were prepared using particle lithography and evaluated using characterizations with atomic force microscopy (AFM). The nanostructures of OTS were used as a resist for patterning fibronectin, an extracellular matrix protein. Particle lithography provides a practical and reproducible approach to generate billions of nanostructures comprised of organic thin films or nanomaterials. A film of mesospheres can be applied as a surface mask to define the periodicity and size of nanopatterns using processes of self-assembly. A close-packed arrangement of mesospheres is produced spontaneously when monodisperse solutions of latex or silica are dried on a …

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Investigations Into Alkene Hydration And Alkene Oxidation Catalysis, William Schreiter Jan 2013

Investigations Into Alkene Hydration And Alkene Oxidation Catalysis, William Schreiter

LSU Doctoral Dissertations

Bimetallic Ni complexes Ni21M and Ni21R and monometallic transition metal complexes were investigated as possible alkene hydration catalysts under a multitude of different reaction conditions. All attempts at performing this catalytic reaction failed to give any alcohol products. Catalytic screening experiments were conducted using a mixture of racemic-et,ph-P4 and meso-et,ph-P4, 1M and 1R, and various transition metals. These experiments gave several different products including 1-phenylethanol from styrene. During the course of the hydration experiments, an aldehyde product was identified from experiments conducted with the bimetallic complexes in air. Experiments have shown that the aldehyde is produced from the oxidative cleavage …

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Exploring Student Perseverance In Problem Solving, Angelique Renee (Treadway) Duncker Jan 2013

Exploring Student Perseverance In Problem Solving, Angelique Renee (Treadway) Duncker

LSU Master's Theses

ABSTRACT Many high school Geometry students lack the perseverance required to complete complex and time-consuming problems. This project tests the hypothesis that if students were provided with a means of organizing their problem solving work they will be less apt to quit when faced with complex and time-consuming mathematical problems. This study involved students enrolled in 10th grade Geometry and 10th grade Honors Geometry in two similar high schools. After trying unsuccessfully to implement methods adapted from an engineering workshop, I designed a graphic organizer that was simple to use and acceptable to the students. Ultimately, I did not detect …

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Enculturational Practices In The Teaching Of Proof In Mathematics, Indira Venkata Chillara Jan 2013

Enculturational Practices In The Teaching Of Proof In Mathematics, Indira Venkata Chillara

LSU Doctoral Dissertations

Mathematics education reform is informed by constructivist theories that forefront student learning of concepts, and by sociocultural theories whose focus is on students’ mastery of mathematical practices. As Cobb (1994) pointed out, these theorizations are inconsistent with one another, leading to conflict as some theorists seek to promote their approach as the correct one. Alternatively, Cobb, and many others in the social constructivism or the situated cognition camps, seek some sort of integration or balancing of these priorities in pedagogical theorizing. Kirshner (2002, 2004, 2008) argued that instead of either selecting one theory or balancing/coordinating the two theories, we should …

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Advancing The Field Of Polypeptoids Through The Synthesis Of Novel Architectures And Thermoresponsive Polymers, Samuel Henry Lahasky Jan 2013

Advancing The Field Of Polypeptoids Through The Synthesis Of Novel Architectures And Thermoresponsive Polymers, Samuel Henry Lahasky

LSU Doctoral Dissertations

Peptidomimetic polymers are an emerging class of polymers that are structurally related to polypeptides. Due to their structural similarities, these polymers can be used to study some of the physical aspects of polypeptides (for example, protein folding). They are also increasingly being used in the fields of biology and drug-delivery. Some members of peptidomimetic polymers include polyacrylamides, polyoxazolines and polypeptoids. Polymer synthesis and characterization has been performed for both polyacrylamides and polyoxazolines, with research dating back to the 1950s and 1980s respectively. Research in the field of polypeptoids has not been as extensive; however, emerging synthetic strategies are allowing for …

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Simple And Fast Reconstruction Of 6 Mv Radiotherapy Doses To The Whole Body, Lydia Joyce Wilson Jan 2013

Simple And Fast Reconstruction Of 6 Mv Radiotherapy Doses To The Whole Body, Lydia Joyce Wilson

LSU Master's Theses

Background: State-of-the-art radiotherapy medical records include reliable estimates of the therapeutic radiation but are known to underestimate the stray radiation exposures by 40% away from the treatment field. Most commonly, stray radiation exposures are reconstructed using empirical formulas and/or lookup tables containing machine-specific dose measurements. The purpose of this study was to develop a physics-based model to calculate exposures to the whole body of patients who receive external beam photon radiotherapy. Methods: We developed a physics-based analytic algorithm to predict absorbed dose from therapeutic, scatter, and leakage radiation. The model includes separate terms to characterize photon production, attenuation, and scattering …

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Toward Digitizing The Human Experience : A New Resource For Natural Language Processing, Jerry Scott Weltman Jan 2013

Toward Digitizing The Human Experience : A New Resource For Natural Language Processing, Jerry Scott Weltman

LSU Doctoral Dissertations

A long-standing goal of Artificial Intelligence is to program computers that understand natural language. A basic obstacle is that computers lack the common sense that even small children acquire simply by experiencing life, and no one has devised a way to program this experience into a computer. This dissertation presents a methodology and proof-of-concept software system that enables non-experts, with some training, to create simple experiences. For the purposes of this dissertation, an experience is a series of time-ordered comic frames, annotated with the changing intentional and physical states of the characters and objects in each frame. Each frame represents …

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Examining Neotropical Primate Community Structure At Regional And Local Scales : Insights From Taxonomic And Phylogenetic Approaches, Maria Mercedes Gavilanez Jan 2013

Examining Neotropical Primate Community Structure At Regional And Local Scales : Insights From Taxonomic And Phylogenetic Approaches, Maria Mercedes Gavilanez

LSU Doctoral Dissertations

Understanding mechanisms underlying distribution of biodiversity remains a central issue in ecology. I integrate ecological and phylogenetic information at multiple spatial scales to better understand neotropical primate distribution and community structure. I investigate the variation within species ranges in relation to species richness and patterns of species relatedness. Results suggest positive associations among species throughout their distributions, whereby species tend to present higher richness within their ranges than average richness for the entire taxon. However, comparing empirical distributions to a null model of range cohesion suggests mechanisms other than dispersal are setting a limit to the number of species capable …

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Matrix-Assisted Laser Desorption Ionization Mass Spectrometry For Identificaiton Of Shrimp, Venkatesulu Salla Jan 2013

Matrix-Assisted Laser Desorption Ionization Mass Spectrometry For Identificaiton Of Shrimp, Venkatesulu Salla

LSU Master's Theses

Matrix-assisted laser desorption ionization (MALDI) time of flight mass spectrometry was used to identify shrimp at the species level using commercial mass spectral fingerprint matching software (Bruker Biotyper). In the first step, a mass spectrum reference database was constructed from the analysis of six shrimp species that are commercially important in the United States: L. setiferus, F. azticus, S. brevirostris, P. robustus, P. dispar and P. platyceros. In the second step, the reference database was tested using 74 unknown shrimp samples from these six species. Correct identification was achieved for 72 of the 74 samples (97 percent): 72 samples were …

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Effects Of Physicochemical Properties And Macrohabitat On The Foraging Ecology And Condition Of The Centrarchid Assemblage Of The Atchafalaya River Basin, Louisiana, Brett A. Miller Jan 2013

Effects Of Physicochemical Properties And Macrohabitat On The Foraging Ecology And Condition Of The Centrarchid Assemblage Of The Atchafalaya River Basin, Louisiana, Brett A. Miller

LSU Master's Theses

The Atchafalaya River Basin (ARB), Louisiana supports a diverse centrarchid assemblage, characterized by abundant populations of largemouth bass Micropterus salmoides, black crappie Pomoxis nigromaculatus, warmouth Lepomis gulosus, bluegill Lepomis macrochirus, redspotted sunfish Lepomis miniatus, longear sunfish Lepomis megalotis and redear sunfish Lepomis microlophus. This dynamic floodplain ecosystem is comprised of a mosaic of macrohabitats, including natural bayous, shallow lakes, dead-end and open pipeline canals. I conducted an extensive feeding ecology study to determine the influence of these macrohabitats on foraging activity through stomach content and stable isotope analyses. I collected 2,036 centrarchids with electrofishing efforts in the summers of 2011 …

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The Effect Of Frequent Quizzing On Student Learning In A High School Physical Science Classroom, Courtney Bailey Norton Jan 2013

The Effect Of Frequent Quizzing On Student Learning In A High School Physical Science Classroom, Courtney Bailey Norton

LSU Master's Theses

This research explores the effects of frequent quizzing versus no quizzing in a high school Physical Science class. The study population included two freshman level Physical Science Honors classes. The content in this study included Classifying Matter, States of Matter, Atomic Bonding, Motion and Forces and Motion. For each chapter covered one class served as a control group, getting no quizzes, and the other class served as an experimental group, getting frequent quizzes. Prior to being taught information on the 5 chapters covered in this study, a 15-question pre-test was administered to the students. The information was delivered in the …

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Phase Composition Control Of Calcium Phosphate Nanoparticles For Tunable Drug Delivery Kinetics And Treatment Of Osteomyelitis. Part 2: Antibacterial And Osteoblastic Response, Vuk Uskoković, Tejal A. Dasai Jan 2013

Phase Composition Control Of Calcium Phosphate Nanoparticles For Tunable Drug Delivery Kinetics And Treatment Of Osteomyelitis. Part 2: Antibacterial And Osteoblastic Response, Vuk Uskoković, Tejal A. Dasai

Pharmacy Faculty Articles and Research

Osteomyelitis has been traditionally treated by the combination of long-term antibiotic therapies and surgical removal of diseased tissue. The multifunctional material was developed in this study with the aim to improve this therapeutic approach by: (a) enabling locally delivered and sustained release of antibiotics at a tunable rate, so as to eliminate the need for repetitive administration of systemically distributed antibiotics; and (b) controllably dissolving itself, so as to promote natural remineralization of the portion of bone lost to disease. We report hereby on the effect of the previously synthesized calcium phosphates (CAPs) with tunable solubilities and drug release time …

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Laser Ablation Sample Transfer For Mass Spectrometry, Sung-Gun Park Jan 2013

Laser Ablation Sample Transfer For Mass Spectrometry, Sung-Gun Park

LSU Doctoral Dissertations

In this research, a new ambient sampling technique for mass spectrometry was developed that uses an infrared laser to ablate materials under ambient conditions that are captured in a solvent or on a surface. An infrared optical parametric oscillator (OPO) laser system at 3 μm wavelength was focused onto samples for ablation at atmospheric pressure. The ablated materials were transferred to a solvent or surface. For off-line electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) analysis, the ablated material was captured in a static solvent droplet that was deposited on a MALDI target or flow-injected into a nanoelectrospray source. The …

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