Digital Commons Network^™

Synthesis Of Orthogonally Protected Azalanthionines (Lanazanines) By Sequential Ring-Opening Of N-Substituted Aziridine 2-Carboxylates, Keith O'Brien, Keith Ó Proinsias, Fintan Kelleher

Articles

Orthogonally protected azalanthionines (lanazanines, 4-azadiaminopimelic acids or b-aminoalaninoalanines) have been synthesised in good yields by the ring-opening of N-protected aziridine 2-carboxylates with suitably protected diaminopropanoic acids (DAPs). The required DAPs were also synthesised by ring-opening of N-protected aziridine 2-carboxylates with para-methoxybenzylamine.

General Genetics Lab, Steelman Library, Todd D. Schraw Dr.

Syllabus Repository

No abstract provided.

Microbiology, Steelman Library, B Mcconchie Dr.

Syllabus Repository

No abstract provided.

Raman Micro Spectroscopy Study Of The Interaction Of Vincristine With A549 Cells Supported By Expression Analysis Of Bcl-2 Protein, Haq Nawaz, Amaya Garcia, Aidan Meade, Fiona Lyng, Hugh Byrne

Articles

Understanding the interaction of anticancer drugs with model cell lines is important to elucidate the mode of action of these drugs as well as to develop cost effective and rapid screening methods. Raman spectroscopy has been demonstrated to be a valuable technique for high throughput, noninvasive analysis. The interaction of vincristine with a human lung adenocarcinoma cell line (A549)was investigated using Raman micro spectroscopy. The results were correlated with parallel measurements from the MTT cytotoxicity assay, which yielded an IC₅₀ value of 0.10 ± 0.03 μM. The Raman spectral data acquired from vincristine treated A549 cells was analysed to …

Sleep Duration And Breast Cancer Phenotype, Ali Khawaja, Santosh Rao, Li Li, Cheryl L. Thompson

Medical College Documents

Emerging evidence suggests that short sleep is associated with an increased risk of cancer; however, little has been done to study the role of sleep on tumor characteristics. In this study, we evaluated the relationship between sleep duration and tumor phenotype in 972 breast cancer patients. Sleep duration was inversely associated with tumor grade (univariate P = 0.032), particularly in postmenopausal women (univariate P = 0.018). This association did not reach statistical significance after adjustments for age, race, body mass index, hormone replacement therapy use, alcohol consumption, smoking, and physical activity in the entire study sample (P = 0.052), but …

United States Of America: The Burden Of Proof In Tax Matters, Henry Ordower

All Faculty Scholarship

This United States report responds to a questionnaire that the general reporters prepared for the 2011 meeting of the European Association of Tax Law Professors in Uppsala, Sweden, June 3-5, 2011. The report describes and analyzes the U.S. law on burden of proof and burden of production in tax matters in the context of tax law procedure, including the settlement function of appeals and information reporting, uncertain tax positions (Form UTP) and foreign accounts of U.S. taxpayers. This report also addresses the interplay of burden of proof and the anti-abuse provisions, including the “economic substance” clarification in section 7701(o) and …

Cave Ventilation Is Influenced By Variations In The Co2-Dependent Virtual Temperature, Enrique P. Sánchez-Cañete, Penélope Serrano-Ortiz, Francisco Domingo, Andrew S. Kowalski

International Journal of Speleology

Dynamics and drivers of ventilation in caves are of growing interest for different fields of science. Accumulated CO₂ in caves can be exchanged with the atmosphere, modifying the internal CO₂ content, affecting stalagmite growth rates, deteriorating rupestrian paintings or creating new minerals. Current estimates of cave ventilation neglect the role of high CO₂ concentrations in determining air density – approximated via the virtual temperature (T_v) –, affecting buoyancy and therefore the release or storage of CO₂. Here we try to improve knowledge and understanding of cave ventilation through the use of T …

Natural And Anthropogenic Factors Which Influence Aerosol Distribution In Ingleborough Show Cave, Uk, Andrew C. Smith B.S.C, Peter M. Wynn, Philip A. Barker Professor

International Journal of Speleology

Monitoring in Ingleborough Show Cave (N. Yorkshire, UK) reveals the influence of tourism and cave management techniques on different parameters of the cave atmosphere. Exploratory aerosol monitoring identified a 0.015 ± 0.03 mg/m³ (≈70%) reduction in airborne particulates within the first 75 meters of cave passage and two major aerosol sources within this artificially ventilated show cave. Autogenic aerosol production was identified close to active stream ways (increases of

Table Of Contents

International Journal of Speleology

No abstract provided.

The Use Of Passive Seismological Imaging In Speleogenetic Studies; An Example From Kanaan Cave, Lebanon, Carole Nehme, Christophe Voisin, Armand Mariscal, Pierre-Charles Gérard, Cécile Cornou, Badr Jabbour-Gédéon, Samer Amhaz, Nancy Salloum, Nada Badaro-Saliba, Jocelyne Adjizian-Gérard, Jean-Jacques Delannoy

International Journal of Speleology

Among many parameters that control the evolution of caves stands the volume of unconsolidated clay sediments generally produced by the alteration of the calcareous rocks. Here we introduce the use of a passive seismological imaging technique to investigate the clay deposits and estimate its total volume in a cave. Applied for the first time for speleogenesis studies, the HVSR (Horizontal / Vertical Spectral Ration) is a geophysical technique that can help better interpret cave geomorphology. We apply seismological spectral techniques (H/V ratio) on ambient noise vibrations to derive the clay volume, as well as its shape. This technique applied on …

Book Review: Water In Karst: Management, Vulnerability, And Restoration, Arthur N. Palmer

International Journal of Speleology

Neven Kresic.
Water in Karst: Management, Vulnerability, and Restoration
New York, McGraw-Hill, 2013. ISBN 978-0-07-175333.3, 19×24 cm, 736 p. + 14 p. of color plates, hardbound,
US $125 (also available as e-book)

Front Cover

International Journal of Speleology

No abstract provided.

Screening Legal Claims Based On Third-Party Litigation Finance Agreements And Other Signals Of Quality, Michael B. Abramowicz, Omer Alper

GW Law Faculty Publications & Other Works

The advent of third-party litigation finance introduces a new gatekeeper to the legal process. Before deciding to lend money to a plaintiff, a litigation finance company will conduct at least some review and make an assessment of the quality of the case.

Since litigation finance loans are generally nonrecourse, a litigation finance company is likely to refuse to loan money to plaintiffs with the weakest cases. Such voluntary claim screening may improve social welfare by reducing the incidence of frivolous claims. But the volume of frivolous claims may still be higher than it would be in a world without third-party …

Effectiveness Of Teacher Professional Learning : Enhancing The Teaching Of Fractions In Primary Schools, Derek Hurrell

Theses: Doctorates and Masters

This study was motivated by the need to develop professional learning for primary school teachers that would support them to more effectively teach the mathematics topic of fractions. What seemed evident, was that previous professional learning attended by teachers had not adequately met their needs.

The aim of this study was to investigate whether professional learning, with a focus on subject content knowledge, pedagogical knowledge and reflective practice could enhance primary school teachers’ PCK for teaching fractions and make them more confident teachers of fractions. Demonstrating this to be the case would have wide implications for the development of professional …

Teaching Excellence : An Illusive Goal In Higher Education Teaching And Learning, Heather Sparrow

Theses: Doctorates and Masters

In the last decades of the 20th Century, and through the first decade of the 21st Century, both the natural world and human society have experienced dramatic change. Contemporary society world-wide has high expectations of the contribution that universities can make in helping people learn to live with change, to lead change, to manage change, and to support improvement in all spheres of life. The global community seeks ‘excellence’ across all higher education roles: community engagement and leadership, research and innovation, and teaching and learning. However, universities are not always regarded as effective in fulfilling the needs of students, business …

Inorganic Hydrogeochemical Responses To Fires In Wetland Sediments On The Swan Coastal Plain, Western Australia, David Blake

Theses: Doctorates and Masters

In the past decade the wetlands of the Swan Coastal Plain (SCP) region of Western Australia have been subject to increasing fire frequency and intensity. Whilst wetland sediment fires (also known as peat fires) on the SCP are not new phenomena, the increased frequency, duration and extent of combustion have been concomitant with an increase in urbanisation and reduction in average annual rainfall for the region. This has led to a decrease in ground- and surface-water levels which, in turn, has increased the susceptibility of the wetland sediments to ignition and combustion events. Increased wetland fire severity has resulted in …

The Reality Of Reform : Teachers Reflecting On Curriculum Reform In Western Australia, Jessica Lyle

Theses: Doctorates and Masters

Australia is implementing its first national curriculum, the Australian Curriculum, after many years of debate regarding the validity and practicality of such an undertaking. Although it is widely accepted that “the effects of education policies and programs depend chiefly on what teachers make of them” (Cohen & Ball, 1990, p. 233), little is known about teachers’ perceptions of the Australian Curriculum or their prior experiences of mandatory curriculum reform as they begin engaging with this unique reform. To provide a means of exploring these perceptions and experiences, 18 teachers, four Head of Learning Areas (HOLAs) and the principal from a …

The Biology And Ecology Of Epinephilidae Speciea And Their Implications To Fisheries Management, Jason R. How

Theses: Doctorates and Masters

This thesis examines the biological and ecological aspects of members of the globally exploited Epinephilidae with reference to fisheries management and in particular the use of closures. The leopard coralgrouper Plectropomus leopardus is a common reef fish throughout the Indo-Pacific region and a major target of both commercial and recreational fisheries. There has been limited research on this species in the eastern Indian Ocean, where there are only two populations. An examination of the species found a number of significant biological differences to their eastern Australian con-specifics. Most noticeable was the strong size-related cue over their protogynous sex change. The …

A Model For Systematically Investigating Relationships Between Variables That Affect The Performance Of Novice Programmers, Vivian Campbell

Theses: Doctorates and Masters

This research was motivated by an interest in novices learning to program

and a desire to understand the factors that affect their learning. The

traditional approach to performing such an investigation has been to select

factors which may be important and then perform statistical tests on a few

potential relationships. A new research model is proposed and tested to

ensure that a thorough and systematic investigation of the data is performed.

This thesis describes the data, defines the model and explains the

application and validation of the model.

The research process is managed by a control algorithm that is the …

Embodied Conflict Resolution: Resurrecting Roleplay-Based Curricula Through Dance, Nadja Alexander, Michelle Lebaron

Research Collection Yong Pung How School Of Law

Moving on from the authors’ seminal 2009 critique of the overuse of role-plays in negotiation teaching, "Death of the Role-Play" (chapter 13 in Rethinking Negotiation Teaching), Alexander and LeBaron have taken the rapidly increasing enthusiasm for experiential learning in a new direction: multiple intelligences. Their particular interest is in a use of experiential learning that focuses on kinesthetic intelligence, employing actual physical movement, particularly dance, to unlock creativity in other mental domains, as well as to encourage authentic participation by people whose skills are not primarily verbal or mathematical. Those who may be inclined to be skeptical should note that …

Preschool Children's Information Processing And Emotional Behavior In Social Conflict Situations, Po Lin B.L. Bailey

Theses: Doctorates and Masters

This study investigated various aspects of the Social Information Processing Model, in particular, young children’s emotional behavior regulation and negative emotionality, in Hong Kong. The sample was N=628 from 12 schools. Using Rasch measurement, linear unidimensional scales were constructed for Emotion and Behaviour Regulation (10 items) and for Negative Emotionality (10 items). The well-known Short Temperament Scale was Rasch analyzed too, but a linear scale could not be created – it had initially been designed under the True Score Test theory paradigm. The children were divided into Type A (high on negative emotionality and low on emotion and behavior regulation, …

An Integrated Computer-Aided Modular Fixture Design System For Machining Semi-Circular Parts, Uday H. Farhan

Theses: Doctorates and Masters

Productivity is one of the most important factors in manufacturing processes because of the high level of market competition. In this regard, modular fixtures (MFs) play an important role in practically improving productivity in flexible manufacturing systems (FMSs) due to this technology using highly productive computer numerical control (CNC) machines. MFs consist of devices called jigs and fixtures for accurately holding the workpiece during different machining operations. The design process is complex, and traditional methods of MF design were not sufficiently productive.

Computer-aided design (CAD) software has rapidly improved as a result of the development of computer technology, and has …

Human Factors And Cultural Influences In Implementing Agile Philosophy And Agility In Global Software Development, Anuradha Sutharshan

Theses: Doctorates and Masters

As software becomes increasingly important to all aspects of industry, developers should be encouraged to adopt best practice and hence improve the quality of the processes used, and achieve targets relating to time, budget and quality. In the software industry, several software methodologies have been used to address software development problems; however some of these processes may be too bureaucratic. The Agile Alliance formed in 2001, sought to address this problem; accordingly, they developed a manifesto and twelve principles, to which all agile software methods adhere. The purpose of the manifesto and its principles is to uncover better ways of …

On A Joint Physical Layer And Medium Access Control Sublayer Design For Efficient Wireless Sensor Networks And Applications, Mahir Lumumba Meghji

Theses: Doctorates and Masters

Wireless sensor networks (WSNs) are distributed networks comprising small sensing devices equipped with a processor, memory, power source, and often with the capability for short range wireless communication. These networks are used in various applications, and have created interest in WSN research and commercial uses, including industrial, scientific, household, military, medical and environmental domains. These initiatives have also been stimulated by the finalisation of the IEEE 802.15.4 standard, which defines the medium access control (MAC) and physical layer (PHY) for low-rate wireless personal area networks (LR-WPAN).

Future applications may require large WSNs consisting of huge numbers of inexpensive wireless sensor …

Improving Classroom Discourse In Inquiry-Based Primary Science Education, Prudence Smith

Theses: Doctorates and Masters

Teachers‟ capacity to use classroom discourse to deepen student learning through sustained conversation is considered crucial to increasing students‟ intellectual development. Learners actively construct knowledge and develop understandings from their shared experiences and via interaction with others (Driver, Asoko, Leach, Mortimer & Scott, 1994). However, talk that fosters students‟ capacity to reason is lacking in many classrooms (Alexander, 2006) and, what is more, teachers tend to control the discourse by asking a predominance of closed questions and using a question-answer recitation script which limits the exploration of students‟ ideas (Nystrand, Gamoran, Kachy, & Prendergast, 1997). The purpose of this study …

Surface Plasmons For Enhanced Metal-Semiconductor-Metal Photodetectors, Ayman A. Karar

Theses: Doctorates and Masters

Surface Plasmon Polaritons (SPPs) are quantized charge density oscillations that occur when a photon couples to the free electron gas of the metal at the interface between a metal and a dielectric. The extraordinary properties of SPP allow for sub-diffraction limit waveguiding and localized field enhancement. The emerging field of surface plasmonics has applied SPP coupling to a number of new and interesting applications, such as: Surface Enhanced Raman Spectroscopy (SERS), super lenses, nano-scale optical circuits, optical filters and SPP enhanced photodetectors. In the past decade, there have been several experimental and theoretical research and development activities which reported on …

The Relationship Between The Meaning Of Water And Sense Of Place : A Grounded Theory Study From Northern Thailand, Katesuda Sitthisuntikul

Theses: Doctorates and Masters

The literature suggests that a subtle relationship exists for communities between the meaning of water and sense of place, making fertile ground for systematic investigation. The relationship has obvious importance in today’s world, where people’s reliance on water, and the need for reliable supplies, form part of a common discourse in natural resource management. Yet, there has been much less discussion of what water means to people, how it connects with peoples’ sense of place, and what that might mean for the way people interact with their surroundings. The methodology of constructivist grounded theory was therefore appropriate to investigate this …

Numeracy Support For Year Two Students, Gillian Dawn Hurle

Theses: Doctorates and Masters

Research of teaching theories and intervention programs internationally and in Australia suggests that the implementation of numeracy support programs can improve student achievement levels (Fuchs, 2005; Ketterlin-Geller, Chard & Fien, 2008; Van Kraayenoord & Elkins, 2004). An intervention program was conducted for a small group of Year Two students with the aim of improving their numeracy skills over a 20 week period. Results of two mathematics assessments, together with information provided by teachers based on classroom observations and informal assessments were combined to select a group of twelve students who were considered to be at risk of developing mathematical difficulties. …

Practice Based Competency Development: A Study Of Resource Geologists And The Jorc Code System, Jacqueline Coombes

Theses: Doctorates and Masters

The mining industry is a major contributor to the Australian economy. The value of mining and exploration shares traded on the Australian Stock Exchange are contingent on the estimates of mineral deposits, which are disclosed publically in accordance with a reporting code maintained by the Australasian Joint Ore Reserves Committee (the JORC Code). Expert resource geologists, known as Competent Persons, provide classified estimates of mineral endowment that underpin these public statements. The JORC Code requirements for qualifying as Competent Persons are membership of an approved professional association and a minimum of five years’ relevant experience. This research set out to …

Lichens As A Biomonitoring Tool For Detecting Heavy Metal Air Pollution Associated With Industrial Activities In Collie, South-Western Australia, Meenu Chathurika Vitarana

Theses: Doctorates and Masters

During the last few decades, various techniques for using lichens as biomonitors have been developed for monitoring air pollution and forest ecosystem health. Lichens have been used effectively to determine the dispersion of heavy metals emitted by industrial point-sources; however the approach has not been commonly used in Australia. This thesis aimed to determine the effectiveness of using a lichen biomonitoring approach to measure the heavy metal pollutants emitted from coal-fired power stations and related industries in Collie, south-western Australia, an area with concern over poor air quality. Three different approaches to lichen biomonitoring were investigated. The first explored lichen …