Digital Commons Network^™

C4a-Hydroperoxyflavin Formation In N -Hydroxylating Flavin Monooxygenases Is Mediated By The 2′-Oh Of The Nicotinamide Ribose Of Nadp⁺, Reeder Robinson, Somayesadat Badieyan, Pablo Sobrado

Chemistry Faculty Research & Creative Works

Flavin-dependent monooxygenases must stabilize a C4a-hydroperoxyflavin intermediate to hydroxylate their respective substrates. Formation and decay of the C4a-hydroperoxyflavin were monitored under rapid reaction kinetic conditions in SidA, an N-hydroxylating monooxygenase involved in siderophore biosynthesis. Solvent kinetic isotope effect studies of flavin oxidation indicate that both hydrogen peroxide elimination and water elimination occur via abstraction of hydrogen from the N5 of the flavin. Kinetic isotope effect and density functional theory results are consistent with the transfer of a proton from the 2′-OH of the nicotinamide ribose of nicotinamide adenine dinucleotide phosphate (NADP+) to the C4a-peroxyflavin to form the C4a-hydroperoxyflavin. This represents …

Structure Based Identification And Characterization Of Flavonoids That Disrupt Human Papillomavirus-16 E6 Function, Elliot J. Androphy, Jonathan J. Cherry, Anne Rietz, Anna Malinkevich, Yuqi Liu, Meng Xie, Matthew D. Bartolowits, Vincent J. Davisson, James D. Baleja

Department of Medicinal Chemistry and Molecular Pharmacology Graduate Student Publications

Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary for viral replication and oncogenesis in cervical cancers. HPV E6 targets the tumor suppressor protein p53 for degradation. To achieve this, “high-risk” HPV E6 proteins bind to and modify the target specificity of the ubiquitin ligase E6AP (E6 associated protein). This E6-dependent loss of p53 enables the virus to bypass host cell defenses and facilitates virally induced activation of the cell cycle progression during viral replication. Disruption of the interaction between E6 and E6AP and stabilization of p53 should decrease viability and proliferation of HPV positive …

A Search For Enhanced Very High Energy Gamma-Ray Emission From The 2013 March Crab Nebula Flare, P. T. Reynolds, Et Al

Physical Sciences Publications

In 2013 March, a flaring episode from the Crab Nebula lasting ~2 weeks was detected by Fermi-LAT (Large Area Telescope on board the Fermi Gamma-ray Space Telescope). The Very Energetic Radiation Imaging Telescope Array System (VERITAS) provides simultaneous observations throughout this period. During the flare, Fermi-LAT detected a 20 fold increase in flux above the average synchrotron flux >100 MeV seen from the Crab Nebula. Simultaneous measurements with VERITAS are consistent with the non-variable long-term average Crab Nebula flux at TeV energies. Assuming a linear correlation between the very high energy flux change >1 TeV and the flux …

Students’ Perceived Utility Of Precision Taught Calculus, Rebecca- Anne Dibbs, David Glassmeyer, Wafa Yacoub

The Qualitative Report

The last decade of calculus research has showed students learn best when lecture is supplemented with thoughtful use of technology and group work; however, educators are given little direction of how they are to balance the already full first semester calculus class. Precision teaching is an instructional model that employs formative assessment to provide information on what topics are understood by students as well as indicate troublesome concepts. With this information, the instructor can adjust class time accordingly by incorporating supplemental activities most beneficial to students. The purpose of this interview study was to explore the perceived utility of precision …

Students' Perceived Utility Of Precision Taught Calculus, Rebecca-Anne Dibbs, David Glassmeyer, Wafa Yacoub

Faculty Articles

The last decade of calculus research has showed students learn best when lecture is supplemented with thoughtful use of technology and group work; however, educators are given little direction of how they are to balance the already full first semester calculus class. Precision teaching is an instructional model that employs formative assessment to provide information on what topics are understood by students as well as indicate troublesome concepts. With this information, the instructor can adjust class time accordingly by incorporating supplemental activities most beneficial to students. The purpose of this interview study was to explore the perceived utility of precision …

Anticipatory Self-Defense In The Cyber Context, Terry D. Gill, Paul A.L. Ducheine

International Law Studies

No abstract provided.

Precision Air Warfare And The Law Of Armed Conflict, Christopher J. Markham, Michael N. Schmitt

International Law Studies

No abstract provided.

Fall Commencement [Program], December 21, 2013, University Of Northern Iowa

UNI Commencement Programs

The program of the commencement ceremonies, including a list of institutional leadership, a list of the departments by college, awards given at the ceremonies, and a list of undergraduate and graduate degree candidates.

Class Notes

Cal Poly Magazine

No abstract provided.

The Cornerstone Of The Cal Poly Education, Sarah Thien

Cal Poly Magazine

No abstract provided.

Taking The Unexpected Path, Cathy Enns

Cal Poly Magazine

No abstract provided.

A Living Symbol, Larry Peña

Cal Poly Magazine

No abstract provided.

University News

Cal Poly Magazine

No abstract provided.

2013 Winter Boise State University Commencement Program, Boise State University Commencement Committee

Commencement Programs

No abstract provided.

Using Expression Profiling To Understand The Effects Of Chronic Cadmium Exposure On Mcf-7 Breast Cancer Cells, Zelmina Lubovac-Pilav, Daniel M. Borras, Esmeralda Ponce, Maggie Louie

Collected Faculty Scholarship

Cadmium is a metalloestrogen known to activate the estrogen receptor and promote breast cancer cell growth. Previous studies have implicated cadmium in the development of more malignant tumors; however the molecular mechanisms behind this cadmium-induced malignancy remain elusive. Using clonal cell lines derived from exposing breast cancer cells to cadmium for over 6 months (MCF-7-Cd4, -Cd6, -Cd7, -Cd8 and -Cd12), this study aims to identify gene expression signatures associated with chronic cadmium exposure. Our results demonstrate that prolonged cadmium exposure does not merely result in the deregulation of genes but actually leads to a distinctive expression profile. The genes deregulated …

Winter Commencement: December 20, 2013, University Of North Dakota

UND Commencement Programs

UND Winter Commencement program from December 20, 2013.

Moa-2010-Blg-328lb: A Sub-Neptune Orbiting Very Late M Dwarf?, K. Furusawa, A. Udalski, T. Sumi, D. P. Bennett, I. A. Bond, A. Gould, U. G. Jørgensen, C. Snodgrass, D. Dominis Prester, M. D. Albrow, F. Abe, C. S. Botzler, P. Chote, M. Freeman, A. Fukui, P. Harris, Y. Itow, C. H. Ling, K. Masuda, Y. Matsubara, N. Miyake, Y. Muraki, K. Ohnishi, N. J. Rattenbury, To Saito, D. J. Sullivan, D. Suzuki, W. L. Sweatman, P. J. Tristram, K. Wada, P. C.M. Yock, M. K. Szymański, I. Soszyński

Faculty Publications

We analyze the planetary microlensing event MOA-2010-BLG-328. The best fit yields host and planetary masses of Mh = 0.11 ± 0.01 M Ȯ and Mp = 9.2 ± 2.2 M ⊕, corresponding to a very late M dwarf and sub-Neptune-mass planet, respectively. The system lies at D L = 0.81 ± 0.10 kpc with projected separation r ⊥ = 0.92 ± 0.16 AU. Because of the host's a priori unlikely close distance, as well as the unusual nature of the system, we consider the possibility that the microlens parallax signal, which determines the host mass and distance, is actually due …

Comment On “Synthesis, Characterization, And Structures Of Persistent Aniline Radical Cation”: It Is A Protonated Aniline And Not An Aniline Radical Cation, Marat R. Talipov, Jeewantha S. Hewage, Sergey V. Lindeman, James R. Gardinier, Rajendra Rathore

Chemistry Faculty Research and Publications

The same, but different: The reaction of tri-tert-butylaniline (TBA) with AgSbF₆ in CH₂Cl₂ produces a green-colored intermediate which undergoes decomposition to form a protonated aniline (TBAH⁺SbF₆⁻). Crystals of the protonated aniline salt (see picture) were analyzed by X-ray diffraction and found to have the same crystal characteristics as the crystals of the supposed cation radical first identified in 2012.

High Yield Solvothermal Synthesis Of Hexaniobate Based Nanocomposites Via The Capture Of Preformed Nanoparticles In Scrolled Nanosheets, Shivaprasad Reddy Adireddy

LSU New Orleans Theses and Dissertations

The ability to encapsulate linear nanoparticle (NP) chains in scrolled nanosheets is an important advance in the formation of nanocomposites.These nanopeapods (NPPs) exhibit interesting properties that may not be achieved by individual entities. Consequently, to fully exploit the potential of NPPs, the fabrication of NPPs must focus on producing composites with unique combinations of morphologically uniform nanomaterials. Various methods can produce NPPs, but expanding these methods to a wide variety of material combinations can be difficult. Recent work in our group has resulted in the in situ formation of peapod-like structures based on chains of cobalt NPs. Building on this …

Ultra-Low Temperature Measurements Of London Penetration Depth In Iron Selenide Telluride Superconductors, Andrei Diaconu

LSU New Orleans Theses and Dissertations

The newly discovered iron based superconductors have captivated the attention of the scientific community due to the unusual mechanism behind their superconductivity and their promise as the next generation high temperature superconductors. After a century of superconductor research, the physical mechanism behind high temperature superconductivity is still not understood. These new materials bring renewed hope in elucidating the pairing mechanism responsible with high temperature superconductors and achieving the ultimate goal of the field, room temperature superconductivity. Consequently, a deeper understanding of the intriguing properties of iron based materials is essential.

A great deal about the pairing mechanism of Cooper electron …

Synthesis Of Novel Azetidines, Amber Thaxton

LSU New Orleans Theses and Dissertations

Azetidine is a four-membered nitrogen-containing heterocyclic ring that has recently received a great deal of attention as a molecular scaffold for the design and preparation of biologically active compounds. Structure-activity studies employing functionalized azetidines have led to the development of variety of drug molecules and clinical candidates encompassing a broad spectrum of biological activities.

Herein, the synthesis a novel series of 3-aryl-3-arylmethoxyazetidines is described. Selected 3-aryl-3-arylmethoxyazetidines were evaluated for their binding affinity to multiple monoaminergic transporters for the potential treatment of methamphetamine addiction. It was discovered that this scaffold exhibits high binding affinity (nM) for both the serotonin and dopamine …

A Collective Case Study Of The Nature Of Form-Focused Instruction Among Secondary English As A Second Language Teachers, Sevda Budak

Department of Teaching, Learning, and Teacher Education: Theses and Other Student Research

The nature of teaching expertise for form-focused instruction (FFI) in secondary schools has received little research attention. FFI research that has been carried out so far has devoted time in exploring the classification of one form of FFI, or the effectiveness of one form of FFI over another. Given that exploring teaching expertise for FFI in a natural classroom setting is necessary in order to bring out the interplay of factors influencing and prioritized by the teacher in choosing how to proceed instructionally. Furthermore, student experiences of teacher FFI have been largely ignored. Giving voice to student perspectives will help …

A Wedge Impact Theory Used To Predict Bow Slamming Forces, Ashok Benjamin Basil Attumaly

LSU New Orleans Theses and Dissertations

The pressures and impact forces acting on a hull while experiencing bow wave slamming is analyzed using Vorus' Impact Theory. The theory extends the hydrodynamic analysis of planing hulls from simple wedges to irregular shapes using a Boundary Element Method. A Fortran-based code developed by the Author is used to analyze hullforms. Linear strip theory is used to extend the analysis over a three dimensional hull. Post-processing of output data gives hull pressure distributions at different time steps and is visually presentable.

Impact pressure, Impact force, Planing, Wave slamming, Bow impact, Vorus' theory, Boundary Element Method, Linear strip theory

Predicting Voltage Abnormality Using Power System Dynamics, Nagendrakumar Beeravolu

LSU New Orleans Theses and Dissertations

The purpose of this dissertation is to analyze dynamic behavior of a stressed power system and to correlate the dynamic responses to a near future system voltage abnormality. It is postulated that the dynamic response of a stressed power system in a short period of time-in seconds-contains sufficient information that will allow prediction of voltage abnormality in future time-in minutes. The PSSE dynamics simulator is used to study the dynamics of the IEEE 39 Bus equivalent test system. To correlate dynamic behavior to system voltage abnormality, this research utilizes two different pattern recognition methods one being algorithmic method known as …

A Nonlinear Ship Wave Solution Method, Li Chen

LSU New Orleans Theses and Dissertations

No abstract provided.

Rocket Motor Diagnostics Using Tunable Diode Laser Spectroscopy For Chemically Non-Reacting Air/Water Vapor Mixture In Internal Flow, Wesley Carleton

LSU New Orleans Theses and Dissertations

This research is for the implementation of non-intrusive measurement techniques in the study of high temperature pipe flow. A low pressure, laboratory scale hybrid rocket motor simulator was built to achieve high temperatures with various gases. A quartz test section was designed, built, and implemented into the existing test setup to accommodate the laser beam of the existing Tunable Diode Laser Absorption Spectrometer (TDLAS) system which was designed to observe water vapor. A super-heated water vapor injector was designed to obtain the desired water vapor concentrations. Flow characteristics were simultaneously recorded using the existing TDLAS system and the DAQ system …

Special Education Co-Teachers' Perceptions: Collaboration, Involvement In Instruction, And Satisfaction, Eden Hagelman

LSU New Orleans Theses and Dissertations

Co-teaching is an approach that is frequently used by schools when students both with and without disabilities are taught in an inclusive classroom. With co-teaching, a general education teacher and a special education teacher share the responsibility of planning and teaching students. This study examined the perceptions of elementary special education co-teachers (n=81) regarding their collaboration with the general educator and their involvement in instruction in the inclusive classroom. In addition, the special education teachers' satisfaction with the co-teaching assignment was investigated. Findings showed that special education co-teachers shared an average of 30 minutes of co-planning a week, teachers who …

Sistas On The Move: An Ethnographic Case Study Of Health And Friendship In Urban Space Among Black Women In New Orleans, Valerie A. Mcmillan

LSU New Orleans Theses and Dissertations

Abstract

Black women are disproportionately affected by adverse health conditions, such as obesity and heart disease. For example, more black women currently die from complications associated with diabetes, obesity and high blood pressure than any other ethnic group in the United States (Gourdine 2011). There are however, increasing numbers of everyday black women who defy these statistics and are positive role models for all women. One such group of women is the New Orleans chapter of Sistas On The Move (SOTM), an all-female running group that emphasizes the importance of black women’s health and builds community around physical activity. Through …

Experimental Investigation Of Mist Film Cooling And Feasibility Study Of Mist Transport In Gas Turbines, Reda M. Ragab

LSU New Orleans Theses and Dissertations

In the modern advanced gas turbines, the turbine inlet temperature may exceed 1500°C as a requirement to increase power output and thermal efficiency. Therefore, it is imperative that the blades and vanes are cooled so they can withstand these extreme temperatures. Film cooling is a cooling technique widely used in high-performance gas turbines. However, the film cooling effectiveness has almost reached plateau, resulting in a bottleneck for continuous improvement of gas turbines' efficiency.

In this study, an innovative cooling scheme, mist film cooling is investigated through experiments. A small amount of tiny water droplets with an average diameter about 10-15 …

A Study On The Integration Of A Novel Absorption Chiller Into A Microscale Combined Cooling, Heating, And Power (Micro-Cchp) System, Scott J. Richard

LSU New Orleans Theses and Dissertations

This study explores the application of micro-CCHP systems that utilize a 30 kW gas microturbine and an absorption chiller. Engineering Equation Solver (EES) is used to model a novel single-effect and double-effect water-lithium bromide absorption chiller that integrates the heat recovery unit and cooling tower of a conventional CCHP system into the chiller’s design, reducing the cost and footprint of the system. The results of the EES model are used to perform heat and material balances for the micro-CCHP systems employing the novel integrated chillers, and energy budgets for these systems are developed. While the thermal performance of existing CCHP …