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Chikungunya Virus Infection Results In Higher And Persistent Viral Replication In Aged Rhesus Macaques Due To Defects In Anti-Viral Immunity, Ilhem Messaoudi, Jennifer Totonchy, Thomas Totonchy, Craig N. Kreklywich, Kristen Haberthur, Laura Springgay, James D. Brien, Michael S. Diamond, Victor R. Defilippis, Daniel N. Streblow

Pharmacy Faculty Articles and Research

Chikungunya virus (CHIKV) is a re-emerging mosquito-borne Alphavirus that causes a clinical disease involving fever, myalgia, nausea and rash. The distinguishing feature of CHIKV infection is the severe debilitating poly-arthralgia that may persist for several months after viral clearance. Since its re-emergence in 2004, CHIKV has spread from the Indian Ocean region to new locations including metropolitan Europe, Japan, and even the United States. The risk of importing CHIKV to new areas of the world is increasing due to high levels of viremia in infected individuals as well as the recent adaptation of the virus to the mosquito species Aedes …

The Impact Of Parental Involvement On A Structured Youth Program Experience: A Qualitative Inquiry, Mat D. Duerden, Peter A. Witt, Christopher J. Harrist

Faculty Publications

Parental involvement is an often proposed, but rarely researched, key element of youth programs. Questions remain regarding the impact of parental involvement on program processes and outcomes. Qualitative data were collected over a one-year period with youth participants (n=46), parents (n=26), and teachers (n=5) associated with an international immersion/service learning program for adolescents. Three main research questions guided the data analysis: (1) what role does parental involvement play in the youths’ experience in the program; (2) how does parental involvement in the program influence the parent/child relationship; and (3) what role does parental involvement play in terms of the program’s …

Community-Based Participatory Research To Partner With The Confederated Salish And Kootenai Tribes In Pharmacogenetics Research, Chelsea Theresa Morales

Graduate Student Theses, Dissertations, & Professional Papers

Pharmacogenetics research has advanced our knowledge of the genetic basis of individual drug responses. The aim of pharmacogenetics research is to provide opportunities for the development of strategies aimed at discovering clinically relevant gene-drug pairs. Further benefits stem from the translation of pharmacogenetics research into the clinic to identify patients who are at high risk of adverse drug events. However, American Indian and Alaska Native (AI/AN) populations have not benefited markedly from genetics-guided therapeutics. A key strategy in engaging AI/AN people in pharmacogenetics research has been the implementation of community-based participatory research (CBPR). CBPR is a qualitative research methodology in …

The Lived Experience Of American Indian Teen Parents From A Northern Plains Tribe, Ann Marie Douglas

Graduate Student Theses, Dissertations, & Professional Papers

Although there is extensive research on the outcomes of teen mothers and their children, there is little research to date on how teen parents, especially American Indian teen parents, are functioning in their new role. This is alarming as the rate of births to American Indian teens is far greater than the same-aged Non-Hispanic White population. This study examined the lived experiences of teen parents currently living on a Northern Plains Indian Reservation. Seven participants were interviewed using a phenomenological method. Interviews were analyzed using NVivo and Giorgi’s method. The themes that emerged were traditional roles (child role, parent role, …

The Influence Of Exotic Plant Invasion On Native Bee Abundance And Demography, And The Pollination And Abundance Of Native Plants, Jennifer Palladini

Graduate Student Theses, Dissertations, & Professional Papers

Flowering plants and bees are fundamentally linked. Bees rely wholly on floral resources for food and many native plants rely on bees to assist in reproduction. Despite this fundamental connection, how plants and their bee pollinators influence one another's abundance remains unclear. Also unclear is how invasion by exotic flowering plants disrupts bee- native plant relationships. I examined how the invasive plant, Euphorbia esula (Euphorbiaceae) influenced the native annual forb, Clarkia pulchella (Onagraceae) by altering pollinator visitation (i.e., indirect effects) and through direct resource competition. I observed pollinator visitation and estimated the extent to which plant reproduction was limited by …

Variations In Wildfire Ash Properties And Implications For Post-Fire Hydrological Response Within Western North American Ecosystems, Victoria Balfour

Graduate Student Theses, Dissertations, & Professional Papers

Within the Rocky Mountain region of the Western U.S.A the average number of wildfires over 40 hectares have quadrupled and the frequency of large wildfires (> 4,000 hectares) have increased seven times since the 1970’s. The effect of this increase on resource management and ecosystem function is of increased interest to agencies and land managers within the region. The research presented in this dissertation aimed to contribute to the growing knowledge of post-fire hydrology, specifically with regards to the role of wildfire ash within recently burned ecosystems. Ash should not be considered a generic term, as it is an important …

The Genetic Basis Of Fitness: Detecting Inbreeding Depression And Selective Sweeps In Bighorn Sheep, Martin Dennis Kardos

Graduate Student Theses, Dissertations, & Professional Papers

Understanding the fitness effects of inbreeding is a crucial and long standing goal in conservation and evolutionary biology. Many studies measure individual inbreeding (F, the proportion of genome that is identical by descent) and its fitness effects using either pedigrees or molecular markers. Knowing which genes most strongly affect fitness can help to explain why some individuals outperform others, and elucidate the mechanisms of inbreeding depression and adaptation. However, identifying adaptive genes is difficult in most species because of limited genomic resources.

I used simulations to evaluate the performance of marker- and pedigree-based measures of F and inbreeding depression. I …

Understanding The Dynamics Of Species Distributions Under Climate Change: Linking Empirical Evidence, Ecological Theory, And Statistical Models, Shawn M. Crimmins

Graduate Student Theses, Dissertations, & Professional Papers

Climate change is threatening biota all over the world through dictating changes in species distributions. The ability to predict the effects of climate on species distributions requires an understanding of how climatic and disturbance factors relate to species distributions. I examined the relationship between climate, disturbance, and geographic distributions of vascular plants in the western United States.

Within the mountain ranges of California, woody plants have largely shifted their distributions downhill during the 20th century. These shifts were strongly related to observed changes in climatic water balance, consistent with theoretical predictions. Downhill shifts were most prominent for species occurring at …

Effects Of Local And Landscape Processes On Animal Distribution And Abundance, Aaron David Flesch

Graduate Student Theses, Dissertations, & Professional Papers

Investigations of processes that drive animal distribution and abundance are often approached at one of two different scales and therefore focus on different processes. At local scales, animals are thought to select home ranges or territory patches in an ideal manner by occupying them in order of their fitness potential, but a variety of processes can decouple choices from their fitness consequences and create non-ideal patterns of distribution. At landscape scales, the spatial arrangement of habitat patches and their size and isolation are thought to influence distribution patterns because extinction probability declines with increasing patch area and colonization probability declines …

Modeling Connectivity In Landscape Genetics: Applications, Optimization And Assessing Uncertainty, Brian Kevin Hand

Graduate Student Theses, Dissertations, & Professional Papers

Connectivity modeling and corridor identification are an essential part of landscape genetics and important tools for the future of conservation biology. The previous decade has shown a steadily increasing interest and rise in publications in landscape genetics. This enthusiasm has led to advances in the methods and theoretical background of the field; however, there remain important, yet unresolved, challenges. Many of these are related to validation and uncertainty testing for resistance surfaces (hypotheses of connectivity). These fundamental issues need to be addressed before landscape genetics can gain the full recognition of a scientific discipline such as population genetics or landscape …

A Spatially-Explicit Decision Support System For Invasive Weed Species Management, Pablo Aracena

Graduate Student Theses, Dissertations, & Professional Papers

Invasive weed species are a recognized problem worldwide causing economic and environmental problems. Management of weeds is complex and challenging because of multiple decisions that need to be made when allocating limited resources to control current infestation areas including which weeds to treat, where to treat, how to treat, and when to treat. Models have been developed to simulate weed spread, however they lack the ability to simulate the short term effects of weed treatments and analyze trade-offs among control allocation options. This trade-off analysis is critical in developing cost-efficient treatment decisions especially when available budget for treatments is limited. …

Interactions Between Arenavirus Proteins And Small Molecule Inhibitors Of Infection, Emily L. Messina

Graduate Student Theses, Dissertations, & Professional Papers

Arenaviruses are globally distributed, negative-sense, single-stranded RNA viruses which persist in specific rodent host species. Of the 32 known arenaviruses, 10 have been associated with human disease. Of these, Lassa, Junín, Machupo, Guanarito, and Sabia viruses cause severe hemorrhagic fevers. The only current option for the treatment of arenavirus infection is the off-label use of ribavirin. However, ribavirin is associated with severe side effects. Clearly, there exists a need for the study of arenavirus biology and of novel drugs for the treatment of arenaviral infection. My work focused on two attractive targets for inhibition of infection: the arenaviral RNA-dependent RNA …

Ecology Of Juvenile Salmon In Large Floodplain Rivers: The Influence Of Habitat Modification By Beavers (Castor Canadensis) On Salmon Growth And Production, Rachel Lanelle Malison

Graduate Student Theses, Dissertations, & Professional Papers

I investigated the influence of beavers on aquatic floodplain habitats and determined how juvenile salmon habitat use, growth, survival, movement, and production varied by habitat type in a large alluvial floodplain of the Kwethluk River in western Alaska. I also compared juvenile salmon production at the floodplain scale in the Kwethluk River (with beavers), to a very similar salmon river in Kamchatka (the Kol) that has no beavers.

Beavers modified 87.5% of the aquatic off-channel habitat of the Kwethluk River, which was composed of three successional stages of beaver ponds (early-, mid-, and latesuccessional), and beaver-influenced spring brooks. Early-successional ponds …

Camouflage Mismatch In Seasonal Coat Color Due To Decreased Snow Duration: Will Snowshoe Hares Keep Up With Climate Change?, Marketa Zimova

Graduate Student Theses, Dissertations, & Professional Papers

As wild species face anthropogenic stressors, they will either adapt, shift their geographic range, or decline, perhaps towards extinction. The relative scope of these responses has not been well studied, especially for climate change where geographic range shifts and population declines have been widely discussed but the potential for adaptation mostly ignored. Adaptation to anthropogenic stressors can occur through phenotypic plasticity and/or evolution. My thesis first establishes, based on field studies of wild snowshoe hares, a novel and high-profile stressor directly linked to climate change. The stressor arises from a decrease in snow duration due to climate change, which causes …

Lithic Technology And Risk: Winter Houses At Bridge River Villages, Kelly French

Graduate Student Theses, Dissertations, & Professional Papers

The 2012 excavation of a single housepit (Housepit 54) at the Bridge River Village site (EeR14) offers the unique opportunity to look at lithic organization and techinological strategies during the Fur Trade era in the Middle Fraser Canyon. The main goal of this research is to understand how the winter occupation of Housepit 54 may have affected the lithic technological strategies carried out at Bride River Village. As a winter pithouse, lithic raw material sources would be inaccessible during the three months of occupation. The hypothesis of this thesis is structured with a theory of risk framework in order to …

Shifts In Caribou Calving Habitat And Space-Use, Daniella Johanna Dekelaita

Graduate Student Theses, Dissertations, & Professional Papers

The woodland caribou (Rangifer tarandus caribou) population in Newfoundland has been declining since the mid-1990s, and will likely continue to decline into the foreseeable future. This decrease in numbers has been accompanied by a large drop in recruitment. Predation is the primary cause of caribou calf mortality in Newfoundland, and since 2003, >80% of radio-collared calves died within the first 6 months of life. Two Newfoundland herds also have shifted their calving grounds over the past 15 to 20 years. Our objective was to investigate why these shifts have occurred. We analyzed female telemetry locations spanning 29 years, to delineate …

Identifying Environmental Factors Influencing Golden Eagle Presence And Reproductive Success, Ross H. Crandall

Graduate Student Theses, Dissertations, & Professional Papers

Declining populations of plant and animal species is a major concern threatening global biodiversity. If we want to conserve threatened species, we must understand the requirements of the species. Recent data suggests Golden Eagle populations in the Western United States are declining. Future threats from expanded energy development, habitat loss and climate change are also a concern. Apparent declines and perceived threats have caused management agencies to classify the Golden Eagle as a species of concern requiring the creation of conservation plans. Yet, an effective conservation plan is dependent on information that is currently lacking. To address this lack of …

Exotic Invasive Plants Drive Different Ecosystem Processes Than Natives In Montana Grasslands, Morgan Marie Luce

Graduate Student Theses, Dissertations, & Professional Papers

Invasion is associated with unexpected increases in aboveground net primary productivity and altered ecosystem function, including increased nitrogen availability and cycling. These shifts are well documented, however many previous studies have been observational, focused on a single plant species, or have not examined belowground microbial communities. I combined field and experimental techniques to examine changes in productivity and ecosystem function, and the abundance of ammonia- oxidizing bacteria (AOB) for the exotic invaders Bromus tectorum, Centaurea stoebe, Euphorbia esula, and Potentilla recta. To quantify effects of these invasive species on N cycling and AOB abundance we compared soil from invaded and …

Is Gun Crime Learned? Social Learning Theory And Guns, Krista Pearl Caffrey

Graduate Student Theses, Dissertations, & Professional Papers

This study examines the relationship between specific childhood experiences and the use of guns in crime in a sample of incarcerated males in American prisons. Two specific childhood experiences are examined: exposure to violence in the home and exposure to guns in the home. Utilizing social learning theory, I argue that adult male felons who used guns in the commission of crimes will have had greater levels of exposure to violence and exposure to guns in their childhood home. Using a data set collected by sociologists James Wright and Peter Rossi, I conducted a binary logistic regression to determine the …

The Constitution Of Queer Identity In The 1972 Apa Panel, "Psychiatry: Friend Or Foe To Homosexuals? A Dialogue", Dustin Vern Edward Schneider

Graduate Student Theses, Dissertations, & Professional Papers

This thesis offers a rhetorical criticism of two speeches delivered from a 1972 panel at the American Psychiatric Association (APA): Franklin Kameny’s “Gay, Proud and Healthy” and John Fryer’s “I am a Homosexual.” Both speeches seek to challenge heteronormative constructions of homosexuality through the construction of a positive homosexual identity. Kameny’s speech uses an extensive set of metaphors to deconstruct the sickness theory of homosexual, challenge the role psychiatrists should play in society, re-conceptualize sexuality, and empower homosexual identity. Fryer’s speech enacts a constitutive rhetoric through the use of consciousness raising strategies and a collective coming out narrative which creates …

Letter From The Editor, Christina Belcher

International Christian Community of Teacher Educators Journal

I have been contemplating my Sunday church service, where the meditation was based on finding peace even in times of productivity, from Philippians 4:6-9. As our academic calendars change gear and progress to a difference pace, giving us space for more peace that may allow more meditative reading, I invite you to join with me in reading our Summer Issue 8(2) of the ICCTE journal. Already, we are receiving and processing manuscripts for our Fall Issue. God has been good to us.

Exposing The Roots Of Low Self-Efficacy For Math: A Multi-Case Study Of Students In An Urban Middle School, Joshua Emmett, Daniel Hall, Corey Mckenna

International Christian Community of Teacher Educators Journal

This multi-case study of historically low-performing 7th grade students in a math class at an urban middle school employed a theoretical framework based upon Bandura’s Social Cognitive Theory to discover the causes of low self-efficacy for math. The study utilized a cross-case analysis of four students who demonstrated varying degrees of self-efficacy. To serve students similarly situated, Christian teachers need to know what these students are experiencing and an understanding of the causes of low self-efficacy can inform their professional practice. Christian teacher educators can also benefit from understanding the context into which teachers of such students will serve so …

Servant Leadership: Making A Difference In University Tesl Programs, Sarah Tahtinen-Pacheco

International Christian Community of Teacher Educators Journal

Teaching English as a Second Language is a broad field with programs designed to teach students from all languages and cultures around the world. Currently, the field is facing an urgent need for qualified teachers and leaders due to increasingly high numbers of immigrants and refugees. To meet this challenge, universities must have a plan for adequately preparing teachers to work with the growing population of non-native English learners.

Creating these programs require an understanding of ways to support English learners academically, linguistically, and culturally as they transition into English speaking schools. Based on the need for support, this article …

Corneal Gene Therapy: Basic Science And Translational Perspective, Rajiv R. Mohan, Jason T. Rodier, Ajay Sharma

Pharmacy Faculty Articles and Research

Corneal blindness is the third leading cause of blindness worldwide. Gene therapy is an emerging technology for corneal blindness due to the accessibility and immune-privileged nature of the cornea, ease of vector administration and visual monitoring, and ability to perform frequent noninvasive corneal assessment. Vision restoration by gene therapy is contingent upon vector and mode of therapeutic gene introduction into targeted cells/tissues. Numerous efficacious vectors, delivery techniques, and approaches have evolved in last decade for developing gene-based interventions for corneal diseases. Maximizing the potential benefits of gene therapy requires efficient and sustained therapeutic gene expression in target cells, low toxicity, …

Causes And Consequences Of Dominance And Diversity In Grasslands, Sarah Pinto

Graduate Student Theses, Dissertations, & Professional Papers

Understanding how species coexist and differ in abundance is central to ecology. Theory predicts competitively superior species should dominate systems and suppress diversity, yet many natural communities characterized by dominants are species rich. Understanding how shifts in dominance among species, and the inherent diversity of communities affect ecosystem function is a second central theme in ecology. For example, decreasing the number of species in local communities can reduce the ability of the community to respond to disturbance. These ideas have captured ecologists' attention because anthropogenic pressures are causing many systems to lose species. In my dissertation I focused on processes …

Measuring Visual Literacy Ability In Graduate Level Pre-Service Teachers, Teresa Farrell

Graduate Student Theses, Dissertations, & Professional Papers

Farrell, Teresa, Ed.D., August 2013 Curriculum and Instruction Measuring Visual Literacy Ability in Graduate Level Pre-service Teachers Chairperson: Dr. Marian J. McKenna The field of visual literacy has been active since its inception in 1969 by John Debes and members of various fields of study such as science, mathematics, psychology, education, and the arts forming the International Visual Literacy Association (IVLA). Recognizing that modern society is increasingly visual by nature, and with the advances in digital technologies, visual literacy is becoming an area of critical importance in education. Although much work has been done within the field to define it …

Emerging Technologies: Webcams And Crowd-Sourcing To Identify Active Transportation, J. Aaron Hipp, Deepti Adlakha, Bill Chang, Amy A. Eyler, Robert B. Pless

Brown School Faculty Publications

Over 25% of adults in the US are obese, contributing to 300,000 deaths and costing the US healthcare system $147 billion annually. Federal governments to local non-profit agencies have instituted policy and built environment (BE) changes in effort to reduce obesity and increase physical activity (PA). A challenge in evaluating the success of policy and BE change is the capacity to capture a priori PA behaviors and the ability to eliminate researcher and respondent bias in assessing post-change environments. A novel transdisciplinary collaboration between public health and computer science is presented here with the goal of automatically analyzing existing public …

Physical Activity Surveillance And Emerging Technologies, J. Aaron Hipp

Brown School Faculty Publications

No abstract provided.

Ciclovía Initiatives: Engaging Communities, Partners, And Policy Makers Along The Route To Success, Susan G. Zieff Phd, J. Aaron Hipp, Amy A. Eyler, Mi-Sook Kim Phd

Brown School Faculty Publications

Recent efforts to increase physical activity through changes to the built environment have led to strategies and programs that use existing public space, including bicycle lanes, temporary parks, and the ciclovia initiative (scheduled events in which streets are closed to motorized vehicles and opened for recreational activities) popularized in South America. Objective: This article describes and compares the processes and structures involved in developing and implementing a ciclovia-type program in 2 US urban contexts: San Francisco, California, and St Louis, Missouri. Considering the current growth of and interest in ciclovia initiatives, important outcomes, lessons learned are offered for application in …

Individual Worker Level Attitudes Toward Empirically Supported Treatments, David A. Patterson Silver Wolf (Adelv Unegv Waya) Phd, Eugene Maguin Phd, Catherine N. Dulmus Phd, Bruce C. Nisbet

Brown School Faculty Publications

Objectives: There is a growing literature indicating that organizational and individual worker-level factors affect decisions about whether or not empirically-supported treatments (EST’s) are adopted within health care agencies. The purpose of this pilot study is to further investigate and measure worker’s attitudes within a community organization. Methods: A small organization participated in the study due to their diversity in services offered. Of the 92 workers eligible for participation in the study, 66 (72%) completed the Evidence-Based Practice Attitude Scale (EBPAS) survey. Results: Multivariate analyses revealed that female workers scored higher on both Openness and total score; workers with nursing, education …