Digital Commons Network^™

The Convention On The Rights Of Persons With Disabilities: Reflections On Four Flaws That Tarnish Its Promise, Lucia A. Silecchia

Journal of Contemporary Health Law & Policy (1985-2015)

No abstract provided.

Research News: 2013, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants and contracts recently awarded

Profil Zat Besi Ibu Hamil Di Daerah Endemis Malaria, Rostika Flora, Bina Melvia, Sigit Purwanto

Kesmas

Pada saat kehamilan, terjadi peningkatan kebutuhan zat besi (Fe) yang diperlukan untuk meningkatkan jumlah sel darah merah ibu dan membentuk sel darah merah janin dan plasenta. Apabila kebutuhan zat besi ini tidak terpenuhi, akan terjadi anemia defisiensi besi. Ibu hamil yang tinggal di daerah endemis malaria rentan terinfeksi malaria, yang berdampak terhadap anemia pada kehamilan. Penelitian ini merupakan penelitian deskriptif dengan desain potong lintang yang bertujuan untuk mengetahui gambaran profil zat besi pada ibu hamil yang berada di daerah endemis malaria vivax kota Bengkulu. Pemeriksaan mikroskopis malaria dan pengambilan sampel darah dilakukan untuk pemeriksaan profil zat besi terhadap 55 orang …

Full Issue, Iajbs Ateneo De Manila University

Journal of Management for Global Sustainability

No abstract provided.

Social Entrepreneurship As Practical Social Justice, Thane Kreiner

Journal of Management for Global Sustainability

No abstract provided.

Frugal Innovation: Core Competencies To Address Global Sustainability, Radha R. Basu,, Preeta M. Banerjee, Elizabeth G. Sweeny

Journal of Management for Global Sustainability

The call for global sustainability is echoed by societal, environmental, and economic needs across the globe. In answering this call, a design innovation process that properly considers the needs and context of citizens in the developing world is necessary in order to develop appropriate, adaptable, affordable, and accessible solutions, products and services. This process, called “Frugal Innovation,” is rapidly becoming a standard against which sustainable solutions are assessed. Through an exploration of Frugal Innovation Core Competencies (Frugal Innovation Lab, Santa Clara University), and corresponding case studies of field solutions, a model is presented to begin sustainably addressing global human needs.

Scaling Impact In The Health Sector, Al Hammond

Journal of Management for Global Sustainability

This essay examines possible routes to achieving significant health improvements in the underserved populations of developing countries. It argues that unconventional strategies, largely outside the health sector as conventionally defined, have the greatest potential to scale sustainably. The essay describes two such strategies—nutrition and safe drinking water. In particular, the essay argues that impact investors focused on social enterprises can best maximize their health impact by looking closely at the strategies described herein.

The Public Health Pbrn Program: A Summative Report, Center For Public Health Systems And Services Research

UKCPHSSR Research Briefs and Reports

This program seeks to expand the volume and quality of evidence on how best to organize, finance, and deliver public health services by: (1) helping to organize and develop practice-based research networks (PBRNs) comprised of public health agencies and skilled research institutions; (2) selecting grantees to receive funding and technical assistance for PBRN research projects; and (3) facilitating the successful development, implementation, and translation of research projects through PBRNs by providing technical assistance, fostering peer learning, and leading selected multi-network research activities.

Activity Of Tobramycin And Polymyxin-E Against Pseudomonas Aeruginosa Biofilm Coated Medical Grade Endotracheal Tubes., Keiko Tarquinio, Confreda, James Shurko, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

Indwelling medical devices have become a major source of nosocomial infections; especially Pseudomonas aeruginosa (P. aeruginosa) infection, which remain the most common cause of ventilator associated pneumonia (VAP) in neonates and children. Using medical grade polyvinyl chloride endotracheal tubes (ETTs), the activity of tobramycin and polymyxin-E was quantified in a simulated prevention and treatment static time kill model using biofilm forming P. aeruginosa. The model simulated three clinical conditions: 1) planktonic bacteria in the presence of antibiotics, tobramycin and polymyxin-E, without ETTs, 2) planktonic bacteria grown in the presence of P. aeruginosa, antibiotic and ETTs (simulating …

Transport, Deposition, And Hygroscopic Growth Of Diverse-Regime Aerosols In Human Respiratory Airways Of Varying Ages, Jongwon Kim

Theses and Dissertations

Determining how many inhaled aerosols deposit in human respiratory airways and where they deposit (i.e., respiratory dosimetry) are of critical importance in a number of fields. Applications of respiratory dosimetry modeling include evaluating health effects of inhaled pollutants, establishing environmental exposure standards, and developing effective techniques for delivering pharmaceutical aerosols to the lung. However, the manifold characteristics of aerosols coupled with the complexity of respiratory tract make such analysis a challenging task as well as a highly multidisciplinary effort, entailing expertise from medicine, engineering, and physiology. In this study, three major factors that affect particle transport and depositions were systematically …

Novel And Predominant Pathogen Responsible For The Enterovirus-Associated Encephalitis In Eastern China, Lei Zhang, Jie Yan, David M. Ojcius, Huakun Lv, Ziping Miao, Yin Chen, Yanjun Zhang, Jvying Yan

All Dugoni School of Dentistry Faculty Articles

Enteroviruses (EV) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (EAE) was not reported in China. From 2002-2012 in Zhejiang, Coxsackieviruses A9, B1, B2, B3, B4, B5; and echoviruses 3, 4, 6, 9, 14, 25, 30 were detected from the unknown etiological encephalitis cases, with coxsackievirus B4 been identified here for the first time. From 2002-2004 and 2010-2012, echovirus 30 was found to be the periodically predominant serotype for in the EAE. The molecular typing results showed that all the EV isolates …

Biofilm Formation On Intrauterine Device And Associated Infections, Sabah Abd Al-Kareem Al-Kattan, Daniz Tarik Burhan, Shafaq Tarik Burhan

Iraqi Postgraduate Medical Journal

Shafaq Tarik Burhan ABSTRACT: BACKGROUND: Intrauterine devices are highly effective methods of contraception; but considered to cause pelvic inflammatory diseases by its colonization by bacteria and /or fungi and form biofilms consisting of layers of host cells and bacteria or fungi embedded within a matrix material. OBJECTIVE: To screen the microbial biofilms on intrauterine devices, and its associated infection in vagina and cervix in intrauterine devices users. METHODS: A case series design was adopted, composed of 50 participants. High vaginal and cervical swabs were taken and intrauterine devices were removed and sent for microbiological examination. RESULTS: Eighty four percent of …

Multi-State Models For Natural History Of Disease, Amy Laird, Rebecca A. Hubbard, Lurdes Y. T. Inoue

UW Biostatistics Working Paper Series

Longitudinal studies are a useful tool for investigating the course of chronic diseases. Many chronic diseases can be characterized by a set of health states. We can improve our understanding of the natural history of the disease by modeling the sequence of visited health states and the duration in each state. However, in most applications, subjects are observed only intermittently. This observation scheme creates a major modeling challenge: the transition times are not known exactly, and in some cases the path through the health states is not known.

In this manuscript we review existing approaches for modeling multi-state longitudinal data. …

Wastewater Disinfection In Enclosed Recirculation Systems With Electromagnetic Waves, Luis G. Mosquera

LSU New Orleans Theses and Dissertations

Finding the most cost-effective and environmental friendly way to treat and disinfect wastewater has been raising concerns around the world. Failure in performing disinfection of wastewater before returning it to the environment could have terrible consequences to human health and the ecosystem. The risks associated to continue with current practices have led to the creation of stringent regulations.

In this research the HYDROPATH technology is tested while attaching a HydroFlow 60i unit to a reactor that works as a closed recirculation system. To determine the feasibility of the HydroFlow 60i unit as an alternative method to chlorine, the EPA method …

Chinese Social Media Reaction To The Mers-Cov And Avian Influenza A (H7n9) Outbreaks, Isaac Chun-Hai Fung, King-Wa Fu, Yuchen Ying, Braydon Schaible, Yi Hao, Chung-Hong Chan, Zion Tsz-Ho Tse

Epidemiology: Faculty Publications (2002-2018)

Background: As internet and social media use have skyrocketed, epidemiologists have begun to use online data such as Google query data and Twitter trends to track the activity levels of influenza and other infectious diseases. In China, Weibo is an extremely popular microblogging site that is equivalent to Twitter. Capitalizing on the wealth of public opinion data contained in posts on Weibo, this study used Weibo as a measure of the Chinese people’s reactions to two different outbreaks: the 2012 Middle East Respiratory Syndrome Coronavirus (MERS-CoV) outbreak, and the 2013 outbreak of human infection of avian influenza A(H7N9) in China. …

The General Hospital At Mount Independence: 18th-Century Health Care At A Revolutionary War Cantonment, David R. Starbuck

Northeast Historical Archaeology

The General Hospital at Mount Independence in Orwell, Vermont, has been examined in order to learn more about the configuration of an 18-century military hospital. Historical research combined with on-site excavation in 1990 exposed the foundation of a 250-foot-long building containing principally archicetural and kitchen debris. While physical remains did not reveal the layout of individual rooms, archaeological and historical evidence have nevertheless provided insights into the appearance and function of this important structure.

Bones And Burial Registers: Infant Mortality In A 19th-Century Cemetery From Upper Canada, Ann Herring, Shelley Saunders, Gerry Boyce

Northeast Historical Archaeology

The fortunate conjunction of a large skeletal sample (n=576) and reliable burial records (n=1,564) for St. Thomas' Anglican Church cemetery (1821-1874) makes it possible to make inferences about patterns of infant death in 19th-century Belleville, Ontario. Analysis of both sets of data indicates that males and females were equally likely to die during infancy and that environmental factors played an important role in Belleville's mortality profile. The parish records reveal elevated risks of infant death in the summer, probably from the weanling diarrhea complex, owing to unsanitary conditions and the presence of acute infectious diseases in the town. The importance …

Septins Of Platyhelminths: Identification, Phylogeny, Expression And Localization Among Developmental Stages Of Schistosoma Mansoni, Ana E. Zeraik, Gabriel Rinaldi, Victoria H. Mann, Anastas Popratiloff, Ana P.U. Araujo, Ricardo Demarco, Paul J. Brindley

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Septins are a family of eukaryotic GTP binding proteins conserved from yeasts to humans. Originally identified in mutants of budding yeast, septins participate in diverse cellular functions including cytokinesis, organization of actin networks, cell polarity, vesicle trafficking and many others. Septins assemble into heteroligomers to form filaments and rings. Here, four septins of Schistosoma mansoni are described, which appear to be conserved within the phylum Platyhelminthes. These orthologues were related to the SEPT5, SEPT10 and SEPT7 septins of humans, and hence we have termed the schistosome septins SmSEPT5, SmSEPT10, SmSEPT7.1 and SmSEPT7.2. Septin transcripts were detected throughout the developmental cycle …

Newly Identified Immune Receptor May Activate B Cells In Autoimmunity, Greg Williams

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No abstract provided.

Is The Annual Gynecological Exam Necessary?, Joyce Cappiello

Biennial Convention (CONV)

Session presented on: Tuesday, November 19, 2013:

Background: The concept of an annual gynecological screening visit to identify disease at an early stage at which an intervention is more effective is an established component of women's health care. Both patients and providers have accepted this schedule of visits as important and the gynecological exam as integral to the visit. However, there is little evidence to support the benefits of routine annual pelvic exams in low risk women. The components of the wellness visit can be better aligned with health improvement priorities of Healthy People and the IOM report on Clinical …

Global Leadership: Building Academic Nursing Scholarship, Education, And Service, Eileen M. Sullivan-Marx, Ann E. Kurth

Biennial Convention (CONV)

Session presented on: Sunday, November 17, 2013:

This panel session is designed to share experiences and lessons learned in building academic nursing scholarship, education, and service. The symposium will move from the macro to the micro level, beginning with a discussion of the context for academic global nursing within a broad university setting (overview of NYU Global Network University structure). Next will be a presentation of strategies employed to build the Global division within NYU College of Nursing and current results. Finally, two illustrative and informative case example presentations will be given: one on a Ghana diabetes project, and one …

Newly Identified Immune Receptor May Activate B Cells In Autoimmunity, Jim Bakken

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No abstract provided.

Which Biomarkers Reveal Neonatal Sepsis?, Kun Wang, Vineet Bhandari, Sofya Chepustanova, Greg Huber, Stephen O′Hara, Corey S. O′Hern, Mark D. Shattuck, Michael Kirby

Publications and Research

We address the identification of optimal biomarkers for the rapid diagnosis of neonatal sepsis. We employ both canonical correlation analysis (CCA) and sparse support vector machine (SSVM) classifiers to select the best subset of biomarkers from a large hematological data set collected from infants with suspected sepsis from Yale-New Haven Hospital's Neonatal Intensive Care Unit (NICU). CCA is used to select sets of biomarkers of increasing size that are most highly correlated with infection. The effectiveness of these biomarkers is then validated by constructing a sparse support vector machine diagnostic classifier. We find that the following set of five biomarkers …

Divergent Antibody Subclass And Specificity Profiles But Not Protective Hla-B Alleles Are Associated With Variable Antibody Effector Function Among Hiv-1 Controllers, Jennifer I. Lai, Anna F. Licht, Anne-Sophie Dugast, Todd Suscovich, Ickwon Choi, Chris Bailey-Kellogg, Galit Alter, Margaret E. Ackerman

Dartmouth Scholarship

Understanding the coordination between humoral and cellular immune responses may be the key to developing protective vaccines, and because genetic studies of long-term HIV-1 nonprogressors have associated specific HLA-B alleles with spontaneous control of viral replication, this subject group presents an opportunity to investigate relationships between arms of the adaptive immune system. Given evidence suggesting that cellular immunity may play a role in viral suppression, we sought to determine whether and how the humoral immune response might vary among controllers. Significantly, Fc-mediated antibody effector functions have likewise been associated with durable viral control. In this study, we compared the effector …

A Hybrid Course Designed To Increase Managerial Export Motivation And Export Engagement, John Andy Wood, Cyril Logar, William Riley

Atlantic Marketing Journal

The paper reviews and explains a new course format at West Virginia University. The content of this course focuses on initiating exporting by companies located in the home state of the university. The attendees include university students and representatives of companies that are interested in starting to export. The content of the course and the participation by company representatives created the need for an atypical delivery of Friday evenings and all day Saturday meeting at two to four week intervals between class sessions. Practical exporting experience is shared by experts from the Department of Commerce, the Export Council, and representative …

The Epidemic Of Extended-Spectrum-Β-Lactamase-Producing Escherichia Coli St131 Is Driven By A Single Highly Pathogenic Subclone, H30-Rx, Lance B. Price, James R. Johnson, Maliha Aziz, Connie Clabots, Brian Johnston, Veronika Tchesnokova, Lora Nordstrom, Maria Billig, Sujay Chattopadhyay, Marc Stegger, Paal S. Andersen, Talima Pearson, Kim Riddell, Peggy Rogers, Delia Scholes, Barbara Kahl, Paul Keim, Evgeni V. Sokurenko

Environmental and Occupational Health Faculty Publications

The Escherichia coli sequence type 131 (ST131) clone is notorious for extraintestinal infections, fluoroquinolone resistance, and extended-spectrum beta-lactamase (ESBL) production, attributable to a CTX-M-15-encoding mobile element. Here, we applied pulsed-field gel electrophoresis (PFGE) and whole-genome sequencing to reconstruct the evolutionary history of the ST131 clone. PFGE-based cluster analyses suggested that both fluoroquinolone resistance and ESBL production had been acquired by multiple ST131 sublineages through independent genetic events. In contrast, the more robust whole-genome-sequence-based phylogenomic analysis revealed that fluoroquinolone resistance was confined almost entirely to a single, rapidly expanding ST131 subclone, designated H30-R. Strikingly, 91% of the CTX-M-15-producing isolates also …

Faculty Become Students To Learn Simulation Training, Clinton Colmenares

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No abstract provided.

Geisler Takes Leadership Role In Physician-Scientist Training, Kendra Carter

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No abstract provided.

Microbicidal Effects Of Α- And Θ-Defensins Against Antibiotic-Resistant Staphylococcus Aureus And Pseudomonas Aeruginosa, Kenneth P. Tai, Karishma Kamdar, Jason Yamaki, Valerie V. Le, Dat Tran, Patti Tran, Michael E. Selsted, Andre J. Ouelette, Annie Wong-Beringer

Pharmacy Faculty Articles and Research

Antibiotic-resistant bacterial pathogens threaten public health. Because many antibiotics target specific bacterial enzymes or reactions, corresponding genes may mutate under selection and lead to antibiotic resistance. Accordingly, antimicrobials that selectively target overall microbial cell integrity may offer alternative approaches to therapeutic design. Naturally occurring mammalian α- and θ-defensins are potent, non-toxic microbicides that may be useful for treating infections by antibiotic-resistant pathogens because certain defensin peptides disrupt bacterial, but not mammalian, cell membranes. To test this concept, clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), including vancomycin heteroresistant strains, and ciprofloxacin-resistant Pseudomonas aeruginosa (Cip^R-PA) were tested for sensitivity to …

Toxicodistribution Of Mercury And Selenium In Pinnipeds Of Alaska, Lucero Correa

Chemistry and Biochemistry

This study is divided into two major parts (chapters) in order to better understand mercury (Hg) and selenium (Se) tissue distribution in pinnipeds. The first part of the study focuses on determining total mercury ([THg]) and selenium ([TSe]) concentrations (mass and molar based) among cardiac and renal tissues of ice seals (focus on bearded seals, Erignathus barbatus) as compared to the more traditionally analyzed tissues (e.g. liver, skeletal muscle). Determining Hg distribution within these tissues is essential in establishing sampling methods for biomonitoring, histopathology and biochemistry of Hg. Age was determined to be an important driver of [THg] and Se:Hg …