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2013

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Δ9-Tetrahydrocannabinol Is Protective Through Pparγ Dependent Mitochondrial Biogenesis In A Cell Culture Model Of Parkinson's Disease., Ml Zeissler, J Eastwood, Hanemann C Oliver, J Zajicek, C Carroll Jan 2013

Δ9-Tetrahydrocannabinol Is Protective Through Pparγ Dependent Mitochondrial Biogenesis In A Cell Culture Model Of Parkinson's Disease., Ml Zeissler, J Eastwood, Hanemann C Oliver, J Zajicek, C Carroll

Peninsula Medical School

Cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC) are neuroprotective in animal and cell culture models of Parkinson's disease (PD). In a PD cell culture model we recently demonstrated that Δ9-THC is neuroprotective through activation of the nuclear receptor peroxisomal proliferator-activated receptor γ (PPARγ). Furthermore, activation by specific agonists rosiglitazone and pioglitazone, has also been found neuroprotective. PPARγ is a nuclear receptor whose activation can lead to the expression of proteins involved in the de novo synthesis of mitochondria. One such protein is the PPARγ co-activator 1 α (PGC1α) as it co-activates NRF-1 mediated gene expression which is essential for the production of …


Exercise Referral For Drug Users Aged 40 And Over: Results Of A Pilot Study In The Uk, Caryl M. Beynon, Amy Luxton, Rhiannon Whitaker, N. Tim Cable, Lucy Frith, Adrian H. Taylor, Lu Zou, Peter Angell, Scott Robinson, D Holland, S Holland, Mark Gabbay Jan 2013

Exercise Referral For Drug Users Aged 40 And Over: Results Of A Pilot Study In The Uk, Caryl M. Beynon, Amy Luxton, Rhiannon Whitaker, N. Tim Cable, Lucy Frith, Adrian H. Taylor, Lu Zou, Peter Angell, Scott Robinson, D Holland, S Holland, Mark Gabbay

Peninsula Medical School

No abstract provided.


An Educational Framework For Managing And Supporting Medication Adherence In Europe, S White, W Clyne, C Mshelia Jan 2013

An Educational Framework For Managing And Supporting Medication Adherence In Europe, S White, W Clyne, C Mshelia

Peninsula Medical School

Introduction: Decisions about taking medicines ultimately lie with patients, so health professionals need to engage with patients to manage and support medication adherence. Health professionals need appropriate education to do this. We aimed to develop an educational framework for health professionals in Europe for managing and supporting medication adherence. Description of the framework: The resulting educational framework comprises a competency framework, a curriculum, a diagnostic tool for competence assessment and a reading list. Quality assurance: Framework development started from a 2007 competency framework for shared decision-making. A literature review and a Europe-wide consultation were conducted and the ABC research team …


Personnel File Of Fr. Ronald L. Bruckner, Catholic Church. Archdiocese Of Santa Fe (N.M.) Jan 2013

Personnel File Of Fr. Ronald L. Bruckner, Catholic Church. Archdiocese Of Santa Fe (N.M.)

Personnel Files

No abstract provided.


Archdiocesan Permanent Review Board Members, Catholic Church. Archdiocese Of Santa Fe (N.M.) Jan 2013

Archdiocesan Permanent Review Board Members, Catholic Church. Archdiocese Of Santa Fe (N.M.)

PRB Administration

No abstract provided.