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Supply Chain Optimization Of Blood Products, Serkan Gunpinar

USF Tampa Graduate Theses and Dissertations

Major challenges in the management of blood supply chain are related to the shortage and wastage of the blood products. Given the perishability characteristics of blood which can be stored up to a limited number of days, if hospitals and blood centers keep an excessive number of blood units on inventory, wastages may occur. On the other hand, if sufficient number of blood units are not stored on inventory, shortages of this resource may cause the cancellations of important activities and increase the fatality rates at hospitals. Three mathematical models have been developed with the goal to improve the efficiency …

Trends In The Contracting Out Of Local Government Services, Cristiane Carvalho Keetch

USF Tampa Graduate Theses and Dissertations

Challenging economic conditions have led local governments to explore alternative methods to deliver public services to residents. This thesis explores historical contracting out trends and offers new research about contracting out activity by local jurisdictions in the state of Florida. Through an e-survey, the new data examines if cities and counties in Florida increased contracting out activity of public services in response to a declining economic environment and changes in population growth trends.

This elaborate and multifaceted task is accomplished through a deliberate interdisciplinary research approach. The literature review consists of well-known publication responsible for creating the foundation of contracting …

Utilizing Tagteach To Enhance Proficiency In Dance Movements, Mallory Joanne Quinn

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to evaluate TAGteach as a training procedure to increase the fluency of three dance movements in a multiple baseline across behaviors design with 4 students of dance. Target behaviors included a pirouette/turn, kick, and a leap/jump, respective of the level of the class. A dance instructor was trained to implement the TAGteach procedure by the primary researcher. The targeted dance movements remained at a stable level during baseline and improved sequentially for each participant following the introduction of the TAGteach training. Implications for future research are discussed.

Continuing Attachment Bonds To The Deceased: A Study Of Bereaved Youth And Their Caregivers, Erica Hill Sirrine

USF Tampa Graduate Theses and Dissertations

Although grief is a universal experience impacting the lives of many children and adolescents each year, not much study has been afforded to this population. In addition, the concept of a continuing attachment bond (CAB) or ongoing relationship to the deceased and its role as adaptive or maladaptive in the bereavement process is in its infancy of research among adult populations and is largely unstudied among bereaved youth. This mixed-methods study attempted to bridge the gap by examining the relationship between CABs among a sample of 50 bereaved youth (ages 11-17) and their bereaved adult caregivers. In addition, the study …

Classification Models In Clinical Decision Making, Eleazar Gil-Herrera

USF Tampa Graduate Theses and Dissertations

In this dissertation, we present a collection of manuscripts describing the development of prognostic models designed to assist clinical decision making. This work is motivated by limitations of commonly used techniques to produce accessible prognostic models with easily interpretable and clinically credible results. Such limitations hinder prognostic model widespread utilization in medical practice.

Our methodology is based on Rough Set Theory (RST) as a mathematical tool for clinical data anal- ysis. We focus on developing rule-based prognostic models for end-of life care decision making in an effort to improve the hospice referral process. The development of the prognostic models is …

An Evaluation Of A Parent Implemented In- Situ Pedestrian Safety Skills Intervention For Individuals With Autism, Bethany Ann Harriage

USF Tampa Graduate Theses and Dissertations

This study evaluated a parent implemented in-situ pedestrian safety skills intervention for three individuals with autism. Specifically, this study examined the utility of using a behavioral skills training (BST) to help parents implement the most-to-least prompting procedures in training their children with autism pedestrian safety skills in community settings. A multiple baseline design across participants was used to assess parent implementation of in-situ pedestrian training as well as child participants' independently performed correct skills. Results indicated that parents implemented most-to-least prompting procedures with high levels of accuracy across streets during intervention and fading of BST. All child participants improved their …

The Acquisition And Usage Of The Sodas Problem Solving Method Among Adults At-Risk For Homelessness, Collin Edward Streetman

USF Tampa Graduate Theses and Dissertations

Individuals experiencing extended homelessness face multifaceted risks in physical health, nutrition, substance use, mental health, continuing unemployment, and incarceration. Some of these adults may benefit from learning a problem-solving decision-making method to assist them in dealing with everyday problems they encounter. This study taught three men with extensive histories of homelessness, but who were currently housed, the SODAS problem-solving decision-making method, and assessed their ability to learn it and guide another adult in the use of the method in simulated role-play problem situations. The acquisition of SODAS from behavioral rehearsal training was evaluated using a multiple-baseline design across participants' role …

Problems Of English For Specific Purpose Course For Medical Students In Iran, Alireza Boniadi, Morteza Ghojazadeh, Neda Rahmatvand

Khazar Journal of Humanities and Social Sciences

It is now widely accepted that the English language has become the language of international communication. The widespread need for English as a second or foreign language puts a great pressure on the educational resources of many countries. ESP courses require specific language and skills that are related to communities of practice and disciplines. Careful examination of the attitudes and perceptions of learners and instructors is seen to be important in determining the problems of ESP courses. This study focuses on an ESP course offered at Tabriz faculty of Medical Sciences in Iran. The instruments used in this study were …

Chronic Lymphocytic Leukemia In Kenya: An Immunophenotypic And Clinicopathologic Study, E. Mulwa-Babu, D. Paresh, M. Riyat

Pathology, East Africa

Objective: To define cases of chronic lymphocytic leukemia (CLL) by immunophenotypic criteria and describe the associated clinical features in patients diagnosed at Aga Khan University Hospital, Nairobi.

Background: Rising to the growing cancer challenge will require improved diagnostic services. CLL is common in elderly patients. The current international standard in diagnosis incorporates findings of immunophenotyping. Facilities for immunophenotyping have generally been unavailable in Kenya.

Method: A cross-sectional survey was conducted between August 2011 and April 2012. Potential cases were identified based on morphologic criteria. Consecutive samples were obtained and subjected to 3 colour immunophenotyping on a Cytomics FC 500 cytometer. …

Malaria Diagnosis And Treatment Practices Following Introduction Of Rapid Diagnostic Tests In Kibaha District, Coast Region, Tanzania, M. Mubi, D. Kakoko, B. Ngasala, Zul Premji, S. Peterson, A. Bjorkman, A. Martensson

Pathology, East Africa

Background: The success of the universal parasite-based malaria testing policy for fever patients attending primary health care (PHC) facilities in Tanzania will depend highly on health workers' perceptions and practices. The aim of this study was, therefore, to assess the present use of malaria diagnostics (rapid diagnostic tests (RDTs) and microscopy), prescription behaviour and factors affecting adherence to test results at PHC facilities in Kibaha District, Coast Region, Tanzania.

Methods: Exit interviews were conducted with fever patients at PHC facilities and information on diagnostic test performed and treatment prescribed were recorded. Interviews with prescribers to assess their understanding, perceptions and …

Temporal Trends Of Molecular Markers Associated With Artemether- Lumefantrine Tolerance/Resistance In Bagamoyo District, Tanzania, M. Malmberg, B. Ngasala, P.E. Ferreira, E. Larsson, I. Jovel, A. Hjalmarsson, M. Petzold, Zul Premji, J.P. Gil, A. Bjorkman, A. Martensson

Pathology, East Africa

Background: Development and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) constitutes a major threat to recent global malaria control achievements. Surveillance of molecular markers could act as an early warning system of ACT-resistance before clinical treatment failures are apparent. The aim of this study was to analyse temporal trends of established genotypes associated with artemether-lumefantrine tolerance/resistance before and after its deployment as first-line treatment for uncomplicated malaria in Tanzania 2006.

Methods: Single nucleotide polymorphisms in the P. falciparum multidrug resistance gene 1 (pfmdr1) N86Y, Y184F, D1246Y and P. falciparum chloroquine transporter gene (pfcrt) K76T were analysed from …

Exploration Of In Vivo Efficacy Of Artemether-Lumefantrine Against Uncomplicated Plasmodium Falciparum Malaria In Under Fives In Tabora Region, Tanzania, D. Joseph, A.M. Kabanywanyi, R. Hulser, Zul Premji, O.M.S. Minzi, K. Mugittu

Pathology, East Africa

Background: Tanzania adopted artemether-lumefantrine (AL) as first-line drug for uncomplicated malaria in 2006. Recently, there was an anecdotal report on high malaria recurrence rate following AL treatment in in the (urban and peri-urban), western part of Tanzania. The current report is an exploratory study to carefully and systematically assess AL efficacy in the area.

Methods: Between June and August 2011, a total of 1,126 patients were screened for malaria, 33 had malaria, of which 20 patients met inclusion criteria and were enrolled and treated with standard dose of AL as recommended in the WHO protocol. Treated patients were followed …

Seeking Modernity, Brain Gain, And Brain Drain: The Historical Evolution Of Chinese Students' Overseas Education In The United States Since Modern China, Di Luo

Master's Theses

This thesis is an historical research project that examines major waves of Chinese students studying in the United States since the mid-nineteenth century, as well as the impact of returned, American-educated Chinese students to the modernization of Chinese society. It also discusses the trend and pattern of the current wave after 1978 and compare it with previous waves. The analysis and examination of this thesis is based on a wide variety of written documents in both Chinese and English, including historical literatures, academic articles, dissertations, surveys, government publications, statistical data from both primary and secondary sources, as well as educational …

Login To Learn: A Content Analysis Of Southeast Asian Policies On Technology And Education, Laura D. Pasley

Master's Theses

In the following thesis, using Aucoin's (2011) theoretical framework, I juxtapose the discourses neoliberalism and humanitarian "access" as they relate to describing the potential outcomes of ICT adoption in education. Through a content analysis, I sought to answer the research question: To what extent have the discourses of neoliberalism and "access" used in regional ASEAN policies influenced ICT policymaking at the national level of its member states? The findings demonstrated a slight difference between ICT policies published prior to the 2011 ASEAN policy, but those published "after" were all also published in 2011 which may point to forces outside of …

Supporting Minority Students Through Mentoring: Best Practices For Formal Mentoring Programs, Elizabeth Stockslager

Master's Theses

Approaches such as universal education, state and national standards, and reform acts have sought to ensure that all students in America receive the same level of education. However, education systems are limited by institutionalized racism. An analysis of the education system through the lens of Critical Race Theory highlights the need to look outside of the traditional school setting, while Culturally Relevant Pedagogy gives insights for understanding the best practices in meeting the needs of minority students. This research considers how mentoring provides support and success for minority students by working with students outside of the school structure. Using the …

The Effect Of Work-Related Programs On Dropout Rates: A Meta-Analysis, Jill Young

Master's Theses

One in four students drop out of school, which has long-lasting implications for the individual, employers, and society at large. Work-related programs, such as those that include career exploration or vocational training, are often employed by schools and communities to reduce school dropout rates. This thesis provides an update to a meta-analysis of experimental and quasi-experimental evaluations of dropout prevention programs conducted by Wilson, Tanner-Smith, Lipsey, Morrison, and Steinka-Frey in 2011, focusing on work-related dropout prevention programs. This study determined through meta-analysis of the logged odds-ratios that work-related programs have an odds-ratio of 1.66, indicating that work-related programs significantly reduce …

Alpha-Synuclein Aggregates Activate The Nlrp3 Inflammasome Following Vesicle Rupture, Rudy Orlando Cedillos

Master's Theses

Parkinson's disease (PD) and related synucleinopathies are progressive neurodegenerative disorders that feature the accumulation of intracellular inclusions known as Lewy bodies (LBs) in the brain. The presynaptic protein α-synuclein is the primary constituent of LBs and has been documented to play a major role in the pathogenesis of synucleinopathies. Recently, aggregated α-synuclein has been implicated in prompting microglia-mediated inflammation, a process associated with the progression of neuronal death in neurodegenerative disorders. Although the mechanisms surrounding the induction of neuroinflammation are not well understood, the recently discovered inflammasome-forming NLR proteins have emerged as regulators of inflammation. In this study, we sought …

Snail Induces Mesenchymal Transition And Promotes Egfr Tki Resistance In Nsclc Cells Harboring Efgr Kinase Domain Mutations, Rutu Gandhi

Master's Theses

Lung cancer is the leading cause of cancer related death, accounting for one third of all deaths from cancer worldwide. About 85-90% of lung cancers are non-small cell lung cancers (NSCLCs). Molecular targeted therapies such as epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) provide an effective treatment option for oncogene addicted NSCLC. However, the development of resistance to EGFR TKIs continues to be the major limitation in the treatment of NSCLC. Resistance to EGFR TKIs has been associated with the loss of canonical epithelial protein E-cadherin, suggesting involvement of epithelial to mesenchymal transition (EMT) in conferring EGFR TKI …

Development Of Cell Based Reporter Assay To Measure Pkc-Delta Promoter Activity, Kushal Prajapati

Master's Theses

Protein kinase C- δ (PKC-δ) acts as a tumor suppressor in skin cancer and is lost in 30% of human Squamous Cell Carcinoma (SCC). This loss is at the transcriptional level and involves the pathway leading to PKC-δ promoter repression after activation of Ras,PI3K,Fyn, and NF-κB. We proposed development of a high throughput, cell-based luciferase reporter assay on Ras transformed keratinocyte cell line, HaCaT-Ras to screen compounds having potential to inhibit this pathway and re-induce PKC-δ expression. First we developed a stable, PKC-δ promoter-reporter transfected HaCaT-Ras cell line. Next, we tested 13 compounds for their abilities to induce PKC-δ …

Social-Environmental Predictors Of Health-Related Quality Of Life In Youth With Spina Bifida, Caitlin Beth Murray

Master's Theses

Health-related quality of life (HRQOL) is a multidimensional construct including an individual's physical and mental health and psychosocial well-being (De Civita et al., 2005), and the measurement of HRQOL has been recognized as a key marker of health outcomes in pediatric populations (Eiser & Jenney, 2007). Due to medical and technological advances, an increasing number of individuals with chronic illnesses are living longer. As such, research that investigates improvements in HRQOL in youth with chronic illnesses has become essential. Indeed, the number of studies examining HRQOL in pediatric populations has increased markedly; spina bifida (SB) is one among several chronic …

Conspiratorial Thinking: How Worldview And Mortality Salience Affect Belief, Eric James Anderson

Master's Theses

Conspiratorial thinking is widespread throughout the world, though the major social sciences have thus far chosen not to study them for a variety of reasons. This study attempts to understand what, in fact, makes individuals believe in conspiracy theories. Using aspects of terror management theory, Kruglanski's theory of lay epistemology, participants' political worldviews, and conspiracy type, this paper will explore what triggers conspiracy-prone individuals to see the world the way they do. It is anticipated that individuals who have thoughts of their death primed in their consciousness will structure the world more rigidly, cling to their worldviews and respond to …

Evidence For Renewal And Reconstitution Of Marginal Zone Macrophages In Young And Aged Mice, Erika Bahamon

Master's Theses

Aging in humans and mice correlates with decline in immune health, affecting both innate and adaptive immunity. Response against blood-borne bacterial pathogens is compromised because of the deterioration of the marginal zones of the spleen and decrease in frequency of marginal zone macrophages (MZM). This thesis asked if low cell turnover is the cause for the decrease of MZM, using cell proliferation to indicate cell turnover in spleens of mice. First, evidence showed MZM proliferation occurred in spleens of young mice and was decreased in the MZM from aged mice. Second, transfer of young bone marrow into old mice replenished …

Factors In Destination Decisions For Cuban Study Abroad, Kari Beall

Master's Theses

In January of 2011, the Obama Administration loosened the regulations on academic travel to Cuba, allowing students to travel to this island nation as part of an academic program. These changes have created an ideal environment in which to study the factors that influence the institutional decision to create a new study abroad program. This is an area that has seen very little if any previous research. This study hopes to investigate the connection between the goals of education abroad as a whole and the reasons a study abroad program, in this case to Cuba, is actually created. Studying the …

Aquatic Macroinvertebrate Response To Invasion And Subsequent Removal Of Typha × Glauca From Great Lakes Coastal Marshes, Kimberly Anne Greene

Master's Theses

Aquatic macroinvertebrates are important in wetland ecosystems; many fish and wildlife species depend upon them for food resources and they aid in nutrient cycling. Wetland macroinvertebrate communities are influenced by plant community composition; as such, this study examined two implications of invasive hybrid cattail, Typha × glauca (Typha), on aquatic macroinvertebrate communities in northern Great Lakes coastal wetlands: 1) how the presence of nearly monotypic stands of Typha alters wetland aquatic macroinvertebrate communities and 2) how manual removal of Typha, via mowing and manual tilling, impacts these invertebrate communities along with wetland plant communities. I found that …

I Am Relieved To Discover My Symptoms Are Normal For My Condition: An Analysis Of Two Irritable Bowel Syndrome Support Communities, Erin Hvizdak

Master's Theses

Symptoms of Irritable Bowel Syndrome (IBS), a "medically unexplained illness," are present in up to 20% of the United States population. Individuals experiencing symptoms of IBS often report that physicians dismiss their experiential and embodied knowledge, leading to a sense of isolation and frustration. Many of these individuals attempt to diminish isolation and also exchange their knowledge in a community setting. In order to enable a more complete understanding of IBS, a survey about community participation was sent to members of a large online support group for IBS located on Facebook, with 81 completed surveys received. Further, an open-ended questionnaire …

Activity Patterns And Spatial Resource Selection Of The Eastern Garter Snake (Thamnophis Sirtalis Sirtalis), Matthew Gregory Most

Master's Theses

Snake species usually exhibit seasonal variations in activity patterns, home-range size and the use of respective habitat. Using mark-recapture protocols I marked 96 individual Thamnophis sirtalis sirtalis specimens in Lake Forest, IL to determine the independent variables that best explained habitat selection in a population of Eastern Garter Snakes (T. s. sirtalis). Specifically, I focused on the relationship between seasonal movement and home range size of male and female garter snakes. I analyzed the habitat preferences and spatial ecology of Eastern Garter Snakes during the 2011 sampling season and modeled the relationship between preferred or avoided habitat, in conjunction with …

Exosomes: Antiviral Agents In The Human Lung, Jennifer Alexandra Novak

Master's Theses

Hundreds of interferon effectors comprise the immediate host response to virus infection. One family of interferon stimulated genes is the IFITM (Interferon-Induced Transmembrane) proteins. IFITM3, in particular, has been shown to block virus cell entry of Influenza A Virus, SARS Coronavirus, and West Nile Virus, among others. IFITM3 has also been identified as an essential factor for host protection against Influenza A Virus in mice and humans. However, the mechanism by which IFITM3 functions remains unclear.

IFITM3 may function both intracellularly and extracellularly to block virus infection in the human lung. The extracellular milieu contains microscopic vesicles termed exosomes which …

The Interactive Effects Of Coping Strategies, Gender, And Stress In The Prediction Of Internalizing Symptoms In African American Youth: An Application Of The Specificity Model, Cynthia Pierre

Master's Theses

The current study utilized a specificity framework in the examination of interactions among coping strategies, stressor domains, and participant gender in the prediction of depressive and anxiety symptoms. Participants were 273 African American adolescents (6th - 8th; mean age = 12.9; 58% female). Participants completed measures of universal and culturally-relevant coping strategies in response to a stressor. Stressors were coded by raters across dichotomous domains: interpersonality (interpersonal vs. non-interpersonal), duration (acute vs. chronic), controllability (controllable vs. non-controllable), and sexuality (sexual vs. non-sexual). T-tests were conducted to examine differences in reported coping across stress domains. Inconsistent with predictions, mean differences of …

The Relation Of Executive Functions To Active Coping Strategies And Internalizing Symptoms In A Community Sample Of African-American Youth, Arie Zakaryan

Master's Theses

The purpose of this study is to examine the relations between stressor appraisals, active coping, executive functions, and internalizing symptoms in a community sample of low-income African-American youth. There is a dearth of studies assessing how executive functions influence the connection between coping and internalizing symptoms, notably in community and minority populations. When faced with distressing, uncontrollable settings straining the capacity to self-regulate, youth with executive functioning deficits may encounter greater challenges in coping with stressors. Yet, since typically adaptive active coping strategies do not benefit some youth and can result in negative outcomes, it is important to identify what …

Sustainable Diverse Communities: A Comparison Of Hammond, Indiana And Chicago's Uptown Neighborhood, Teresa Neumann

Master's Theses

According to US Census data Hammond, IN - a midsized American City - and Chicago's Uptown neighborhood both have census tracts that have been racially, ethnically and economically diverse over the past 20-30 years. Utilizing the engaged methodology of community-based research this project uses the voice of community leaders from both Hammond and Uptown to inform and illustrate what is happening behind the Census data. This includes the role of civic institutions, local government and local business. Through long form structured interviews individuals offered their perspectives, concerns and ideas about how this diversity came about and what challenges and opportunities …