Digital Commons Network^™

4-Isoxazolyl-1,4-Dihydropyrirines Bind The Multidrug-Resistance Transporter, Scott Steiger

Graduate Student Theses, Dissertations, & Professional Papers

The development of multidrug resistance in tumor cells has been recognized as a major obstacle to successful cancer treatment. Tumor cells in vitro and in vivo can develop multidrug resistance (MDR) to the lethal effects of a variety of cytotoxic drugs used to treat cancerous tumor cells. The over expression of multiple drug resistance gene 1 has been correlated with the expression of multi drug resistance protein 1(MDR1, also known as P-glycoprotein or P-gp). MDR1's role in altering uptake, distribution and bioavailability is considered a significant factor when examining drugs for clinical administration, and represents a viable drug target for …

Chronic Trauma Effects On Personality Trait Trajectory In Police Officers, Jennifer Leigh Wills

Graduate Student Theses, Dissertations, & Professional Papers

The impact of chronic trauma exposure on personality trajectories over time was examined in a sample of urban police officers. Scores from a personality measure taken in pre-hire psychological evaluations were compared with follow up scores administered for this study five to ten years later. An urban police agency of approximately 1000 commissioned police officers agreed to allow its officers to be recruited as participants. The consulting psychologist who performed the agency’s pre-hire psychological evaluations during the applicable period supplied historical data with participant consent and agency approval. Personality change between the two times was analyzed using hierarchical regression analysis, …

Costs And Benefits Of An Extended Phenotype: Chambers Made By Manduca Sexta Larvae, Jonathan Cooley Sprague

Graduate Student Theses, Dissertations, & Professional Papers

Extended phenotypes can serve interesting physiological functions and their externality provides ready opportunity to manipulate and examine their functions and costs. One such set of extended phenotypes are below-ground pupation chambers made by a wide range of insects and whose function is unknown and costs unquantified. We use a series of lab and field experiments to examine the cost and benefit of chambers made by the hawkmoth, Manduca sexta (Sphingidae), whose larvae lose up to 60% of their body mass during chamber construction. Our study shows that these chambers provide critically important free space in which individuals transition from larvae …

Examining The Impact Of Hepatitis C In Montana: A Descriptive Case Study, Blair Rice Snyder

Graduate Student Theses, Dissertations, & Professional Papers

The purpose of this study was to gather information about how Hepatitis C (HCV) affects Montanans. Montana specific information was collected about HCV transmission; factors influencing transmission; physical, social and psychological effects of having HCV and undergoing treatment; barriers to prevention and treatment; current available resources to those infected with HCV and ways to improve prevention and treatment. Secondary data consisted of a comprehensive literature review to describe the above factors and epidemiological information. Primary data was collected through key informant interviews and summary reports completed by people living with HCV. The findings suggest that HCV is primarily transmitted through …

Intercollegiate Tennis Coaches' Perceptions Of And Preferences For Continuing Education, Collin M. Fehr

Graduate Student Theses, Dissertations, & Professional Papers

The purpose of this study was to better understand U.S. intercollegiate tennis coaches’ perceptions of professional development and the factors that influence their participation in such endeavors. Based on discussions in the literature, a survey was created to quantify this population’s attitudes toward various components of continuing education. The survey included several closed-ended questions as well as rating questions, on a 5-point Likert scale. 181 participants (Male= 136, Female= 45) responded to the survey, representing 93 intercollegiate tennis conferences in the United States. The major findings of this study were: (i) the majority of intercollegiate tennis coaches perceive continuing education …

Mapping The Distribution And Abundance Of Western Larch (Larix Occidentalis Nutt.) With Multi-Temporal Satellite Imagery And Gradient Modeling, Steven Joseph Touzel

Graduate Student Theses, Dissertations, & Professional Papers

Western larch (Larix occidentalis Nutt.) is one of three native North American larch species, it occupies the mountainous regions of northwestern North America, and it is a deciduous conifer. Western larch is among the most ecologically and economically important conifer tree species in the northern Rockies region. This study explores the viability of mapping western larch via the analysis of multi-temporal Landsat imagery and gradient modeling. Larch presence and abundance data from 300 field plots correlated with Normalized Difference Vegetation Index seasonal change (NDVIsc) explains 46% of the variability in larch basal area. Multivariate models built with NDVIsc and additional …

Locomotor Ontogeny And The Evolution Of Avian Flight, Ashley Margaret Heers

Graduate Student Theses, Dissertations, & Professional Papers

Understanding the origins of organismal diversity is one of biology's most enduring quests. Many authors have posited that modularity, or the developmental decoupling of body parts into discrete functional units, facilitates adaptive radiation by allowing body parts to become independently and functionally specialized without compromising one another. This may be particularly true in birds, which have compartmentalized the single locomotor unit of their ancestors into discrete wing and leg locomotor modules, and exploited terrestrial and aerial environments. Specializing one set of limbs for terrestrial locomotion and one set for flight presumably facilitates navigation of aerial environments without compromising terrestrial locomotion, …

Motivation And Education: Performance, Commitment, And Satisfaction Among Pharmacy Students, Michael Dustin King

Graduate Student Theses, Dissertations, & Professional Papers

This study examines the relationship between academic motivation and three different educational outcomes: academic performance, commitment, and satisfaction. This research explores these relationships by focusing on pharmacy students at The University of Montana. Pharmacy students tend to be driven by relatively high levels of external motivations (e.g., motivated by money or prestige), especially when compared to other health profession students. In contrast to previous work that simply describes the motivations of students, I uncover the links between motivation and various educational outcomes. This investigation contributes to a better understanding of motivations and their impact on education, especially among the specific …

Developmental Stress In Birds: Phenotypic And Fitness, Ondi L. Crino

Graduate Student Theses, Dissertations, & Professional Papers

The environment animals experience during development can have important effects on phenotype, performance, and fitness across multiple life-history stages. Environmental cues experienced during development can provide information to animals about the environment they will soon inhabit and promote phenotypic changes which affect fitness. Increasing evidence suggests that physiological stress may be one such cue that conveys environmental information to developing animals. Here, I explore the short- and long-term consequences of developmental stress in captive and free-living birds. In chapter one, I explore the effects of developmental stress on body size and physiological stress responses across life-history stages in zebra finches …

Full Issue, Issues In Religion And Psychotherapy

Issues in Religion and Psychotherapy

No abstract provided.

The Power And Promise Of Procedure: Examining The Class Action Landscape After Wal-Mart V. Dukes, Suzette M. Malveaux

Publications

No abstract provided.

The Jury (Or More Accurately The Judge) Is Still Out For Civil Rights And Employment Cases Post-Iqbal, Suzette M. Malveaux

Publications

No abstract provided.

An Exploration Of The Development And Proliferation Of Hydraulic Fracturing, Ellee G. Cook, Travis Dodson, Kara Shervanick, Alice Whitten

Environmental Studies Student Works

No abstract provided.

Exploring The Future Of Friesenhahn Cave, Dylana Watford, Katherine Banick, Graham Bates, Tori Carey

Earth and Environmental Geosciences Student Works

Friesenhahn Cave in San Antonio, Texas, offers a wealth of paleontological artifacts. The cave is owned by Concordia University and is primarily managed by Dr. Laurence Meissner, professor of biology at Concordia. Since its discovery in the early twentieth century, researchers have discovered numerous Pleistocene fossils; aside from the La Brea Tar Pits in California, Friesenhahn Cave is the most Pleistocene fossil-rich site in the United States. Recently, little research has been conducted in the cave, though it is believed that many fossils remain to be discovered. We propose the establishment of the Friesenhahn Cave Foundation, a non-profit organization whose …

From Space-Off To Represented Space, Lolita Buckner Inniss

Publications

In Reimagining Equality: Stories of Gender, Race, and Finding Home, author Anita Hill explores some of the literal and figurative meanings of "home," focusing specifically on African-American women in their quest for home. Hill layers discussions of law, literature, and culture with stories of individual women, both historic and contemporary. In Reimagining Equality, Hill takes on a topic clearly distinct from the Clarence Thomas Senate confirmation hearings, the episode for which she is best known. Her work here is, nonetheless, evocative of her struggle in those hearings, because the book addresses the interrelation between gender, race, place, space, …

Value Conflicts In Psychotherapy, Aaron P. Jackson, Jamie Hansen, Juliann M. Cook-Ly

Issues in Religion and Psychotherapy

Psychotherapy has historically been viewed as value neutral; however, over the last half-century, developments have led many scholars to conclude that we can no longer dismiss the role of values in therapy. Our position is that therapists and clients will inevitably encounter value conflicts during the course of psychotherapy. This article postulates how such conflicts can be addressed so as to preserve and promote the integrity and well-being of both client and clinician. We review challenges to value neutrality and summarize ethical considerations. We discuss strategies to manage values in psychotherapy and conclude by recommending areas for consideration in professional …

Unintended Consequences: Lucas, The Public Trust Doctrine, And The Erosion Of Private Property Rights Under The Takings Clause, Timothy M. Bagshaw

Utah Law Review

This Note considers the relationship between the public trust doctrine and private property rights under the Takings Clause. Traditionally, the public trust doctrine vests authority in state governments to protect navigable waterways and related lands. But in recent years, state governments and state courts have begun to use the doctrine to achieve broader environmental ends. While increased environmental protection at the state level serves vital public interests, it is not an unambiguous good. Under current takings analysis, the public trust doctrine constitutes one of several affirmative defenses to just compensation liability; where state governments invoke the public trust doctrine, they …

Impact Of Climate Change On Occupational Health And Safety, Ariane Adam-Poupart, France Labrèche, Audrey Smargiassi, Patrice Duguay, Marc-Antoine Busque, Charles Gagné, Joseph Zayed

Rapports de recherche scientifique

Les effets des changements climatiques (CC) sont souvent discutés en fonction de leurs impacts sur l’environnement et sur la population générale. Toutefois, leurs conséquences sur la santé et la sécurité des travailleurs (SST) n'ont été que très peu abordées par la communauté scientifique. Pourtant, les travailleurs peuvent être directement ou indirectement affectés par les CC notamment par des contraintes thermiques auxquelles ils peuvent être exposés ou encore, par des modifications aux écosystèmes qui sont à la base de leurs activités économiques. L’objectif général de cette étude était d’explorer les avenues de recherche en regard de l’impact négatif des changements climatiques …

Using A Corpus-Based Approach To Russian As A Foreign Language Materials Development, Edie Furniss

Russian Language Journal

The increase in availability and sophistication of corpora in recent years has facilitated the application of usage-based approaches to language pedagogy. Although the use of corpus data is certainly not without its difficulties, it offers great pedagogical promise. Corpora, consisting of natural language culled from a multitude of sources and genres, provide valuable information about language in use. While a corpus can provide us with contextualized linguistic data and statistics on the behavior of lexicon (with respect to frequency and collocation), a connection needs to be forged between the data and their practical use. Two main areas ripe for the …

Our Russian Classrooms And Students: Who Is Choosing Russian, Why, And What Cultural Content Should We Offer Them?, Jason Merrill

Russian Language Journal

Language instructors are well aware of the many challenges facing our profession. Financial pressures and fluctuating enrollments have caused many institutions to look critically at their language programs and curricula. Adding to these concerns is the lingering sentiment in some areas that foreign languages are not something that “you (really) need to know,” as Lawrence Summers stated in 2012 (Summers). Colleagues have produced impassioned defenses of the many benefits of language study (e.g. Geisler 2012), but ultimately we, as a profession, need to combine such efforts with the most effective and relevant language instruction we can provide. Geisler is not …

The Fall Of The Yellow Wallpaper, Rachel Payne

AWE (A Woman’s Experience)

Many have acknowledged the Gothic influence of Poe’s “The Fall of the House of Usher” on Gilman’s “The Yellow Wallpaper.” Critics often examine the opposition of genres in “The Yellow Wallpaper,” arguing it as either a feminist movement or Gothic tale. However, the Female Gothic genre centers the female role inside a Gothic tale. This genre typifies a criticism of oppressive patriarchies and support for female independence. Both “The Fall of the House of Usher” and “The Yellow Wallpaper” demonstrate women who overcome repressed voices by finding their expressions through writing.

Language, Politics, And History: An Introductory Essay, José Del Valle

Publications and Research

This book chapter examines different articulations of language and history and introduces a new configuration that focuses on the political dimension of language.

Strengths And Limitations Of Qualitative Approaches To Research In Occupational Health Psychology, Irvin Sam Schonfeld, Joseph J. Mazzola

Publications and Research

Like all research methods, qualitative methods have strengths and limitations. This chapter describes seven strengths and five limitations. With an understanding of their strengths and limitations and how to minimize and/or balance them, occupational health psychology (OHP) researchers can benefit from qualitative methods. It is important to understand that qualitative findings do not establish generalizable cause-effect relations. However, qualitative methods can help an OHP researcher develop a theory of causality and derive hypotheses related to the theory and, thus, motivate quantitatively organized research designed to test the hypotheses. The challenge for the OHP researcher is to be mindful of what …

A Novel Mammogram Registration Algorithm For Improving Breast Cancer Detection, Stephanie Cleveland Cunningham

Theses

Accurate mammogram registration is vital to future breast cancer research. In order to detect changes over time and/or bilateral asymmetry, computer aided detection algorithms must first be able to accurately align two mammogram images. The registration algorithm in this thesis is a novel process designed to accurately register two mammogram images using the Pompeiu-Hausdorff distance as a similarity measure. The algorithm identifies the optimal translation and rotation that can be used to properly align the two mammogram images by computing the optimized Pompeiu-Hausdorff distance between extracted feature point-sets and adaptively fine tuning the parameters with each iteration. This automated algorithm, …

Peerj, Michael J. Hughes

Library Faculty Research

PeerJ is the Open Access (OA) publisher of a biomedical journal, also called PeerJ. In addition to its peer-reviewed flagship, it runs a preprint server, PeerJ Preprints, to which authors can submit draft, incomplete, and final papers for informal peer review, and to establish precedent. The company’s chief innovation, however, is a novel if untried business model: extending to authors lifetime publication privileges in exchange for a one-time fee. This strategy adheres to the basic formula of fee-based Gold OA in that an upfront charge pays for the operations of the journal. PeerJ diverges from its predecessors in that it …

Issues And Methods In Researching Social Networks: Tools, Trends, And Applications To Language Learning Research, Dan Dewey, Jennifer Brown, Shayla Johnson

Faculty Publications

No abstract provided.

Exploring Nurse Case Managers' Language Describing Health Needs And Interventions With Populations, Kathleen I. Gremel

Open Access Dissertations

Major advances in health information technologies, safety and quality initiatives, and health policy changes have fueled the development and implementation of the Electronic Health Record (EHR). Any discipline’s work and contribution to patient care exist in the EHR only as they are coded. Thus, coding nursing’s knowledge, work and contribution to patient care in meaningful ways requires nurses to have a language that defines nursing concepts and works consistently and reliably. Currently the American Nurses Association (ANA) recognizes twelve (12) nursing languages being used in the EHR. Over the last forty years many research efforts have validated these nursing languages …

Asleep Behind The Wheel: Experiences Of Night Shift Nurses On The Commute Home, Shirley A. Sargent

Open Access Dissertations

Aim: The aim of this study was to obtain descriptions of nurses’ perceptions and experiences of falling asleep behind the wheel on the drive home after a worked night shift.

Background: While the evidence suggests that the problem of drowsy driving and fall asleep driving is a strong contributor to vehicular accidents, little is known about nursing perceptions of the issue.

Methods: The design of the study is qualitative and descriptive. Face-to-face interviews were conducted with 12 registered nurses who had experienced falling asleep behind the wheel on the drive home from work after a worked night shift. The interviews …

Connecting School And Child Welfare Systems To Students In Foster Care: An Empowering Intervention, Tonya Glantz

Open Access Dissertations

Barriers to collaboration between professionals in the school and child welfare systems are impeded by poor communication, a lack of cross-disciplinary language, and confusion regarding professional practices. This study, the Education Collaboration Project (ECP), addresses the importance of understanding school success for students in foster care through the voices and actions of the key constituent groups: students with foster care histories and professionals from the school and child welfare systems. Also included in a small component of this study were foster parents who participated via an anonymous survey. The theoretical framework combined critical pedagogy, elements of critical discourse analysis, adaptive …

Undue Burdens In Texas, Jennifer S. Hendricks

Publications

No abstract provided.