Digital Commons Network^™

Descriptions Of Clinical Teaching Excellence In The First Two Years Of Medical School: The Views Of Academic And Community-Based Preceptors, Patricia Anne Stubenberg

USF Tampa Graduate Theses and Dissertations

The changing dynamics in patient care, along with the increasing role of early clinical experiences and community-based teaching models, can be a catalyst in furthering important research and training for clinical teaching excellence. Curricular challenges as well as limited scholarly work generate educational possibilities for study. Embracing a strong educational doctrine of teaching excellence in undergraduate medical education will help shape the future of health care and ultimately enhance patient care.

This grounded theory study (a) described and explained descriptions of teaching excellence among first and second year academic and community-based preceptors in the Longitudinal Clinical Experience (LCE) program at …

Knowledge, Attitudes And Traditions Regarding Water Consumption And Sanitary Practices Of The Ngäbe-Buglé Indigenous Women In The Chiriquí Province In Panama, Natalia Vega

USF Tampa Graduate Theses and Dissertations

Background: In 2007, approximately 66.2% of the population of the Comarcas (indigenous reservations) in Panama had access to potable water. However, over 50% of this population lacked access to sanitation. As a result, the leading causes of death in the Comarca Ngäbe-Buglé are due to severe diarrhea and gastroenteritis of infectious origin. The present project assessed the need for an in-depth understanding of the Ngäbe-Buglé women and their communities regarding their knowledge, attitudes, beliefs and behaviors about water and sanitation. Methodology: In this cross-sectional exploratory study, a convenience sample of 52 women were interviewed, utilizing a questionnaire guided by the …

Anti-Parasitic And Anti-Bacterial Agents: Studies On 1,4-Dihydropyridines And 2,4-Diaminoquinazolines, Kurt Steven Van Horn

USF Tampa Graduate Theses and Dissertations

Thirty-three 1,4-dihydropyridine diastereomeric pairs were synthesized and the structure-activity relationship studied in a Plasmodium falciparum in vitro model. Twenty-nine of these derivatives contained a 6-position oxygen, with 2.31, 2.32, 2.52 and 2.53 having single and double digit nanomolar activities. This SAR study revealed some insightful information about the 1,4-dihydropyridine substitution pattern. Substitution at the 7-position other than 3,4-dimethoxy severely reduced the activity. 4-phenyl substitution with 2- or 4- halo or methyl formed active compounds while substitution at the 3-position or with methoxy or conjugated aryl systems resulted in inactive compounds. The 2-position was found to majorly affect the activity, with …

The Black Freedom Struggle And Civil Rights Labor Organizing In The Piedmont And Eastern North Carolina Tobacco Industry, Jennifer Wells

USF Tampa Graduate Theses and Dissertations

This thesis examines labor organizing in the U.S. South, specifically the Piedmont and eastern regions of North Carolina in the mid-twentieth century. It aims to uncover an often overlooked local history of civil rights labor organizing which challenged the southern status quo before America's 'mainstream' civil rights era of the 1950s and 1960s. This study argues that through labor organizing, African American tobacco workers challenged the class, gender, and race hierarchy of North Carolina's very profitable tobacco industry during the first half of the twentieth century. In doing so, the thesis contributes to the historiography of black working class protest, …

The Role Of Nature In Physiological Recovery From Stress: A Critical Examination Of Restorative Environments Theory, Kristi Elizabeth White

USF Tampa Graduate Theses and Dissertations

Recently, health researchers have become interested in "eco-friendly" or "green" healthcare. One of the current trends in the green healthcare movement involves incorporating natural elements into health care settings to promote the health of patients and healthcare workers. Research based on Restorative Environments Theory (RET) provides insight into the rationale behind incorporating nature into the healthcare setting. RET posits that pleasant natural environments help promote stress recovery by increasing positive affect, decreasing negative affect, and reducing physiological arousal. However, the components of this theory have not been sufficiently tested using a controlled laboratory environment. The purpose of the present study …

The Effectiveness Of A Structured Functiona Behavior Assessment Procedure: Teacher Training As A Moderator, Bonnie Woods

USF Tampa Graduate Theses and Dissertations

Prevent-Teach-Reinforce (PTR) is a collaborative, standardized process that was developed as a way to address identified barriers to completing effective functional behavior assessments (FBAs) in public schools. Current research literature documents the effectiveness of the PTR process in decreasing problematic behaviors and increasing social skills and academic engaged time for students in kindergarten through 8th grade. In addition, PTR demonstrates high acceptability by school personnel implementing the process. While PTR has demonstrated success in schools, questions still exist regarding variables that impact the effectiveness of this process. Therefore, the current study investigated the moderating effect of prior teacher training in …

Indicators Of The Metroscape: Change In Employment, Elizabeth Morehead

Metroscape

Overview of Employment by Industry in Portland Metropolitan Statistical Area

Preparing Teachers To Apply Research To Mathematics Teaching: Using Design-Based Research To Define And Assess The Process Of Evidence-Based Practice, Sarah Van Ingen

USF Tampa Graduate Theses and Dissertations

Persistent lack of mathematics achievement and disparity in achievement has led to the publication of research findings related to equitable teaching practices. Although the publication of such research provides insights about approaches for potentially increasing equity in mathematics education, teachers must be able to apply what has been learned from these studies to their classroom teaching practices. Despite the widespread expectation that teachers use research-supported teaching strategies to meet the needs of their diverse classrooms, the research to practice gap persists. Little research is currently available to guide mathematics teacher educators in how to prepare future teachers to apply research …

Statistical Analysis And Modeling Of Prostate Cancer, Yiu Ming Chan

USF Tampa Graduate Theses and Dissertations

The objective of the present study is to address some important questions related to prostate cancer treatments and survivorship among White and African American men. It is commonly understood that the risk of developing prostate cancer is higher in African American men than the other races. However, using parametric analysis, this study demonstrates that this perception is a "myth" not a "reality". The study further identifies the existence of racial/ethnic disparities by comparing the average mean tumor size, the median of survival time, and the survival function between White and African American men. These results underline the necessity of understanding …

Prehispanic Water Management At Takalik Abaj, Guatemala, Alicia E. Alfaro

USF Tampa Graduate Theses and Dissertations

Land and water use at archaeological sites is a growing field of study within Mesoamerican archaeology. In Mesoamerica, similar to elsewhere in the world, landscapes were settled based partially upon the characteristics of the environment and the types of food and water resources available. Across Mesoamerica, landscape concepts were also important to religious beliefs and ritual activity in a manner that may have had the potential to influence the power dynamics of a site. This thesis focuses on the management of water at the site of Takalik Abaj in Guatemala during the Middle to Late Preclassic periods (c. 1000 B.C. …

The Influence Of Campus Culture On Mental Health Help-Seeking Intentions, Jason I. Chen

USF Tampa Graduate Theses and Dissertations

Mental health issues are widespread on college campuses. However, the majority of these individuals do not seek help. Prior research suggests many factors which may be related to mental health help-seeking including age, gender, and prior treatment experience. There has however been little work considering the context of the college campus on mental health help-seeking, specifically the influence of campus culture. Accounting for the context of mental health help-seeking may help to determine which social groups have the greatest influence on mental health treatment processes.

The purpose of this study was to explore the relationship between perceived peer, student body, …

The Assessment Of An In-Vitro Model For Evaluating The Role Of Parp In Ethanol-Mediated Hepatotoxicity, Jayme Coyle

USF Tampa Graduate Theses and Dissertations

This investigation assesses the role of poly(ADP-ribose) polymerase in ethanol-mediated hepatotoxicity using the untransfected HepG2 hepatocellular carcinoma line, an established, well-characterized toxicological model. HepG2 cells were treated with ethanol at concentrations between 100 mM and 800 mM, and assessed for markers of cytotoxicity. PARP-1 activity in total cell protein lysates was quantified as a proxy of apoptotic induction at six hours. Our results demonstrated a 1.43-fold AST activity increase in culture medium isolates of cells exposed to 800 mM without significant effect on cellular viability. PARP-1 activity varied greatly and results for enzyme activity remained inconclusive. The results suggest a …

Rural Communities: How Do Individuals Perceive Change When Industry Enters The Area?, Katherine Danielle Ferrari

USF Tampa Graduate Theses and Dissertations

As the landscape of the United States changes and world resources face depletion, shale gas development has become a major social justice issue. Social workers may be called upon to help support communities undergoing change from industry as well as the environmental and social justice concerns that are arising in areas with rich natural resource supplies.

This research examines how a rural population perceives change when industry enters an area. It explores community change and social justice concerns that are occurring with shale gas development in order to help determine implications for social work practice.

Using a phenomenological approach, this …

Cd44 Containing Complexes As A Therapeutic Target In Multiple Myeloma, Anthony Gebhard

USF Tampa Graduate Theses and Dissertations

Our laboratory recently reported that treatment with the d-amino acid containing peptide HYD1 induces necrotic cell death in multiple myeloma (MM) cell lines. Due to the intriguing biological activity and promising in vivo activity of HYD1, we pursued strategies for increasing the therapeutic efficacy of the parent linear peptide. These efforts led to the development of a cyclized peptidomimetic, MTI-101, with increased in vitro activity and robust in vivo activity as a single agent using two myeloma models that consider the bone marrow microenvironment. MTI-101 treatment resulted in mechanistically similar hallmarks of HYD1 induced cell death, namely the generation of …

A Three Dimensional Scaffold For Anticancer Drug Development, Yvonne Girard

USF Tampa Graduate Theses and Dissertations

Attrition rates for anticancer drugs are much higher than any other therapeutic area. Only 5%#37; of the agents that demonstrate anticancer activity in the preclinical stages of development demonstrate clinical efficacy in phase III trials. This high attrition rate becomes alarming when we consider that the cost of research and development can amount to 1 billion dollars. To exacerbate this problem, many new cancer drugs are being discontinued, withdrawn or suspended. The reasons for this high attrition rate are complex and may be partly attributed to suboptimal preclinical strategies such as the use of two-dimensional (2D) cell culture systems to …

Predictors Of The Incidence And Charges For Lumbar Spinal Fusion Surgery In Florida Hospitals During 2010, Anna Ialynychev

USF Tampa Graduate Theses and Dissertations

Over the past several decades rates of spine surgeries in the U.S. have increased dramatically. Spinal fusion surgery rates, in particular, have grown exponentially despite being one of the most costly, invasive, and controversial methods for treating patients suffering from back conditions. Furthermore, lumbar fusion surgeries continue to be performed at increasing rates despite a lack of scientific evidence and consensus that they are cost-effective and produce better clinical outcomes than less radical treatment of lower back pain. As a result, large amounts of healthcare dollars continue to be invested in these costly procedures which are potentially dangerous and have …

A Monte Carlo Approach To Change Point Detection In A Liver Transplant, Alexia Melissa Makris

USF Tampa Graduate Theses and Dissertations

Patient survival post liver transplant (LT) is important to both the patient and the center's accreditation, but over the years physicians have noticed that distant patients struggle with post LT care. I hypothesized that patient's distance from the transplant center had a detrimental effect on post LT survival. I suspected Hepatitis C (HCV) and Hepatocellular Carcinoma (HCC) patients would deteriorate due to their recurrent disease and there is a need for close monitoring post LT. From the current literature it was not clear if patients' distance from a transplant center affects outcomes post LT. Firozvi et al. (Firozvi AA, 2008) …

The Determinants Of Antiretroviral Therapy Adherence And The Relationship Of Healthcare Expenditures To Adherence Among Florida Medicaid-Insured Patients Diagnosed With Hiv Or Aids, Zachary Pruitt

USF Tampa Graduate Theses and Dissertations

Research supports the clinical and societal benefits of antiretroviral treatment (ART) for people living with HIV or AIDS (PLWHA). However, factors associated with ART adherence and the relationship of ART adherence to total healthcare expenditures are not well understood.

The research data included Florida Medicaid claims for five years (July 2006 through June 2011). All subjects (n=514) were HIV-positive, adult, non-pregnant, and ART naïve for at least 12 months prior to their 24 month measurement period. Each subject was categorized as adherent (>90%#37;) or non-adherent (<90%#37;) based upon medication possession ratios (MPR). Total expenditures were payments Medicaid made to providers and pharmacies.

Objective 1 modeled the logit probability of a subject being non-adherent to ART …

Resistance And Tolerance To Trematode Parasites In Larval Anurans, Brittany Sears

USF Tampa Graduate Theses and Dissertations

Nearly every species on the planet has at least one parasite, which, by definition, incurs a

cost in the host. Therefore, organisms must resist parasites - preventing or reducing infections -

or tolerate parasites - reducing the costs of infection - in order to maintain their fitness despite

the presence of parasites. Here, I investigated: 1) whether parasitic, larval trematodes (cercariae)

can detect the least resistant tadpole host species, 2) a hypothetical framework for how host life

history impacts the utilization of inflammation and thus, resistance and tolerance, 3) whether a

common anesthesia technique used in experimental infections immunocompromises tadpoles, …

Continuing Attachment Bonds To The Deceased: A Study Of Bereaved Youth And Their Caregivers, Erica Hill Sirrine

USF Tampa Graduate Theses and Dissertations

Although grief is a universal experience impacting the lives of many children and adolescents each year, not much study has been afforded to this population. In addition, the concept of a continuing attachment bond (CAB) or ongoing relationship to the deceased and its role as adaptive or maladaptive in the bereavement process is in its infancy of research among adult populations and is largely unstudied among bereaved youth. This mixed-methods study attempted to bridge the gap by examining the relationship between CABs among a sample of 50 bereaved youth (ages 11-17) and their bereaved adult caregivers. In addition, the study …

Colors And Mapping: The Right To Receive Information, Kathryn Stephanie Skupien

USF Tampa Graduate Theses and Dissertations

Color is used in everything we see and do and it often can be used for effect and representation, particularly on maps and transportation signage. This study explores the issues that the color blind population exhibits when viewing these maps and signs. Seeing that 8%#37; of the male population is afflicted with some form of color blindness, it is pertinent that research reflect these issues and take into consideration the Right to Receive Information for this population. A qualitative method using Photovoice and interviews was used to determine whether this population considers itself having a disability and what solutions can …

Innate Immune Responses To Respiratory Syncytial Virus: Age-Associated Changes, Terianne Maiko Wong

USF Tampa Graduate Theses and Dissertations

Respiratory syncytial virus (RSV) infection causes ~64 million cases of respiratory disease and 200,000 deaths annually worldwide, yet there is no broadly effective prophylactic or treatment regimen. RSV can produce acute respiratory illness in patients of all ages but strikes the age extremes, infants and the elderly, with highest frequency presumably due to innate immune deficiencies. A higher morbidity and mortality has been reported for the elderly above 65 years of age, which has been attributed to immune senescence. Efforts to generate an effective vaccine have thus far been unsuccessful.

The innate immune system provides the first line of defense …

When Celebrity Women Tweet: Examining Authenticity, Empowerment, And Responsibility In The Surveillance Of Celebrity Twitter, Megan M. Wood

USF Tampa Graduate Theses and Dissertations

This thesis is a textual analysis of stories in online celebrity news articles about celebrity women and their use of Twitter. It adds to the burgeoning discussion about gendered and racialized bodies online using scholarship from critical feminist, surveillance, and digital media studies. Throughout, my work attends to notions of authenticity and surveillance, examining how what I term a "call to authenticity"--the use of technologies of self-surveillance to verify "authentic" displays of the self--serves to animate contradictory post-feminist paradigms of femininity which function together to discipline and subjugate femininity. I ask: How do post-feminist questions of empowerment and responsibility become …

Development Of A Novel Method For Deriving Thresholds Of Toxicological Concern (Ttcs) For Vaccine Constituents, Jennifer Jessica White

USF Tampa Graduate Theses and Dissertations

Abstract

Safety assessment relating to the presence of impurities, residual materials and contaminants in vaccines is a focus area of research at the United States Food and Drug Administration (FDA). Sponsors who submit Investigational New Drug (IND) applications for new vaccine products must report the results of safety assessments to the Division of Vaccines and Related Products Applications (DVRPA). Scientifically defining thresholds of toxicological concern (TTCs) as they apply to vaccine constituents will provide a useful aid to the sponsors and public regarding safety assessments of compounds for which there is little or no toxicity data. TTCs are mathematically modeled …

Histone Deacetylases As Targets For Melanoma Immunotherapy, David Michael Woods

USF Tampa Graduate Theses and Dissertations

Cancer represents the second leading cause of death in the United States. For many malignancies, currently available treatment options offer little long-lasting survival benefits to patients. However, recent studies have shown immunotherapeutic approaches to be an attractive strategy to cancer treatment. While many current immunotherapeutic strategies convey durable responses, such responses are only seen in a minority of patients. An increased understanding of the mechanisms governing tumor immunogenicity and the biology of immune responses is crucial to improving upon the efficacy of current and future cancer immunotherapies. Histone deacetylases (HDACs), enzymes classically associated with regulation of gene expression, have been …

Synthesis Of Amphiphilic Α- And Γ-Aapeptides For Antimicrobial, Self-Assembly, And Mineralization Studies, Mohamad N. Amin

USF Tampa Graduate Theses and Dissertations

Seven novel, amphiphilic AApeptides were prepared. Two cationic, lipo-α-AApeptides, NA-75 and NA-77 were found to possess potent antimicrobial activity against Gram-positive bacteria, with almost no hemolytic activity. In addition to NA-75 and 77, four amphiphilic, γ-AApeptides, NA-133, 135, 137, and 139, and one anionic lipo-α-AApeptide, NA-81, were prepared for molecular self-assembly studies, with several interesting nanostructures observed by TEM. Mineralization of calcium carbonate from gaseous CO2 and Ca2+ in the presence of the 7 AApeptide amphiphiles was also observed by optical microscopy. Several AApeptides were found to be able to influence CaCO3 crystal morphology. Another α-AApeptide, NA-63, was synthesized by …

Investigation Of Colored Dissolved Organic Matter (Cdom) Optical Properties, Nutrients, And Salinity In Coastal Florida: Springshed To Estuaries, Ana Rosa Arellano

USF Tampa Graduate Theses and Dissertations

Optical parameters measured via absorption spectroscopy and high-resolution fluorescence spectroscopy were used to characterize dissolved organic matter (DOM) in the springshed of Kings Bay, a spring-fed estuary located on Florida's Springs Coast. Over the past 40 years, springs supplying groundwater to Kings Bay have shown an increase in nitrate concentration. The overall goal of this project was to fingerprint wells and spring sites with elevated nitrogen concentrations using CDOM optical properties and establish relationships between nutrient and optical parameters. Samples were obtained from various sites: springs, Kings Bay surface (KBS), wells, coastal waters in and at the mouth of Crystal …

Nonword Processing In Bilingual Five Year Olds: Do Phonotactics Count?, Kyna Betancourt

USF Tampa Graduate Theses and Dissertations

Phonotactic processing is foundational to the word processing task in both monolingual and bilingual children (Li & Farkas, 2002; Pierrehumbert, 2001; Shook & Marian, 2013; Storkel & Morrisette, 2002). While the use of phonotactic information in word processing in monolingual children is relatively well documented, it is less well understood in bilingual children. The purpose of this study was to investigate how bilingual kindergartners process the phonotactic probabilities of their two languages. A set of nonwords was developed that manipulated the strength of phonotactic probability across both Spanish and English while also controlling the language environment of the experimental task …

Defining Semantic Space And Degree Of Association Using Brainwaves: An Erp Investigation Of Alcohol Expectancies, Ty Brumback

USF Tampa Graduate Theses and Dissertations

The current study investigated the cognitive organization of alcohol expectancies using event-related potentials (ERPs). Building on previous behavioral and ERP paradigms, the goal of the current study was to quantify the relationship among alcohol expectancies using ERP indices of salience, congruence, and cognitive distance. The ERP components being evaluated fit perfectly into the alcohol expectancy theory and research; however, implementing specific paradigms to reliably measure individual differences in alcohol expectancies using ERPs has proven to be more elusive than originally thought. This study utilized established cognitive modeling techniques coupled with ERP responses to linguistic stimuli. In essence, this study provides …

Predictors Of Student Enrollment Patterns In High School Career Academies, E. Daniel Cox

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to describe participation patterns at the district level of students enrolled in career academies and determine whether participation in career academies is a function of demographic and/or prior learning experience and prior performance variables. Ex-post facto data was used to determine six-year enrollment trends. In addition, both binary logistic regression and multinomial logistic regression methods were employed to determine the extent demographic along with prior learning experience and prior performance variables could be used to predict participation within career academies. Trend data results indicated slight increases in the proportions of students of color (including …