Digital Commons Network^™

Predictors Of The Incidence And Charges For Lumbar Spinal Fusion Surgery In Florida Hospitals During 2010, Anna Ialynychev

USF Tampa Graduate Theses and Dissertations

Over the past several decades rates of spine surgeries in the U.S. have increased dramatically. Spinal fusion surgery rates, in particular, have grown exponentially despite being one of the most costly, invasive, and controversial methods for treating patients suffering from back conditions. Furthermore, lumbar fusion surgeries continue to be performed at increasing rates despite a lack of scientific evidence and consensus that they are cost-effective and produce better clinical outcomes than less radical treatment of lower back pain. As a result, large amounts of healthcare dollars continue to be invested in these costly procedures which are potentially dangerous and have …

A Monte Carlo Approach To Change Point Detection In A Liver Transplant, Alexia Melissa Makris

USF Tampa Graduate Theses and Dissertations

Patient survival post liver transplant (LT) is important to both the patient and the center's accreditation, but over the years physicians have noticed that distant patients struggle with post LT care. I hypothesized that patient's distance from the transplant center had a detrimental effect on post LT survival. I suspected Hepatitis C (HCV) and Hepatocellular Carcinoma (HCC) patients would deteriorate due to their recurrent disease and there is a need for close monitoring post LT. From the current literature it was not clear if patients' distance from a transplant center affects outcomes post LT. Firozvi et al. (Firozvi AA, 2008) …

The Determinants Of Antiretroviral Therapy Adherence And The Relationship Of Healthcare Expenditures To Adherence Among Florida Medicaid-Insured Patients Diagnosed With Hiv Or Aids, Zachary Pruitt

USF Tampa Graduate Theses and Dissertations

Research supports the clinical and societal benefits of antiretroviral treatment (ART) for people living with HIV or AIDS (PLWHA). However, factors associated with ART adherence and the relationship of ART adherence to total healthcare expenditures are not well understood.

The research data included Florida Medicaid claims for five years (July 2006 through June 2011). All subjects (n=514) were HIV-positive, adult, non-pregnant, and ART naïve for at least 12 months prior to their 24 month measurement period. Each subject was categorized as adherent (>90%#37;) or non-adherent (<90%#37;) based upon medication possession ratios (MPR). Total expenditures were payments Medicaid made to providers and pharmacies.

Objective 1 modeled the logit probability of a subject being non-adherent to ART …

Resistance And Tolerance To Trematode Parasites In Larval Anurans, Brittany Sears

USF Tampa Graduate Theses and Dissertations

Nearly every species on the planet has at least one parasite, which, by definition, incurs a

cost in the host. Therefore, organisms must resist parasites - preventing or reducing infections -

or tolerate parasites - reducing the costs of infection - in order to maintain their fitness despite

the presence of parasites. Here, I investigated: 1) whether parasitic, larval trematodes (cercariae)

can detect the least resistant tadpole host species, 2) a hypothetical framework for how host life

history impacts the utilization of inflammation and thus, resistance and tolerance, 3) whether a

common anesthesia technique used in experimental infections immunocompromises tadpoles, …

Continuing Attachment Bonds To The Deceased: A Study Of Bereaved Youth And Their Caregivers, Erica Hill Sirrine

USF Tampa Graduate Theses and Dissertations

Although grief is a universal experience impacting the lives of many children and adolescents each year, not much study has been afforded to this population. In addition, the concept of a continuing attachment bond (CAB) or ongoing relationship to the deceased and its role as adaptive or maladaptive in the bereavement process is in its infancy of research among adult populations and is largely unstudied among bereaved youth. This mixed-methods study attempted to bridge the gap by examining the relationship between CABs among a sample of 50 bereaved youth (ages 11-17) and their bereaved adult caregivers. In addition, the study …

Colors And Mapping: The Right To Receive Information, Kathryn Stephanie Skupien

USF Tampa Graduate Theses and Dissertations

Color is used in everything we see and do and it often can be used for effect and representation, particularly on maps and transportation signage. This study explores the issues that the color blind population exhibits when viewing these maps and signs. Seeing that 8%#37; of the male population is afflicted with some form of color blindness, it is pertinent that research reflect these issues and take into consideration the Right to Receive Information for this population. A qualitative method using Photovoice and interviews was used to determine whether this population considers itself having a disability and what solutions can …

Innate Immune Responses To Respiratory Syncytial Virus: Age-Associated Changes, Terianne Maiko Wong

USF Tampa Graduate Theses and Dissertations

Respiratory syncytial virus (RSV) infection causes ~64 million cases of respiratory disease and 200,000 deaths annually worldwide, yet there is no broadly effective prophylactic or treatment regimen. RSV can produce acute respiratory illness in patients of all ages but strikes the age extremes, infants and the elderly, with highest frequency presumably due to innate immune deficiencies. A higher morbidity and mortality has been reported for the elderly above 65 years of age, which has been attributed to immune senescence. Efforts to generate an effective vaccine have thus far been unsuccessful.

The innate immune system provides the first line of defense …

When Celebrity Women Tweet: Examining Authenticity, Empowerment, And Responsibility In The Surveillance Of Celebrity Twitter, Megan M. Wood

USF Tampa Graduate Theses and Dissertations

This thesis is a textual analysis of stories in online celebrity news articles about celebrity women and their use of Twitter. It adds to the burgeoning discussion about gendered and racialized bodies online using scholarship from critical feminist, surveillance, and digital media studies. Throughout, my work attends to notions of authenticity and surveillance, examining how what I term a "call to authenticity"--the use of technologies of self-surveillance to verify "authentic" displays of the self--serves to animate contradictory post-feminist paradigms of femininity which function together to discipline and subjugate femininity. I ask: How do post-feminist questions of empowerment and responsibility become …

Development Of A Novel Method For Deriving Thresholds Of Toxicological Concern (Ttcs) For Vaccine Constituents, Jennifer Jessica White

USF Tampa Graduate Theses and Dissertations

Abstract

Safety assessment relating to the presence of impurities, residual materials and contaminants in vaccines is a focus area of research at the United States Food and Drug Administration (FDA). Sponsors who submit Investigational New Drug (IND) applications for new vaccine products must report the results of safety assessments to the Division of Vaccines and Related Products Applications (DVRPA). Scientifically defining thresholds of toxicological concern (TTCs) as they apply to vaccine constituents will provide a useful aid to the sponsors and public regarding safety assessments of compounds for which there is little or no toxicity data. TTCs are mathematically modeled …

Histone Deacetylases As Targets For Melanoma Immunotherapy, David Michael Woods

USF Tampa Graduate Theses and Dissertations

Cancer represents the second leading cause of death in the United States. For many malignancies, currently available treatment options offer little long-lasting survival benefits to patients. However, recent studies have shown immunotherapeutic approaches to be an attractive strategy to cancer treatment. While many current immunotherapeutic strategies convey durable responses, such responses are only seen in a minority of patients. An increased understanding of the mechanisms governing tumor immunogenicity and the biology of immune responses is crucial to improving upon the efficacy of current and future cancer immunotherapies. Histone deacetylases (HDACs), enzymes classically associated with regulation of gene expression, have been …

Synthesis Of Amphiphilic Α- And Γ-Aapeptides For Antimicrobial, Self-Assembly, And Mineralization Studies, Mohamad N. Amin

USF Tampa Graduate Theses and Dissertations

Seven novel, amphiphilic AApeptides were prepared. Two cationic, lipo-α-AApeptides, NA-75 and NA-77 were found to possess potent antimicrobial activity against Gram-positive bacteria, with almost no hemolytic activity. In addition to NA-75 and 77, four amphiphilic, γ-AApeptides, NA-133, 135, 137, and 139, and one anionic lipo-α-AApeptide, NA-81, were prepared for molecular self-assembly studies, with several interesting nanostructures observed by TEM. Mineralization of calcium carbonate from gaseous CO2 and Ca2+ in the presence of the 7 AApeptide amphiphiles was also observed by optical microscopy. Several AApeptides were found to be able to influence CaCO3 crystal morphology. Another α-AApeptide, NA-63, was synthesized by …

Investigation Of Colored Dissolved Organic Matter (Cdom) Optical Properties, Nutrients, And Salinity In Coastal Florida: Springshed To Estuaries, Ana Rosa Arellano

USF Tampa Graduate Theses and Dissertations

Optical parameters measured via absorption spectroscopy and high-resolution fluorescence spectroscopy were used to characterize dissolved organic matter (DOM) in the springshed of Kings Bay, a spring-fed estuary located on Florida's Springs Coast. Over the past 40 years, springs supplying groundwater to Kings Bay have shown an increase in nitrate concentration. The overall goal of this project was to fingerprint wells and spring sites with elevated nitrogen concentrations using CDOM optical properties and establish relationships between nutrient and optical parameters. Samples were obtained from various sites: springs, Kings Bay surface (KBS), wells, coastal waters in and at the mouth of Crystal …

Nonword Processing In Bilingual Five Year Olds: Do Phonotactics Count?, Kyna Betancourt

USF Tampa Graduate Theses and Dissertations

Phonotactic processing is foundational to the word processing task in both monolingual and bilingual children (Li & Farkas, 2002; Pierrehumbert, 2001; Shook & Marian, 2013; Storkel & Morrisette, 2002). While the use of phonotactic information in word processing in monolingual children is relatively well documented, it is less well understood in bilingual children. The purpose of this study was to investigate how bilingual kindergartners process the phonotactic probabilities of their two languages. A set of nonwords was developed that manipulated the strength of phonotactic probability across both Spanish and English while also controlling the language environment of the experimental task …

Defining Semantic Space And Degree Of Association Using Brainwaves: An Erp Investigation Of Alcohol Expectancies, Ty Brumback

USF Tampa Graduate Theses and Dissertations

The current study investigated the cognitive organization of alcohol expectancies using event-related potentials (ERPs). Building on previous behavioral and ERP paradigms, the goal of the current study was to quantify the relationship among alcohol expectancies using ERP indices of salience, congruence, and cognitive distance. The ERP components being evaluated fit perfectly into the alcohol expectancy theory and research; however, implementing specific paradigms to reliably measure individual differences in alcohol expectancies using ERPs has proven to be more elusive than originally thought. This study utilized established cognitive modeling techniques coupled with ERP responses to linguistic stimuli. In essence, this study provides …

Predictors Of Student Enrollment Patterns In High School Career Academies, E. Daniel Cox

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to describe participation patterns at the district level of students enrolled in career academies and determine whether participation in career academies is a function of demographic and/or prior learning experience and prior performance variables. Ex-post facto data was used to determine six-year enrollment trends. In addition, both binary logistic regression and multinomial logistic regression methods were employed to determine the extent demographic along with prior learning experience and prior performance variables could be used to predict participation within career academies. Trend data results indicated slight increases in the proportions of students of color (including …

Alliance And Mechanisms Of Medication Adherence In Pediatric Psychiatric Practice, Alessandro Stevens De Nadai

USF Tampa Graduate Theses and Dissertations

Psychiatric medications have been established as an efficacious treatment for pediatric psychopathology (Comer, Olfson, & Mojtabai, 2010), with approximately 3.9% of American children receiving psychotropic medication in a given year (Olfson, Marcus, Weissman, & Jensen, 2002). However, medication adherence for these conditions is suboptimal, with over 50% of children discontinuing treatment before the period recommended for full therapeutic benefit (e.g., Gau et al., 2006; Murray, de Vries, & Wong, 2004). This is highly problematic because pediatric psychopathology is associated with substantial functional impairment and reduced quality of life, as well as increased risk for suicidality (e.g., Bridge, Goldstein, & Brent, …

The Political Economy Of Maternal Health In A Medically Pluralistic Environment: A Case Study In The Callejón De Huaylas, Isabella Chan

USF Tampa Graduate Theses and Dissertations

This thesis examines maternal decision-making regarding prenatal care and childbirth in the rural, north-central Andes in the province of Carhuaz. Semi-structured interviews (n=30) and participatory action research workshops (n=7) were conducted with local women to elucidate how they conceptualize, experience, and negotiate the shifting landscape of prenatal care and childbirth practices and providers. Semi-structured interviews with obstetricians, midwives, and social workers (n=9) were also conducted to compare perspectives and identify disconnects in knowledge and practices existing between these two groups in order to facilitate an open conversation on how to jointly improve the maternal experience and reduce maternal mortality and …

Predictors Of Quality Of Life In Patients With Cutaneous T Cell Lymphoma, Darcie Marie Deaver

USF Tampa Graduate Theses and Dissertations

Abstract

Cutaneous T cell lymphoma (CTCL) is a rare, incurable, chronic disease accounting for approximately 3% of non-Hodgkin's lymphoma diagnoses every year. Patients with CTCL have skin lesions that can vary in severity putting patients at risk for developing symptoms that may impair their quality of life (QOL). The disease burden can lead to increased depressive symptoms, fatigue distress, and anxiety that the disease may be worsening. Seventy-five participants agreed to take part in an exploratory, prospective study to evaluate depressive symptoms, anxiety, fatigue distress, and spirituality as predictors of QOL in CTCL patients. Demographic variables including stage of disease, …

Optical Investigations Of Neurohypophysial Excitability And Amyloid Fibril Formation, Joseph Leo Foley

USF Tampa Graduate Theses and Dissertations

This dissertation describes the work done on two distinct projects. In the first part I sought to unravel the mechanisms that underlie the activity-dependent modulation of response in the excitation-secretion coupling of the neurohypophysis. In the second part, I optically monitored and analyzed the secondary structure changes accompanying amyloid fibril formation along multiple pathways, under both denaturing and near-physiological conditions.

Neuronal plasticity plays an important role in regulating various biological systems by modulating release of hormones or neurotransmitters. The changing response to the same stimulus, depending on the context and previous stimulation events, is also the basis of learning and …

Asbestos Exposure In The Research Laboratory, Ediberto D. Garcia

USF Tampa Graduate Theses and Dissertations

Introduction: Asbestos has been employed in a myriad of industrial applications for more than a century. Of the 181 Mt of asbestos produced worldwide, over 31 Mt was consumed in the U.S. The production and consumption of this mineral eventually was found to cause asbestosis, lung cancer and mesothelioma. While the brunt of the human exposure to asbestos occurred in insulation work, many more workers in other jobs were expose to asbestos fibers. Very little is known about the potential exposure to asbestos in research labs.

Goal: In order to investigate potential research lab work exposures, we simulated lab work …

Effects Of Speech Production Ability On A Measure Of Speech Perception Capacity In Young Children With Cochlear Implants And Their Articulation-Matched Peers, Victoria Beatriz Gonzalez

USF Tampa Graduate Theses and Dissertations

With reductions in the age criterion for cochlear implantation, the need for age-appropriate measures of speech perception skills has increased. One recently developed tool that shows great promise for the clinical assessment of auditory speech perception capacity in young children with cochlear implants is the On-Line Imitative Test of Speech-Pattern Contrast Perception (OlimSpac). The OlimSpac requires a child to imitate nonword utterances by providing a verbal response. The child's perceptual abilities are inferred from the child's productions through having a listener, who is masked to the stimulus select the utterance produced by the child in an eight-alternative force-choice task. Although …

An(Other) Rhetoric: Rhetoric, Ethics, And The Rhetorical Tradition, Kathleen Sandell Hardesty

USF Tampa Graduate Theses and Dissertations

Rhetoric as a discipline is still touched by the shadow of ancient Greece. Rhetoric was defined famously by Aristotle as the "available means of persuasion," codified into five canons in classical Rome, and has since been a central part of Western education to train speakers and writers to effectively move their audiences. However, particularly beginning in the mid-20th Century, the discipline's understanding of rhetoric as a means of persuasion (or even manipulation) passed down from our ancient roots began to shift to a sense of rhetoric as matters of ethics and a concern for the other. It begs the question: …

Metabolism In Corals From Antarctica, The Deep-Sea, And The Shallow Subtropics: Contrasts In Temperature, Depth, And Light, Lara Henry

USF Tampa Graduate Theses and Dissertations

Coral habitats span the range from tropical to polar, extremely shallow to thousands of meters deep. The differences in light and temperature experienced in these varied habitats likely affect the metabolic rates of the corals residing there. The metabolism of three coral species from different habitats have been examined to elucidate the effects of these environmental parameters on metabolism, an under-studied aspect of coral biology. For all three species, measurements of oxygen uptake, ammonium excretion, and activity of the enzymes lactate dehydrogenase (LDH), malate dehydrogenase (MDH), and citrate synthase (CS) were used to characterize their metabolism. Off Florida's Gulf coast, …

The Perception Of Emergency Department Physicians Regarding Economic And Regulatory Factors Impacting Management Of Drug Seeking Patients, Sharon Susanne Kelley

USF Tampa Graduate Theses and Dissertations

Abstract

Physicians in the emergency department (ED) are facing a number of unique challenges in the currently changing healthcare and economic climates. Dramatic increases in ED patient volumes have been noted nationwide with visits related to prescription opioid abuse and misuse alone having increased by 111% between 2004 and 2008.

Ironically, several challenges ED physicians are facing arise from regulatory and economic initiatives which were originally designed for the protection of patients. Regulatory requirements to address pain as the fifth vital sign, along with entities utilizing patient satisfaction based reimbursement, have inadvertently created an environment conducive to exploitation by the …

Climate, Neo-Spinozism, And The Ecological Worldview, Nancy M. Kettle

USF Tampa Graduate Theses and Dissertations

The global community faces ecological problems with the natural environment and cultural impediments to solving them. Natural systems are constantly changing and so are cultural practices. Humans need to address both: the interaction between those dynamic systems, the natural and cultural, because what happens in one system changes things in the other. The changes to the ecosystems are rapid and sometimes irreversible while dealing with them has been inadequate. Environmental movements, including deep ecology, have been at the forefront of the efforts to engage the public, various groups, politicians, and world governments to address environmental problems on a coordinated large …

Ocbs And Strain: The Moderating Role Of Control, Kevin Loo

USF Tampa Graduate Theses and Dissertations

Organizational citizenship behaviors (OCBs) are typically assumed to be beneficial to employees and organizations. However, research has recently questioned this assumption. This study seeks to identify when OCBs are related to various strains and are detrimental to the employee or the organization. Specifically, using a stressor-strain model, it is hypothesized that in general, OCBs will be related to work effort; however, when employees feel pressured to perform OCBs, and thereby feel less control, OCBs will be more related to various strains. The hypotheses were partially supported: under all conditions, OCBs were related to effort, but under conditions of feeling forced, …

A Case Study Of Jamaican Children's Lived Play Experiences, Carol Ann Long

USF Tampa Graduate Theses and Dissertations

Although research on children's play is abundant and considerable advances have been made in young children's play, the majority of these studies have been based in western developed countries and written from adults' perspectives rather than with children. Additionally, very little research has been done on children's play with active participants from smaller developing countries. The voices of society's youngest members have been lost or are only marginally represented.

The purpose of this qualitative research is to explore, understand, and describe young Jamaican children's lived play experiences as related through their eyes. The theoretical frameworks used to guide this study …

Efficacy Of A Dissonance-Based Intervention For Self-Objectification: A Randomized Controlled Trial, Jessie Erin Menzel

USF Tampa Graduate Theses and Dissertations

Self-objectification is the process by which women take on a third-person perspective in evaluating their physical appearance and sexual attributes. Objectification theory states that self-objectification may lead to negative mental health outcomes in women; a growing body of cross-sectional and experimental research supports the connection between self-objectification and the experience of shame, disordered eating, depression, and sexual dysfunction. This study sought to evaluate an intervention designed to reduce self-objectification behaviors and beliefs in order to prevent the development of disordered eating, depression, and sexual dysfunction. An efficacious prevention program using cognitive dissonance induction was adapted to target self-objectification. The efficacy …

Evaluating Habitat Vulnerability And Sustainability Of Urban Seagrass Resources To Sea Level Rise, Cynthia A. Meyer

USF Tampa Graduate Theses and Dissertations

The seagrass resource provides essential ecosystem functions for many marine species. This research evaluated the vulnerability and sustainability of the seagrass resource in an urbanized area to the effects of sea level rise. The assessment required analysis of information regarding the biogeography of the seagrass resource, and developing a method to model the spatial extent of the suitable habitat for seagrass, and applying the model to predict the implications of simulated sea level rise scenarios on the seagrass resource.

Examining the biogeography of the seagrass resource required the development of a seagrass monitoring and assessment field survey and a comprehensive …

Social Determinants Of Racial And Ethnic Disparities In Perinatal Morbidity: Social Origins Of Perinatal Health Study, Abraham A. Salinas-Miranda

USF Tampa Graduate Theses and Dissertations

BACKGROUND: The social causation of preterm birth remains elusive, without an adequate explanatory framework. Thus, this study proposed and evaluated a conceptual model of the social determinants of perinatal health for the understanding of perinatal health disparities.

METHODS: A prospective cohort study was conducted with pregnant women between 20 and 35 weeks gestation who were participating in two Healthy Start programs in Central Florida, from July 2011-August 2013. Perinatal health was operationalized based on gestational age, birth weight, and healthy start infant risk screen score. The predictors were: early life adversity, social position, maternal health-related quality of life, maternal stress, …