Digital Commons Network^™

Insights Into Distinct Modulation Of α7 And α7β2 Nicotinic Acetylcholine Receptors By The Volatile Anesthetic, David D. Mowrey, Qiang Liu, Vasyl Bondarenko, Qiang Chen, Edom Seyoum, Yan Xu, Jie Wu, Pei Tang

Translational Neuroscience

Nicotinic acetylcholine receptors (nAChRs) are targets of general anesthetics, but functional sensitivity to anesthetic inhibition varies dramatically among different subtypes of nAChRs. Potential causes underlying different functional responses to anesthetics remain elusive. Here we show that in contrast to the α7 nAChR, the α7β2 nAChR is highly susceptible to inhibition by the volatile anesthetic isoflurane in electrophysiology measurements. Isoflurane-binding sites in β2 and α7 were found at the extracellular and intracellular end of their respective transmembrane domains using NMR. Functional relevance of the identified β2 site was validated via point mutations and subsequent functional measurements. Consistent with their functional responses …

Sheet Metal Workers Intl Assn V. E.P. Donnelly, Inc

2013 Decisions

USDC for the District of New Jersey

Usa V. Jaime Snyder

2013 Decisions

USDC for the District of Delaware

James Calender V. Nvr Inc

2013 Decisions

USDC for the District of New Jersey

A Mightier Pin: Creating A Credible Reference Library On Pinterest At Murray State University, Rebecca Richardson, Candace Vance, Elizabeth Price, Jeffrey Henry

Faculty Research and Creative Activity

This case study shows how the reference librarians at Murray State University use Pinterest as an added component in reference services. Statistics were collected in an attempt to monitor the number of items shared with the number of people who actively follow each board. This study will help interested reference librarians gain an understanding of how this social media site can be used to promote online resources, both those owned by the institution and those available freely on the internet. It will also serve as an example of how reference librarians can build a reference library within the confines of …

Direction Package Advisory Board Notes - December 13, 2013, Direction Package Advisory Board

Direction Package

No abstract provided.

Brazil Responds To U.S. Spying With International Diplomacy And Domestic Lawmaking, Gregory Scruggs

NotiSur

No abstract provided.

Ucc Minutes Dec 13, 2013, Undergraduate Curriculum Council

Undergraduate Currirculum Committee Minutes

No abstract provided.

Motivation And The Sat: What Factors Help Determine College Success Past Standardized Testing, Alexandra Vartanian

Theses and Dissertations

The purpose of this study was to examine the effects motivation plays in determining the success of a student in post secondary education. The relationship between high school GPA (HSGPA), SAT Scores, college GPA (CGPA), and motivation factors were examined. Motivation was measured on the Motivational Strategies for Learning Questionnaire (MSLQ) developed by Paul Pintrich and Elizabeth de Groot. Ninety-two participants responded to the survey. Results corroborated findings from previous research. SAT scores correlate with CGPA; relationships were also observed across several other factors, including HSGPA and CGPA, SAT and Motivation, and HSGPA and SAT scores.

The Effect Of Separating Ownership From Control On Corporate Leverage, Josephat Lotto

Business Management Review

This paper aims to examine how corporate leverage is affected by the separation of ownership from control .Using data from a sample of 643 listed UK firms, the results show supportive evidence of a statistically significant positive relationship between the largest shareholder ' s ownership concentration and debt ratio. More importantly, the results of the paper show a statistically significant and positive relationship between control-wedge (deviation between control rights and cash flow rights) and the debt ratio confirming that control attracts controlling shareholders to extract private benefits. This finding offers directly evidence for the debt-increasing effect of the hypothesis formulated …

Implementation Plan For Emr And Beyond, Lori Katterhagen

Doctor of Nursing Practice (DNP) Projects

Change is never easy for anyone, but how we implement change can make the difference in how an innovation is accepted. Over the last two years, a small community hospital in California has introduced a new electronic medical record (EMR) to meet the requirements of meaningful use mandated by the Centers for Medicare and Medicaid (CMS) for all hospitals across the United States. EMRs are expected to improve quality in many areas, especially to improve outcomes, while safely reducing costs (U.S. Department of Health & Human Services, 2012). Adoption of EMR’s is not optional, if facilities want to avoid penalties …

The Design, Implementation And Evaluation Of A Technology Solution To Improve Discharge Planning Communication In A Complex Patient Population, Susan M. Manfredi

Doctor of Nursing Practice (DNP) Projects

Unnecessary delays in discharge planning can extend the length of stay (LOS) and add non-reimbursable days for socially and medically complex patients thereby increasing the financial burden to healthcare organizations. The literature supports enhanced discharge communication strategies and the use of checklists to facilitate safe and timely discharges. Following root cause analyses of significant discharge delays, one hospital identified gaps in communication as key precursors associated with discharge planning breakdown when discharging patients to skilled nursing facilities. Review of these events demonstrated the need for concurrent communication strategies between multidisciplinary care team members in planning for complex discharges.

Following a …

Learning To Teach Mathematics And To Analyze Teaching Effectiveness: Evidence From A Video- And Practice-Based Pre-Service Course, Rossella Santagata, Cathery Yeh

Education Faculty Articles and Research

Although emerging consensus exists that practice-based approaches to teacher preparation assist in closing the distance between university coursework and fieldwork experiences and in assuring that future teachers learn to implement innovative research-based instructional strategies, little empirical research has investigated teacher learning from this approach. This study examines the impact of a video- and practice-based course on prospective teachers’ mathematics classroom practices and analysis of their own teaching. Two groups of elementary prospective teachers participated in the study—one attended the course and one did not. Findings reveal that the course assisted participants in making student thinking visible and in pursuing it …

Oser V. State Appellant's Brief 1 Dckt. 41249

Not Reported

No abstract provided.

Factors Influencing Youth Self-Perceptions Of Overweight And Obesity, Caitlin Helen Sommers

Dissertations and Theses

This study sought to examine whether participation in physical activity affects the ability to correctly classify body size, based on body mass index classifications. Secondarily, this study determined whether adolescents who incorrectly classified their body size overestimated or underestimated their size. Self-report data from the Youth Risk Behavior Surveillance Survey collected by the Centers for Disease Control and Prevention were analyzed. Logistic regression was performed to examine relationships between self-perception of body size and physical activity, television viewing time, computer/video game use, physical education class time, and extracurricular sports activities. Significance was set to p<0.05. Physical activity was the only statistically significant independent variable (p=0.058, OR = 1.060). Although physical activity was shown to be statistically significant, it did not appear to meaningfully increase the ability of youth to correctly classify body size. Secondary analysis showed that adolescents who incorrectly classified their body size were more likely to underestimate their body size. Females more frequently underestimated their body size (females=673; males=384).

Ideological Entrenchment And The Academy: An Undergraduate’S Defense Of Religious Belief In Public Universities, Joseph Hogan

Honors Projects

No abstract provided.

State V. Nicolescu Appellant's Reply Brief Dckt. 40985

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Corgatelli V. Steel West Cross Respondent's Reply Brief Dckt. 41012

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Atomic Data For S Ii—Toward Better Diagnostics Of Chemical Evolution In High-Redshift Galaxies, Romas Kisielius, Varsha P. Kulkarni, Gary J. Ferland, Pavel Bogdanovich, Matt L. Lykins

Physics and Astronomy Faculty Publications

Absorption-line spectroscopy is a powerful tool used to estimate element abundances in both the nearby and distant universe. The accuracy of the abundances thus derived is naturally limited by the accuracy of the atomic data assumed for the spectral lines. We have recently started a project to perform new extensive atomic data calculations used for optical/UV spectral lines in the plasma modeling code Cloudy using state of the art quantal calculations. Here, we demonstrate our approach by focussing on S II, an ion used to estimate metallicities for Milky Way interstellar clouds as well as distant damped Lyman-alpha (DLA) and …

Disembodied Sovereignty: Power And Personhood In Rawlsian Liberalism, Rheuben Bundy

Political Science Theses

The works of John Rawls manifest a deep concern with developing a stable, well-ordered society that is built on a reciprocal understanding of justice. In Rawlsian thought, however, the very forms of power that Rawls seeks to ameliorate are recreated in more pernicious forms, as they are ubiquitous, rather than localized in the person of a sovereign. This work explores the impact of power operations on the person in political space in Rawls thought through the works of contemporarian and post-modern theorists. In doing so, it not only offers a critique of the operations of power in Rawls' well-ordered society …

Striae Re-Negotiated: The Self-Definition Of The Yiddish-Speaking Jewish Community In The Era Of Mexicos Raza Cósmica, Beth Merfish

Research Papers

This essay examines Mexican Jewish documents through which that community navigated the political terrain of post-Revolution Mexico. Central to this discussion is tension between Jewish desires to become part of this new nation and the imperative to remain a discreet cultural and religious community. I first examine the pressures of assimilation in 1920s Mexico exemplified by José Vasconcelos 1925 La raza cosmica and then probe the Yiddish-speaking Jewish community's response and self-definition in relation to a rapidly developing nation, using two case studies: the Jewish community's political position publicized in the 1929 Asociación de Jóvenes Israelitas de México bulletin and …

The Shift In Pedagogy: Authoritarian And Egalitarian Styles Of Teaching, Cayley Yamashita

Dance Department Best Student Papers

No abstract provided.

Effects Of Increasing Temperature And Ocean Acidification On The Microstages Of Two Populations Of Saccharina Latissima In The Northwest Atlantic, Sarah Redmond

Master's Theses

Saccharina latissima (Linnaeus) C.E.Lane, C.Mayes, L.D. Druehl and G.W.Saunders, is the most widely distributed species of kelp in the western North Atlantic, occurring from the Arctic to Long Island Sound. The effects of global climate change on these ecologically and economically important cold temperate species at the southern range of their distribution are unknown. This study investigated the impact of the combined stressors of increased temperature (16, 19, 22, 25 & 28°C) and reduced pH (7.9, 7.8, 7.7, & 7.6) on the gametophyte and juvenile sporophyte stages of sugar kelp populations from Maine and Long Island Sound. Spore germination and …

Algorithms For Multisample Reads Binning, Gabriel S.I. Ilie

Master's Theses

Metatranscriptomics is the study of gene expression levels in uncultured microbial communities sampled directly from their environment. In cultured microbes, the sequencing data comes from a single clone, making assembly and annotation tractable. However, in metatranscriptomics, the data comes from communities with diverse microbial compositions, possibly containing thousands of species. The assembly of transcripts from these complex samples represents a serious computational challenge. The development of genome-independent methods is essential because of the lack of trusted reference genomes that can be used to guide the assembly process. The predominant assembly formalism used for short-read datasets is the de Bruijn graph. …

Social Marketing And California High-Speed Rail: A Framework For Behavioral Change Towards Sustainability, Spenser Dill

Master's Projects and Capstones

In this analytical paper, I advocate for the use of social marketing techniques in a campaign targeted towards Central Valley communities with the primary objective of reducing this population’s opposition to the state’s High-Speed Rail project. A secondary objective is to use this strategy to promote positive attitudes towards sustainable practices in general. The goal is to stimulate a change in regional culture, which will support the behavioral changes needed to protect California’s natural resources and reduce our state’s contribution to climate change. I argue: 1) creating a sustainable transit infrastructure with high-speed rail as its centerpiece will reduce harmful …

Biochemical Assay Optimization And Computational Screening Efforts To Identify Potential Luxs Inhibitors, Keeshia Q. Wang

Master's Theses

Quorum sensing (QS) is a process of coordination of bacterial gene expression in response to cell population. System two QS is regulated by the small signaling molecule autoinducer-2 (AI-2) and is implicated in the infectious behaviors of various bacterial species. AI-2 is biosynthesized from S-ribosylhomocysteine (SRH) by the enzyme LuxS and induces interspecies cell-to-cell communication. Inhibition of LuxS would therefore inhibit interspecies QS. Herein, a search for novel molecular species that will competitively bind with SRH in the LuxS binding site is performed in silico. Computational screening results are then validated in vitro using an optimized LuxS inhibition …

Interpretation Of The Potentiometric Surface Along The Rio Grande At Selected Locations In Albuquerque, New Mexico, Jeffrey Worthington

Water Resources Professional Project Reports

The U.S. Geological Survey installed over 240 piezometers and 27 surface-water gages along the Rio Grande in Albuquerque, NM from 2003 to 2009, to monitor groundwater and surface-water levels and water temperatures. Spanning a 20 mile distance between the bridges at Alameda Blvd. and Interstate 25, there were 8 selected locations each consisting of paired east-west transects situated perpendicular to the river (Figure 1). Paired transects comprise two parallel cross-sections of the Rio Grande inner valley that were positioned approximately 500 ft. apart and extend to the riverside drains on both sides of the river. Each transect consisted of piezometers …

Effect Of Full-Annular Pressure Pulses On Axial Turbine Performance, Mark H. Fernelius

Theses and Dissertations

Pulse detonation engines show potential to increase the efficiency of conventional gas turbine engines if used in place of the steady combustor. However, since the interaction of pressure pulses with the turbine is not yet well understood, a rig was built to compare steady flow with pulsing flow. Compressed air is used in place of combustion gases and pressure pulses are created by rotating a ball valve with a motor. This work accomplishes two main objectives that are different from previous research in this area. First, steady flow through an axial turbine is compared with full annular pulsed flow closely …

An Experimental Analysis Of The Weighted Sum Of Spatial Gradients Minimization Quantity In Active Structural Acoustic Control Of Vibrating Plates, Daniel R. Hendricks

Theses and Dissertations

Active Structural Acoustic Control (ASAC) is a subcategory of the more widely known field of Active Noise control (ANC). ASAC is different from traditional ANC methods because it seeks to attenuate noise by altering the noise producing structure instead of altering the acoustic waves traveling through the air. The greatest challenge currently facing ASAC researchers is that a suitable parameter has not yet been discovered which can be easily implemented as the minimization quantity in the control algorithms. Many parameters have been tried but none effectively attenuate the sound radiation in a way that can be easily implemented. A new …

The Bg News December 13, 2013, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. December 13, 2013. Volume 93-Issue 47.