Digital Commons Network^™

Lack Of Csk-Mediated Negative Regulation In A Unicellular Src Kinase, Kira Schultheiss

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Tyrosine kinases play important roles in cellular communication in animals. c-Src is a nonreceptor tyrosine kinase that is involved in survival, angiogenesis, proliferation, and invasion pathways. There are 9 Src family kinases, and they have a conserved domain arrangement (SH3-SH2-kinase) that is necessary for regulation. The basal activity of c-Src is normally kept low due to phosphorylation by C-terminal Src kinase (Csk). This regulatory relationship has been conserved throughout the evolution of animals. Until recently, it was thought that complex signaling molecules, such as the tyrosine kinases, did not exist outside of multicellular animals. Newly discovered unicellular precursors to mammalian …

Investigation Of The Mouse Sperm Acrosome Reaction With Synthetic Glycopolymers, Linghui Wu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The sperm acrosome reaction (AR), an essential step in mammalian fertilization, is mediated by a highly species-specific interaction of sperm surface molecules with glycan moieties on the egg. Many previous studies indicate that a subset of terminal carbohydrate residues on the mouse egg zona pellucida (ZP) trigger the AR by cross-linking or aggregating receptors on the sperm membrane. However, the exact role of those carbohydrates in AR has not been identified and the mechanism underlying the induction of the AR still needs further investigation. To study this process, a series of synthetic glycopolymers were synthesized. The glycopolymer is composed of …

Tell Me Something Good: Depression And The Social Sharing Of Positive Life Events, Rachel Eva Hershenberg

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation examined the social sharing of positive life events, referred to as capitalization, among a sample of individuals with a range of current depressive symptomatology. Capitalization is an interpersonal strategy that has the potential to enhance positive emotions, build cognitive resources, and strengthen relationships. Remiss in the depression research has been an examination of responses to positive life events in an interpersonal context. Some data suggests that those with depressive symptoms may be particularly responsive to the capitalization process; other data suggests that those with greater depressive symptoms may be less likely to engage in this behavior and might …

Identifying Disease Characteristics, Parent Experience And Coping Strategies When Predicting Pediatric Illness-Related Stress In Parents Of Children With Mitochondrial Disease, Brenda Senger

Nursing Faculty Scholarship

Mitochondrial disease (mito) is a group of rare, inherited, chronic, life-limiting, incurable neurodegenerative disorders known to affect children early in life that result from failure of the mitochondria to turn food into energy. The diagnosis of mito is elusive and complex, with a variety of clinical manifestations, multisystem involvement and the lack of a reliable biological marker for screening and diagnosis. The unpredictable prognosis and erratic nature of this illness can be overwhelming to parents who bear the daily responsibilities of managing the child's care. Little is known about the experience of parents caring for a child with mito.

Objective …

Declarative And Yes/No Question Intonation In Montevideo Spanish, Deborah Silva De Araujo

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This study offers for the first time empirical and theoretical data on the intonation of the Spanish variety spoken in Montevideo, the capital city of Uruguay. It proposes a phonological analysis of broad focus declarative and yes/no question utterances of simple, coordinated, and subordinated sentences recorded during fieldwork in Montevideo. The analysis relies on the Autosegmental-Metrical (AM) model (Pierrehumbert 1980) and the Sp_ToBI transcription system (Beckman et al 2002, Estebas-Vilaplana and Prieto 2009). The analysis of the F0 track shows that coordinated and subordinated sentences of both declarative and yes/no question utterances were parsed into utterance-medial IP (aligned with the …

Manufacturing Malinche: Socio-Sexual Narratives Of Imperialism, Colonialism, And Nationalism, Sibyl Gallus-Price

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Malinche's ever changing myth has contributed to the view that one woman is answerable for the legacy of conquest. This view, evoking worship and revile, operates more as a litmus test of the prevailing weltanschauung than as a claim of historical authenticity. In the context of imperialism, colonialism, and post-colonialism, this study seeks to examine the socio-sexual system as it defines the production of an enduring national mythic symbol. Exposing the ideological underpinnings of the narratives that have contributed to the Malinche myth, exemplar works will demonstrate the impact of: the ontological understanding of gendered models of imperialism; the historical …

Blood Of The Earth: Natural Resources, Economic Visions, And Revolution In La Paz, Bolivia, 1927-1971, Kevin Young

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Natural resource extraction and resource nationalism are central to understanding recent protests around the world. These mobilizations have important precedents in mid-twentieth-century Bolivia. The quest for national control over natural resources--particularly tin and oil--was the central factor uniting urban sectors in the years before and after the 1952 Bolivian Revolution, which brought to power the Movimiento Nacionalista Revolucionario (MNR) party. Focusing on La Paz, this dissertation examines the contours of popular economic thought and the conflicts among urban popular sectors, the MNR regime, and the United States to define economic policy. Natural resources were the key locus of contention in …

Scalable Particle And Mesh Algorithms For Elliptic Components Of Multiphase Problems, Tongfei Guo

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

New mesh and meshless algorithms for elliptic boundary and elliptic interface problems have been developed. By utilizing the embedded boundary method, a mesh based algorithm to solve elliptic interface problem is implemented as an extension of hybrid Eulerian-Lagrangian hydrodynamic library FronTier which employs the method of front tracking for interface propagation and this implementation is parallelized for distributed memory clusters. The use of embedded boundary method supports arbitrary discontinuities of density and other physics properties across the interfaces and significantly improves methods that smear interface discontinuities across several grid cells. This code has been applied to process simulation for heat …

What You Like In Design Use To Correct Bad-Smells, Marouane Kessentini, Rim Mahaouachi, Khaled Ghedira

Computer Science Faculty Research & Creative Works

Over the past decades, many techniques and tools have been developed to support maintenance activities in order to improve software quality. One of the most efficient ones is software refactoring to eliminate bad smells. A majority of existing work propose "standard" refactoring solutions that can be applied by hand for each kind of defect. However, it is difficult to prove or ensure the generality of these solutions to any kind of bad-smells or software codes. In this paper, we propose an approach to correct bad smells using well-designed code. We use genetic algorithms to generate correction solutions defined as a …

2013 December, Office Of Communications & Marketing, Morehead State University.

Morehead State Press Release Archive, 1961 to the Present

Press releases for December of 2013.

The Role Of The Musical - Self In Promoting Career Longevity Among Music Therapists, Peter Davis

Theses & Dissertations

To attend to the musical and clinical needs of music therapy consumers, music therapists must attend to their own music so as to nurture their musical-self (Bruscia, 1987; Priestley, 1994; Robbins & Robbins, 1998). Yet, despite the fact that music is the basic tool music therapists rely upon to conduct their work (Aigen, 2005b; Brookins, 1984), the topic of nurturing the musical-self has received scarce, if any attention in the music therapy literature. The purpose of this study was to understand the views of professional music therapists in regard to the role of the musical-self in promoting career longevity among …

President’S Corner

NASIG Newsletter

No abstract provided.

December 2013 Committee Reports/Updates

NASIG Newsletter

No abstract provided.

December 2013 Full Issue

NASIG Newsletter

No abstract provided.

Customizable Workstation, Kimberly Luly

Theses

Through research, product development, and user feedback this thesis project focuses on the development of a customizable, supplemental workstation that allows users to customize and adjust their approach to work within the ever-changing work environment of today and tomorrow. My project's purpose is to provide versatility and adaptability in the work environment to various users and work scenarios. Its design aims to improve workplace health, comfort, and productivity by allowing the user to select with ease, a standing or sitting position, as well as incorporate ease of mobility by allowing the user to easily transport the workstation wherever it may …

The Effects Of Timing And Visual Cues On Social Anxiety In Online Communication, Michael R. Knobeloch

All-Inclusive List of Electronic Theses and Dissertations

No abstract provided.

Openline Newsletter, December 2013, Civil Service Council

OpenLine Newsletter

A monthly newsletter for Civil Service employees, Volume XXXVIII, Number 6, December 2013.

The Research Skills Of Graduate Students In The Master Degree Of Education At Kuwait University, Wafaa S. Al-Yaseen

Journal of Educational and Psychological Studies

The aim of this study was to identify theresearch skills of graduate studentsin the College of Education at Kuwait University.The study sample comprised of 68 graduate students. For the purpose of the study, the researcher developed a questionnaire that consisted of 48 items covering two domains: required research skills, and research difficulties. The validity of the questionnaire was checked by agroup of professors in the College of Education. Cronbach's alpha reliability coefficientwas found to be adequate. Results revealed that MA students have certain needs which should be fulfilled to be able to conduct research properly. In addition, they encounter certain …

Social Networks Sites: Usage And Effects, Ahmed Y. Abdelraheem

Journal of Educational and Psychological Studies

The aim of this paper is to explore the students’ use of social networks sites (SNSs) and its effects on students’ achievement. A questionnaire using a Liker type scale was distributed to a sample of 120 undergraduate students who participated in the study. The results show that students use SNSs for social matters more than for academic purposes. In this regard, there is no significant difference in the use of social network sites between female and male students. Students with smart mobile phones use SNSs more than those with normal mobiles. Facebook was the most used site. There is no …

Students’ Perceptions Of Religious Beliefs As Gained From Jordanian Universities Religious Educational Courses, Mahir S. Al-Hawamleh

Journal of Educational and Psychological Studies

The present study looked at the educational religious beliefs as gained from university courses using a self-reported questionnaire as well as semi-structured interviews. 591 students chosen through stratified random design responded to the questionnaire. 64 students from the study's sample were interviewed. The current study presented evidence to support the identification and comparison of the educational religious perceptions held by the two sets of students from Mu'tah University and Al al-Bayt University. The analysis concluded that religious education courses influenced deeply and with varying degrees students’ perceptions of religious affiliation to a large extent at Al-al Bayt University; nevertheless, it …

Teacher Evaluation In Oman: Policy, Implementation, And Challenges, Hamed H. Al-Yahmadi

Journal of Educational and Psychological Studies

Teacher evaluation is a significant means for ensuring accountability and promoting teacher professional development. However, the road to good implementation of teacher evaluation system rarely goes without challenges and constraints. The fourteen interviewees who participated in this study faced several constraints in implementing teacher evaluation in the Sultanate of Oman. Some of these obstacles were: Lack of incentives; inadequate evaluators’ training; heavy burden of administrative duties with less empowerment; lack of teachers and evaluators’ commitment towards teacher evaluation system. These organizational and technical factors inhibit the performance of teachers and evaluators alike. The study recommends that teachers and evaluators must …

Impact Of Plug In Electric Vehicle Battery Charging On A Distribution System Based On Real-Time Digital Simulator, Abdulelah Yousef Alharbi

Masters Theses and Doctoral Dissertations

This study investigates the impact of the electric vehicles (EVs’) battery charging on the distribution system in terms of maximum voltage deviation, voltage unbalance at various locations, transformers overloading, and introducing new peaks into the system. In this research, a 12.47 kV real distribution network has been modeled using real time digital simulator, using real data from a power distributor. The study presents four different scenarios of uncoordinated EVs integration for two different charging times (evening and night) and two different charging rates (level I and level II) at different penetration levels ranging from 10% to 100%. Voltage unbalance at …

A New Software Framework For Unstructured Mesh Representation And Manipulation, Craig R. Tanis

Masters Theses and Doctoral Dissertations

This research presents a unique new software framework for representing and manipulating unstructured meshes in parallel, for use in modern scientific simulation codes. Due to the central nature of the unstructured mesh, this framework provides a variety of functionality, desirable throughout the lifecycle of an application, such as IO, parallel partitioning, phantom node data updates, adaptive refinement, derefinement and load balancing. What makes the framework unique is a focus on generality: like a database, the user provides a programmatic schema defining the structure of the mesh, including topological descriptions of the valid mesh entities. The system extracts adjacency information from …

“Until The Trial Is Complete You Can’T Really Say Whether It Helped You Or Not, Can You?”: Exploring Cancer Patients’ Perceptions Of Taking Part In A Trial Of Acupressure Wristbands, Jg Hughes, W Russell, M Breckons, Et Al

School of Nursing and Midwifery

BACKGROUND: Nested qualitative studies within clinical trials provide data on patients' experiences of receiving trial interventions and can inform and improve trial designs. The present study explored patients' experiences of participating in a randomised controlled trial of acupressure wristbands for chemotherapy related nausea. METHODS: A randomised three-group sham-controlled trial was carried out to evaluate the effectiveness of acupressure wristbands in the management of chemotherapy-related nausea. A convenience sample of 26 patients volunteered to participate in a qualitative study to explore their experiences of using acupressure wristbands, and taking part in the clinical trial. Participants were recruited from each of the …

Review Of Mr. Tuba By Harvey Phillips, Jason S. Ladd

College of Communication Faculty Research and Publications

No abstract provided.

Social Media Hype In Times Of Crises: Nature, Characteristics And Impact On Organizations, Augustine Pang

Research Collection Lee Kong Chian School Of Business

This article extends Vasterman’s (2005) concept of media hype by analyzing how it applies in the social media context. It then develops the concept of social media hype, its nature, characteristics through examination of five cases that attracted much social media attention. Social media hype can be defined as a netizen-generated hype that causes huge interest that is triggered by a key event and sustained by a self-reinforcing quality in its ability for users to engage in conversation. It involves a trigger event, followed by interest waves, and sustaining of the interests on different social media platforms. In response, organizations …

Socialization Tactics: Antecedents For Goal Interdependence And Newcomer Adjustment And Retention, Serena Changhong Lu, Dean Tjosvold

Research Collection Lee Kong Chian School Of Business

This study argues that Deutsch's theory of goal interdependence is useful to examine the dynamics of serial and investiture tactics on newcomer adjustment and retention in work team contexts. Structural equation results of interviews of specific incidents collected from one hundred and two newcomers support the hypothesized model that serial and investiture tactics used by teams promote cooperative goal interdependence and weaken competitive goal interdependence and independent goal relationship between newcomers and their teams. Cooperative goals were also found to promote positive attitudes and strong co-worker relationships whereas competitive and independent goals resulted in intentions to quit and low levels …

Gpaq-R: Development And Psychometric Properties Of A Version Of The General Practice Assessment Questionnaire For Use For Revalidation By General Practitioners In The Uk, M Roland, M Roberts, V Rhenius, J Campbell

Peninsula Medical School

BACKGROUND: The General Practice Assessment Questionnaire (GPAQ) has been widely used to assess patient experience in general practice in the UK since 2004. In 2013, new regulations were introduced by the General Medical Council (GMC) requiring UK doctors to undertake periodic revalidation, which includes assessment of patient experience for individual doctors. We describe the development of a new version of GPAQ - GPAQ-R which addresses the GMC's requirements for revalidation as well as additional NHS requirements for surveys that GPs may need to carry out in their own practices. METHODS: Questionnaires were given out by doctors or practice staff after …

Neutral No More: Secondary Effects Analysis And The Quiet Demise Of The Content-Neutrality Test, Mark Rienzi, Stuart Buck

Fordham Law Review

    When the Supreme Court introduced the “secondary effects” doctrine to allow for zoning of adult businesses, critics fell into two camps. Some, like Justice William Brennan, predicted dire consequences for the First Amendment, particularly if the doctrine was used in political speech cases. Others, like Professor Laurence Tribe, predicted secondary effects analysis would be limited to sexually explicit speech and would not threaten the First Amendment. The modern consensus is that the doctrine has, in fact, been limited to cases about sex.

    Recent cases demonstrate, however, that the impact of the secondary effects doctrine on the First Amendment has been …

Bayesian Methods To Determine Performance Differences And To Quantify Variability Among Centers In Multi-Center Trials: The Ihast Trial, Eo Bayman, Km Chaloner, Bj Hindman, Mm Todd, Ihast Investigators

Peninsula Medical School

BACKGROUND: To quantify the variability among centers and to identify centers whose performance are potentially outside of normal variability in the primary outcome and to propose a guideline that they are outliers. METHODS: Novel statistical methodology using a Bayesian hierarchical model is used. Bayesian methods for estimation and outlier detection are applied assuming an additive random center effect on the log odds of response: centers are similar but different (exchangeable). The Intraoperative Hypothermia for Aneurysm Surgery Trial (IHAST) is used as an example. Analyses were adjusted for treatment, age, gender, aneurysm location, World Federation of Neurological Surgeons scale, Fisher score …