Digital Commons Network^™

Comparison Of Systemic And Mucosal Immunization Withhelper-Dependent Adenoviruses For Vaccination Against Mucosal Challenge With Shiv, Eric A. Weaver, Pramod N. Nehete, Bharti P. Nehete, Guojun Yang, Stephanie J. Buchl, Patrick W. Hanley, Donna Palmer, David C. Montefiori, Guido Ferrari, Philip Ng, K. Jagannadha Sastry, Michael A. Barry

School of Biological Sciences: Faculty Publications

Most HIV-1 infections are thought to occur at mucosal surfaces during sexual contact. It has been hypothesized that vaccines delivered at mucosal surfaces may mediate better protection against HIV-1 than vaccines that are delivered systemically. To test this, rhesus macaques were vaccinated by intramuscular (i.m.) or intravaginal (ivag.) routes with helperdependent adenoviral (HD-Ad) vectors expressing HIV-1 envelope. Macaques were first immunized intranasally with species C Ad serotype 5 (Ad5) prior to serotype-switching with species C HD-Ad6, Ad1, Ad5, and Ad2 vectors expressing env followed by rectal challenge with CCR5-tropic SHIV-SF162P3. Vaccination by the systemic route generated stronger systemic CD8 T …

Optimization Of Properties Of Injectable Bone Cement For Vertebral Augmentation Procedures: Application Of Response Surface Methodology, Daniel Mamushet Werdofa

Electronic Theses and Dissertations Archive

The literature on the interaction effects of explanatory variables on properties of injectable bone cements used in the vertebral augmentation procedures of vertebroplasty and ballon kyphoplasty is sparse. In the present work, response surface methodology was used to investigate the direct and interaction effects of variables on three properties of a poly (methyl methacrylate) bone cement (maximum exotherm temperature, residual monomer content (RMC), and degradability) and three properites of a calcium phosphate cement (CPC) (injectability, final setting time (F), and compressive strength). Some main findings were 1) interaction effects were statistically significant for some properties, such as F, but not …

Attentional Guiding Through Embodied And Image Cues In An Intelligent Tutoring System, Whitney Layne Cade

Electronic Theses and Dissertations Archive

While the impact of pedagogical agent pointing and dynamic visual aids in intelligent tutoring systems has been evaluated by many researchers, there remains a question as to how the combination of the two can impact a student's learning and agent perceptions. In this study, 34 university students were exposed to four Biology lectures delivered by a lifelike agent. The impact of two attentional guiding techniques (agent pointing and sequential image display) on students' opinions of the agent, learning, and gaze behavior were investigated. Agent pointing had no effect on perception of the agent or learning. Sequential display was found to …

Interview With Cynthia Venables - Oh 278, Cynthia Venables

Winthrop University Oral History Program

In her July 3, 2013 interview with Martha Manning, Cynthia Burris Venables shares her experiences at Winthrop from 1985-1989, as well as her career teaching English. Discussed is Venables coursework as an English major and the rigor of her studies. Additionally, Venables talks about Latin and Biology courses and who her favorite professors were. Venables details what it is like teaching in the 21^st Century, her opinions on technology and teaching, and her accomplishments as an educator.

Campaign To End Bullfighting In Mexico Draws Mixed Reactions, Carlos Navarro

SourceMex

No abstract provided.

Pedal Talk The Fall And Rise Of Bikes And Bike Sharing In The Twin Cities, Alex Schieferdecker

Cities in the 21st Century

No abstract provided.

Marriage And Civil Law, Michael F. Walsh

St. John's Law Review

No abstract provided.

Teaching The Design Of Narrative Visualization: Using Metaphor For Financial Literacy And Decision Making, Aaron Fry, Jennifer Wilson, Carol Overby

Learn X Design Conference Series

The authors provide a scholarly definition for metaphor-rich, story-driven “narrative visualization,” and assert the importance of this methodology in contemporary design education. They propose “narrative visualization” as especially useful in promoting financial literacy: a context in which design can both facilitate understanding and possibly influence behavior. This emotionally-engaging means has the potential to affect the “System 1” intuitive decision-making processes that Kahneman and others have identified as the primary drivers of financial behavior.The case study here presents a recent design course that was customized to teach “narrative visualization” in a financial-literacy context. Student work from that course is examined through …

The Proton Pump Inhibitor Lansoprazole Improves The Skeletal Phenotype In Dystrophin Deficient Mdx Mice, Arpana Sali, Gina M. Many, Heather Gordish-Dressman, Jack Van Der Meulen, Aditi Phadke, Christopher F. Spurney, Avital Cnaan, Eric P. Hoffman, Kanneboyina Nagaraju

Genomics and Precision Medicine Faculty Publications

Background

In Duchenne muscular dystrophy (DMD), loss of the membrane stabilizing protein dystrophin results in myofiber damage. Microinjury to dystrophic myofibers also causes secondary imbalances in sarcolemmic ion permeability and resting membrane potential, which modifies excitation-contraction coupling and increases proinflammatory/apoptotic signaling cascades. Although glucocorticoids remain the standard of care for the treatment of DMD, there is a need to investigate the efficacy of other pharmacological agents targeting the involvement of imbalances in ion flux on dystrophic pathology.

Methodology/Principal Findings

We designed a preclinical trial to investigate the effects of lansoprazole (LANZO) administration, a proton pump inhibitor, on the dystrophic muscle …

Livestock-Associated Methicillin And Multidrug Resistant Staphylococcus Aureus Is Present Among Industrial, Not Antibiotic-Free Livestock Operation Workers In North Carolina, Jessica L. Rinsky, Maya Nadimpalli, Steve Wing, Devon Hall, Dothula Baron, Lance B. Price, Jesper Larsen, Marc Stegger, Jill Stewart, Christopher D. Heaney

Environmental and Occupational Health Faculty Publications

Objectives

Administration of antibiotics to food animals may select for drug-resistant pathogens of clinical significance, such as methicillin-resistant Staphylococcus aureus (MRSA). In the United States, studies have examined prevalence of MRSA carriage among individuals exposed to livestock, but prevalence of multidrug-resistant S. aureus (MDRSA) carriage and the association with livestock raised with versus without antibiotic selective pressure remains unclear. We aimed to examine prevalence, antibiotic susceptibility, and molecular characteristics of S. aureus among industrial livestock operation (ILO) and antibiotic-free livestock operation (AFLO) workers and household members in North Carolina.

Methods

Participants in this cross-sectional study were interviewed and provided a …

Cognitively Normal Individuals With Ad Parents May Be At Risk For Developing Aging-Related Cortical Thinning Patterns Characteristic Of Ad, Derin J. Cobia, Katherine Reiter, Kathryn I. Alpert, Mary J. Kwasny, John C. Morris, John G. Csernansky, Lei Wang

Faculty Publications

Children of Alzheimer's Disease (AD) patients are at heightened risk of developing AD due to genetic influences, including the apolipoprotein E4 (ApoE4) allele. In this study, we assessed the earliest cortical changes associated with AD in 71 cognitively healthy, adult children of AD patients (AD offspring) as compared with 69 with no family history of AD (non-AD offspring). Cortical thickness measures were obtained using FreeSurfer from 1.5T magnetic resonance (MR) scans. ApoE genotyping was obtained. Primary analyses examined family history and ApoeE4 effects on cortical thickness. Secondary analyses examined age effects within groups. All comparisons were adjusted using False Discovery …

Effective Treatment Of Esophogeal Adenocarcinoma Using Triciribine And Related Compounds, Jin Q. Cheng

USF Patents

The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat esophogeal adenocarcinoma by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug.

Control Of Harmful Algal Blooms By Induction Of Programmed Cell Death, John H. Paul, Iii, David John

USF Patents

The subject invention pertains to compositions, apparatus, and methods for controlling harmful algae and harmful algal bloom (HAB) based on the induction of the programmed cell death (PCD; apoptosis) pathway in the harmful algae, and to kits for determining algal susceptibility to PCD induction.

A Two-Minute Paper And Pencil Test Of Symbolic And Nonsymbolic Numerical Magnitude Processing Explains Variability In Primary School Children’S Arithmetic Competence, Nadia Nosworthy, Stephanie Bugden, Lisa Archibald, Barrie Evans, Daniel Ansari

Faculty Publications

Recently, there has been a growing emphasis on basic number processing competencies (such as the ability to judge which of two numbers is larger) and their role in predicting individual differences in school-relevant math achievement. Children’s ability to compare both symbolic (e.g. Arabic numerals) and nonsymbolic (e.g. dot arrays) magnitudes has been found to correlate with their math achievement. The available evidence, however, has focused on computerized paradigms, which may not always be suitable for universal, quick application in the classroom. Furthermore, it is currently unclear whether both symbolic and nonsymbolic magnitude comparison are related to children’s performance on tests …

Not Your Everyday Story Of Cuttlefish, St. Norbert College

St. Norbert College Magazine 2013-2018

On the fast track to superstardom in saltwater aquaria through his work with the fragile cuttlefish, Bret Grasse ’08 has found his methods so successful that he has become the world’s go-to expert in culturing generations of cuttlefish.

Impact Of Graphical Fidelity On A Player’S Emotional Response In Video Games, Vivianette Ocasio De Jesus

Department of Computer Graphics Technology Degree Theses

Higher quality computer graphics in the areas of virtual reality and games is generally assumed to create a more immersive experience for the end user. This assumption was examined by testing to what degree graphical fidelity was associated with physiological arousal as measured by a galvanic skin response (GSR) sensor. Thirty-six subjects played two different video games, Crysis and Dead Space, at the highest and lowest graphical quality settings while their GSR activity was measured. No significant difference in GSR was observed as associated with graphical quality. However, when asked how the user would rate graphical fidelity usage in Dead …

Transmissible Gastroenteritis Virus: Identification Of M Protein-Binding Peptide Ligands With Antiviral And Diagnostic Potential, Hao Zou, Dante S. Zarlenga, Karol Sestak, Siqingaowa Suo, Xiaofeng Ren

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

The membrane (M) protein is one of the major structural proteins of coronavirus particles. In this study, the M protein of transmissible gastroenteritis virus (TGEV) was used to biopan a 12-mer phage display random peptide library. Three phages expressing TGEV-M-binding peptides were identified and characterized in more depth. A phage-based immunosorbent assay (phage-ELISA) capable of differentiating TGEV from other coronaviruses was developed using one phage, phTGEV-M7, as antigen. When the phage-ELISA was compared to conventional antibody-based ELISA for detecting infections, phage-ELISA exhibited greater sensitivity. A chemically synthesized, TGEV-M7 peptide (pepTGEV-M7; HALTPIKYIPPG) was evaluated for antiviral activity. Plaque-reduction assays revealed that …

The Distribution Of Fruit And Seed Toxicity During Development For Eleven Neotropical Trees And Vines, Noelle G. Beckman

Biology Faculty Publications

Secondary compounds in fruit mediate interactions with natural enemies and seed dispersers, influencing plant survival and species distributions. The functions of secondary metabolites in plant defenses have been well-studied in green tissues, but not in reproductive structures of plants. In this study, the distribution of toxicity within plants was quantified and its influence on seed survival was determined in Central Panama. To investigate patterns of allocation to chemical defenses and shifts in allocation with fruit development, I quantified variation in toxicity between immature and mature fruit and between the seed and pericarp for eleven species. Toxicity of seed and pericarp …

Neurophysiological Processing Of Emotion And Parenting Interact To Predict Inhibited Behavior: An Affective-Motivational Framework, Ellen M. Kessel, Rebecca F. Huselid, Jennifer M. Decicco, Tracy A. Dennis

Publications and Research

Although inhibited behavior problems are prevalent in childhood, relatively little is known about the intrinsic and extrinsic factors that predict a child's ability to regulate inhibited behavior during fear- and anxiety-provoking tasks. Inhibited behavior may be linked to both disruptions in avoidance-related processing of aversive stimuli and in approach-related processing of appetitive stimuli, but previous findings are contradictory and rarely integrate consideration of the socialization context. The current exploratory study used a novel combination of neurophysiological and observation-based methods to examine whether a neurophysiological measure sensitive to approach- and avoidance-oriented emotional processing, the late positive potential (LPP), interacted with observed …

Dominant Inheritance Of Field-Evolved Resistance To Bt Corn In Busseola Fusca, Pascal Campagne, Marlene Kruger, Rémy Pasquet, Bruno Le Ru, Johnnie Van Den Berg

All Peer-Reviewed Publications

Transgenic crops expressing Bacillus thuringiensis (Bt) toxins have been adopted worldwide, notably in developing countries. In spite of their success in controlling target pests while allowing a substantial reduction of insecticide use, the sustainable control of these pest populations is threatened by the evolution of resistance. The implementation of the "high dose/refuge" strategy for managing insect resistance in transgenic crops aims at delaying the evolution of resistance to Bt crops in pest populations by promoting survival of susceptible insects. However, a crucial condition for the "high dose/refuge" strategy to be efficient is that the inheritance of resistance should be functionally …

Humanitarianism And The Anthropology Of Hunger, Kate Klein

Undergraduate Theses—Unrestricted

While the early view of hunger as the product of a world population too large to sustain has largely been eliminated, and the mainstream international community has come to accept that food insecurity results from issues of distribution rather than an insufficient global food supply, the emphasis on biotechnology in agriculture, humanitarianism in international aid, and social justice in international human rights law in the contemporary era has contributed to other barriers that prevent hunger alleviation.

In this thesis, I argue that these previous contemporary developments have had the capacity to hide hunger. My analysis of technology and humanitarian aid …

Automated Conserved Non-Coding Sequence (Cns) Discovery Reveals Differences In Gene Content And Promoter Evolution Among Grasses, Gina Marie Turco, James C. Schnable, Brent S. Pedersen, Michael Freeling

Department of Agronomy and Horticulture: Faculty Publications

Conserved non-coding sequences (CNS) are islands of non-coding sequence that, like protein coding exons, show less divergence in sequence between related species than functionless DNA. Several CNSs have been demonstrated experimentally to function as cis-regulatory regions. However, the specific functions of most CNSs remain unknown. Previous searches for CNS in plants have either anchored on exons and only identified nearby sequences or required years of painstaking manual annotation. Here we present an open source tool that can accurately identify CNSs between any two related species with sequenced genomes, including both those immediately adjacent to exons and distal sequences separated by …

The Effects Of Gain Of Function Mutant P53 And P63 On Eps8 And Cxcl5 Expression In Head And Neck Squamous Cell Carcinoma, Rubana Masood

Theses and Dissertations

Head and neck squamous cell carcinoma (HNSCC) is one of the ten most common cancers worldwide, with a survival rate of less than 50%. A class of mutant p53, known as gain of function (GOF) mutant p53, has been found to be expressed in tumors in these patients. GOF mutant p53 not only loses the wild type tumor suppressor functions, but also gains aberrant functions that have been linked to tumorigenesis. In this current study, we utilized a model system consisting of cells derived from HNSCC tumors in order to investigate our hypothesis that GOF mutant p53 enhances, and p63 …

Considering Two Audiences When Recording Lectures As Lecturecasts, Brandon I. Collier-Reed

The African Journal of Information Systems

This article presents the outcome of an investigation into the provision of lecturecasts to students. The objective was to ensure that both those who attended live lectures of a second-year engineering course and/or watched recorded versions of the lectures had an experience that supported their learning. A range of data was drawn on including the personal reflection of the lecturer of the course, questionnaires, and student interviews. The qualitative data were analysed through an inductive process that drew on the principles of grounded theory and the findings that emerged included the role of the “talking head” in recordings, balancing the …

Imagine That: The Gender Of War Rhetoric And Conceptual Complications, Meg Barboza

The Review: A Journal of Undergraduate Student Research

Although it will go without saying at least two paragraphs into this essay, the basis of my argument is both linguistic and social. In this paper I examine how the ways in which humans use language affects the way they conceive of war, particularly how their perception of war reinforces ideas about the male gender and how that gender communicates. Before I jump into analysis, historical precedent or theory, I feel it best to lay the linguistic groundwork.

Essentially, the linguistic basis of my argument purports that if there is even a grain of truth to the linguistic conditions of …

Allusions In Dante's Infemo, Sarah Landas

The Review: A Journal of Undergraduate Student Research

In lieu of an abstract, below is the essay's first paragraph.

"Vexilla regis produent inferni; the banners of the king go forth, the king of Hell" (Vergani 74). In a place called Dis, the demon Satan resides. He has three hideous heads and spends his time crying from six eyes, while the tears mingle with the blood of three tortured sinners. These sinners, Brutus, Cassius, and Judas Iscariot, are ground to bits by Lucifer's gnashing teeth, while Judas alone receives the benefit of also having his back stripped of its skin as retribution for him being the greatest sinner to …

Wolf Reintroduction Into Yellowstone National Park, Erin Quartley

The Review: A Journal of Undergraduate Student Research

In lieu of an abstract, below is the essay's first paragraph.

" ... My, what big eyes you have grandmother. 'All the better to see you with, my dear.' My, what big teeth you have grandmother. 'All the better to eat you with, my dear. ' ... " The story of Little Red Riding Hood is one that commonly surfaces when people talk about and picture wolves. The negative image that has been placed upon wolves originates from folklore, fairy tales, and Hollywood. This same falsified image is one that has greatly contributed to the past and present plight of …

How Children Perceive Mass Media, Erin Gill

The Review: A Journal of Undergraduate Student Research

In lieu of an abstract, below is the essay's first paragraph.

The media offers entertainment, news, sports, and even education. The media is an important part of our lives, but how do children perceive the media? What is it that children learn from watching television? Do they really understand what it is the media is trying to tell them? This paper will attempt to prove that a child's perception of TV can be related to a mass communication theory known as the schema theory. The schema theory basically states that people use prior knowledge or experiences to help them better …

Asperger's Syndrome In The Classroom, Erin Ells

The Review: A Journal of Undergraduate Student Research

In lieu of an abstract, below is the essay's first paragraph.

A German doctor, Hans Asperger, first described Asperger's syndrome in 1944. Asperger's syndrome, AS, has been classified as a type of autism, which itself was first described in 1943. Although no two children that suffer from AS are alike, "typically [they are] viewed as eccentric and peculiar by classmates ... [they] lack understanding of human relationships and the rules of social convention; they are naive and conspicuously lacking in common sense" (Williams). However, children with AS are noted to be of average to above-average intelligence and are characterized to …

Storage Technique Preserves Citrus, Kills Pathogens, Gayle Volk, Jan Suszkiw

Agricultural Research Magazine

Americans consume about 84 pounds of fresh and processed citrus per person each year, with oranges topping the list at 61 pounds annually. The availability of these favored fruits in grocery stores, fresh markets, and other consumer outlets is a testament to growers’ success in managing the ever-present threat of pests and diseases to the nation’s $3.4 billion citrus crop (2011-12), most of which is produced in Florida and California.

A major threat is citrus greening disease, also known as “Huanglongbing.” First detected in Florida in August 2005, citrus greening today is the target of a multifaceted effort by federal, …