Digital Commons Network^™

Localization Of Wolbachia-Like Gene Transcripts And Peptides In Adult Onchocerca Flexuosa Worms Indicates Tissue Specific Expression, Samantha N. Mcnulty, Kerstin Fischer, Kurt C. Curtis, Gary J. Weil, Norbert W. Brattig, Peter U. Fischer

Open Access Publications

No abstract provided.

Stream-Related Preferences Of Inputs To The Superior Colliculus From Areas Of Dorsal And Ventral Streams Of Mouse Visual Cortex, Quanxin Wang, Andreas Burkhalter

Open Access Publications

No abstract provided.

Transcriptome Analyses Reveal Protein And Domain Families That Delineate Stage-Related Development In The Economically Important Parasitic Nematodes, Ostertagia Ostertagi And Cooperia Oncophora, Esley Heizer, Dante S. Zarlenga, Bruce Rosa, Xin Gao, Robin B. Gasser, Jessie De Graef, Peter Geldhof, Makedonka Mitreva

Open Access Publications

No abstract provided.

A Drosophila Functional Evaluation Of Candidates From Human Genome-Wide Association Studies Of Type 2 Diabetes And Related Metabolic Traits Identifies Tissue-Specific Roles For Dhhex, Jay Pendse, Prasanna V. Ramachandran, Jianbo Na, Narisu Narisu, Jill L. Fink, Ross L. Cagan, Francis S. Collins, Thomas J. Baranski

Open Access Publications

No abstract provided.

Bright Light Exposure Reduces Th-Positive Dopamine Neurons: Implications Of Light Pollution In Parkinson's Disease Epidemiology, Stefania Romeo, Cristina Viaggi, Daniela Di Camillo, Allison W. Willis, Luca Lozzi, Cristina Rocchi, Marta Capannolo, Gabriella Aliosi, Francesca Vaglini, Rita Maccarone, Matteo Caleo, Cristina Missale, Brad A. Racette, Giovanni U. Corsini, Roberto Maggio

Open Access Publications

No abstract provided.

Binding Of The Radioligand Sil23 To Alpha-Synuclein Fibrils In Parkinson Disease Brain Tissue Establishes Feasibility And Screening Approaches For Developing A Parkinson Disease Imaging Agent, Devika P. Bagchi, Lihai Yu, Joel S. Perlmutter, Jinbin Xu, Robert H. Mach, Zhude Tu, Paul T. Kotzbauer

Open Access Publications

No abstract provided.

Vigabatrin Inhibits Seizures And Mtor Pathway Activation In A Mouse Model Of Tuberous Sclerosis Complex, Bo Zhang, Sharon S. Mcdaniel, Nicholas R. Rensing, Michael Wong

Open Access Publications

No abstract provided.

Defining The Transcriptional And Cellular Landscape Of Type 1 Diabetes In The Nod Mouse, Javier A. Carrero, Boris Calderon, Fadi Towfic, Maxim N. Artyomov, Emil R. Unanue

Open Access Publications

No abstract provided.

Constitutive Activation Of Gli2 Impairs Bone Formation In Postnatal Growing Mice, Kyu Sang Joeng, Fanxin Long

Open Access Publications

No abstract provided.

Irf-3, Irf-5, And Irf-7 Coordinately Regulate The Type I Ifn Response In Myeloid Dendritic Cells Downstream Of Mavs Signaling, Helen M. Lazear, Alissa Lancaster, Courtney Wilkins, Mehul S. Suthar, Albert Huang, Sarah C. Vick, Lisa Clepper, Larissa Thackray, Margaret M. Brassil, Herbert W. Virgin, Janko Nikolich-Zugich, Ashlee V. Moses, Michael Gale Jr., Klaus Fruh, Michael S. Diamond

Open Access Publications

No abstract provided.

Therapeutic Efficacy Of Antibodies Lacking Fcgammar Against Lethal Dengue Virus Infection Is Due To Neutralizing Potency And Blocking Of Enhancing Antibodies, Katherine L. Williams, Soila Sukupolvi-Petty, Martina Beltramello, Syd Johnson, Federica Sallusto, Antonio Lanzavecchia, Michael S. Diamond, Eva Harris

Open Access Publications

No abstract provided.

Cerebellar White Matter Abnormalities Following Primary Blast Injury In Us Military Personnel, Christine Mac Donald, Ann Johnson, Dana Cooper, Thomas Malone, James Sorrell, Joshua Shimony, Matthew Parsons, Abraham Snyder, Marcus Raichel, Raymond Fang, Stephen Flaherty, Michael Russell, David L. Brody

Open Access Publications

No abstract provided.

The Oxytricha Trifallax Macronuclear Genome: A Complex Eukaryotic Genome With 16,000 Tiny Chromosomes, Vincent Magrini, Patrick Minx, Robert S. Fulton, Amy Ly, Sean Mcgrath, Kevin Haub, Richard K. Wilson, Elaine R. Mardis, Et Al

Open Access Publications

No abstract provided.

Probabilistic Identification Of Cerebellar Cortical Neurones Across Species, Hui Meng, Dora E. Angelaki, Et Al

Open Access Publications

No abstract provided.

In Vivo Measurement Of Apolipoprotein E From The Brain Interstitial Fluid Using Microdialysis, Jason D. Ulrich, Jack M. Burchett, Jessica L. Restivo, Dorothy R. Schuler, Philip B. Verghese, Thomas E. Mahan, Gary E. Landreth, Joseph M. Castellano, Hong Jiang, John R. Cirrito, David M. Holtzman

Open Access Publications

No abstract provided.

Emerging Roles For Immunomodulatory Functions Of Free Isg15, Jessica A. Campbell, Deborah J. Lenschow

Open Access Publications

No abstract provided.

Diapause And Anhydrobiosis In Embryos Of Artemia Franciscana : Metabolic Depression, Lea Proteins And Water Stress., Steven Handel, Yuvraj Patil, Shumin Li, Nilay Charkraborty, Arpurva Borcar, Michael Menze, Leaf Boswell, Daniel Moore, Mehmet Toner

Faculty and Staff Scholarship

Metabolic depression is typically correlated with extended survival of environmental challenge and energy-limitation in early life stages of various invertebrates and vertebrates. Diapause is an ontogenetically-programmed reduction of development and often metabolism seen in many invertebrates. When embryos of Artemia franciscana enter the state of diapause, the overall metabolic depression is estimated to be greater than 99%. These embryos also contain trehalose and express multiple isoforms of Late Embryogenesis Abundant (LEA) proteins, constituents often present in a number of such anhydrobiotic animals. The mRNA levels for LEA proteins are highest in diapause and post-diapause embryos that possess desiccation tolerance, but …

Grutter's Denouement: Three Templates From The Roberts Court, Ellen D. Katz

Articles

Precedent from the Roberts Court shows the Justices taking three distinct approaches to precedent they dislike. Each provides a template for the Court to criticize race-based affirmative action in higher education, as Fisher v. University of Texas at Austin is widely expected to do. Most narrowly, the Court might use Fisher to issue a warning, much like it did in 2009 when it sidestepped a constitutional challenge to the Voting Rights Act; under this approach, the opinion would spell out why the Justices think the diversity celebrated in Grutter v. Bollinger no longer provides sufficient justification for the use of …

Transcriptome Of The Eastern Oyster Crassostrea Virginica In Response To Bacterial Challenge, Ian Mcdowell

Open Access Master's Theses

The Eastern oyster Crassostrea virginica, an ecologically and economically important estuarine organism, suffers mortalities as high as 90-100% in affected areas due to Roseovarius Oyster Disease (ROD), caused by the bacterial pathogen, Roseovarius crassostreae. Advanced genotypic breeding techniques necessitate information regarding markers and genes associated with disease resistance. As yet, the host-pathogen interaction between C. virginica and R. crassostreae is poorly understood at the molecular level. The identification of potential genes and pathways responsible for an effective host defense response in the Eastern oyster to R. crassostreae is important not only to provide a basis for enhanced breeding techniques, …

Myostatin And Tgf-Β Function In The Regulation Of Myogenesis In Rainbow Trout (Oncorhynchus Mykiss), A Basal Teleost, Ian Morrison Jaffe

Open Access Master's Theses

Myogenesis in vertebrates is a complex and intricately regulated process, various mechanisms of which have been alternately conserved or lost throughout the course of vertebrate evolution. Mammalian myogenesis is highly regulated by myostatin, a member of the Transforming Growth Factor-β (TGF-β) family of cytokines, however, a similar role for myostatin in fish currently remains the subject of inquiry. Myostatin initiates signal transduction by means of the activin type IIb receptor, and shares considerable sequence and structural homology across vertebrate taxa, though its functional homology remains unclear. Two families of transgenic (TG) rainbow trout (RBT), one in which myostatin was inhibited …

Limited Entry In Rhode Island Tracing An Idea From Open Access To License Limitation To Catch Shares, Jonathon M. Peros

Open Access Master's Theses

For centuries fisheries institutions have shaped Rhode Island’s storied fishing tradition, a hallmark of which has been access to marine resources by the residents of the state. In 2001, after a series of moratoriums on commercial fishing licenses, Rhode Island embarked on an extensive public process through the Coastal Institute at the University of Rhode Island to identify fishery management options based on the input of stakeholders. The outcome of that process was the passage of Senate Bill 2771 sub A – otherwise known as Rhode Island Gen. Law 20.2-1 (2002). The legislation ended a moratorium on the issuance of …

Modulation Of Cd8+ T Cell Responses To Aav Vectors With Igg-Derived Mhc Class Ii Epitopes, Daniel J. Hui, Etiena Banser-Tschakarjan, Yifeng Chen, Robert J. Davidson, George Buchlis, Mustafa Yazicioglu, Gary C. Pien, Jonathan D. Finn, Virginia Haurigot, Alex Tai, David W. Scott, Leslie P. Cousens, Shangzhen Zhou, Anne S. De Groot, Federico Mingozzi

Institute for Immunology and Informatics Faculty Publications

Immune responses directed against viral capsid proteins constitute a main safety concern in the use of adeno-associated virus (AAV) as gene transfer vectors in humans. Pharmacological immunosuppression has been proposed as a solution to the problem; however, the approach suffers from several potential limitations. Using MHC class II epitopes initially identified within human IgG, named Tregitopes, we showed that it is possible to modulate CD8⁺ T cell responses to several viral antigens in vitro. We showed that incubation of peripheral blood mononuclear cells with these epitopes triggers proliferation of CD4⁺CD25⁺FoxP3⁺ T cells that …

Making Vaccines "On Demand", Anne S. De Groot, Leo Einck, Leonard Moise, Michael Chambers, John Ballantyne, Robert W. Malone, Matthew Ardito, William Martin

Institute for Immunology and Informatics Faculty Publications

The integrated US Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) has made great strides in strategic preparedness and response capabilities. There have been numerous advances in planning, biothreat countermeasure development, licensure, manufacturing, stockpiling and deployment. Increased biodefense surveillance capability has dramatically improved, while new tools and increased awareness have fostered rapid identification of new potential public health pathogens. Unfortunately, structural delays in vaccine design, development, manufacture, clinical testing and licensure processes remain significant obstacles to an effective national biodefense rapid response capability. This is particularly true for the very real threat of “novel pathogens” such as the avian-origin influenzas H7N9 …

Degradation Of Mangrove Tissues By Arboreal Termites (Nasutitermes Acajutlae) And Their Role In The Mangrove C Cycle (Puerto Rico): Chemical Characterization And Organic Matter Provenance Using Bulk Δ13C, C/N, Alkaline Cuo Oxidation‐Gc/Ms, And Solid‐State 13C Nmr, Christopher H. Vane, Alexander W. Kim, Vicky Moss-Hayes, Collin E. Snape, Miguel Castro Diaz, Nicole S. Khan, Simon E. Engelhart, Benjamin P. Horton

Geosciences Faculty Publications

Arboreal termites are wood decaying organisms that play an important role in the first stages of C cycling in mangrove systems. The chemical composition of Rhizophora mangle, Avicennia germinans, and Laguncularia racemosa leaf, stem, and pneumatophore tissues as well as associated sediments was compared to that of nests of the termite Nasutitermes acajutlae. Nests gave δ¹³C values of −26.1 to −27.2‰ (±0.1) and C/N of 43.3 (±2.0) to 98.6 (±16.2) which were similar to all stem and pneumatophores but distinct from mangrove leaves or sediments. Organic matter processed by termites yielded lignin phenol …

Regulatory T Cell Epitopes (Tregitopes) In Igg Induce Tolerance In Vivo And Lack Immunogenicity Per Se, Yan Su, Robert Rossi, Anne S. De Groot, David W. Scott

Institute for Immunology and Informatics Faculty Publications

Tregitopes are a set of epitopes, derived from IgG, that bind to MHCII, activate nTregs, and promote tolerance. We have now confirmed that coadministration of Tregitopes with a range of proteins (autoantigens and nominal antigens, such as OVA) in vitro and in vivo leads to suppression of T cell and antibody responses to the test antigens. In this study, we demonstrate that Tregitopes are not immunogenic in vivo even when emulsified with strong adjuvants, such as IFA or CFA. Moreover, in vivo administration of Tregitopes with IFA or CFA does not induce Th1 or Th2 cytokine expression under restimulation conditions …

Program Evaluation In The Nonprofit Sector : An Exploratory Study Of Leaders' Perceptions, Gail A. Patin

UNF Graduate Theses and Dissertations

The purpose of the study was to understand the role of and capacity for program evaluation from the perspectives of leaders in the Northeast Florida nonprofit sector. The study was a two-phased qualitative design and had three research questions related to the role of program evaluation, the capacity for program evaluation, and the influence of the relationship between providers and funders on these efforts. The first phase was a nominal group process using the Delphi survey method. The second phase involved in-depth interviews. Study participants were chosen based on specific criteria.

The Delphi phase had four rounds of surveys. Findings …

Communication And Language Recovery In People With Aphasia: Using Gestures In Speech-Language Therapy, Amanda M. Mokaya

Research Papers

No abstract provided.

Animal-Assisted Therapy And The Child-Animal Bond: Children's Well-Being And Behavior, Connie I. Jacobs

Research Papers

No abstract provided.

Examining The Role Of Interagency Coordination When Addressing Flood Risk Management And Flood Disasters In Southern Illinois, Irene J. Upson

Research Papers

No abstract provided.

From Sidebets To Sideshow: The Influence Of Gambling On The Development Of Professional Wrestling In America, 1870-1911, Lee Casebolt

Dissertations and Theses @ UNI

While boxing and baseball have been common subjects of historical study, other sports of the nineteenth century have been comparatively neglected by historians. Professional wrestling, in particular, has received very little attention as a sport, as opposed to its twentieth century “sports entertainment” incarnation. What attention it has received has most commonly been through the lens of social history, focusing on wrestling as theater or its psychosexual overtones. Missing from its history is any consideration of the economic factors which influence the evolution of any professional endeavor. This paper explores the relationship between a wrestler’s payment and performance. Specifically, it …