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2013

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Msx1 Mutations And Their Binding Interactions, Divakar Prakash Jan 2013

Msx1 Mutations And Their Binding Interactions, Divakar Prakash

All ETDs from UAB

Orofacial clefting (OFC), also called cleft lip and/or palate, is the most common congenital birth anomaly that involve the craniofacial region in humans. The etiology of Non-Syndromic OFC (NS-OFC) is complex and multifactorial; a slew of genetic mutations, standing alone or in combinations, along with several environmental factors, play a major role in the disease process. Numerous linkage and association studies in humans, as well as expression studies and knockout mouse models, have implicated Muscle segment homeobox gene 1 (MSX1), which encodes a homeodomain/DNA binding domain (HD) containing transcription factor as a strong candidate contributing to NS-OFC and Tooth Agenesis …

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The Role Of Complement In Experimental Cerebral Malaria, Theresa N. Ramos Jan 2013

The Role Of Complement In Experimental Cerebral Malaria, Theresa N. Ramos

All ETDs from UAB

Cerebral malaria (CM) is one of the most severe clinical complications of P. falciparum malaria with a fatality rate of 15-30%, and 10% of CM survivors have permanent neurological sequelae. Since inflammation is a central pathophysiological tenet of CM, we began examining the role of the complement system in pathogenesis of experimental cerebral malaria (ECM) using Plasmodium berghei ANKA (PbA) model. Previous studies using this model indicated that mice naturally deficient in complement component C5 were protected from cerebral complications, and wild type mice treated with anti-C5aR antibody were also protected. To determine the protective mechanism of naturally-C5 deficient mice, …

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Mesocorticolimbic Abnormalities In Schizophrenia: A Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging Study, Meredith A. Reid Jan 2013

Mesocorticolimbic Abnormalities In Schizophrenia: A Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging Study, Meredith A. Reid

All ETDs from UAB

Schizophrenia is a complex, often debilitating chronic mental disorder that affects approximately 1% of people worldwide. Recently, there has been growing interest in identifying non-invasive biomarkers of schizophrenia. Understanding the molecular and structural mechanisms underlying clinical features of schizophrenia and patients' drug response is an important step in identifying biomarkers and potential targets for novel medications, treatment strategies, and interventions. The primary objective of this dissertation research was to use non-invasive magnetic resonance imaging techniques, specifically magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI), to examine the neurochemical and structural correlates of symptoms, cognition, and treatment response to antipsychotic …

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Commensal Microbiota And Its Impact On Health And Autoimmune Diabetets, Kyle James Wolf Jan 2013

Commensal Microbiota And Its Impact On Health And Autoimmune Diabetets, Kyle James Wolf

All ETDs from UAB

Environmental exposures such as diet, use of antibiotics, and lifestyle have significant impact on the health of an individual. One mechanism that acts as a major pathway in these environmental exposures is the role intestinal commensal microbiota play in both metabolic and immunological responses. Metabolic pathways are altered through changes in metabolites provided by commensal microbiota; alterations in microbial make-up can have drastic impacts on metabolic function. Similarly, the development and maturation of the immune system is dependent on the intestinal microbes to induce tolerance and act as both an immune modulator as well as a barrier against pathogens. We …

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Characterization Of The Mumps Virus Replicase, Robert Marsden Cox Jan 2013

Characterization Of The Mumps Virus Replicase, Robert Marsden Cox

All ETDs from UAB

Negative strand RNA viruses (NSV) are unique because their nucleocapsids are used directly as the template for both transcription and replication. The viral genomic RNA is coated by the nucleoprotein (N) for the entirety of the NSV replication cycle. The viral polymerase, which is composed of the L and P proteins, can only recognize encapsidated RNA as the template for RNA synthesis. Our previous studies have solved the EM structure of the MuV N-RNA complex at 25Ņ. This structure revealed how the nucleocapsid is assembled and provides an initial model for examining how the viral polymerase may recognize the …

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Sulindac Sulfide Amide As A Novel Agent For The Prevention And Treatment Of Lung Cancer, Evrim Gurpinar Jan 2013

Sulindac Sulfide Amide As A Novel Agent For The Prevention And Treatment Of Lung Cancer, Evrim Gurpinar

All ETDs from UAB

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac sulfide (SS) have shown promising antineoplastic activity in multiple tumor types, but toxicities resulting from cyclooxygenase (COX) inhibition limit their use in cancer prevention. We recently described a N,N-dimethylethyl amine derivative of SS, sulindac sulfide amide (SSA), that does not inhibit COX-1 or -2, yet displays potent tumor cell growth inhibitory activity. Here, we studied the basis for the growth inhibitory effects of SSA on human lung adenocarcinoma cell lines and evaluated its preclinical pharmacology. SSA potently inhibited the growth of lung tumor cells with IC50 values of 2-5 μ compared with 44-52 …

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Clinical Consequences Of Micrornas In Colorectal Cancer, Liselle C. Bovell Jan 2013

Clinical Consequences Of Micrornas In Colorectal Cancer, Liselle C. Bovell

All ETDs from UAB

Colorectal cancer (CRC) is a heterogeneous disease, and factors such as tumor location, the environment, genetics, and ethnic differences, can influence its development and progression. Over the last few decades, overall CRC mortality rates have declined; however, racial disparities in mortality rates have increased. The discovery of biomarkers that focus on identifying individual differences based on confounders such as tumor stage and patient race/ethnicity is needed, for such biomarkers can lead to development of personalized therapeutic approaches to target these molecules. MicroRNAs (miRNAs) are a class of small molecules that regulate genes at the post-transcriptional level. Altered miRNA expression levels …

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Therapeutic Potential Of Genetically-Engineered Mesenchymal Stem Cells In Multiple Myeloma, Jerome T. Higgs Jan 2013

Therapeutic Potential Of Genetically-Engineered Mesenchymal Stem Cells In Multiple Myeloma, Jerome T. Higgs

All ETDs from UAB

ABSTRACT Multiple Myeloma (MM) remains the second most common hematologic malig-nancy occurring in adults, which primarily affects the skeletal system causing severe bone destruction, spinal cord compression and hypercalcemia. Current therapies, which include chemotherapy, radiotherapy, autologouos stem cell transplantation and in some cases surgery, have extended the median survival between 3 and 10 years. However, MM is still incurable and therefore improving current therapies or developing newer ones to reduce the burden of osteolytic damage and extend survival rate will be highly beneficial for patient management. The long-term goal of this study is to develop a novel therapeutic approach to …

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Exploring Rti Reading Intervention For Hispanic English Learning Kindergarten Students In Central Alabama:, Kelly Leah Hill Jan 2013

Exploring Rti Reading Intervention For Hispanic English Learning Kindergarten Students In Central Alabama:, Kelly Leah Hill

All ETDs from UAB

This study addressed issues in implementing RTI Tier II reading intervention in kindergarten classrooms which contained Hispanic students learning English. In addition, the scope of reading progress of Hispanic students learning English was explored. The purpose of this research was to examine the frequency in providing RTI reading interventions and how they were implemented in kindergarten with Hispanic children who are learning English. This study employed an explanatory sequential (Quan QUAL) mixed methods design (Creswell & Plano Clark, 2011). To address the purpose of the study, the overarching mixed methods question was: What is the frequency of RTI Tier II …

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Determinant Of G-Chain Mediated Fc Receptor Signaling, Spandan Shah Jan 2013

Determinant Of G-Chain Mediated Fc Receptor Signaling, Spandan Shah

All ETDs from UAB

Fc receptors provide an interface between humoral immunity and cellular immunity by binding to the Fc portion of immunoglobulin and mediating effector functions. Cells expressing Fc receptors play a major role in immune complex clearance via phagocytosis, leading to a context dependent pro- or anti-inflammatory environment. Signaling by multi-chain Fc receptor complexes, including FcgRI, FcgRIII, FceRI and FcaRI is mediated by the ITAM-containing common FceRIg (g-chain) subunit. However, despite the use of a common g-chain, different Fc receptor complexes elicit specific cellular programs, suggesting additional layers of regulation of tyrosine based signaling by g-chain. We hypothesized that the unique g-chain …

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Neuropathological Alterations In Alzheimer's Disease: An Up Close Look At Sympathetic Sprouting, Amy Renee Nelson Jan 2013

Neuropathological Alterations In Alzheimer's Disease: An Up Close Look At Sympathetic Sprouting, Amy Renee Nelson

All ETDs from UAB

Pathological hallmarks of AD include neurofibrillary tau tangles, amyloid beta (Abeta) accumulation and cholinergic degeneration. Cholinergic degeneration can be mimicked in rats by lesioning cholinergic neurons in medial septum. Hippocampal cholinergic denervation disrupts retrograde transport of nerve growth factor (NGF), leading to its accumulation, which subsequently triggers sprouting of noradrenergic sympathetic fibers from the superior cervical ganglia into hippocampus. Dr. McMahon's lab previously reported that coincident with this sprouting, there is an increase in cholinergic innervation that correlates with a recovery of M1 muscarinic receptor dependent plasticity at CA3-CA1 synapses and visual cortex. These findings suggest that noradrenergic sympathetic sprouting …

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Repellency Efficacy Of Essential Oils Of Selected Plants Growing In Western Kenya And Their Eag-Active Constituent Blends Against Anopheles Gambiae, David Otieno Ywaya Jan 2013

Repellency Efficacy Of Essential Oils Of Selected Plants Growing In Western Kenya And Their Eag-Active Constituent Blends Against Anopheles Gambiae, David Otieno Ywaya

All Master’s Theses

Control of disease vectors by use of synthetic chemical pesticides has been associated with a series of problems, including resistance development, environmental pollution, and safety risks for humans and domestic animals. Plant-based products have been used for generations in traditional practices to control different arthropods. These have been used in space or personal protection either to repel the arthropods from distance or to deter them from blood-feeding on contact. In the present study, the repellence of essential oils of three plants (Ocimum gratissimum L., Vitex keniensis Turill and Hyptis suaveolens (L.) Poit used in Siaya County in western Kenya were …

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Work And Life Harmony: An Exploratory Case Study Of Entrepinays, Divina M. Edralin Jan 2013

Work And Life Harmony: An Exploratory Case Study Of Entrepinays, Divina M. Edralin

DLSU Business & Economics Review

This study aims to explore how Filipina entrepreneurs (EntrePinays) harmonize their work demands with their family responsibilities and personal needs in order to sustain their business and at the same time live a meaningful and happy life. As an exploratory study utilizing nine participants, the case study approach based on the multiple case dimensions was used. Findings revealed that there are positive and negative spillover effects of work-life relationships. The negative spillover induces stress among the EntrePinays and the positive spillover can lead to their high levels of life satisfaction. Results also showed that EntrePinays are able to harmonize their …

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Better Ways To Study Regulatory Elephants, Jonathan B. Wiener, Brendon Swedlow, James K. Hammitt, Michael D. Rogers, Peter H. Sand Jan 2013

Better Ways To Study Regulatory Elephants, Jonathan B. Wiener, Brendon Swedlow, James K. Hammitt, Michael D. Rogers, Peter H. Sand

Faculty Scholarship

No abstract provided.

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Annual Report Of The Risd Fleet Library 2012-2013, Fleet Library, Carol Terry Jan 2013

Annual Report Of The Risd Fleet Library 2012-2013, Fleet Library, Carol Terry

Annual Reports

No abstract provided.

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Animal Science E-Newsletter, January 2013, University Of Arkansas, Fayetteville. Department Of Animal Sciences Jan 2013

Animal Science E-Newsletter, January 2013, University Of Arkansas, Fayetteville. Department Of Animal Sciences

Animal Science e-Newsletter

No abstract provided.

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Cupola, 2013, Western New England University Jan 2013

Cupola, 2013, Western New England University

Yearbooks

Western New England University was founded in 1919 as the Springfield Division of Northeastern University. The senior yearbooks bore the name of Northeastern University in some way until 1953. The yearbook was given its present day title, The Cupola, in 1961. Yearbooks contain photos of graduating seniors, campus events, student clubs and organizations, faculty and staff, athletic teams and events, and other memorable occasions from the academic year.

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Welcome To The Doll House, Francie Latour, Risd Xyz Jan 2013

Welcome To The Doll House, Francie Latour, Risd Xyz

RISD XYZ Fall/Winter 2013: Out of Bounds

From the Barbie dresses he made as a boy to his first splash in the New York art world, Martín Gutierrez 12 PR is working to perfect what he has always done naturally.

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Risd Xyz Fall/Winter 2013/14: Out Of Bounds | Full Issue, Liisa Silander Jan 2013

Risd Xyz Fall/Winter 2013/14: Out Of Bounds | Full Issue, Liisa Silander

RISD XYZ Fall/Winter 2013: Out of Bounds

ARTISTS AND DESIGNERS TEND TO QUESTION, PUSH, CHALLENGE, take risks—as part of the pure pleasure of making. These are things you’re expected to do, just as you’re expected to think outside the box, color outside the lines, question the rules, defy expectations. The freedom of thought art and design offer may be what has inspired people to make objects of beauty and wonder since well before we began writing and recording our own history. Yet, as liberating as it sounds, that freedom is also a challenge. As alums you know how to probe and ponder, and deliberately work with materials …

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Toward A Sustainable Future: An Environmental Agenda For The Second Term Of The Obama Administration, David M. Uhlmann Jan 2013

Toward A Sustainable Future: An Environmental Agenda For The Second Term Of The Obama Administration, David M. Uhlmann

Other Publications

Much was at stake in the Presidential election of 2012, which was marked by heated debate over the trajectory of the economy, the expiration of the Bush tax cuts, and the fat of the President's health care plan. The candidates disagreed about nearly every issue from foreign policy and the war on terror to a woman's right to choose and same-sex marriage. Lost amid the din and never mentioned in the Presidential debates or most of the campaign speeches was another divisive topic: how our environmental laws and policies should address global climate change and chart a sustainable future for …

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Ash2 Acts As An Ecdysone Receptor Coactivator By Stabilizing The Histone Methyltransferase Trr., Albert Carbonell, Alexander Mazo, Florenci Serras, Montserrat Corominas Jan 2013

Ash2 Acts As An Ecdysone Receptor Coactivator By Stabilizing The Histone Methyltransferase Trr., Albert Carbonell, Alexander Mazo, Florenci Serras, Montserrat Corominas

Department of Biochemistry and Molecular Biology Faculty Papers

The molting hormone ecdysone triggers chromatin changes via histone modifications that are important for gene regulation. On hormone activation, the ecdysone receptor (EcR) binds to the SET domain-containing histone H3 methyltransferase trithorax-related protein (Trr). Methylation of histone H3 at lysine 4 (H3K4me), which is associated with transcriptional activation, requires several cofactors, including Ash2. We find that ash2 mutants have severe defects in pupariation and metamorphosis due to a lack of activation of ecdysone-responsive genes. This transcriptional defect is caused by the absence of the H3K4me3 marks set by Trr in these genes. We present evidence that Ash2 interacts with Trr …

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Identification Of Phosphorylation Sites In The Cooh-Terminal Tail Of The Μ-Opioid Receptor., Ying-Ju Chen, Sue Oldfield, Adrian J. Butcher, Andrew B. Tobin, Kunal Saxena, Vsevolod V. Gurevich, Jeffrey L. Benovic, Graeme Henderson, Eamonn Kelly Jan 2013

Identification Of Phosphorylation Sites In The Cooh-Terminal Tail Of The Μ-Opioid Receptor., Ying-Ju Chen, Sue Oldfield, Adrian J. Butcher, Andrew B. Tobin, Kunal Saxena, Vsevolod V. Gurevich, Jeffrey L. Benovic, Graeme Henderson, Eamonn Kelly

Department of Biochemistry and Molecular Biology Faculty Papers

Phosphorylation is considered a key event in the signalling and regulation of the μ opioid receptor (MOPr). Here, we used mass spectroscopy to determine the phosphorylation status of the C-terminal tail of the rat MOPr expressed in human embryonic kidney 293 (HEK-293) cells. Under basal conditions, MOPr is phosphorylated on Ser(363) and Thr(370), while in the presence of morphine or [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin (DAMGO), the COOH terminus is phosphorylated at three additional residues, Ser(356) , Thr(357) and Ser(375). Using N-terminal glutathione S transferase (GST) fusion proteins of the cytoplasmic, C-terminal tail of MOPr and point mutations of the same, we …

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Biodiesel Production From Candlenut And Calodendrum Capense Seeds: Process Design And Technological Assessment, Dennis Mogire Ndaya Jan 2013

Biodiesel Production From Candlenut And Calodendrum Capense Seeds: Process Design And Technological Assessment, Dennis Mogire Ndaya

All Master’s Theses

This project was based on biodiesel production from candlenut and calodendrum capense seeds using conventional and biotechnological technique and determination of the oil yields and biodiesel quality. The driving force for large-scale use of biodiesel has been the need to reduce the harmful emissions that result from the burning of petroleum oil as well as our dependence on diminishing reserves of petroleum oil. The aim of the study was to extract oil from Candlenut tree and Calodendrum capense seeds using conventional techniques and determine conditions for optimum oil yields. The oil from the two non-edible plant feedstocks was obtained using …

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Characterization Of Flavonoids From Candidate Striga Weed Controlling Food Legumes; Cicer Arietinum L. And Vigna Radiata L., Anna Akumu Anyango Jan 2013

Characterization Of Flavonoids From Candidate Striga Weed Controlling Food Legumes; Cicer Arietinum L. And Vigna Radiata L., Anna Akumu Anyango

All Master’s Theses

In Africa, intercropping of some legumes with cereal crops has been found to cause remarkable reduction of Striga infestation and improved production of cereal crop. Desmodium uncinatum controls Striga infestation in intercrop with cereals through an allelopathic mechanism, which involves post-germination growth inhibitors exuded from the roots. Allelopathy is a natural and environmentally friendly technique, which has a potential to be a new approach for weed control. A standardized profiling method based on Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) and Liquid Chromatography coupled with Mass Spectrometry (LC/MS) was used to identify flavonoids in extracts of chickpea (Cicer arietinum) and mung …

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Current Approaches In Chemical Ecology Using Regionally Adapted Sustainable Methods, Eva Winter Jan 2013

Current Approaches In Chemical Ecology Using Regionally Adapted Sustainable Methods, Eva Winter

All Master’s Theses

Kenya is an African developing country situated at the equator ranking 157th of 177 countries in the human development index. Agriculture is next to tourism the most important economic sector with 24 % of the GDP. Poverty prevalence is highest with small holder farmers. A promissing approach to reduce this precarious condition is the implementation of organic agriculture. 1. Establishment of certified organic cash crop production for a domestic and/or an export market and 2. dissemination of common methods in organic agriculture to subsistently living small holder farmers are the two major strategies of the approach. Both have different positive …

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Writing The Visual In "Baroni: Un Viaje" And Other Recent Work By Sergio Chejfec, Margaret Carson Jan 2013

Writing The Visual In "Baroni: Un Viaje" And Other Recent Work By Sergio Chejfec, Margaret Carson

Dissertations, Theses, and Capstone Projects

This dissertation has three parts. First, I explore the ways in which word intersects with image in several recent texts by the contemporary Argentine writer Sergio Chejfec, whose oeuvre is replete with verbal descriptions of visual artifacts. Second, as a complement to the critical essay, I present my English translation of Chejfec's Baroni: un viaje (2007), a novel featuring the Venezuelan artist Rafaela Baroni, whose extraordinary wood carvings of Virgins, saints and other figures are described in key passages. Third, as a bridge between these two parts, I reflect on the related critical discourses of ekphrasis and translation and on …

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Responses To Pyrethroids In Heavy Metal Tolerant Anopheles Gambiae Vector Of Malaria, Fauzia Khagai Musasia Jan 2013

Responses To Pyrethroids In Heavy Metal Tolerant Anopheles Gambiae Vector Of Malaria, Fauzia Khagai Musasia

All Master’s Theses

Anopheles gambiae mosquito, the principle Afro-tropical vector of malaria, has been documented in habitats with heavy metals in excess of natural loads. The mosquito has also displayed resistance to most conventional insecticides, and potential to resist challenges by heavy metals. Investigations were conducted in strains of An. gambiae ss, in which tolerance to cadmium and lead heavy metals were established. This study was undertaken to determine any putative relationship between tolerance to (cadmium and lead) heavy metals, and resistance to pyrethroid insecticide in An. gambiae. Tolerance to cadmium and lead heavy metals was developed in larval stages and this development …

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Protective Role Of Antioxidant In Ameliorating African Trypanosomiasis - Induced Brain Degeneration In A Mouse Model, James Nyabuga Nyariki Jan 2013

Protective Role Of Antioxidant In Ameliorating African Trypanosomiasis - Induced Brain Degeneration In A Mouse Model, James Nyabuga Nyariki

All Master’s Theses

Late stage Human African Trypanosomiasis (HAT) is manifested by brain degeneration following infection by Trypanasoma brucei rhodensiense and Trypanasoma brucei gambiense parasites. This stage can only be treated with melarsoprol (Mel B) which inadvertently induces Post Treatment Reactive Encephalopathy (PTRE) and a mortality of 5% among HAT infected patients. This is an unacceptable mortality for a modern human drug. Investigations were conducted to establish the protective role of Coenzyme Q10 (CoQ10) and endogenous antioxidants (Manganese Superoxide dismutase (MnSOD), Glutathione Reductase (GR), Copper-Zinc Superoxide dismutase (SOD-1) and reduced glutathione (GSH)) against PTRE and putative resultant brain degeneration in a mouse model. …

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Effect Of Temperature On The Efficacy Of Metarhizium Anisopliae (Metchnikoff) Sorokin In The Control Of Western Flower Thrips In French Beans, Maureen Nandwa Kuboka Jan 2013

Effect Of Temperature On The Efficacy Of Metarhizium Anisopliae (Metchnikoff) Sorokin In The Control Of Western Flower Thrips In French Beans, Maureen Nandwa Kuboka

All Master’s Theses

Metarhizium anisopliae isolate ICIPE69 is a highly virulent fungal pathogen against several thrips species such as western flower thrips (Frankliniella occidentalis), bean flower thrips (Megalurothrips sjostedti), onion thrips (Thrips tabaci) and others infesting key vegetable crops in Africa. Recently the isolate has been commercialized for pest control under the trade name, Campaign ®. The efficacy of the entomopathogenic fungi is known to be influenced by the prevailing climatic conditions with temperature being a key climate driver. This study aimed to predict the efficacy of Campaign® for thrips control in different Agro ecological zones (AEZ) in Kenya. To achieve this, effects …

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Log Ratio Methodology For Analysis Of Compositional Data: A Case Of Olfactometer Bioassay Data From Insect Behavioural Studies, Anthony Raymond Epel Jan 2013

Log Ratio Methodology For Analysis Of Compositional Data: A Case Of Olfactometer Bioassay Data From Insect Behavioural Studies, Anthony Raymond Epel

All Master’s Theses

Researchers are often times confronted with compositional data in insect choice studies. The choice of a statistical method to model this type of data is always not obvious. In this study, three approaches for analysis of compositional data from choice tests made by the predatory parasitoid Cotesia sesamaie Cameron in a four-arm olfactometer was explored using centered, additive and isometric log ratio transformations. Oviposition induced plant volatiles (OIPVs), herbivore induced plant volatiles (HIPVs), and two controls were tested in the four-arm olfactometer. The response variable measured was time spent in each field of the olfactometer, when the time to observe …

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