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2013

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Articles 18331 - 18360 of 19503

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Hdl And Glut1 Inhibition Reverse A Hypermetabolic State In Mouse Models Of Myeloproliferative Disorders, Emmanuel L. Gautier, Marit Westerterp, Neha Bhagwat, Serge Cremers, Alan Shih, Omar Abdel-Wahab, Dieter Lütjohann, Gwendalyn J. Randolph, Ross L. Levine, Alan R. Tall, Laurent Yvan-Charvet Jan 2013

Hdl And Glut1 Inhibition Reverse A Hypermetabolic State In Mouse Models Of Myeloproliferative Disorders, Emmanuel L. Gautier, Marit Westerterp, Neha Bhagwat, Serge Cremers, Alan Shih, Omar Abdel-Wahab, Dieter Lütjohann, Gwendalyn J. Randolph, Ross L. Levine, Alan R. Tall, Laurent Yvan-Charvet

Open Access Publications

A high metabolic rate in myeloproliferative disorders is a common complication of neoplasms, but the underlying mechanisms are incompletely understood. Using three different mouse models of myeloproliferative disorders, including mice with defective cholesterol efflux pathways and two models based on expression of human leukemia disease alleles, we uncovered a mechanism by which proliferating and inflammatory myeloid cells take up and oxidize glucose during the feeding period, contributing to energy dissipation and subsequent loss of adipose mass. In vivo, lentiviral inhibition of Glut1 by shRNA prevented myeloproliferation and adipose tissue loss in mice with defective cholesterol efflux pathway in leukocytes. Thus, …


Lncipedia: A Database For Annotated Human Lncrna Transcript Sequences And Structures, Pieter-Jan Volders, Kenny Helsens, Xiaowei Wang, Bjorn Menten, Lennart Martens, Kris Gevaert, Jo Vandesompele, Pieter Mestdagh Jan 2013

Lncipedia: A Database For Annotated Human Lncrna Transcript Sequences And Structures, Pieter-Jan Volders, Kenny Helsens, Xiaowei Wang, Bjorn Menten, Lennart Martens, Kris Gevaert, Jo Vandesompele, Pieter Mestdagh

Open Access Publications

No abstract provided.


Molecular Insight Into The Association Between Cartilage Regeneration And Ear Wound Healing In Genetic Mouse Models: Targeting New Genes In Regeneration, Muhammad Farooq Rai, Eric J. Schmidt, Audrey Mcalinden, James M. Cheverud, Linda J. Sandell Jan 2013

Molecular Insight Into The Association Between Cartilage Regeneration And Ear Wound Healing In Genetic Mouse Models: Targeting New Genes In Regeneration, Muhammad Farooq Rai, Eric J. Schmidt, Audrey Mcalinden, James M. Cheverud, Linda J. Sandell

Open Access Publications

No abstract provided.


Cd2ap Links Cortactin And Capping Protein At The Cell Periphery To Facilitate Formation Of Lamellipodia, Jianping Zhao, Serawit Bruck, Saso Cemerski, Lei Zhang, Boyd Butler, Adish Dani, John A. Cooper, Andrey S. Shaw Jan 2013

Cd2ap Links Cortactin And Capping Protein At The Cell Periphery To Facilitate Formation Of Lamellipodia, Jianping Zhao, Serawit Bruck, Saso Cemerski, Lei Zhang, Boyd Butler, Adish Dani, John A. Cooper, Andrey S. Shaw

Open Access Publications

Understanding the physiology of complex relationships between components of signaling pathways and the actin cytoskeleton is an important challenge. CD2AP is a membrane scaffold protein implicated in a variety of physiological and disease processes. The physiological function of CD2AP is unclear, but its biochemical interactions suggest that it has a role in dynamic actin assembly. Here, we report that CD2AP functions to facilitate the recruitment of actin capping protein (CP) to the Src kinase substrate, cortactin, at the cell periphery, and that this is necessary for formation of the short branched filaments that characterize lamellipodium formation and are required for …


Investigation Of Neovascularization In Three-Dimensional Porous Scaffolds In Vivo By A Combination Of Multiscale Photoacoustic Microscopy And Optical Coherence Tomography, Xin Cai, Yu Zhang, Li Li, Sung-Wook Choi, Matthew R. Macewan, Junjie Yao, Chulhong Kim, Younan Xia, Lihong V. Wang Jan 2013

Investigation Of Neovascularization In Three-Dimensional Porous Scaffolds In Vivo By A Combination Of Multiscale Photoacoustic Microscopy And Optical Coherence Tomography, Xin Cai, Yu Zhang, Li Li, Sung-Wook Choi, Matthew R. Macewan, Junjie Yao, Chulhong Kim, Younan Xia, Lihong V. Wang

Open Access Publications

No abstract provided.


Gene-Alcohol Interactions Identify Several Novel Blood Pressure Loci Including A Promising Locus Near Slc16a9, Jeannette Simino, Yun Ju Sung, Rezart Kume, Karen Schwander, D. C. Rao Jan 2013

Gene-Alcohol Interactions Identify Several Novel Blood Pressure Loci Including A Promising Locus Near Slc16a9, Jeannette Simino, Yun Ju Sung, Rezart Kume, Karen Schwander, D. C. Rao

Open Access Publications

No abstract provided.


Oct4/Sox2 Binding Sites Contribute To Maintaining Hypomethylation Of The Maternal Igf2/H19 Imprinting Control Region, David L. Zimmerman, Craig S. Boddy, Christopher S. Schoenherr Jan 2013

Oct4/Sox2 Binding Sites Contribute To Maintaining Hypomethylation Of The Maternal Igf2/H19 Imprinting Control Region, David L. Zimmerman, Craig S. Boddy, Christopher S. Schoenherr

Open Access Publications

No abstract provided.


Brain Mapping In A Patient With Congenital Blindness – A Case For Multimodal Approaches, Jared L. Roland, Carl D. Hacker, Jonathan D. Breshears, Charles M. Gaona, R. Edward Hogan, Harold Burton, Maurizio Corbetta, Eric C. Leuthardt Jan 2013

Brain Mapping In A Patient With Congenital Blindness – A Case For Multimodal Approaches, Jared L. Roland, Carl D. Hacker, Jonathan D. Breshears, Charles M. Gaona, R. Edward Hogan, Harold Burton, Maurizio Corbetta, Eric C. Leuthardt

Open Access Publications

No abstract provided.


Age-Related Vulnerability In The Neural Systems Supporting Semantic Processing, Jonathan E. Peelle, Keerthi Chandrasekaran, John Powers, Edward E. Smith, Murray Grossman Jan 2013

Age-Related Vulnerability In The Neural Systems Supporting Semantic Processing, Jonathan E. Peelle, Keerthi Chandrasekaran, John Powers, Edward E. Smith, Murray Grossman

Open Access Publications

No abstract provided.


Changes In Auditory Perceptions And Cortex Resulting From Hearing Recovery After Extended Congenital Unilateral Hearing Loss, Jill B. Firszt, Ruth M. Reeder, Timothy A. Holden, Harold Burton, Richard A. Chole Jan 2013

Changes In Auditory Perceptions And Cortex Resulting From Hearing Recovery After Extended Congenital Unilateral Hearing Loss, Jill B. Firszt, Ruth M. Reeder, Timothy A. Holden, Harold Burton, Richard A. Chole

Open Access Publications

No abstract provided.


Normal Cognition In Transgenic Bri2-Aβ Mice, Jungsu Kim, Paramita Chakrabarty, Amanda Hanna, Amelia March, Dennis W. Dickson, David R. Borchelt, Todd Golde, Christopher Janus Jan 2013

Normal Cognition In Transgenic Bri2-Aβ Mice, Jungsu Kim, Paramita Chakrabarty, Amanda Hanna, Amelia March, Dennis W. Dickson, David R. Borchelt, Todd Golde, Christopher Janus

Open Access Publications

No abstract provided.


Timps Of Parasitic Helminths – A Large-Scale Analysis Of High-Throughput Sequence Datasets, Cinzia Cantacessi, Andreas Hofmann, Darren Pickering, Severine Navarro, Makedonka Mitreva, Alex Loukas Jan 2013

Timps Of Parasitic Helminths – A Large-Scale Analysis Of High-Throughput Sequence Datasets, Cinzia Cantacessi, Andreas Hofmann, Darren Pickering, Severine Navarro, Makedonka Mitreva, Alex Loukas

Open Access Publications

No abstract provided.


Phenotypic Characteristics Of Early Wolfram Syndrome, Bess A. Marshall, M. Alan Permutt, Alexander R. Paciorkowski, James Hoekel, Roanne Karzon, Jon Wasson, Amy Viehover, Neil H. White, Joshua S. Shimony, Linda Manwaring, Paul Austin, Timothy E. Hullar, Tamara Hershey, Washington University Wolfram Study Group Jan 2013

Phenotypic Characteristics Of Early Wolfram Syndrome, Bess A. Marshall, M. Alan Permutt, Alexander R. Paciorkowski, James Hoekel, Roanne Karzon, Jon Wasson, Amy Viehover, Neil H. White, Joshua S. Shimony, Linda Manwaring, Paul Austin, Timothy E. Hullar, Tamara Hershey, Washington University Wolfram Study Group

Open Access Publications

No abstract provided.


Ion Permeabilities In Mouse Sperm Reveal An External Trigger For Slo3-Dependent Hyperpolarization, Julio C. Chavez, Jose L. De La Vega-Beltran, Jessica Escoffier, Pablo E. Visconti, Claudia L. Trevino, Alberto Darszon, Lawrence Salkoff, Celia M. Santi Jan 2013

Ion Permeabilities In Mouse Sperm Reveal An External Trigger For Slo3-Dependent Hyperpolarization, Julio C. Chavez, Jose L. De La Vega-Beltran, Jessica Escoffier, Pablo E. Visconti, Claudia L. Trevino, Alberto Darszon, Lawrence Salkoff, Celia M. Santi

Open Access Publications

No abstract provided.


Rapamycin Attenuates The Development Of Posttraumatic Epilepsy In A Mouse Model Of Traumatic Brain Injury, Dongjun Guo, Linghui Zeng, David L. Brody, Michael Wong Jan 2013

Rapamycin Attenuates The Development Of Posttraumatic Epilepsy In A Mouse Model Of Traumatic Brain Injury, Dongjun Guo, Linghui Zeng, David L. Brody, Michael Wong

Open Access Publications

No abstract provided.


Proteomic Analysis Of Oesophagostomum Dentatum (Nematoda) During Larval Transition, And The Effects Of Hydrolase Inhibitors On Development, Martina Ondrovics, Katja Silbermayr, Makedonka Mitreva, Neil D. Young, Ebrahim Razzazi-Fazeli, Robin B. Gasser, Anja Joachim Jan 2013

Proteomic Analysis Of Oesophagostomum Dentatum (Nematoda) During Larval Transition, And The Effects Of Hydrolase Inhibitors On Development, Martina Ondrovics, Katja Silbermayr, Makedonka Mitreva, Neil D. Young, Ebrahim Razzazi-Fazeli, Robin B. Gasser, Anja Joachim

Open Access Publications

No abstract provided.


Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways And Maintains Beta-Cell Phenotype In Human Islets, Nidhi Rohatgi, Haytham Aly, Connie A. Marshall, William G. Mcdonald, Rolf F. Kletzien, Jerry R. Colca, Michael L. Mcdaniel Jan 2013

Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways And Maintains Beta-Cell Phenotype In Human Islets, Nidhi Rohatgi, Haytham Aly, Connie A. Marshall, William G. Mcdonald, Rolf F. Kletzien, Jerry R. Colca, Michael L. Mcdaniel

Open Access Publications

No abstract provided.


Guanylate-Binding Protein 1 (Gbp1) Contributes To Cell-Autonomous Immunity Against Toxoplasma Gondii, Elizabeth M. Selleck, Sarah J. Fentress, Wandy L. Beatty, Daniel Degrandi, Klaus Pfeffer, Herbert W. Virgin Iv, John D. Macmicking, L. David Sibley Jan 2013

Guanylate-Binding Protein 1 (Gbp1) Contributes To Cell-Autonomous Immunity Against Toxoplasma Gondii, Elizabeth M. Selleck, Sarah J. Fentress, Wandy L. Beatty, Daniel Degrandi, Klaus Pfeffer, Herbert W. Virgin Iv, John D. Macmicking, L. David Sibley

Open Access Publications

No abstract provided.


Identification Of A Mitochondrial Target Of Thiazolidinedione Insulin Sensitizers (Mtot)— Relationship To Newly Identified Mitochondrial Pyruvate Carrier Proteins, Patrick A. Vigueira, Brian N. Finck, Et Al Jan 2013

Identification Of A Mitochondrial Target Of Thiazolidinedione Insulin Sensitizers (Mtot)— Relationship To Newly Identified Mitochondrial Pyruvate Carrier Proteins, Patrick A. Vigueira, Brian N. Finck, Et Al

Open Access Publications

No abstract provided.


A Multicenter, Prospective Study Of A New Fully Covered Expandable Metal Biliary Stent For The Palliative Treatment Of Malignant Bile Duct Obstruction, Bert T. Petersen, Michel Kahaleh, Richard A. Kozarek, David Loren, Kapil Gupta, Thomas Kowalski, Martin Freeman, Yang K. Chen, Malcolm S. Branch, Steven Edmundowicz, Michael Gluck, Kenneth Binmoeller, Todd H. Baron, Raj J. Shah, Timothy Kinney, William Ross, Paul Jowell, David Carr-Locke Jan 2013

A Multicenter, Prospective Study Of A New Fully Covered Expandable Metal Biliary Stent For The Palliative Treatment Of Malignant Bile Duct Obstruction, Bert T. Petersen, Michel Kahaleh, Richard A. Kozarek, David Loren, Kapil Gupta, Thomas Kowalski, Martin Freeman, Yang K. Chen, Malcolm S. Branch, Steven Edmundowicz, Michael Gluck, Kenneth Binmoeller, Todd H. Baron, Raj J. Shah, Timothy Kinney, William Ross, Paul Jowell, David Carr-Locke

Open Access Publications

No abstract provided.


Alcohol-Induced Apoptosis Of Oligodendrocytes In The Fetal Macaque Brain, Catherine E. Creeley, Krikor T. Dikranian, Stephen A. Johnson, Nuri B. Farber, John W. Olney Jan 2013

Alcohol-Induced Apoptosis Of Oligodendrocytes In The Fetal Macaque Brain, Catherine E. Creeley, Krikor T. Dikranian, Stephen A. Johnson, Nuri B. Farber, John W. Olney

Open Access Publications

No abstract provided.


Ttm-1 Encodes Cdf Transporters That Excrete Zinc From Intestinal Cells Of C. Elegans And Act In A Parallel Negative Feedback Circuit That Promotes Homeostasis, Hyun Cheol Roh, Sara Collier, Krupa Deshmukh, James Guthrie, David Robertson, Kerry Kornfeld Jan 2013

Ttm-1 Encodes Cdf Transporters That Excrete Zinc From Intestinal Cells Of C. Elegans And Act In A Parallel Negative Feedback Circuit That Promotes Homeostasis, Hyun Cheol Roh, Sara Collier, Krupa Deshmukh, James Guthrie, David Robertson, Kerry Kornfeld

Open Access Publications

No abstract provided.


Myocardial Ablation Of G Protein–Coupled Receptor Kinase 2 (Grk2) Decreases Ischemia/Reperfusion Injury Through An Anti-Intrinsic Apoptotic Pathway, Qian Fan, Mai Chen, Lin Zou, Xiying Shang, Maggie Z. Huang, Michele Ciccarelli, Philip Raake, Henriette Brinks, Kurt J. Chuprun, Gerald W. Dorn Ii, Walter J. Koch, Erhe Gao Jan 2013

Myocardial Ablation Of G Protein–Coupled Receptor Kinase 2 (Grk2) Decreases Ischemia/Reperfusion Injury Through An Anti-Intrinsic Apoptotic Pathway, Qian Fan, Mai Chen, Lin Zou, Xiying Shang, Maggie Z. Huang, Michele Ciccarelli, Philip Raake, Henriette Brinks, Kurt J. Chuprun, Gerald W. Dorn Ii, Walter J. Koch, Erhe Gao

Open Access Publications

No abstract provided.


Motivational Disturbances And Effects Of L-Dopa Administration In Neurofibromatosis-1 Model Mice, David F. Wozniak, Kelly A. Diggs-Andrews, Sara Conyers, Carla M. Yuede, Joshua T. Dearborn, Jacquelyn A. Brown, Kazuhiro Tokuda, Yukitoshi Izumi, Charles F. Zorumski, David H. Gutmann Jan 2013

Motivational Disturbances And Effects Of L-Dopa Administration In Neurofibromatosis-1 Model Mice, David F. Wozniak, Kelly A. Diggs-Andrews, Sara Conyers, Carla M. Yuede, Joshua T. Dearborn, Jacquelyn A. Brown, Kazuhiro Tokuda, Yukitoshi Izumi, Charles F. Zorumski, David H. Gutmann

Open Access Publications

No abstract provided.


In Vivo Visualization Of Notch1 Proteolysis Reveals The Heterogeneity Of Notch1 Signaling Activity In The Mouse Cochlea, Zhiyong Liu, Zhenyi Liu, Bradley J. Walters, Thomas Owen, Raphael Kopan, Jian Zuo Jan 2013

In Vivo Visualization Of Notch1 Proteolysis Reveals The Heterogeneity Of Notch1 Signaling Activity In The Mouse Cochlea, Zhiyong Liu, Zhenyi Liu, Bradley J. Walters, Thomas Owen, Raphael Kopan, Jian Zuo

Open Access Publications

No abstract provided.


Deficiency Of Leishmania Phosphoglycans Influences The Magnitude But Does Not Affect The Quality Of Secondary (Memory) Anti-Leishmania Immunity, Dong Liu, Ifeoma Okwor, Zhirong Mou, Stephen M. Beverley, Jude E. Uzonna Jan 2013

Deficiency Of Leishmania Phosphoglycans Influences The Magnitude But Does Not Affect The Quality Of Secondary (Memory) Anti-Leishmania Immunity, Dong Liu, Ifeoma Okwor, Zhirong Mou, Stephen M. Beverley, Jude E. Uzonna

Open Access Publications

No abstract provided.


Germinal Center B-Cells Resist Transformation By Kras Independently Of Tumor Suppressor Arf, Chelsea D. Mullins, Mack Y. Su, Vishwanathan Hucthagowder, Liang Chu, Lan Lu, Shashikant Kulkarni, Deborah Novack, Ravi Vij, Michael H. Tomasson Jan 2013

Germinal Center B-Cells Resist Transformation By Kras Independently Of Tumor Suppressor Arf, Chelsea D. Mullins, Mack Y. Su, Vishwanathan Hucthagowder, Liang Chu, Lan Lu, Shashikant Kulkarni, Deborah Novack, Ravi Vij, Michael H. Tomasson

Open Access Publications

No abstract provided.


Bcl11a Controls Flt3 Expression In Early Hematopoietic Progenitors And Is Required For Pdc Development In Vivo, Xiaodi Wu, Ansuman T. Satpathy, Wumesh Kc, Pentao Liu, Theresa L. Murphy, Kenneth M. Murphy Jan 2013

Bcl11a Controls Flt3 Expression In Early Hematopoietic Progenitors And Is Required For Pdc Development In Vivo, Xiaodi Wu, Ansuman T. Satpathy, Wumesh Kc, Pentao Liu, Theresa L. Murphy, Kenneth M. Murphy

Open Access Publications

No abstract provided.


Antibody Responses In Humans Infected With Newly Emerging Strains Of West Nile Virus In Europe, Stefan Chabierski, Gustavo R. Makert, Alexandra Kerzhner, Luisa Barzon, Petra Fiebig, Uwe G. Liebert, Anna Papa, Justin M. Richner, Matthias Niedrig, Michael S. Diamond, Giorgio Palu, Sebastian Ulbert Jan 2013

Antibody Responses In Humans Infected With Newly Emerging Strains Of West Nile Virus In Europe, Stefan Chabierski, Gustavo R. Makert, Alexandra Kerzhner, Luisa Barzon, Petra Fiebig, Uwe G. Liebert, Anna Papa, Justin M. Richner, Matthias Niedrig, Michael S. Diamond, Giorgio Palu, Sebastian Ulbert

Open Access Publications

No abstract provided.


Central Nervous System Pathology Progresses Independently Of Kc And Cxcr2 In Globoid-Cell Leukodystrophy, Adarsh S. Reddy, Jigisha R. Patel, Carole Vogler, Robyn S. Klein, Mark S. Sands Jan 2013

Central Nervous System Pathology Progresses Independently Of Kc And Cxcr2 In Globoid-Cell Leukodystrophy, Adarsh S. Reddy, Jigisha R. Patel, Carole Vogler, Robyn S. Klein, Mark S. Sands

Open Access Publications

No abstract provided.