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2013

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Articles 14281 - 14310 of 19719

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Modulation Of Cd8+ T Cell Responses To Aav Vectors With Igg-Derived Mhc Class Ii Epitopes, Daniel J. Hui, Etiena Banser-Tschakarjan, Yifeng Chen, Robert J. Davidson, George Buchlis, Mustafa Yazicioglu, Gary C. Pien, Jonathan D. Finn, Virginia Haurigot, Alex Tai, David W. Scott, Leslie P. Cousens, Shangzhen Zhou, Anne S. De Groot, Federico Mingozzi Jan 2013

Modulation Of Cd8+ T Cell Responses To Aav Vectors With Igg-Derived Mhc Class Ii Epitopes, Daniel J. Hui, Etiena Banser-Tschakarjan, Yifeng Chen, Robert J. Davidson, George Buchlis, Mustafa Yazicioglu, Gary C. Pien, Jonathan D. Finn, Virginia Haurigot, Alex Tai, David W. Scott, Leslie P. Cousens, Shangzhen Zhou, Anne S. De Groot, Federico Mingozzi

Institute for Immunology and Informatics Faculty Publications

Immune responses directed against viral capsid proteins constitute a main safety concern in the use of adeno-associated virus (AAV) as gene transfer vectors in humans. Pharmacological immunosuppression has been proposed as a solution to the problem; however, the approach suffers from several potential limitations. Using MHC class II epitopes initially identified within human IgG, named Tregitopes, we showed that it is possible to modulate CD8+ T cell responses to several viral antigens in vitro. We showed that incubation of peripheral blood mononuclear cells with these epitopes triggers proliferation of CD4+CD25+FoxP3+ T cells that …

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Making Vaccines "On Demand", Anne S. De Groot, Leo Einck, Leonard Moise, Michael Chambers, John Ballantyne, Robert W. Malone, Matthew Ardito, William Martin Jan 2013

Making Vaccines "On Demand", Anne S. De Groot, Leo Einck, Leonard Moise, Michael Chambers, John Ballantyne, Robert W. Malone, Matthew Ardito, William Martin

Institute for Immunology and Informatics Faculty Publications

The integrated US Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) has made great strides in strategic preparedness and response capabilities. There have been numerous advances in planning, biothreat countermeasure development, licensure, manufacturing, stockpiling and deployment. Increased biodefense surveillance capability has dramatically improved, while new tools and increased awareness have fostered rapid identification of new potential public health pathogens. Unfortunately, structural delays in vaccine design, development, manufacture, clinical testing and licensure processes remain significant obstacles to an effective national biodefense rapid response capability. This is particularly true for the very real threat of “novel pathogens” such as the avian-origin influenzas H7N9 …

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Degradation Of Mangrove Tissues By Arboreal Termites (Nasutitermes Acajutlae) And Their Role In The Mangrove C Cycle (Puerto Rico): Chemical Characterization And Organic Matter Provenance Using Bulk Δ13C, C/N, Alkaline Cuo Oxidation‐Gc/Ms, And Solid‐State 13C Nmr, Christopher H. Vane, Alexander W. Kim, Vicky Moss-Hayes, Collin E. Snape, Miguel Castro Diaz, Nicole S. Khan, Simon E. Engelhart, Benjamin P. Horton Jan 2013

Degradation Of Mangrove Tissues By Arboreal Termites (Nasutitermes Acajutlae) And Their Role In The Mangrove C Cycle (Puerto Rico): Chemical Characterization And Organic Matter Provenance Using Bulk Δ13C, C/N, Alkaline Cuo Oxidation‐Gc/Ms, And Solid‐State 13C Nmr, Christopher H. Vane, Alexander W. Kim, Vicky Moss-Hayes, Collin E. Snape, Miguel Castro Diaz, Nicole S. Khan, Simon E. Engelhart, Benjamin P. Horton

Geosciences Faculty Publications

Arboreal termites are wood decaying organisms that play an important role in the first stages of C cycling in mangrove systems. The chemical composition of Rhizophora mangle, Avicennia germinans, and Laguncularia racemosa leaf, stem, and pneumatophore tissues as well as associated sediments was compared to that of nests of the termite Nasutitermes acajutlae. Nests gave δ13C values of −26.1 to −27.2‰ (±0.1) and C/N of 43.3 (±2.0) to 98.6 (±16.2) which were similar to all stem and pneumatophores but distinct from mangrove leaves or sediments. Organic matter processed by termites yielded lignin phenol …

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Regulatory T Cell Epitopes (Tregitopes) In Igg Induce Tolerance In Vivo And Lack Immunogenicity Per Se, Yan Su, Robert Rossi, Anne S. De Groot, David W. Scott Jan 2013

Regulatory T Cell Epitopes (Tregitopes) In Igg Induce Tolerance In Vivo And Lack Immunogenicity Per Se, Yan Su, Robert Rossi, Anne S. De Groot, David W. Scott

Institute for Immunology and Informatics Faculty Publications

Tregitopes are a set of epitopes, derived from IgG, that bind to MHCII, activate nTregs, and promote tolerance. We have now confirmed that coadministration of Tregitopes with a range of proteins (autoantigens and nominal antigens, such as OVA) in vitro and in vivo leads to suppression of T cell and antibody responses to the test antigens. In this study, we demonstrate that Tregitopes are not immunogenic in vivo even when emulsified with strong adjuvants, such as IFA or CFA. Moreover, in vivo administration of Tregitopes with IFA or CFA does not induce Th1 or Th2 cytokine expression under restimulation conditions …

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Communication And Language Recovery In People With Aphasia: Using Gestures In Speech-Language Therapy, Amanda M. Mokaya Jan 2013

Communication And Language Recovery In People With Aphasia: Using Gestures In Speech-Language Therapy, Amanda M. Mokaya

Research Papers

No abstract provided.

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Animal-Assisted Therapy And The Child-Animal Bond: Children's Well-Being And Behavior, Connie I. Jacobs Jan 2013

Animal-Assisted Therapy And The Child-Animal Bond: Children's Well-Being And Behavior, Connie I. Jacobs

Research Papers

No abstract provided.

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Examining The Role Of Interagency Coordination When Addressing Flood Risk Management And Flood Disasters In Southern Illinois, Irene J. Upson Jan 2013

Examining The Role Of Interagency Coordination When Addressing Flood Risk Management And Flood Disasters In Southern Illinois, Irene J. Upson

Research Papers

No abstract provided.

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What Was Wrong With The Record?, Ellen D. Katz Jan 2013

What Was Wrong With The Record?, Ellen D. Katz

Articles

Shelby County v. Holder offers three reasons for why the record Congress amassed to support the 2006 reauthorization of the Voting Rights Act (VRA) was legally insufficient to justify the statute's continued regional application: (1) the problems Congress documented in 2006 were not as severe as those that prompted it to craft the regime in 1965; (2) these problems did not lead Congress to alter the statute's pre-existing coverage formula; and (3) these problems did not exclusively involve voter registration and the casting of ballots.

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The Eternal Present: Slow Knowledge And The Renewal Of Time, Douglas E. Christie Jan 2013

The Eternal Present: Slow Knowledge And The Renewal Of Time, Douglas E. Christie

Theological Studies Faculty Works

No abstract provided.

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‘Jesus Wept’: Mourning As Imitation Of Christ In Bernard’S Sermon Twenty-Six On The Song Of Songs, Anna Harrison Jan 2013

‘Jesus Wept’: Mourning As Imitation Of Christ In Bernard’S Sermon Twenty-Six On The Song Of Songs, Anna Harrison

Theological Studies Faculty Works

No abstract provided.

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Cortical Thickness In Amnestic Mild Cognitive Impairment And Its Relationships With Neuropsychological Functioning And Financial Capacity, Jacquelynn Nicosia Copeland Jan 2013

Cortical Thickness In Amnestic Mild Cognitive Impairment And Its Relationships With Neuropsychological Functioning And Financial Capacity, Jacquelynn Nicosia Copeland

All ETDs from UAB

Diagnostic criteria for amnestic mild cognitive impairment (aMCI) include subjective memory complaint, objective memory impairment, preserved general cognitive function, intact functional abilities, and absence of dementia diagnosis (Petersen, 2004). However, there is evidence to suggest that some aMCI patients show declines in complex instrumental activities of daily living. Under the conceptual model proposed in this study, neuropathological changes occurring in the brain of aMCI and Alzheimer's disease (AD) patients underlie specific forms of neurocognitive dysfunction, which in turn drive decline in everyday functional skills such as financial capacity. The current study examined the relationships between structural brain changes in aMCI, …

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Tuberculosis Verrucosa Cutis In A Patient With Keloid Over Ear Lobule, Muhammad Sohail Halim, Sadaf Qadeer Ahmed, Montasir Junaid, Muhammad Rizwan Bashir Jan 2013

Tuberculosis Verrucosa Cutis In A Patient With Keloid Over Ear Lobule, Muhammad Sohail Halim, Sadaf Qadeer Ahmed, Montasir Junaid, Muhammad Rizwan Bashir

Section of Otolaryngology, Head & Neck Surgery

Tuberculosis (TB) is a global health problem with predominance in resource-poor countries. Extrapulmonary TB constitutes approximately 10% of the cases and can present as different forms depending on the route of entry. Cutaneous TB is a small subset of the extrapulmonary TB. Cutaneous TB can either be of primary origin or secondary origin or it can be a part of a systemic infection. TB verrucosa cutis (TBVC) is the exogenous reinfection of TB in a previously sensitised patient. Routine cultures do not have a high yield in TBVC due to the paucibacillary nature of the organism. Here we are presenting …

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Msx1 Mutations And Their Binding Interactions, Divakar Prakash Jan 2013

Msx1 Mutations And Their Binding Interactions, Divakar Prakash

All ETDs from UAB

Orofacial clefting (OFC), also called cleft lip and/or palate, is the most common congenital birth anomaly that involve the craniofacial region in humans. The etiology of Non-Syndromic OFC (NS-OFC) is complex and multifactorial; a slew of genetic mutations, standing alone or in combinations, along with several environmental factors, play a major role in the disease process. Numerous linkage and association studies in humans, as well as expression studies and knockout mouse models, have implicated Muscle segment homeobox gene 1 (MSX1), which encodes a homeodomain/DNA binding domain (HD) containing transcription factor as a strong candidate contributing to NS-OFC and Tooth Agenesis …

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The Role Of Complement In Experimental Cerebral Malaria, Theresa N. Ramos Jan 2013

The Role Of Complement In Experimental Cerebral Malaria, Theresa N. Ramos

All ETDs from UAB

Cerebral malaria (CM) is one of the most severe clinical complications of P. falciparum malaria with a fatality rate of 15-30%, and 10% of CM survivors have permanent neurological sequelae. Since inflammation is a central pathophysiological tenet of CM, we began examining the role of the complement system in pathogenesis of experimental cerebral malaria (ECM) using Plasmodium berghei ANKA (PbA) model. Previous studies using this model indicated that mice naturally deficient in complement component C5 were protected from cerebral complications, and wild type mice treated with anti-C5aR antibody were also protected. To determine the protective mechanism of naturally-C5 deficient mice, …

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Commensal Microbiota And Its Impact On Health And Autoimmune Diabetets, Kyle James Wolf Jan 2013

Commensal Microbiota And Its Impact On Health And Autoimmune Diabetets, Kyle James Wolf

All ETDs from UAB

Environmental exposures such as diet, use of antibiotics, and lifestyle have significant impact on the health of an individual. One mechanism that acts as a major pathway in these environmental exposures is the role intestinal commensal microbiota play in both metabolic and immunological responses. Metabolic pathways are altered through changes in metabolites provided by commensal microbiota; alterations in microbial make-up can have drastic impacts on metabolic function. Similarly, the development and maturation of the immune system is dependent on the intestinal microbes to induce tolerance and act as both an immune modulator as well as a barrier against pathogens. We …

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Sulindac Sulfide Amide As A Novel Agent For The Prevention And Treatment Of Lung Cancer, Evrim Gurpinar Jan 2013

Sulindac Sulfide Amide As A Novel Agent For The Prevention And Treatment Of Lung Cancer, Evrim Gurpinar

All ETDs from UAB

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac sulfide (SS) have shown promising antineoplastic activity in multiple tumor types, but toxicities resulting from cyclooxygenase (COX) inhibition limit their use in cancer prevention. We recently described a N,N-dimethylethyl amine derivative of SS, sulindac sulfide amide (SSA), that does not inhibit COX-1 or -2, yet displays potent tumor cell growth inhibitory activity. Here, we studied the basis for the growth inhibitory effects of SSA on human lung adenocarcinoma cell lines and evaluated its preclinical pharmacology. SSA potently inhibited the growth of lung tumor cells with IC50 values of 2-5 μ compared with 44-52 …

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Clinical Consequences Of Micrornas In Colorectal Cancer, Liselle C. Bovell Jan 2013

Clinical Consequences Of Micrornas In Colorectal Cancer, Liselle C. Bovell

All ETDs from UAB

Colorectal cancer (CRC) is a heterogeneous disease, and factors such as tumor location, the environment, genetics, and ethnic differences, can influence its development and progression. Over the last few decades, overall CRC mortality rates have declined; however, racial disparities in mortality rates have increased. The discovery of biomarkers that focus on identifying individual differences based on confounders such as tumor stage and patient race/ethnicity is needed, for such biomarkers can lead to development of personalized therapeutic approaches to target these molecules. MicroRNAs (miRNAs) are a class of small molecules that regulate genes at the post-transcriptional level. Altered miRNA expression levels …

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Repellency Efficacy Of Essential Oils Of Selected Plants Growing In Western Kenya And Their Eag-Active Constituent Blends Against Anopheles Gambiae, David Otieno Ywaya Jan 2013

Repellency Efficacy Of Essential Oils Of Selected Plants Growing In Western Kenya And Their Eag-Active Constituent Blends Against Anopheles Gambiae, David Otieno Ywaya

All Master’s Theses

Control of disease vectors by use of synthetic chemical pesticides has been associated with a series of problems, including resistance development, environmental pollution, and safety risks for humans and domestic animals. Plant-based products have been used for generations in traditional practices to control different arthropods. These have been used in space or personal protection either to repel the arthropods from distance or to deter them from blood-feeding on contact. In the present study, the repellence of essential oils of three plants (Ocimum gratissimum L., Vitex keniensis Turill and Hyptis suaveolens (L.) Poit used in Siaya County in western Kenya were …

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Work And Life Harmony: An Exploratory Case Study Of Entrepinays, Divina M. Edralin Jan 2013

Work And Life Harmony: An Exploratory Case Study Of Entrepinays, Divina M. Edralin

DLSU Business & Economics Review

This study aims to explore how Filipina entrepreneurs (EntrePinays) harmonize their work demands with their family responsibilities and personal needs in order to sustain their business and at the same time live a meaningful and happy life. As an exploratory study utilizing nine participants, the case study approach based on the multiple case dimensions was used. Findings revealed that there are positive and negative spillover effects of work-life relationships. The negative spillover induces stress among the EntrePinays and the positive spillover can lead to their high levels of life satisfaction. Results also showed that EntrePinays are able to harmonize their …

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Better Ways To Study Regulatory Elephants, Jonathan B. Wiener, Brendon Swedlow, James K. Hammitt, Michael D. Rogers, Peter H. Sand Jan 2013

Better Ways To Study Regulatory Elephants, Jonathan B. Wiener, Brendon Swedlow, James K. Hammitt, Michael D. Rogers, Peter H. Sand

Faculty Scholarship

No abstract provided.

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Annual Report Of The Risd Fleet Library 2012-2013, Fleet Library, Carol Terry Jan 2013

Annual Report Of The Risd Fleet Library 2012-2013, Fleet Library, Carol Terry

Annual Reports

No abstract provided.

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Animal Science E-Newsletter, January 2013, University Of Arkansas, Fayetteville. Department Of Animal Sciences Jan 2013

Animal Science E-Newsletter, January 2013, University Of Arkansas, Fayetteville. Department Of Animal Sciences

Animal Science e-Newsletter

No abstract provided.

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Cupola, 2013, Western New England University Jan 2013

Cupola, 2013, Western New England University

Yearbooks

Western New England University was founded in 1919 as the Springfield Division of Northeastern University. The senior yearbooks bore the name of Northeastern University in some way until 1953. The yearbook was given its present day title, The Cupola, in 1961. Yearbooks contain photos of graduating seniors, campus events, student clubs and organizations, faculty and staff, athletic teams and events, and other memorable occasions from the academic year.

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Welcome To The Doll House, Francie Latour, Risd Xyz Jan 2013

Welcome To The Doll House, Francie Latour, Risd Xyz

RISD XYZ Fall/Winter 2013: Out of Bounds

From the Barbie dresses he made as a boy to his first splash in the New York art world, Martín Gutierrez 12 PR is working to perfect what he has always done naturally.

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Risd Xyz Fall/Winter 2013/14: Out Of Bounds | Full Issue, Liisa Silander Jan 2013

Risd Xyz Fall/Winter 2013/14: Out Of Bounds | Full Issue, Liisa Silander

RISD XYZ Fall/Winter 2013: Out of Bounds

ARTISTS AND DESIGNERS TEND TO QUESTION, PUSH, CHALLENGE, take risks—as part of the pure pleasure of making. These are things you’re expected to do, just as you’re expected to think outside the box, color outside the lines, question the rules, defy expectations. The freedom of thought art and design offer may be what has inspired people to make objects of beauty and wonder since well before we began writing and recording our own history. Yet, as liberating as it sounds, that freedom is also a challenge. As alums you know how to probe and ponder, and deliberately work with materials …

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Toward A Sustainable Future: An Environmental Agenda For The Second Term Of The Obama Administration, David M. Uhlmann Jan 2013

Toward A Sustainable Future: An Environmental Agenda For The Second Term Of The Obama Administration, David M. Uhlmann

Other Publications

Much was at stake in the Presidential election of 2012, which was marked by heated debate over the trajectory of the economy, the expiration of the Bush tax cuts, and the fat of the President's health care plan. The candidates disagreed about nearly every issue from foreign policy and the war on terror to a woman's right to choose and same-sex marriage. Lost amid the din and never mentioned in the Presidential debates or most of the campaign speeches was another divisive topic: how our environmental laws and policies should address global climate change and chart a sustainable future for …

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Biodiesel Production From Candlenut And Calodendrum Capense Seeds: Process Design And Technological Assessment, Dennis Mogire Ndaya Jan 2013

Biodiesel Production From Candlenut And Calodendrum Capense Seeds: Process Design And Technological Assessment, Dennis Mogire Ndaya

All Master’s Theses

This project was based on biodiesel production from candlenut and calodendrum capense seeds using conventional and biotechnological technique and determination of the oil yields and biodiesel quality. The driving force for large-scale use of biodiesel has been the need to reduce the harmful emissions that result from the burning of petroleum oil as well as our dependence on diminishing reserves of petroleum oil. The aim of the study was to extract oil from Candlenut tree and Calodendrum capense seeds using conventional techniques and determine conditions for optimum oil yields. The oil from the two non-edible plant feedstocks was obtained using …

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Characterization Of Flavonoids From Candidate Striga Weed Controlling Food Legumes; Cicer Arietinum L. And Vigna Radiata L., Anna Akumu Anyango Jan 2013

Characterization Of Flavonoids From Candidate Striga Weed Controlling Food Legumes; Cicer Arietinum L. And Vigna Radiata L., Anna Akumu Anyango

All Master’s Theses

In Africa, intercropping of some legumes with cereal crops has been found to cause remarkable reduction of Striga infestation and improved production of cereal crop. Desmodium uncinatum controls Striga infestation in intercrop with cereals through an allelopathic mechanism, which involves post-germination growth inhibitors exuded from the roots. Allelopathy is a natural and environmentally friendly technique, which has a potential to be a new approach for weed control. A standardized profiling method based on Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) and Liquid Chromatography coupled with Mass Spectrometry (LC/MS) was used to identify flavonoids in extracts of chickpea (Cicer arietinum) and mung …

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Current Approaches In Chemical Ecology Using Regionally Adapted Sustainable Methods, Eva Winter Jan 2013

Current Approaches In Chemical Ecology Using Regionally Adapted Sustainable Methods, Eva Winter

All Master’s Theses

Kenya is an African developing country situated at the equator ranking 157th of 177 countries in the human development index. Agriculture is next to tourism the most important economic sector with 24 % of the GDP. Poverty prevalence is highest with small holder farmers. A promissing approach to reduce this precarious condition is the implementation of organic agriculture. 1. Establishment of certified organic cash crop production for a domestic and/or an export market and 2. dissemination of common methods in organic agriculture to subsistently living small holder farmers are the two major strategies of the approach. Both have different positive …

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Responses To Pyrethroids In Heavy Metal Tolerant Anopheles Gambiae Vector Of Malaria, Fauzia Khagai Musasia Jan 2013

Responses To Pyrethroids In Heavy Metal Tolerant Anopheles Gambiae Vector Of Malaria, Fauzia Khagai Musasia

All Master’s Theses

Anopheles gambiae mosquito, the principle Afro-tropical vector of malaria, has been documented in habitats with heavy metals in excess of natural loads. The mosquito has also displayed resistance to most conventional insecticides, and potential to resist challenges by heavy metals. Investigations were conducted in strains of An. gambiae ss, in which tolerance to cadmium and lead heavy metals were established. This study was undertaken to determine any putative relationship between tolerance to (cadmium and lead) heavy metals, and resistance to pyrethroid insecticide in An. gambiae. Tolerance to cadmium and lead heavy metals was developed in larval stages and this development …

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