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2013

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Biological Effects Of Trogocytosis On Cd4+ T Lymphocytes, Douglas Grant Osborne Jan 2013

Biological Effects Of Trogocytosis On Cd4+ T Lymphocytes, Douglas Grant Osborne

Graduate Student Theses, Dissertations, & Professional Papers

Antigen recognition by CD4+ T cells leads to large-scale spatial and temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological synapse. The mechanism and biological significance of this process, termed trogocytosis, is still unclear. In this thesis I examined the impact that trogocytosis has on the individual T cell after capturing molecules from the antigen presenting cell. I employed murine fibroblast cell lines expressing an I-Ek molecule loaded with a covalently attached antigenic peptide (moth cytochrome C 88-103) and with or without …

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Care And Companionism: Animal Ethics At The End Of Life, Casie Jean Dunleavy Jan 2013

Care And Companionism: Animal Ethics At The End Of Life, Casie Jean Dunleavy

Graduate Student Theses, Dissertations, & Professional Papers

In this philosophical project, I discuss the different kinds of companion animal and human relations, or in other words, and provide an argument that specifies our ethical obligations to the animals we live with—-our ‘pets.’ In the first chapter, I suggest that there are three types of relationships that humans can have with animals. These are a relation of instrumentalism, paternalism, and companionism, respectively. Such relations rest along a spectrum, but I will argue that companionism is the ideal. After making and defending such conceptual distinctions between human-animal relations, the next chapter will tackle the problem of animal minds. Specifically, …

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Changes In Litter Inputs And Decomposition In Headwater Streams During A Mountain Pine Beetle Infestation Of Whitebark Pine, Hilary Genevieve Eisen Jan 2013

Changes In Litter Inputs And Decomposition In Headwater Streams During A Mountain Pine Beetle Infestation Of Whitebark Pine, Hilary Genevieve Eisen

Graduate Student Theses, Dissertations, & Professional Papers

Headwater streams in forested landscapes are generally lacking in primary productivity and rely on allochthonous inputs to fuel secondary production. This close association with the forested landscape makes these streams sensitive to terrestrial disturbances. In the Greater Yellowstone Ecosystem (GYE) a climate change induced mountain pine beetle (Dendroctonus ponderosae, MPB) outbreak has been decimating whitebark pine (Picea albicaulis, WbP) forests over an extremely short time period. Among the possible implications of widespread WbP die-off, I predicted an increase in litter inputs to headwater streams and an increase in the quality (nitrogen content) of these litter inputs both of which would …

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Climate As Assemblage: Imagining An Ecological Metaphysic, Andrea Rae Gammon Jan 2013

Climate As Assemblage: Imagining An Ecological Metaphysic, Andrea Rae Gammon

Graduate Student Theses, Dissertations, & Professional Papers

Human interventions have resulted in striking changes to the global climate. I work from the understanding of anthropogenic climate change as the product of 250 years of emissions brought about through industrialization and continued by our fossil fuel economies and lifestyles. The instrumentalism of such activities can be traced back to our modern metaphysic, where inanimate matter becomes object and falls away from ‘man,’ the knowing, active subject. In this thesis, I specifically address how this division of passive object from active subject pervades our understanding of climate and conditions the ethics of our human responses to climate change. I …

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Comparison Of Wild-Domestic Sheep Interaction Policies In Bighorn Disease Outbreak Locations In The Continental U.S., 1990-2010, Tristan Howard Jan 2013

Comparison Of Wild-Domestic Sheep Interaction Policies In Bighorn Disease Outbreak Locations In The Continental U.S., 1990-2010, Tristan Howard

Graduate Student Theses, Dissertations, & Professional Papers

For over 100 years, disease has significantly limited bighorn sheep (Ovis canadensis) in the western U.S. Interaction with domestic sheep (Ovis aries) has been a primary cause of fatal bighorn disease (typically pneumonia), which has severely reduced or eliminated entire populations. Various wild-domestic sheep interaction policies exist to address the disease problem. In this analysis, six case study locations are compared and analyzed in an effort to evaluate policy efficacy. Locations examined and their bighorn die-off dates include: the Tobin Range, NV (1991); Aldrich Mountain, OR (1991); the Highland/Pioneer Mountains, MT (1994-1995); the Tarryall/Kenosha Mountains, CO (1997-2000); the Hays Canyon …

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Land-Cover Change Within The Peatlands Along The Rocky Mountain Front, Montana: 1937-2009, Joseph Tyler Milbrath Jan 2013

Land-Cover Change Within The Peatlands Along The Rocky Mountain Front, Montana: 1937-2009, Joseph Tyler Milbrath

Graduate Student Theses, Dissertations, & Professional Papers

Aerial photographs of nine peatlands along the Rocky Mountain Front, Montana, were analyzed in a GIS. The boundary of wetland extent was hand-digitized and the area within was classified into land-cover types including: total area, open fen, open water, woody vegetation, and non-wetland/agriculture. Changes in wetland extent and land-cover categories were evaluated from the earliest available imagery in 1937 to the last available imagery in 2009. Images prior to 1995 were orthorectified to correct inherent distortions. Results indicate little change in overall peatland area between 1937 and 2009 despite increasing air temperatures in the region. Open water area and the …

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Liars Like Him, Samantha Lynne Duncan Jan 2013

Liars Like Him, Samantha Lynne Duncan

Graduate Student Theses, Dissertations, & Professional Papers

This is a collection of short stories, which fall somewhere between the realist and absurdist genres of fiction. Most of them take place in or around Ohio. Birds and humans often appear side by side.

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Locomotor Ontogeny And The Evolution Of Avian Flight, Ashley Margaret Heers Jan 2013

Locomotor Ontogeny And The Evolution Of Avian Flight, Ashley Margaret Heers

Graduate Student Theses, Dissertations, & Professional Papers

Understanding the origins of organismal diversity is one of biology's most enduring quests. Many authors have posited that modularity, or the developmental decoupling of body parts into discrete functional units, facilitates adaptive radiation by allowing body parts to become independently and functionally specialized without compromising one another. This may be particularly true in birds, which have compartmentalized the single locomotor unit of their ancestors into discrete wing and leg locomotor modules, and exploited terrestrial and aerial environments. Specializing one set of limbs for terrestrial locomotion and one set for flight presumably facilitates navigation of aerial environments without compromising terrestrial locomotion, …

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Narrative Reflection And Anatomical Introspection In Thomas Carlyle's Sartor Resartus And Herman Melville's Moby Dick, Torey Elizabeth Davie Jan 2013

Narrative Reflection And Anatomical Introspection In Thomas Carlyle's Sartor Resartus And Herman Melville's Moby Dick, Torey Elizabeth Davie

Graduate Student Theses, Dissertations, & Professional Papers

Thomas Carlyle’s Sartor Resartus (1831) and Herman Melville’s Moby Dick or, the Whale (1851) combine the novel and the anatomy, creating a plot as well as a reflection on the human condition. The result of this combination produces a narrator whose single-minded focus on an object both propels events forward while at the same time stalling the progress of a traditional plot. The aspects of the text that connect to the novel, such as character and plot, offer a reflection of the effect truth and society have on character. Aspects that connect to the anatomy, such as the exhaustive knowledge …

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Novel Ribosome Biogenesis In The Lyme Disease Spirochete Borrelia Burgdorferi, Melissa Lynn Hargreaves Jan 2013

Novel Ribosome Biogenesis In The Lyme Disease Spirochete Borrelia Burgdorferi, Melissa Lynn Hargreaves

Graduate Student Theses, Dissertations, & Professional Papers

Here we demonstrate the first characterization of an RNase III enzyme from a spirochete and its role in processing rRNA transcripts from the unusual rRNA gene operons of Borrelia burgdorferi. In most bacteria, the three rRNA transcripts (16S, 23S, and 5S rRNAs) that form the ribosome are produced as a single transcript from an operon with minimal spacing between genes. In the B. burgdorferi genome, however, a single 16S rRNA gene is encoded more than 3 kb from the bicistronic 23S-5S rRNA operons. The 23S-5S operons are tandemly duplicated, yielding an uneven number of rRNA genes, a feature unique to …

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Only From Montana: A Family's Experience Eating Locally, Emily Joan Wendler Jan 2013

Only From Montana: A Family's Experience Eating Locally, Emily Joan Wendler

Graduate Student Theses, Dissertations, & Professional Papers

This is a 30-minute radio documentary on one family’s experience eating all locally grown food, for two weeks in September of 2012, and two weeks during January 2013. For the project we considered locally grown food as food grown and processed in Montana. If the food was grown here, then left to be processed in another state, it did not count as local. The participants were a family of three from Missoula, Montana—a Mom, Dad, and their 2-year-old son. The point of the project was to answer the question: What is it like for a family, who normally does not …

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Development Of Cell-Based Functional Assays To Identify And Characterize Novel Gabab Receptor Allosteric Modulators, Maria De Lourdes Aitken Jan 2013

Development Of Cell-Based Functional Assays To Identify And Characterize Novel Gabab Receptor Allosteric Modulators, Maria De Lourdes Aitken

Harriet L Wilkes Honors College Theses 2010 - 2019

Dysfunction of GABAB-receptor (GABAB-R)-mediated synaptic transmission underlies various nervous system disorders including epilepsy, depression, schizophrenia, and addiction. Currently, only one GABAB-R orthosteric ligand is in clinical use. However, side effects such as sedation, tolerance, and motor impairment limit its use. A dissociation of the therapeutic effects from the side effects may be achievable with drugs enhancing the endogenous physiological cellular response. The development of GABAB-R allosteric modulators has provided new modes of efficacy that may facilitate the development of novel therapeutic agents. In the present study, we investigated the effects of novel, newly synthesized GABAB-R allosteric ligands using a HEK-293 …

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Aliens Are Animals Too! Ethics And Stigmatization Within Invasive Species Rhetoric, Gina A. Brockway Jan 2013

Aliens Are Animals Too! Ethics And Stigmatization Within Invasive Species Rhetoric, Gina A. Brockway

Harriet L Wilkes Honors College Theses 2010 - 2019

Management of nonnative invasive species (NIS) frequently involves removing animals or plants from an area in order to conserve native communities. Methods of removing invasive animals include killing individuals, justified as a means of protecting broader ecological values. This management approach, however, is often controversial and highlights differences between discourses of environmental and animal rights. The former values life at a holistic level while the latter emphasizes the value of individual lives. Language both reflects and shapes belief and action, and to assess these divergent views, I compare invasive species rhetoric of a prominent environmental organization with that of an …

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The Importance Of Sea Turtle Conservation On Nesting Trends Of Sea Turtles Along Florida’S Atlantic Coast: 1982--‐2012, Barbara Cody Jan 2013

The Importance Of Sea Turtle Conservation On Nesting Trends Of Sea Turtles Along Florida’S Atlantic Coast: 1982--‐2012, Barbara Cody

Harriet L Wilkes Honors College Theses 2010 - 2019

Sea turtles have been an important factor of the world’s oceans for millions of years. Until about 100 years ago, they were not protected at all, and in the last 40 years they have received greater protection. This increase in protection, along with conservation efforts of organizations around the globe, has contributed to increased nesting trends for at least Florida’s three main species of sea turtles: Loggerhead(Caretta caretta), Green (Chelonia mydas), and Leatherback (Dermochelys coriacea). These three species have all had a positive increase in nesting activity along Florida’s Atlantic coast since 1989. This rise in nesting activity can be …

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Seasonal Effects On The Prevalence And Intensity Of The Parasite Bonamia Spp. In Bivalves From The Indian River Lagoon, Kaitlin Gallagher Jan 2013

Seasonal Effects On The Prevalence And Intensity Of The Parasite Bonamia Spp. In Bivalves From The Indian River Lagoon, Kaitlin Gallagher

Harriet L Wilkes Honors College Theses 2010 - 2019

Bonamia spp., a haplosporidian protistan parasite, was first reported in Florida in 2007 in oyster species cultured at Harbor Branch Oceanographic Institute in water from the Indian River Lagoon. Previous research (summer 2010 and 2011) evaluated prevalence and intensity of infections in IRL bivalve species. This study seeks to examine the seasonal effect on parasite prevalence and infection intensity. Bivalves from three sites in the IRL were sampled summer, fall, and winter 2012. Prevalence (general and species specific) was evaluated using PCR. Intensity of infection was evaluated using fluorescent in situ hybridization. Highest prevalence (31.9-48.9%) was seen at all three …

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Feminist Environmental Justice: Confronting Legacies Of Racial Segregation In Jupiter, Florida, Britni Hiatt Jan 2013

Feminist Environmental Justice: Confronting Legacies Of Racial Segregation In Jupiter, Florida, Britni Hiatt

Harriet L Wilkes Honors College Theses 2010 - 2019

Despite pervasive claims that the United States is a ‘post-racial’ society, racial segregation did not end after Jim Crow and the Civil Rights movement. Today, environmentally hazardous zoning and biotechnology land developments continue to determine which families are most exposed to risks of pollution and displacement, and which families are not. Utilizing documentation of local history and research in Women’s Studies, Eco-Feminism, and Critical Race Studies, I examine the legacy of racial segregation in Jupiter, Florida, by charting the biotechnology ‘cluster’ encroaching upon the historical Limestone Creek community. In this feminist analysis are challenges to assumptions about race, gender, class, …

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A Critical Feminist Science Studies Critique Of The Term 'Pseudoscience', Zoe Lewycky Jan 2013

A Critical Feminist Science Studies Critique Of The Term 'Pseudoscience', Zoe Lewycky

Harriet L Wilkes Honors College Theses 2010 - 2019

Using a Critical Feminist Science Studies perspective, I examine how the term 'pseudoscience’ rewrites science’s history, preventing science from being held accountable for its power structures and hierarchical narratives. I first examine the historical and cultural origins of science, the figure of the scientist, and 'objectivity.' Then, I explore science's obsession with the body in the many works and theories that have been developed since its origination in the seventeenth century. Finally, I apply critical feminist science studies to Michael Shermer's usage of the word 'pseudoscience' in his book, Why People Believe Weird Things. My proposed solution is that we …

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Using Oral Cancer Cell Line Upci: Scc078 To Purify Numa Protein, Ana Rodrigues Jan 2013

Using Oral Cancer Cell Line Upci: Scc078 To Purify Numa Protein, Ana Rodrigues

Harriet L Wilkes Honors College Theses 2010 - 2019

Formation of multipolar spindles is closely linked to increased genomic instability and tumor progression. Centrosome hyperamplification is insufficient to initiate this mitotic defect, centrosome coalescence must be interrupted. Studies have indicated that cytoplasmic dynein is a key factor in preventing multipolarity, and overexpression of the NuMA protein is sufficient to mislocalize dynein from the spindle and abrogate the coalescence machinery. Because the mechanism by which NuMA can inhibit dynein is unclear, we are purifying NuMA to use in in vitro studies, to better understand how NuMA blocks dynein activity. Purifying NuMA from recombinant sources has not been successful; therefore we …

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Household Organization In The Fur Trade Era: Socioeconomic And Spatial Organizations Of Housepit 54, Alexandra Christine Williams Jan 2013

Household Organization In The Fur Trade Era: Socioeconomic And Spatial Organizations Of Housepit 54, Alexandra Christine Williams

Graduate Student Theses, Dissertations, & Professional Papers

Households are fundamental units of society that possess powerful explanatory potential; however, few studies have approached household organization during the critical contact period within the Mid-Fraser Canyon. The 2012 excavation of Bridge River’s Housepit 54 (HP 54) offers a rare opportunity to investigate such socioeconomic relationships and their spatial manifestations. Hypotheses structured with a household archaeology theoretical framework emphasize household socioeconomic strategies. The first hypothesis outlines a network strategy characterized by greater centralization of power, hierarchical complexity, and material-wealth that is reflected in residential units with individual features and disparate accumulations of prestige goods and high utility resources. Such floor …

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Imagining Boundaries: (Post) Humanist Understandings And Ecological Ethics In The Fiction Of Margaret Atwood, Megan Kathleen Telligman Jan 2013

Imagining Boundaries: (Post) Humanist Understandings And Ecological Ethics In The Fiction Of Margaret Atwood, Megan Kathleen Telligman

Graduate Student Theses, Dissertations, & Professional Papers

Atwood’s concern for the environment has spanned nearly the entirety of her career, informing her fears about the future and providing the grounding for her speculative fiction. In Atwood’s understanding, ecological ruin stems from human estrangement from the natural environment, an estrangement fortified by capitalism and consumerism in contemporary societies. Instead, she strives to situate the creative, imaginative human species within a larger natural order that inspires ethical treatment of the more-than-human world. Atwood attempts to provide us with a model of interconnection and respect for nature that we must imagine if we desire to avoid the apocalyptic future she …

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The Blackfoot Demonstrative System: Function, Form, And Meaning, Shannon Scott Schupbach Jan 2013

The Blackfoot Demonstrative System: Function, Form, And Meaning, Shannon Scott Schupbach

Graduate Student Theses, Dissertations, & Professional Papers

This thesis presents a comprehensive analysis of the Blackfoot demonstrative system. Previous research on Blackfoot (Uhlenbeck 1938, Taylor 1969, Frantz 2009) identifies sixteen morphemes that make up demonstrative words in the language. I propose a demonstrative template that takes into account the fixed morpheme ordering observed in demonstrative forms. Based on the proposed template, I motivate the analysis of the suffix -ka as encoding motion towards the speaker as this accounts for its position together with the suffixes -ya, -ma, and -hka, each of which encode features of motion or visibility. In describing situational functions of each …

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The Archaeological Investigation Of Cedar Bark Basket Trees In Western Montana: Background, Methods, And Trial Study Of Culturally Modified Trees, Dean Sonneah Nicolai Jan 2013

The Archaeological Investigation Of Cedar Bark Basket Trees In Western Montana: Background, Methods, And Trial Study Of Culturally Modified Trees, Dean Sonneah Nicolai

Graduate Student Theses, Dissertations, & Professional Papers

This thesis explores the potential for archaeological investigations of culturally modified trees (CMTs) in the northern Rocky Mountain region of Western Montana. Culturally modified trees are considered to be living artifacts, representations of traditional culture, and a lasting physical manifestation of long term use by inhabitants. The goal of this thesis is to offer an archaeological perspective for investigation of cultural modifications of the cedar basket tree (Thuja plicata), and to contribute to the development of a method for inquiry and analysis. Two primary research questions were posed: How does the study of behavioral archaeology and the methodological approach presented …

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The Moral Layers Of Fracking: From Basic Rights And Obligations To Human Flourishing, Angela L. Hotaling Jan 2013

The Moral Layers Of Fracking: From Basic Rights And Obligations To Human Flourishing, Angela L. Hotaling

Graduate Student Theses, Dissertations, & Professional Papers

As it is currently being discussed, hydraulic fracturing or “fracking” is the unconventional method of drilling and extracting oil and natural gas. Fracking starts at the earth’s surface where the technology is created and the sites are constructed. The process continues downward: drills pierce thousands of feet vertically and then horizontally underground. Then, millions of gallons of water mixed with sand and chemicals (referred to as “fracking fluid” or “slick water”) are pumped at high pressure through the pipe so as to fracture shale deposits and release gas or oil. Whether to allow fracking and its associated industrial activity is …

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Touch-Screan Mss, Colin Post Jan 2013

Touch-Screan Mss, Colin Post

Graduate Student Theses, Dissertations, & Professional Papers

This is a poetry manuscript that examines the epic form, concrete poetic techniques, and science fiction concepts so as to posit a created world of surfaces.

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Silent Sentinels: Archaeology, Magic, And The Gendered Control Of Domestic Boundaries In New England, 1620-1725, C. Riley Auge Jan 2013

Silent Sentinels: Archaeology, Magic, And The Gendered Control Of Domestic Boundaries In New England, 1620-1725, C. Riley Auge

Graduate Student Theses, Dissertations, & Professional Papers

The following dissertation is an historical archaeological study of the material culture of gendered protective magic used by Anglo-Europeans in seventeenth-century New England as a tactic to construct boundaries that mitigated perceived personal, social, spiritual, and environmental dangers. Such boundary construction was paramount in the seventeenth-century battle between good and evil epitomized by the belief in and struggle against witchcraft. This dissertation sought to answer three interrelated research questions: 1) What constitutes protective magical material culture in seventeenth-century contexts and how is it recognizable in the archaeological record? 2) What signifies gender specific protective magical practices and what can these …

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Striking A Balance: The New Generation Of Tiger Tourism In India, Apoorva Prasanna Joshi Jan 2013

Striking A Balance: The New Generation Of Tiger Tourism In India, Apoorva Prasanna Joshi

Graduate Student Theses, Dissertations, & Professional Papers

In rural central India, thousands of domestic and foreign tourists flock to see wild Bengal tigers each year. An international debate about whether tourism is good or bad for tigers was heard by India’s Supreme Court in 2012. After new guidelines were implemented, tiger reserves across the country had to review and manage their tourism policies. Set 550 miles east of the city of Mumbai, the Tadoba-Andhari tiger reserve is on the cusp of ‘tiger tourism’. The reserve’s eco-tourism policy was recently extended by using it as precedence for other protected areas in the state of Maharashtra. A cap on …

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Surviving Probation: The Challenges Sexual Offenders Are Faced With In Mainstream Society, Krystal Stevenson Jan 2013

Surviving Probation: The Challenges Sexual Offenders Are Faced With In Mainstream Society, Krystal Stevenson

Graduate Student Theses, Dissertations, & Professional Papers

"Society sees us [sexual offenders] as terrible people. Either lock us up or kill us. They don't want us in their community." Sexual offenders are seen as some of the most repulsive criminals through society's eyes. The term "sexual offender" encompasses many different types of people with regards to their crime, but society sees all sexual offenders as child molesters. This causes an over-whelming problem for sexual offenders, specifically in terms of housing, since there are many restrictions on where they can live. Legislation is implementing housing restrictions to prevent these criminals from re-offending, but in some cases, it can …

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Women’S Water, Women’S Work: Evaluating Decentralized Management Of Deep Borehole Wells For Improved Rural Water Access In Tawa Fall Village, Senegal, Tenly Elizabeth Snow Jan 2013

Women’S Water, Women’S Work: Evaluating Decentralized Management Of Deep Borehole Wells For Improved Rural Water Access In Tawa Fall Village, Senegal, Tenly Elizabeth Snow

Graduate Student Theses, Dissertations, & Professional Papers

Throughout the developing world, countries face a number of issues regarding the health and welfare of their populations. One issue that stands out with critical and growing importance is the availability-and accessibility-of water. Across the Sahel, access to potable water for domestic use, as well as contaminant-free water for agricultural and animal husbandry purposes is of growing concern. This study evaluates Government of Senegal efforts at improving rural water access through public-private operation contracts to manage deep groundwater resources. In West Africa, Senegal currently counts itself among the few Sahelian countries having sufficient freshwater supplies to support its population’s growing …

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Getting On Nicely In The Dark: The Perils And Rewards Of Annotating Ulysses, Barbara Nelson Jan 2013

Getting On Nicely In The Dark: The Perils And Rewards Of Annotating Ulysses, Barbara Nelson

Graduate Student Theses, Dissertations, & Professional Papers

The problem of how to provide useful contextual and extra-textual information to readers of Ulysses has vexed Joyceans for years. The debate has generated lively and opinionated discussions in print and at Joyce meetings, forums and listservs. On one side are scholars who argue for scaled-down annotations that present only basic information as simply as possible, minimizing the amount of interpretation involved. On the other side are the actual first-time readers, struggling to make sense of Joyce’s complex, highly allusive text, and willing to accept help wherever it may be found. The work of annotation is both complicated and enriched …

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Here For Life: A Chapter & Stories, Gil Filar Jan 2013

Here For Life: A Chapter & Stories, Gil Filar

Graduate Student Theses, Dissertations, & Professional Papers

Four short stories and a novel chapter.

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