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2012

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"A Very Amusing Bit Of Blasphemy": Honoré Daumier's Histoire Ancienne, Nicole Jordan Jan 2012

"A Very Amusing Bit Of Blasphemy": Honoré Daumier's Histoire Ancienne, Nicole Jordan

All ETDs from UAB

During the early nineteenth century, Neoclassical artists depicted scenes of antiquity, both real and imagined, by exemplifying their nobility and idealism. The first artist to break the walls around this infallible representation was the caricaturist Honoré Daumier (1808-79). Daumier explored the myths and legends of antiquity minus the trappings of a classical education. The result was Histoire ancienne, a series of fifty prints published in Le Charivari between December 1841 and January 1843 that ridiculed the same subjects that artists such as Jean-Auguste-Dominique Ingres (1780-1867) and Jacques-Louis David (1748-1825) exalted. In 1857, critic Charles Baudelaire said of Histoire ancienne, "Daumier …

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Influence Of Surface Treatment Of Y-Tzp And Luting Cements On Retention Of Y-Tzp Crown, Mehdi Karimipour-Saryazdi Jan 2012

Influence Of Surface Treatment Of Y-Tzp And Luting Cements On Retention Of Y-Tzp Crown, Mehdi Karimipour-Saryazdi

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Clinicians for a single tooth restoration, due to improved esthetics, often select all ceramic crowns. Zirconium Oxide has been utilized for many years to full fill the requirement of esthetics, high mechanical properties and biocompatibility. The purpose of this study is to evaluate the effect of different surface treatments and luting agents on retention of a zirconium oxide crown. Material and Methods: Ninety extracted teeth were obtained. Teeth were mounted in Ortho JetTM resin (Lang Dental Manufacturing Co., Inc. IL, USA). Occlusal surface was cut flat using Isomet (Buhler Ltd). Diamond burs were used to cut axial walls under water …

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The Effect Of Structured Background On Smooth Pursuit With Real And Simulated Central Scotoma, Thomas Keith Jan 2012

The Effect Of Structured Background On Smooth Pursuit With Real And Simulated Central Scotoma, Thomas Keith

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The purpose of the study was to better understand the role of the fovea in smooth pursuit eye movements in human subjects. The research entailed a systematical study of a previously unstudied condition where the foveal inputs of both the background and the pursuit target were eliminated through simulation but the anatomic fovea was intact; and a comprehensive study of smooth pursuit eye movements of human subjects with real central scotoma. Ten normally sighted subjects (NS) and three central scotoma subjects (CS) were asked to visually pursuit a 0.87o yellow dot moving along either a horizontal or a vertical trajectory …

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Vote, People, Vote! W.C. Patton, The Naacp, And The Birmingham Black Community, Scott Clifford Kennedy Jan 2012

Vote, People, Vote! W.C. Patton, The Naacp, And The Birmingham Black Community, Scott Clifford Kennedy

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VOTE, PEOPLE, VOTE W.C. PATTON, THE NAACP, AND THE BIRMINGHAM BLACK COMMUNITY HISTORY ABSTRACT With the Civil Rights Movement often portrayed as a movement led from the top down, the career of William C. Patton showed the importance of the efforts of the person on the street. Patton struggled long and hard for voting rights for African Americans, working for the NAACP for years in his efforts to help black Americans gain their civil rights. His lack of national fame does nothing to detract from his untiring efforts on behalf of the rights of black Americans. Born in 1910 in …

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A Study Of The Genetic Mechanisms Used To Regulate The Third Complementarity Determining Region Of The Immunoglobulin H Chain, Mohamed Khass Jan 2012

A Study Of The Genetic Mechanisms Used To Regulate The Third Complementarity Determining Region Of The Immunoglobulin H Chain, Mohamed Khass

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Developing B cells exhibit sequential changes in the representation of immunoglobulin (Ig) heavy (H) chain sequences with excess hydrophobic or charged amino acids in complementarity determining region 3 (CDR-H3). To begin to elucidate the mechanisms by which this process occurs, we used Bromodeoxy Uridine (BrdU) incorporation and Annexin V binding to quantify B cell turnover and cell cycle progression in developing B cell subsets in the bone marrow, spleen and peritoneal cavity of wild-type BALB/c mice. To magnify the effects of hydrophobicity and charge, we included in this analysis mice limited to the use of an IgH allele with a …

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Is P53 A Target Of Hpv-18 E6 In The Viral Life Cycle?, Eun-Young Kho Jan 2012

Is P53 A Target Of Hpv-18 E6 In The Viral Life Cycle?, Eun-Young Kho

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The large family of human papillomaviruses (HPVs) infects the cutaneous or mucosal epithelia causing benign hyper proliferative diseases. Infections by the high-risk (HR) HPV genotypes in the anogenital tracts can progress to high grade lesions and cancers in men and women. Because the viral productive program requires squamous differentiation of epithelia, HPV encodes oncoproteins that recondition the differentiated cells that have withdrawn from the cell cycle to support viral DNA amplification. The HR HPV E6 and E7 oncogenes are selectively expressed in cervical carcinomas and are necessary to maintain the malignant state. In vitro, constitutive expression of the HR HPV …

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Regulation Of Cell Death By Autophagy In Glial Neoplasms, Latika R. Kohli Jan 2012

Regulation Of Cell Death By Autophagy In Glial Neoplasms, Latika R. Kohli

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Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive malignancies of the peripheral nervous system. The majority of MPNSTs arise in patients of the autosomal dominant genetic disorder neurofibromatosis type I (NF1) although they also arise sporadically. In the absence of any effective chemotherapeutic options and with surgery constituting the mainstay of treatment, MPNST patients face an extremely poor prognosis. This underscores the need to develop novel therapeutic strategies against this tumor type. It is well accepted that the crosstalk between autophagy and apoptosis can be exploited to derive maximal therapeutic benefit, especially through combinatorial therapies. However, this interaction is extremely …

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Factors Associated With Posttraumatic Stress Disorder And Mild Traumatic Brain Injury In Veterans Of Operations Iraqi Freedom And Enduring Freedom: The Role Of Neuropsychological Assessment, Donald R. Labbe Jan 2012

Factors Associated With Posttraumatic Stress Disorder And Mild Traumatic Brain Injury In Veterans Of Operations Iraqi Freedom And Enduring Freedom: The Role Of Neuropsychological Assessment, Donald R. Labbe

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Traumatic Brain Injury (TBI) and Posttraumatic Stress Disorder (PTSD) have been referred to as "signature injuries" among veterans of Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF). The aims of the current study were to identify demographic and injury related variables associated with the co-occurrence of mild Traumatic Brain Injury (mTBI) and PTSD and to identify neuropsychological assessment measures that differentiate individuals with mTBI from those with co-occurring mTBI and PTSD. A total of 81 OIF/OEF veterans participated in this study comprising the mTBI (n=21) and combined (n=60) groups. The results of logistic regression analyses indicated that Caucasians were …

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The Effects Of Psychological Stress, Depressive Symptoms, And Cortisol On Body Mass And Central Adiposity In 10-To12-Year-Old Children, Hong-Thuy Lam Jan 2012

The Effects Of Psychological Stress, Depressive Symptoms, And Cortisol On Body Mass And Central Adiposity In 10-To12-Year-Old Children, Hong-Thuy Lam

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The percentage of children with elevated body mass and central adiposity has tripled in the U.S. over the past thirty years. While physical factors, such as decreased physical activity and poor nutrition, have been noted to influence elevated body mass and central adiposity in school-aged children, less is known about psychological factors, such as psychological stress and depressive symptoms, especially in 10-to12-year-old children. Further, it has been suggested that cortisol, a biomarker of psychological stress, plays a role in the underlying mechanism that links psychological stress and depressive symptoms to increased body mass and central adiposity, but this has not …

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Mechanism Of Nfi-C Functionin During Tooth Root Formation, Ejvis Lamani Jan 2012

Mechanism Of Nfi-C Functionin During Tooth Root Formation, Ejvis Lamani

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Currently, very little is known regarding tissue-specific gene regulation during the later stages of tooth development, especially those associated with root formation. Re-cent studies have identified nuclear factor I-C (NFI-C) as a critical factor for root for-mation in mammals. NFI-C functions as a cellular transcription factor and adenovirus DNA replication factor. Its role in root formation first became evident when Nfi-c null mice were shown to lack molar roots. A similar phenotype of incomplete or absent root formation is observed in patients with the autosomal dominant disease Radicular Dentin Dysplasia (RDD; MIM125400) also known as Rootless Teeth or Dentin Dysplasia …

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Academic Realignment: An Investigation Of Change Within A New Academic Unit At A Research University, Abbygail Tull Langham Jan 2012

Academic Realignment: An Investigation Of Change Within A New Academic Unit At A Research University, Abbygail Tull Langham

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Even in normal times, limited resources require U.S. universities to be more open to change. In late 2007, however, a global recession, the worst since the Great Depression of the 1930s, intensified constraints on higher education. To achieve intended outcomes, leaders at colleges and universities often reorganize or realign their organizations during challenging times. Indeed, one public doctorate-granting research university with very high research activity in the southeastern United States has responded to the economic crisis by realigning four academic schools into one large college. Scholarly inquiry was needed to understand the impact of this realignment. The purpose of this …

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Development Of An Adenoviral Vector Platform For Selective Gene Delivery To Neurons, Travis Benjamin Lewis Jan 2012

Development Of An Adenoviral Vector Platform For Selective Gene Delivery To Neurons, Travis Benjamin Lewis

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Parkinson disease (PD) is a devastating movement disorder affecting between 500,000 and 1,000,000 individuals in the United States alone, and for which there is currently no cure. Therapies such as dopamine replacement help initially, but with disease progression these lose efficacy and do not alter the underlying degenerative process. Gene therapy is the delivery of exogenous genetic material to correct an underlying disorder. A major advantage of this approach is the ability to distribute potent therapies to specific targets over an extended duration, properties necessary for the treatment of progressive degenerative diseases such as PD. A number of clinical trials …

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Design Of An Underground Storage Tank Involving Water Collection For Water Reuse To Irrigate The Campus Green Area Of The Uab Campus, Zhuo Li Jan 2012

Design Of An Underground Storage Tank Involving Water Collection For Water Reuse To Irrigate The Campus Green Area Of The Uab Campus, Zhuo Li

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The UAB Campus Recreation Center is located in the Birmingham city block whose boundaries are University Blvd., 10th Avenue South, 14th Street South, and 16th Street South. The water supply of the UAB Campus Recreation Center is based on a natural underground water source, which is use such needs as pool water. The underground water is continuously pumped from its foundation in order to avoid flooding the basement of the Recreation Center. As a result, in addition to the water usage of the Recreation Center, the additional water pumped underground could be utilized to irrigate the campus green area. A …

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The Role Of The Mirror Neuron System In Mental State Attribution In Autism: An Fmri Study, Lauren E. Libero Jan 2012

The Role Of The Mirror Neuron System In Mental State Attribution In Autism: An Fmri Study, Lauren E. Libero

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The ability to interpret others' intentions based on their actions is a vital skill that helps us infer and understand their thoughts and plans. However, individuals with autism have been found to have difficulty in attributing intentions to others (Baron-Cohen et al., 1985; Baron-Cohen, 1995; Happe & Frith, 1996; Williams et al., 2001). The present study investigated the neural mechanisms of inferring intentions from actions in high-functioning adults with autism spectrum disorders (ASD) and typically developing control participants. fMRI data were acquired while participants made judgments about the means (how an action is performed) and intentions (why an action is …

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Regulation Of P27kip1 By Trip6 And Its Implications In Cancer Progression, Victor T G Lin Jan 2012

Regulation Of P27kip1 By Trip6 And Its Implications In Cancer Progression, Victor T G Lin

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TRIP6 is a focal adhesion molecule that functions as an adaptor protein to mediate diverse cellular functions, including motility and antiapoptotic signaling, through a wide variety of protein-protein interactions. We were able to characterize a novel interaction between TRIP6 and p27KIP1, a CDK inhibitor which can both suppress and promote tumorigenesis, depending on its regulation. TRIP6 expression specifically promotes the AKT-mediated phosphorylation of p27KIP1 at T157, which leads to its cytosolic retention, and accelerates the protein turnover rate of p27KIP1. We also found that phosphorylation of T157 by itself promotes cell motility and can be linked to the formation of …

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Multiscale Modeling Of The Mouse Femur, Shannon Lisenbee Jan 2012

Multiscale Modeling Of The Mouse Femur, Shannon Lisenbee

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This paper seeks to advance the knowledge base for bones and how they respond to mechanical stimuli through the use of multiscale modeling. First, a simple but effective approach for segmenting bone from computed tomography images using MATLAB is presented. Using edge detection and gradient operators to identify areas of bone within an image allows for much more accurate and consistent bone segmentation than simpler techniques like thresholding. This technique is applied to the femur of a female mouse for use in further modeling and testing. Next a representative volume element (RVE) for lamellar cortical bone is created based on …

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The Effect Of Acetylcholine Receptor Activation On The Response Properties Of Retinal Ganglion Cells, Ye Long Jan 2012

The Effect Of Acetylcholine Receptor Activation On The Response Properties Of Retinal Ganglion Cells, Ye Long

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Acetylcholine (ACh) is the first identified neurotransmitter and acts in areas including the peripheral nervous system (PNS) and the central nervous system (CNS). The effects of ACh are mediated by nicotinic and muscarinic acetylcholine receptors (AChRs), both of which are extensively distributed in CNS, including the retina. The expression and distribution of nicotinic AChRs (nAChRs) and muscarinic AChRs (mAChRs) have been studied with RT-PCR, western blot, and immunohistochemical techniques in the retinas of different species (Kaneda et al., 1995; Keyser et al., 2000; Yamada et al., 2003; Strang et al., 2005; Dmitrieva et al., 2007; Liu et al., 2009; Strang …

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Regulation Of Membrane Traffic By The Big2 Member Of Guanine Nucleotide Exchange Factors, Jason Lowery Jan 2012

Regulation Of Membrane Traffic By The Big2 Member Of Guanine Nucleotide Exchange Factors, Jason Lowery

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Vesicular transport is an essential cellular process that facilitates the movement of molecules within a cell. The importance of vesicular transport is highlighted by numerous human diseases that result from mutations affecting protein trafficking. The Brefeldin A-inhibited guanine nucleotide exchange factor 2 (BIG2) has emerged as a key regulator of protein trafficking within the late secretory pathway, between the trans-Golgi Network (TGN) and endosomal compartments and within the recycling endosomal pathway. Mutations in BIG2 lead to Autosomal Recessive Periventricular Heterotopia with Microcephly (ARPHM), a disorder characterized by severe brain malformations. BIG2 stimulates nucleotide exchange of GDP for GTP on ADP-ribosylation …

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Geometric Fitting Of Quadratic Curves And Surfaces, Hui Ma Jan 2012

Geometric Fitting Of Quadratic Curves And Surfaces, Hui Ma

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Fitting quadratic curves and surfaces to observed images is one of the basic tasks in pattern recognition and computer vision. The most accurate and robust fit is obtained by minimizing geometric (orthogonal) distances, but this problem has no closed form solution. All known algorithms are heuristic and either computationally costly or have drawbacks in accuracy and convergence. We develop a mathematically rigorous approach to the study of the geometric fitting problem. We begin with a thorough investigation of relevant theoretical aspects of the problem and then move on to its practical solution. We focus on image processing applications, where data …

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The Effects Of Media Violence On Anxiety In Emerging Adults, Anjana Madan Jan 2012

The Effects Of Media Violence On Anxiety In Emerging Adults, Anjana Madan

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Media violence exposure is associated with anxiety among children and younger adolescents, but less is known about its effects on anxiety in emerging adults. This experimental study examines whether media violence exposure affects state anxiety and physiological reactivity (as measured through systolic blood pressure, diastolic blood pressure, heart rate, and mean arterial pressure) in emerging adult college students, as well as whether these effects are moderated by previous violence exposure (both in real life and through media). In the present study, participants viewed either violent or nonviolent high-action movie clips, had their physiological reactivity monitored while viewing the clips, and …

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Regulation Of Alpha-Synuclein Accumulation By The Autophagy-Lysosome Pathway In A Preclinical Model Of Parkinson Disease, Leandra Rosa Mangieri Jan 2012

Regulation Of Alpha-Synuclein Accumulation By The Autophagy-Lysosome Pathway In A Preclinical Model Of Parkinson Disease, Leandra Rosa Mangieri

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Finding novel therapeutics that delay or halt the progression of Parkinson Disease (PD) is key to providing symptomatic relief of debilitating symptoms. A defining pathological feature of PD is characterized by the formation of Lewy bodies, intraneuronal inclusions comprised mainly of α-synuclein (ASYN) (4). Vacuolar ATPase (V-ATPase), an enzyme complex comprised of two multi-subunit-containing domains, critically regulates the acidification of vesicles such as lysosomes and thus proper function of the autophagy-lysosome pathway (ALP), which is critical for the degradation of ASYN. Compromises to V-ATPase have been shown to negatively affect lysosome function and its ability to clear toxic forms of …

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An Examination Of The Relationship Between The External Environment And Care Coordination, Olena Mazurenko Jan 2012

An Examination Of The Relationship Between The External Environment And Care Coordination, Olena Mazurenko

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This study addressed a gap in the care coordination literature by exploring the factors predictive of care coordination, with particular attention to the external environment. The first paper of this dissertation conducted a systematic review of empirical studies that looked at the predictors of care coordination. Based on the 22 papers that fulfilled the inclusion criteria, the evidence to support the relationships between care coordination and factors that are predictive of care coordination was shown to be weak to moderate depending on the types of factors you look at. This study has revealed a significant inconsistency in how predictors of …

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The Effects Of Venlafaxine On Functional Recovery Following Spinal Cord Injury, Don E. Mccormick Jan 2012

The Effects Of Venlafaxine On Functional Recovery Following Spinal Cord Injury, Don E. Mccormick

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Spinal cord injury (SCI) can significantly alter a person's physical and psychological health over their lifetime. Depression in persons with SCI is often treated with antidepressants which alter serotonergic and adrenergic signaling, both regulators of plasticity. However, the effects of antidepressants functional recovery after SCI have never been evaluated. Therefore, we hypothesize that antidepressant therapy would alter functional recovery and neuropathic pain behaviors in a SCI rodent model. The aim of this study was to evaluate the effects of venlafaxine (VEN) administration on functional recovery in the rehabilitation setting using a SCI rodent model. Adult male Sprague-Dawley rats received a …

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The Effects Of Direct To Consumer Advertising On Healthcare Utilization Among Medicaid Children With Asthma, Luceta C. Mcroy Jan 2012

The Effects Of Direct To Consumer Advertising On Healthcare Utilization Among Medicaid Children With Asthma, Luceta C. Mcroy

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National guidelines recommend treatment of asthma with preventive long term medication, but adherence remains low, resulting in high healthcare utilization among those affected by the chronic disease. The increase in DTCA since the easing of restrictions by the FDA in 1997 has prompted much debate on the effects of the DTCA, with critics arguing that it is harmful while proponents see many benefits such as increased medication adherence. This study examines the impact of DTCA on healthcare utilization and asthma medication use by combining Medicaid administrative data and a national advertising data set on asthma medication from 1999 to 2002. …

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A Study Of Early Adopters Of Innovation, John B. Mcwhorter Jan 2012

A Study Of Early Adopters Of Innovation, John B. Mcwhorter

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This research study focused on identification of environmental and organizational variables that influence the rate of adoption of administrative innovation in organizations, and specifically hospitals that have adopted nurse magnet programs. The study identified both organizational and environmental factors as statistically significant among early adopters of magnet programs in hospitals, with organizational influences stronger than environmental influences in determining the rate of adoption of innovation. Organizational complexity, size, control of domain, presence of a competitor, and available resources were the factors identified as influencing the early adoption of innovation among hospitals.

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Genome-Wide Dna Methylation Changes During Breast Tumorigenesis, Natalie E. Mitchell Jan 2012

Genome-Wide Dna Methylation Changes During Breast Tumorigenesis, Natalie E. Mitchell

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Neoplastic reprogramming generates cancerous cells from normal derivatives, enabling researchers to create a model of the early stages of oncogenesis and analyze molecular changes in real-time. Aberrations in DNA methylation are considered a major mechanism contributing to the acquisition and maintenance of a cancerous phenotype; however, little research exists regarding gene-specific changes in DNA methylation during the transition from a normal to neoplastic cell. Human mammary epithelial cells (HMECs) underwent neoplastic transformation through the addition of three defined genetic elements to generate one line of semi-transformed, pre-malignant cells (SHMECs) and two separate lines of fully transformed, malignant cells (THMECs). We …

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Socioeconomic Patterning Of Obesity Among African American Women In The Jackson Heart Study, Tonya Moore Jan 2012

Socioeconomic Patterning Of Obesity Among African American Women In The Jackson Heart Study, Tonya Moore

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Objectives: The purpose of this study was to expand upon what has been observed in literature about obesity and its ties to socioeconomic status (SES) among African American Women (AAW) participants of the Jackson Heart Study (JHS). Methods: This secondary analysis was a sub-study of the JHS and focused on four SES variables: education, income, occupation and wealth; and five outcome variables: body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). Two analytic samples were created in order to examine data collected during Exam 1 (2000-2004) and Exam 2 (2005-2008). …

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An Information Theoretical Modeling And Analysis Of Systems, Bunyamin Ozaydin Jan 2012

An Information Theoretical Modeling And Analysis Of Systems, Bunyamin Ozaydin

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The growth of the service industry also comes with problems and complications because of its inherent error proneness. As the complexity of systems increases, whether the system of interest is a service product or a natural phenomenon, it only proves that there is always a need for improved modeling approaches. In this study, we approach systems from an information theoretical perspective. More specifically, we model systems by noisy communication channels and analyze them by a structure of relationships whose elements are commonly used analysis tools in science and engineering. We call this modeling approach and the structure of relationships it …

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A Repeated Measures Quantitative Prospective Inquiry Into The Change In Medical Student Self-Reported Empathy In Clinical Rotations, Kristina T C Panizzi Woodley Jan 2012

A Repeated Measures Quantitative Prospective Inquiry Into The Change In Medical Student Self-Reported Empathy In Clinical Rotations, Kristina T C Panizzi Woodley

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This dissertation study examined whether or not there were quantitative changes in medical student self-reported empathy scores over time and across gender within third- and fourth-year cohorts enrolled in an integrated curriculum at a Southeastern U.S. medical school. The dependent variable was quantitative empathy scores at time 1 and time 2 using the Jefferson Scale of Empathy (JSE, medical student S-Version). Primary independent variables were cohort year and gender. Variables of clinical campus site, rotation orientation category, and specialty interest orientation category were also explored. The study found that empathy increased for the third-year complete cohort but decreased for the …

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Using Mouse Models To Investigate Ciliopathies, Raymond Carl Pasek Jan 2012

Using Mouse Models To Investigate Ciliopathies, Raymond Carl Pasek

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Cilia and flagella are microtubule based organelles found on nearly every cell type in the mammalian body. Flagella have an essential role in sperm locomotion and reproduction, while motile cilia have a known role in fluid movement in the brain, lungs, and portions of the female reproductive tract. While the role of most primary cilia remained unknown for decades, they are now recognized as being essential to mammalian development, renal homeostasis, and satiety, just to name a few. Because of their widespread presence and importance, dysfunction of cilia and flagella can lead to a variety of human diseases, collectively referred …

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