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Articles 27841 - 27870 of 28622
Full-Text Articles in Entire DC Network
Insights From A Synthesis Of Old And New Climate-Proxy Data From The Pyramid And Winnemucca Lake Basins For The Period 48 To 11.5 Cal Ka, Larry Benson, J.P. Smoot, S.P. Lund, S.A. Mensing, F.F. Foit Jr., R.O. Rye
Insights From A Synthesis Of Old And New Climate-Proxy Data From The Pyramid And Winnemucca Lake Basins For The Period 48 To 11.5 Cal Ka, Larry Benson, J.P. Smoot, S.P. Lund, S.A. Mensing, F.F. Foit Jr., R.O. Rye
United States Geological Survey: Staff Publications
A synthesis of old and new paleoclimatic data from the Pyramid and Winnemucca lake basins indicates that, between 48.0 and 11.5∙103 calibrated years BP (hereafter ka), the climate of the western Great Basin was, to a degree, linked with the climate of the North Atlantic. Paleomagnetic secular variation (PSV) records from Pyramid Lake core PLC08-1 were tied to the GISP2 ice-core record via PSV matches to North Atlantic sediment cores whose isotopic and(or) carbonate records could be linked to the GISP2δ18O record. Relatively dry intervals in the western Great Basin were associated with cold Heinrich events and …
Improved Mapping Of National Atmospheric Deposition Program Wet-Deposition In Complex Terrain Using Prism-Gridded Data Sets, Natalie E. Latysh, Gregory Alan Wetherbee
Improved Mapping Of National Atmospheric Deposition Program Wet-Deposition In Complex Terrain Using Prism-Gridded Data Sets, Natalie E. Latysh, Gregory Alan Wetherbee
United States Geological Survey: Staff Publications
High-elevation regions in the United States lack detailed atmospheric wet-deposition data. The National Atmospheric Deposition Program/ National Trends Network (NADP/NTN) measures and reports precipitation amounts and chemical constituent concentration and deposition data for the United States on annual isopleth maps using inverse distance weighted (IDW) interpolation methods. This interpolation for unsampled areas does not account for topographic influences. Therefore, NADP/NTN isopleth maps lack detail and potentially underestimate wet deposition in high-elevation regions. The NADP/NTN wet-deposition maps may be improved using precipitation grids generated by other networks. The Parameter-elevation Regressions on Independent Slopes Model (PRISM) produces digital grids of precipitation estimates …
Wildlife Toxicology: Environmental Contaminants And Their National And International Regulation, K. Christiana Grim, Anne Fairbrother, Barnett A. Rattner
Wildlife Toxicology: Environmental Contaminants And Their National And International Regulation, K. Christiana Grim, Anne Fairbrother, Barnett A. Rattner
United States Geological Survey: Staff Publications
Wildlife toxicology is the study of potentially harmful effects of toxic agents in wild animals, focusing on amphibians, reptiles, birds, and mammals. Fish and aquatic invertebrates are not usually included as part of wildlife toxicology since they fall within the field of aquatic toxicology, but collectively both disciplines often provide inSight into one another and both are integral parts of ecotoxicology (Hoffman et al. 2003). It entails monitoring, hypothesis testing, forensics, and risk assessment; encompasses molecular through ecosystem responses and various research venues (laboratory, mesocosm, field); and has been shaped by chemical use and misuse, ecological mishaps, and biomedical research. …
Development And Application Of Methods Used To Source Prehistoric Southwestern Maize: A Review, Larry Benson
Development And Application Of Methods Used To Source Prehistoric Southwestern Maize: A Review, Larry Benson
United States Geological Survey: Staff Publications
Archaeological cobs free of mineral contaminants should be used to source the soils in which they were grown. Mineral contaminants often contain much higher concentrations of metals than vegetal materials and can alter a cob’s apparent metal and heavy-isotope content. Cleaning a cob via immersion in an acid solution for more than a few minutes will result in the incongruent and sometimes complete leaching of metals, including strontium (Sr), from the cob. When using 87Sr/86Sr to determine the location of potential agriculture fields, it is best to either integrate several depth-integrated soil samples or to integrate several …
Metabolic Engineering Of Novel Lignin In Biomass Crops, Ruben Vanholme, Kris Morreel, Chiarina Darrah, Paula Oyarce, John H. Grabber, John Ralph, Wout Boerjan
Metabolic Engineering Of Novel Lignin In Biomass Crops, Ruben Vanholme, Kris Morreel, Chiarina Darrah, Paula Oyarce, John H. Grabber, John Ralph, Wout Boerjan
United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications
Lignin, a phenolic polymer in the secondary wall, is the major cause of lignocellulosic biomass recalcitrance to efficient industrial processing. From an applications perspective, it is desirable that second-generation bioenergy crops have lignin that is readily degraded by chemical pretreatments but still fulfill its biological role in plants. Because plants can tolerate large variations in lignin composition, often without apparent adverse effects, substitution of some fraction of the traditional monolignols by alternative monomers through genetic engineering is a promising strategy to tailor lignin in bioenergy crops. However, successful engineering of lignin incorporating alternative monomers requires knowledge about phenolic metabolism in …
Heme Oxygenase-1 Regulates The Immune Response To Influenza Virus Infection And Vaccination In Aged Mice, Nathan W. Cummins, Eric A. Weaver, Shannon M. May, Anthony J. Croatt, Oded Foreman, Richard B. Kennedy, Gregory A. Polan, Michael A. Barry, Karl A. Nath, Andrew D. Badley
Heme Oxygenase-1 Regulates The Immune Response To Influenza Virus Infection And Vaccination In Aged Mice, Nathan W. Cummins, Eric A. Weaver, Shannon M. May, Anthony J. Croatt, Oded Foreman, Richard B. Kennedy, Gregory A. Polan, Michael A. Barry, Karl A. Nath, Andrew D. Badley
Nebraska Center for Virology: Faculty Publications
Underlying mechanisms of individual variation in severity of influenza infection and response to vaccination are poorly understood. We investigated the effect of reduced heme oxygenase-1 (HO-1) expression on vaccine response and outcome of influenza infection. HO-1-deficient and wild-type (WT) mice (kingdom, Animalia; phylum, Chordata; genus/species, Mus musculus) were infected with influenza virus A/PR/8/34 with or without prior vaccination with an adenoviral-based influenza vaccine. A genome-wide association study evaluated the expression of single-nucleotide polymorphisms (SNPs) in the HO-1 gene and the response to influenza vaccination in healthy humans. HO-1-deficient mice had decreased survival after influenza infection compared to WT mice (median …
Long-Term Impacts Of Invasive Species On A Native Top Predator In A Large Lake System, Scott A. Rush, Gordon Paterson, Tim B. Johnson, Ken G. Drouillard, Gordon D. Haffner, Craig E. Hebert, Michael T. Arts, Daryl J. Mcgoldric, Sean M. Backus, Brian F. Lantry, Jana R. Lantry, Ted Schaner, Aaron T. Fisk
Long-Term Impacts Of Invasive Species On A Native Top Predator In A Large Lake System, Scott A. Rush, Gordon Paterson, Tim B. Johnson, Ken G. Drouillard, Gordon D. Haffner, Craig E. Hebert, Michael T. Arts, Daryl J. Mcgoldric, Sean M. Backus, Brian F. Lantry, Jana R. Lantry, Ted Schaner, Aaron T. Fisk
United States Geological Survey: Staff Publications
1. Declining abundances of forage fish and the introduction and establishment of non-indigenous species have the potential to substantially alter resource and habitat exploitation by top predators in large lakes.
2. We measured stable isotopes of carbon (δ13C) and nitrogen (δ15N) in field-collected and archived samples of Lake Ontario lake trout (Salvelinus namaycush) and five species of prey fish and compared current trophic relationships of this top predator with historical samples.
3. Relationships between δ15N and lake trout age were temporally consistent throughout Lake Ontario and confirmed the role of lake trout …
Lake Sturgeon Population Attributes And Reproductive Structure In The Namakan Reservoir, Minnesota And Ontario, S. L. Shaw, S. R. Chipps, Steve K. Windels, M. A. H. Webb, Darryl T. Mcleod, D. W. Willis
Lake Sturgeon Population Attributes And Reproductive Structure In The Namakan Reservoir, Minnesota And Ontario, S. L. Shaw, S. R. Chipps, Steve K. Windels, M. A. H. Webb, Darryl T. Mcleod, D. W. Willis
United States Geological Survey: Staff Publications
Quantified were the age, growth, mortality and reproductive structure of lake sturgeon (Acipenser fulvescens) collected in the US and Canadian waters of the Namakan Reservoir. The hypotheses were tested that (i) age and growth of lake sturgeon in the Namakan Reservoir would differ by sex and reproductive stage of maturity, and (ii) that the relative strength of year classes of lake sturgeon in the reservoir would be affected by environmental variables. To quantify age, growth and mortality of the population, existing data was used from a multiagency database containing information on all lake sturgeon sampled in the reservoir …
The Driving Forces Of Land Change In The Northern Piedmont Of The United States, Roger F. Auch, Darrell E. Napton, Steven Kambly, Thomas R. Moreland Jr., Kristi L. Sayler
The Driving Forces Of Land Change In The Northern Piedmont Of The United States, Roger F. Auch, Darrell E. Napton, Steven Kambly, Thomas R. Moreland Jr., Kristi L. Sayler
United States Geological Survey: Staff Publications
Driving forces facilitate or inhibit land-use / land-cover change. Human driving forces include political, economic, cultural, and social attributes that often change across time and space. Remotely sensed imagery provides regional land-change data for the Northern Piedmont, an ecoregion of the United States that continued to urbanize after 1970 through conversion of agricultural and forest land covers to developed uses. Eight major driving forces facilitated most of the land conversion; other drivers inhibited or slowed change. A synergistic web of drivers may be more important in understanding land change than individual drivers by themselves.
Remote Sensing Of Sagebrush Canopy Nitrogen, Jessica J. Mitchell, Nancy F. Glenn, Temuulen T. Sankey, Dewayne R. Derryberry, Matthew J. Germino
Remote Sensing Of Sagebrush Canopy Nitrogen, Jessica J. Mitchell, Nancy F. Glenn, Temuulen T. Sankey, Dewayne R. Derryberry, Matthew J. Germino
United States Geological Survey: Staff Publications
This paper presents a combination of techniques suitable for remotely sensing foliar Nitrogen (N) in semiarid shrublands – a capability that would significantly improve our limited understanding of vegetation functionality in dryland ecosystems. The ability to estimate foliar N distributions across arid and semi-arid environments could help answer process-driven questions related to topics such as controls on canopy photosynthesis, the influence of N on carbon cycling behavior, nutrient pulse dynamics, and post-fire recovery. Our study determined that further exploration into estimating sagebrush canopy N concentrations from an airborne platform is warranted, despite remote sensing challenges inherent to open canopy systems. …
Forest Bioenergy Feedstock Harvesting Effects On Water Supply, Daniel G. Neary, Karen A. Koestner
Forest Bioenergy Feedstock Harvesting Effects On Water Supply, Daniel G. Neary, Karen A. Koestner
United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications
Water flowing from forested catchments, both unmanaged and managed, is highly valued in terms of both quantity and quality. Increasing energy production using wood feedstocks produces varying degrees of impacts and thereby raises concerns about environmental impacts on the highly valued water supply resources of forest ecosystems. The term water supply encompasses both key components of water quantity and water quality. Water quantity considers the amount of increases or decreases, timing, consistency, and relative magnitude of water yields. Plant nutrients (anions and cations), fertilizers, herbicides, ash additions, temperature, dissolved oxygen, pH, bacteria, and sediment comprise water quality. Within the life …
Chloroviruses: Not Your Everyday Plant Virus, James L. Van Etten, David D. Dunigan
Chloroviruses: Not Your Everyday Plant Virus, James L. Van Etten, David D. Dunigan
Nebraska Center for Virology: Faculty Publications
Viruses infecting higher plants are among the smallest viruses known and typically have four to ten protein-encoding genes. By contrast, many viruses that infect algae (classified in the virus family Phycodnaviridae) are among the largest viruses found to date and have up to 600 protein- encoding genes. This brief review focuses on one group of plaque-forming phycodnaviruses that infect unicellular chlorella-like green algae. The prototype chlorovirus PBCV-1 has more than 400 protein-encoding genes and 11 tRNA genes. About 40% of the PBCV-1 encoded proteins resemble proteins of known function including many that are completely unexpected for a virus. In many …
Regional Dissemination Of A Trimethoprim-Resistance Gene Cassette Via A Successful Transposable Element, Amy S. Labar '10, Jennifer S. Millman '09, E. Ruebrush, Iruka N. Okeke
Regional Dissemination Of A Trimethoprim-Resistance Gene Cassette Via A Successful Transposable Element, Amy S. Labar '10, Jennifer S. Millman '09, E. Ruebrush, Iruka N. Okeke
Biology Faculty Scholarship
No abstract provided.
Leveraging Information About Patents: Settlements, Portfolios, And Holdups, Mark R. Patterson
Leveraging Information About Patents: Settlements, Portfolios, And Holdups, Mark R. Patterson
Faculty Scholarship
The purpose of this essay is twofold. First, it serves to emphasize the role played by uncertainty in three otherwise very different categories of cases, involving “reverse payment” settlements, patent portfolios and package licensing, and deception in standard-setting. The source of the uncertainty at issue in each of the cases is different, but in each the unavailable information is not protected by patent law. Second, the essay points out that in these cases the courts nevertheless apply rules that are more appropriate for the information about inventions that patent law is intended to protect. Patent law grants patentees the exclusive …
The Flood Of U.S. Lawyers: Natural Fluctuation Or Professional Climate Change?, Bruce A. Green
The Flood Of U.S. Lawyers: Natural Fluctuation Or Professional Climate Change?, Bruce A. Green
Faculty Scholarship
This paper considers how US courts, which regulate the US legal profession, should respond to the perceived excess of lawyers (i.e. to the lack of adequate employment opportunities for lawyers). It begins by summarizing the courts’ regulatory role. It then situates the contemporary flood-of-lawyers problem in the unavailability of well-paid legal work, not in the absence of a need for lawyers’ services: many people need lawyers, but they cannot afford them. Next, the paper explores whether the problem is simply a product of natural economic fluctuation which will be solved naturally, particularly if potential law school applicants become better informed, …
Effects Of Mining-Derived Metals On Riffle-Dwelling Crayfish In Southwestern Missouri And Southeastern Kansas, Usa, Ann L. Allert, Robert J. Distefano, Christopher J. Schmitt, James F. Fairchild, William G. Brumbaugh
Effects Of Mining-Derived Metals On Riffle-Dwelling Crayfish In Southwestern Missouri And Southeastern Kansas, Usa, Ann L. Allert, Robert J. Distefano, Christopher J. Schmitt, James F. Fairchild, William G. Brumbaugh
United States Geological Survey: Staff Publications
Riffle-dwelling crayfish populations were sampled at 16 sites in 4 tributaries of the Spring River located within the Tri-State Mining District in southwest Missouri. Crayfish density, physical habitat quality, and water quality were examined at each site to assess the ecological effects of mining-derived metals on crayfish. Metals (lead, zinc, and cadmium) were analyzed in samples of surface water, sediment, detritus, and whole crayfish. Sites were classified a posteriori into reference, mining, and downstream sites primarily based on metal concentrations in the materials analyzed. Three species of crayfish (Orconectes neglectus neglectus, O. macrus, and O. virilis) were collected …
Spin Filtering With Euo: Insight From The Complex Band Structure, Pavel Lukashev, Aleksander L. Wysocki, Julian P. Velev, Mark Van Schilfgaarde, Sitaram Jaswal, Kirill D. Belashchenko, Evgeny Y. Tsymbal
Spin Filtering With Euo: Insight From The Complex Band Structure, Pavel Lukashev, Aleksander L. Wysocki, Julian P. Velev, Mark Van Schilfgaarde, Sitaram Jaswal, Kirill D. Belashchenko, Evgeny Y. Tsymbal
Kirill Belashchenko Publications
Spin-filter tunneling is a promising way to create highly-spin-polarized currents. So far the understanding of the spin-filtering effect has been limited to a free-electron description based on the spin-dependent tunneling barrier height. In this work we explore the complex of EuO as a representative ferromagnetic insulator used in spin-filter tunneling experiments and show that the mechanism of spin filtering is more intricate than it has been previously thought. We demonstrate the importance of the multiorbital band structure with an indirect band gap for spin-filter tunneling. By analyzing the symmetry of the complex bands and the decay rates for different wave …
Wildlife Services—A Leader In Developing Tools And Techniques For Managing Carnivores, Kathleen A. Fagerstone, Gail Keirn
Wildlife Services—A Leader In Developing Tools And Techniques For Managing Carnivores, Kathleen A. Fagerstone, Gail Keirn
United States Department of Agriculture Wildlife Services: Staff Publications
Did you ever wonder who invented the breakaway snare or the Livestock Protection Collar? These and many other wildlife management tools and techniques are the result of the ingenuity and creativity of U.S. Department of Agriculture Wildlife Services (WS) program scientists, technicians, and field specialists, with the help of collaborators at universities, other federal and state agencies, and private partners. This manuscript will highlight some of the tools and methods that were developed, tested, or registered by WS National Wildlife Research Center scientists for use in predator damage management.
Understanding The Effect Of Ferroelectric Polarization On Power Conversion Efficiency Of Organic Photovoltaic Devices, Yongbo Yuan, Pankaj Sharma, Zhengguo Xiao, Shashi Poddar, Alexei Gruverman, Stephen Ducharme, Jinsong Huang
Understanding The Effect Of Ferroelectric Polarization On Power Conversion Efficiency Of Organic Photovoltaic Devices, Yongbo Yuan, Pankaj Sharma, Zhengguo Xiao, Shashi Poddar, Alexei Gruverman, Stephen Ducharme, Jinsong Huang
Stephen Ducharme Publications
It is demonstrated that the power conversion efficiency (PCE) of organic photovoltaic devices can be increased by inserting an ultrathin film of a ferroelectric co-polymer, poly(vinylidenefluoridetrifluoroethylene) (P(VDF-TrFE)), at the metal–organic interface, due to an enhancement of the charge extraction efficiency. Specifically, the effect of P(VDF-TrFE) crystallinity on its function in ferroelectric organic photovoltaic (FE-OPV) devices has been studied by several methods. Highly crystalline and amorphous P(VDF-TrFE) films have been prepared by the Langmuir–Blodgett method and spincoating from acetone solution, respectively. The polymer solar cell devices with a crystalline P(VDFTrFE) interfacial layer at the cathode have larger PCE than the structures …
Effects Of Glycerol And Creatine Hyperhydration On Doping-Relevant Blood Parameters, Thelma P. Polyviou, Chris Easton, Lukas Beis, Dalia Malkova, Pantazis Takas, Cathertine Hambly, John R. Speakman, Karsten Koehler, Yannis P. Pitsiladis
Effects Of Glycerol And Creatine Hyperhydration On Doping-Relevant Blood Parameters, Thelma P. Polyviou, Chris Easton, Lukas Beis, Dalia Malkova, Pantazis Takas, Cathertine Hambly, John R. Speakman, Karsten Koehler, Yannis P. Pitsiladis
Department of Nutrition and Health Sciences: Faculty Publications
Glycerol is prohibited as an ergogenic aid by the World Anti-Doping Agency (WADA) due to the potential for its plasma expansion properties to have masking effects. However, the scientific basis of the inclusion of Gly as a “masking agent” remains inconclusive. The purpose of this study was to determine the effects of a hyperhydrating supplement containing Gly on doping-relevant blood parameters. Nine trained males ingested a hyperhydrating mixture twice per day for 7 days containing 1.0 g·kg−1 body mass (BM) of Gly, 10.0 g of creatine and 75.0 g of glucose. Blood samples were collected and total hemoglobin (Hb) …
Rabies In North America: A Model Of The One Health Approach, Kurt C. Vercauteren, Christine Ellis, Richard Chipman, Thomas J. Deliberto, Stephanie A. Shwiff, Dennis Slate
Rabies In North America: A Model Of The One Health Approach, Kurt C. Vercauteren, Christine Ellis, Richard Chipman, Thomas J. Deliberto, Stephanie A. Shwiff, Dennis Slate
United States Department of Agriculture Wildlife Services: Staff Publications
The One Health concept merges environmental, wildlife, domestic animal, and human health into a global, interconnected context. Though recently a popular catchphrase due to the emergence and reemergence of diseases such as foot-and-mouth disease (FMD), bluetongue, bovine spongiform encephalopathy (BSE), Q Fever, Rift Valley fever, Nipah virus, West Nile virus (WNV), severe acute respiratory syndrome (SARS), highly pathogenic H5N1 avian influenza, and plague, the One Health concept is not new. The One Health approach to managing infectious diseases aims to promote and implement meaningful collaboration and communication between multiple allied disciplines working locally, nationally, and internationally to attain optimal health …
Using Three-Dimensional Flight Patterns At Airfields To Identify Hotspots For Avian-Aircraft Collisions, W. David Walter, Justin W. Fischer, John S. Humphrey, Trey S. Daughtery, Michael P. Milleson, Eric A. Tillman, Michael L. Avery
Using Three-Dimensional Flight Patterns At Airfields To Identify Hotspots For Avian-Aircraft Collisions, W. David Walter, Justin W. Fischer, John S. Humphrey, Trey S. Daughtery, Michael P. Milleson, Eric A. Tillman, Michael L. Avery
United States Department of Agriculture Wildlife Services: Staff Publications
In the United States, black vulture (Coragyps atratus) and turkey vulture (Cathartes aura) pose significant birdstrike risks to aircraft. Understanding flight behaviors of vultures in and around military and civilian airfields is necessary to alleviate these risks. Using satellite telemetry data collected from 11 black vultures and 7 turkey vultures equipped with Global Positioning System backpack harness technology, we collected data on location and altitude near the Marine Corps Air Station (MCAS) in Beaufort, South Carolina from September 2006 to September 2008. We used military aircraft flight landing patterns to visualize a new concept, a flight …
Return To Beringia: Parasites Reveal Cryptic Biogeographic History Of North American Pikas, Kurt E. Galbreath, Eric P. Hoberg
Return To Beringia: Parasites Reveal Cryptic Biogeographic History Of North American Pikas, Kurt E. Galbreath, Eric P. Hoberg
Harold W. Manter Laboratory of Parasitology: Faculty Publications
Traditional concepts of the Bering Land Bridge as a zone of predominantly eastward expansion from Eurasia and a staging area for subsequent colonization of lower latitudes in North America led to early inferences regarding biogeographic histories of North American faunas, many of which remain untested. Here we apply a host–parasite comparative phylogeographical (HPCP) approach to evaluate one such history, by testing competing biogeographic hypotheses for five lineages of host-specific parasites shared by the collared pika (Ochotona collaris) and American pika (Ochotona princeps) of North America. We determine whether the southern host species (O. princeps) …
Law, Politics, And Cost-Benefit Analysis, Daniel H. Cole
Law, Politics, And Cost-Benefit Analysis, Daniel H. Cole
Articles by Maurer Faculty
This Article explores the significant role cost–benefit analysis (CBA) plays in facilitating or impeding legislative and regulatory policy decisions. The Article centers around three case studies of CBAs the EPA prepared under three different presidents: (1) Clinton Administration changes to Clean Air Act air quality standards for ozone and particulate matter; (2) President Obama’s recent decision to suspend the EPA’s reconsideration of the Bush Administration’s air quality standard for ozone; and (3) the George W. Bush Administration’s “Clear Skies” legislative initiative. The first two case studies demonstrate, between them, how well-constructed CBAs can facilitate social-welfare-enhancing and impede welfare-reducing rules, even …
States Side Story: Career Paths Of International Ll.M. Students, Or "I Like To Be In America", Carole Silver
States Side Story: Career Paths Of International Ll.M. Students, Or "I Like To Be In America", Carole Silver
Articles by Maurer Faculty
This Article draws on an empirical study of the careers of international law graduates who earned an LL.M. in the United States, and considers the role of a U.S. LL.M. as a path for building a legal career in the United States. It identifies the institutional, political, and economic forces that present challenges to graduates who attempt to stay in the United States. While U.S. law schools prize the international diversity of their graduate students, this study reveals that the U.S. legal profession is most accessible to international students from English-speaking common law countries, whose language and background allow them …
Inciting Curiosity And Creating Meaning: Teaching Information Evaluation Through The Lens Of “Bad Science”, Catherine Fraser Riehle
Inciting Curiosity And Creating Meaning: Teaching Information Evaluation Through The Lens Of “Bad Science”, Catherine Fraser Riehle
University of Nebraska-Lincoln Libraries: Faculty Publications
Ability to evaluate information is a critical component of information literacy. This article provides strategies for engaging students in learning about information evaluation in the contexts of the scientific publication cycle and communication in the digital age. Also included are recent findings regarding undergraduate student research behavior and ideas for integrating constructivist learning theory in order to develop effective learning activities that encourage curiosity and critical thinking.
Systems And Synthetic Biology Of The Vessel Wall, Jennifer Frueh, Nataly Maimari, Ying Lui, Zoltan Kis, Vikram Mehta, Negin Pormehr, Calum Grant, Emmanuel Chalkias, Mika Falck-Hansen, Sandra Bovens, Ryan M. Pedrigi, Taka Homma, Gianfillippo Coppola, Rob Krams
Systems And Synthetic Biology Of The Vessel Wall, Jennifer Frueh, Nataly Maimari, Ying Lui, Zoltan Kis, Vikram Mehta, Negin Pormehr, Calum Grant, Emmanuel Chalkias, Mika Falck-Hansen, Sandra Bovens, Ryan M. Pedrigi, Taka Homma, Gianfillippo Coppola, Rob Krams
Department of Mechanical and Materials Engineering: Faculty Publications
Atherosclerosis is intimately coupled to blood flow by the presence of predilection sites. The coupling is through mechanotransduction of endothelial cells and approximately 2000 gene are associated with this process. This paper describes a new platform to study and identify new signalling pathways in endothelial cells covering an atherosclerotic plaque. The identified networks are synthesized in primary cells to study their reaction to flow. This synthetic approach might lead to new insights and drug targets.
Nanotopographic Cell Culture Substrate: Polymer-Demixed Nanotextured Films Under Cell Culture Conditions, Jung Yul Lim, Christopher A. Siedlecki, Henry J. Donahue
Nanotopographic Cell Culture Substrate: Polymer-Demixed Nanotextured Films Under Cell Culture Conditions, Jung Yul Lim, Christopher A. Siedlecki, Henry J. Donahue
Department of Mechanical and Materials Engineering: Faculty Publications
Modulating physical cell culture environments via nanoscale substrate topographic modification has recently been of significant interest in regenerative medicine. Many studies have utilized a polymer-demixing technique to produce nanotextured films and showed that cellular adhesion, proliferation, and differentiation could be regulated by the shape and scale of the polymer-demixed nanotopographies. However, little attention has been paid to the topographic fidelity of the polymer-demixed films when exposed to cell culture conditions. In this brief article, two polymer-demixing systems were employed to assess topographic changes in polymer-demixed films after fibronectin (FN) extracellular matrix protein adsorption and after incubation in phosphate-buffered saline at …
Usability Assessment Of Two Different Control Modes For The Master Console Of A Laparoscopic Surgical Robot, Xiaoli Zhang, Carl A. Nelson, Dmitry Oleynikov
Usability Assessment Of Two Different Control Modes For The Master Console Of A Laparoscopic Surgical Robot, Xiaoli Zhang, Carl A. Nelson, Dmitry Oleynikov
Department of Mechanical and Materials Engineering: Faculty Publications
The objective of this study is to evaluate potential interface control modes for a compact fourdegree- of-freedom (4-DOF) surgical robot. The goal is to improve robot usability by incorporating a sophisticated haptics-capable interface. Two control modes were developed using a commercially available haptic joystick: (1) a virtually point-constrained interface providing an analog for constrained laparoscopic motion (3-DOF rotation and 1-DOF translation), and (2) an unconstrained Cartesian input interface mapping more directly to the surgical tool tip motions. Subjects (n = 5) successfully performed tissue identification and manipulation tasks in an animal model in point-constrained and unconstrained control modes, respectively, with …
Tool Sequence Trends In Minimally Invasive Surgery: Statistical Analysis And Implications For Predictive Control Of Multifunction Instruments, Carl A. Nelson, Evan Luxon, Dmitry Oleynikov
Tool Sequence Trends In Minimally Invasive Surgery: Statistical Analysis And Implications For Predictive Control Of Multifunction Instruments, Carl A. Nelson, Evan Luxon, Dmitry Oleynikov
Department of Mechanical and Materials Engineering: Faculty Publications
This paper presents an analysis of 67 minimally invasive surgical procedures covering 11 different procedure types to determine patterns of tool use. A new graph-theoretic approach was taken to organize and analyze the data. Through grouping surgeries by type, trends of common tool changes were identified. Using the concept of signal/noise ratio, these trends were found to be statistically strong. The tool-use trends were used to generate tool placement patterns for modular (multi-tool, cartridge-type) surgical tool systems, and the same 67 surgeries were numerically simulated to determine the optimality of these tool arrangements. The results indicate that aggregated tool-use data …