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Book Reviews, Criticism Editors

Criticism

Ambition and Privilege: The Social Tropes of Elizabethan Courtesy Theory (Frank Whigham) (Reviewed by Jonathan Goldberg, Brown University)

Love Known: Theology and Experience in George Herbert's Poetry (Richard Strier) (Reviewed by Ilona Bell, Williams College)

The Sacred Complex: On the Psychogenesis of "Paradise Lost" (William Kerrigan) (Reviewed by William G. Riggs, Boston University)

Realism, Myth, and History in Defoe'S Fiction (Maximillian E. Novak) (Reviewed by John Richetti, Rutgers University)

Defoe and the Idea of Fiction, 1713-1719 (Geoffrey M. Sill) (Reviewed by John Richetti, Rutgers University)

Romantic Contraries: Freedom versus Destiny (Peter L. Thorselv) (Reviewed by Stephen C. Behrendt, University of …

Book Reviews, Criticism Editors

Criticism

Michel Foucault and the Subversion of Intellect (Karlis Racevskis) (Reviewed by Michael Sprinker, SUNY--Stony Brook)

Michel Foucault: Social Theory as Transgression (Charles C. Lemert) (Reviewed by Michael Sprinker, SUNY--Stony Brook)

Michel Foucault: Beyond Structuralism and Hermeneutics (Hubert L. Dreyfus and Paul Rabinow) (Reviewed by Michael Sprinker, SUNY--Stony Brook)

Jane Austen: New Perspectives (Janet Todd) (Reviewed by Julia L. Epstein, Drexel University)

Bread and Circuses: Theories of Mass Culture as Social Decay (Patrick Brantlinger) (Reviewed by Martha Vicinus, University of Michigan)

The Land Before Her: Fantasy and Experience of the American Frontiers, 1630-1860 (Annette Kolodny) (Reviewed by Mitchell Breitwieser, The University …

Modeling Environmental Contamination Of Antibiotic-Resistant Bacteria In Hospitals, Lei Wang

Open Access Dissertations

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that causes infections in different parts of the body. It is tougher to treat than most strains of Staphylococcus aureus or staph, because it is resistant to some commonly used antibiotics. In this work, we investigate the role of environmental contamination on the clinical epidemiology of antibiotic-resistant bacteria in hospitals. A compartmental model is constructed to describe the transmission characteristics of MRSA in hospital setting. The deterministic epidemic model includes five compartments: colonized and uncolonized patients, contaminated and uncontamincated health care workers (HCWs), and bacterial load in environment. Basic reproduction number R0 is …

Active Induction Of Experimental Autoimmune Encephalomyelitis By Mog35-55 Peptide Immunization Is Associated With Differential Responses In Separate Compartments Of The Choroid Plexus, Nivetha Murugesan, Debayon Paul, Yen Lemire, Bandana Shrestha, Shujun Ge, Joel S. Pachter

UCHC Articles - Research

Background

There is increasing awareness that, aside from producing cerebrospinal fluid, the choroid plexus (CP) might be a key regulator of immune activity in the central nervous system (CNS) during neuroinflammation. Specifically, the CP has recently been posited to control entry of sentinel T cells into the uninflamed CNS during the early stages of neuroinflammatory diseases, like multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). As the CP is compartmentalized into a stromal core containing fenestrated capillaries devoid of typical blood–brain barrier properties, surrounded by a tight junction-expressing choroidal epithelium, each of these compartments might mount unique …

Modeling Sleep Fragmentation In Populations Of Sleep Hypnograms, Bruce J. Swihart, Naresh M. Punjabi, Ciprian M. Crainiceanu

Johns Hopkins University, Dept. of Biostatistics Working Papers

We introduce methods for the analysis of large populations of sleep architectures (hypnograms) that respect the 5-state 20-transition-type structure defined by the American Academy of Sleep Medicine. By applying these methods to the hypnograms of 5598 subjects from the Sleep Heart Health Study we: 1) provide the firrst analysis of sleep hypnogram data of such size and complexity in a community cohort with a 4-level comorbidity; 2) compare 5-state 20-transition-type sleep to 3-state 6-transition-type sleep for a check of feasibility and information-loss; 3) extend current approaches to multivariate survival data analysis to populations of time-to-transition processes; and 4) provide scalable …

A Phase I Bayesian Adaptive Design To Simultaneously Optimize Dose And Schedule Assignments Both Among And Within Patients, Thomas M. Braun, Jin Zhang

The University of Michigan Department of Biostatistics Working Paper Series

In traditional schedule or dose-schedule finding designs, patients are assumed to receive their assigned dose-schedule combination throughout the trial even though the combination may be found to have an undesirable toxicity profile, which contradicts actual clinical practice. Since no systematic approach exists to optimize intra-patient dose-schedule as- signment, we propose a Phase I clinical trial design that extends existing approaches that optimize dose and schedule solely among patients by incorporating adaptive variations to dose-schedule assignments within patients as the study proceeds. Our design is based on a Bayesian non-mixture cure rate model that incorporates multiple administrations each patient receives with …

2012 August 7 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

08/07/2012 Obituary Records, Hawaii Obituaries

Obituaries

List of Obituaries for individuals who passed away on 08/07/2012. Scroll down to see the names and obituary description.

Flow Valve Diagnostics For Label-Free, Quantitative Biomarker Detection: Device Fabrication, Surface Modification, And Testing, Danielle Scarlet Mansfield

Theses and Dissertations

Diseases are often diagnosed by detection of disease-specific biomarkers in fluid samples. However, many state-of-the-art detection methods require a lab with complex machinery, trained operators, and/or lengthy analysis time. In contrast, point-of-care (POC) devices are brought to the patient's location, they are easy to use, and results are obtained almost immediately. Many current POC devices are too difficult to be used without a skilled assistant, and although many are able to detect analytes above a threshold value, they give little or no quantitative information. This work presents the development of polymer-based microfluidic devices capable of sensing and quantifying biomarkers in …

Report: The Illinois State University Faculty-Staff Newsletter, August 7, 2012, Illinois State University

Illinois State University Report (1966-2012)

Illinois State University bi-weekly employee newsletter.

Electromanipulation Method, Andrew M. Hoff, Richard Gilbert, Richard Heller, Mark J. Jaroszeski

USF Patents

The present invention is a method for electromanipulation of chemical species in vivo relative to a target tissue utilizing a nonconductive, conformable array base adapted to be placed coincident to the target tissue, a plurality of electrode elements projecting from the array base towards the target tissue, the electrode elements addressable individually, an electrical source coupled to the plurality of electrodes, a control means interposed between the electrical source and the plurality of electrode elements and in circuit communication therein, the control means adapted to establish an electrical potential between at least two electrodes, and a delivery means adapted to …

Formation Of Cyclopentene Nitro-Ester And Derivatives, Kirpal S. Bisht, Pasha M. Khan, Alberto Van Olphen, Ruizhi Wu

USF Patents

Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (>99% ee) was influenced by desymmetrization catalyzed by Pseudomonas cepacia lipase and the stereoselective nature of the palladium catalyzed transformations.

The Cell Collective: Toward An Open And Collaborative Approach To Systems Biology., Tomáš Helikar, Brian Kowal, Sean Mcclenathan, Mitchell Bruckner, Thaine Rowley, Alex Madrahimov, Ben Wicks, Manish Shrestha, Kahani Limbu, Jim A. Rogers

Mathematics Faculty Publications

Background: Despite decades of new discoveries in biomedical research, the overwhelming complexity of cells has been a significant barrier to a fundamental understanding of how cells work as a whole. As such, the holistic study of biochemical pathways requires computer modeling. Due to the complexity of cells, it is not feasible for one person or group to model the cell in its entirety. Results: The Cell Collective is a platform that allows the world-wide scientific community to create these models collectively. Its interface enables users to build and use models without specifying any mathematical equations or computer code - addressing …

Reference Databases Usage Statistics 2011-2012, Michael A. Cerbo Ii, Sarah Bannister

Technical Services Reports and Statistics

Statistics on the use of online reference databases at the University of Rhode Island during the period from July 2011 through June 2012. Includes COUNTER-compliant data on sessions, searches, turnaways, full text articles downloaded, cost per search, and other metrics.

Characterization Of The Cellular And Organellar Dynamics That Occur With A Partial Depletion Of Mitochondrial Dna When Arabidopsis Organellar Dna Polymerase Ib Is Mutated, John D. Cupp

Theses and Dissertations

Plant mitochondrial genomes are large and complex, and the mechanisms for maintaining mitochondrial DNA (mtDNA) remain unclear. Arabidopsis thaliana has two DNA polymerase genes, polIA and polIB, that have been shown to be dual localized to mitochondria and chloroplasts but are unequally expressed within primary plant tissues involved in cell division or cell expansion. PolIB expression is observed at higher levels in both shoot and root apexes, suggesting a possible role in organelle DNA replication in rapidly dividing or expanding cells. It is proposed that both polIA and polIB are required for mtDNA replication under wild type conditions. An Arabidopsis …

Synthesis And Biological Evaluation Of Various Derivatives Of A Broad-Spectrum Anticancer Nucleoside, Jadd R. Shelton

Theses and Dissertations

Recently the Peterson lab discovered a promising anticancer adenosine derivative-- 2´,3´-bis-O-tert-butyldimethylsilyl-5´-deoxy-5´-[N-(methylcarbamoyl)amino]-N6-(N-phenylcarbamoyl)adenosine. This compound showed selective toxicity against human colon cancer cells in vitro with LC50's = 6--10 µM. It was hypothesized that the lead compound exerted its cytotoxic effects by interacting with a protein kinase. A systematic Structure Activity Relationship (SAR) was undertaken in an attempt to increase the kinase-binding affinity of the lead compound. Many regions of the lead compound were examined: the N6-phenyl urea moiety, the 5´-N-methyl urea group, the 2´,3´-bis-O-TBS groups, the nucleobase, and the ribose sugar. Results of these studies produced some promising new derivatives. In …

The Forgotten Medium: The Impact Of Reading Violent Literature On Aggressive Thoughts, Mckay Robert Stevens

Theses and Dissertations

Media violence in television, film, video games, and music has been linked to increased aggression. Only in recent years have researchers begun to investigate the impact that reading violent literature can have on individuals. The present study exposed individuals to either a violent or nonviolent story and measured aggressive cognitions. No significant effect was found for story type on aggressive cognitions but a gender effect for aggressive word completions was found. Discussion centers on possible differences between media types as well as future suggestions for investigations into violent literature.

Pairwise Protein Expression Classifier For Candidate Biomarker Discovery For Early Detection Of Human Disease Prognosis, Parminder Kaur, Daniela Schlatzer, Kenneth Cooke, Mark R. Chance

Faculty Scholarship

Background: An approach to molecular classification based on the comparative expression of protein pairs is presented. The method overcomes some of the present limitations in using peptide intensity data for class prediction for problems such as the detection of a disease, disease prognosis, or for predicting treatment response. Data analysis is particularly challenging in these situations due to sample size (typically tens) being much smaller than the large number of peptides (typically thousands). Methods based upon high dimensional statistical models, machine learning or other complex classifiers generate decisions which may be very accurate but can be complex and difficult to …

Grandparent Kinship Caregivers, Anna Leonard

Marquette Elder's Advisor

With more children having grandparents as their primary caregivers, the informal nature of this relationship in the past is being transformed into a more formalized structure as public financial aid is needed by either the children or their grandparents or both. Leonard explores the difficulties grandparents encounter and the financial ramifications and legal options, including kinship foster care, which must be considered.

Elder Law And Estate Planning For Gay And Lesbian Individuals And Couples, Ralph Randazzo

Marquette Elder's Advisor

This comprehensive article discusses the unique problems in estate planning encountered by gays and lesbians. Among the items explored are joint representation, advance directives, guardianship, long-term care planning and insurance, Medicare and Medicaid planning, nursing home care, exempt transfers, wills, revocable trusts, gift taxation, and the unique problems encountered which counselors must consider when representing gay and lesbian clients.

Adult Adoption And The Elder Population , Angela Chaput Foy

Marquette Elder's Advisor

The author explains how adult adoption differs from the adoption of minors, tells how different states establish varying requirements, and shows that the protections for adopted minors may not always be available to adopted adults. The reasons for and the ramifications of adult adoption (such as inheritance rights) and the resulting effects on the extended families of both parties are examined in detail.

Elders And End-Of-Life Medical Decisions: Legal Context, Psychological Issues, And Recommendations To Attorneys Serving Seniors , Ed De St. Aubin, Sheila Baer, Joan Ravenelli Miller

Marquette Elder's Advisor

Much more than the disposition of worldly goods must be considered when preparing legal documents for end-of-life situations. This article stresses the necessity of client autonomy in preparing dispositional gifts as well as decision planning for medical care and treatment for senior citizens, and also explains the concept of Generatively: the desire to contribute to the well-being of . . . future generations.

Fillial Responsibility: A Survey Across Time And Oceans , Andrea Rickles-Jordan

Marquette Elder's Advisor

In the United States, Medicare and Medicaid are helping fund the cost of caring for the elderly. However, long before these programs existed, several states enacted statutes requiring children to care for their elderly parents. These filial responsibility statutes still exist in many states today, although their effectiveness and use has been called into question by opponents. To understand the current need for these statutes, this article first looks at the reasons the statutes were created. The article then follows their growth throughout the history of the world and the United States. As further means of comparison, the article examines …

A Survey Of The Fifty States' Grandparent Visitation Statutes, Michael K. Goldberg

Marquette Elder's Advisor

No abstract provided.

International Rights Of Older Persons: What Difference Would A New Convention Make To Lives Of Older People?, Israel Doron, Itai Apter

Marquette Elder's Advisor

This article tries to answer the following question: What difference, if any, would a new convention on the rights of older persons make to the lives of older people in light of the previous experiences with the Convention on the Eliminations of All Forms of Discrimination Against Women (CEDAW) and the Convention on the Rights of the Child (CRC)? In order to answer this question, the authors focus on the existing legal literature on international human rights law, with a particular focus on international human rights treaties. To better understand international human rights treaties, the article also discusses the CRC …

"Gray Touch": Professional Issues In The Uncertain Zone Between "Good Touch" And "Bad Touch", Joseph L. Daly, Michael S. Maza, Colleen M. Daly

Marquette Elder's Advisor

This article explores “good touch,” “bad touch,” and the uncertain area of “gray touch.” First, this article examines the concept of “good touch.” Then, this article moves to the concept of “bad touch” and examines the role of the law in regulating touch. Finally, this article introduces the concept of “gray touch” and explores ways for professionals to approach the often misunderstood and troublesome issue of “touch” in our current murky and litigious environment.

Bringing Age Discrimination And Disability Discrimination Together: Too Few Intersections, Too Many Interstices, Leslie Pickering Francis, Anita Silvers

Marquette Elder's Advisor

Old age and disability would seem to have adverse features in common. Membership in either group suggests depleted capability, decreased social contribution, significant fragility, and heightened susceptibility to maltreatment by other people. Yet some have argued that no wrong occurs when advanced age is made disadvantageous, for the elderly have had a fair chance at the goods of life. By contract, this argument goes, there is never a fair chance for people with disabilities. This article challenges the view that takes discrimination based on disability and discrimination based on age as so discrepant that they do not deserve similar efforts …

Old Lawyers, Blue Eyes, And The Medicalization Of Aging, Michael J. Myers

Marquette Elder's Advisor

The article examines the "medicalization" of the aging process and the pitfalls of the increased medical care and myths about what constitutes "healthy" later in life. Financial reward and fear of death drive the increasing amount and extensiveness of care for chronic disease encountered in older adults, sometimes to an unnecessary end. The author puts forth the theory that older adults are now part of a weakened generation, rooted in a refusal to "suffer their reality" and ignore the fact that aging is not a disease, that is, not until it is placed under a doctor's care.

Disability And Aging: Historical And Contemporary Challenges, William N. Myhill, Peter Blanck

Marquette Elder's Advisor

This article discusses the challenges that elderly with disabilities face in the work place. The article explores the theme historically and today as they impact qualify of life for persons with and aging into disability.

The Decline Of The Confrontation Clause In New York - People V. Encarnacion, Anthony Fasano

Touro Law Review

No abstract provided.