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Ultraviolet Radiation–Induced Cataract In Mice: The Effect Of Age And The Potential Biochemical Mechanism, Jie Zhang, Hong Yan, Stefan Lofgren, Xiaoli Tian, Marjorie F. Lou

School of Veterinary and Biomedical Sciences: Faculty Publications

PURPOSE. To study the effect of age on the morphologic and biochemical alterations induced by in vivo exposure of ultraviolet radiation (UV).

METHODS. Young and old C57BL/6 mice were exposed to broadband UVBþUVA and euthanized after 2 days. Another batch of UV-exposed young mice was monitored for changes after 1, 2, 4, and 8 days. Age-matched nonexposed mice served as controls. Lens changes were documented in vivo by slit-lamp biomicroscopy and dark field microscopy photographs ex vivo. Lens homogenates were analyzed for glutathione (GSH) level, and the activities of thioredoxin (Trx), thioltransferase (TTase), and glyceraldehyde-3-phosphate dehydrogenase (G3PD). Glutathionylated lens proteins …

Behavioral And Physiological Female Responses To Male Sex Ratio Bias In A Pond-Breeding Amphibian, Kristine L. Grayson, Stephen P. De Lisle, Jerrah E. Jackson, Samuel J. Black, Erica J. Crespi

Biology Faculty Publications

Introduction: The phenomenon of sexual conflict has been well documented, and in populations with biased operational sex ratios the consequences for the rarer sex can be severe. Females are typically a limited resource and males often evolve aggressive mating behaviors, which can improve individual fitness for the male while negatively impacting female condition and fitness. In response, females can adjust their behavior to minimize exposure to aggressive mating tactics or minimize the costs of mating harassment. While male-male competition is common in amphibian mating systems, little is known about the consequences or responses of females. The red-spotted newt (Notophthalmus …

Single-Sex Public Schools And Classes: A Dangerous Lesson In Stereotypes?, Joanna L. Grossman

Hofstra Law Faculty Scholarship

A public middle school in West Virginia was recently ordered to immediately stop its practice of segregating boys and girls into different classes for several subjects. The judge issued a temporary injunction against Van Devender Middle School, based on the strong likelihood that the single-sex programming would be found to violate federal law because the class assignments were mandatory, rather than voluntary.

The American Civil Liberties Union (ACLU) brought the lawsuit, as part of its nationwide investigation into single-sex public-school classes that were green-lighted by a 2006, George W. Bush Administration change in federal education regulations, but seem to operate …

The George-Anne, Georgia Southern University

The George-Anne

• Constitution Day Sparks Political Discussion
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A Gis Suitability Analysis Of Wolf Habitat In Maine, Wendy Sicard ('05)

Atlas of Maine

The range of the Gray Wolf (Canis lupus), once covering most of North America, has been drastically reduced by an estimated 95% due to habitat loss and extermination by humans. The wolf was extirpated from Maine in the 1800’s. Wolf reintroductions have been suggested for Maine, but there is some debate about how much land is suitable for wolves. I developed a wolf habitat suitability analysis using ArcGIS and data from the Maine Office of GIS and the United States National Atlas. The model incorporates land cover, presence of major roads and railways, conservation land, industrial, non-industrial, and public woodlot …

Wisconsin Liberal Arts Colleges’ Collaborative Program Awarded $1.1 Million Grant, Lawrence University

Press Releases

A highly successful and unique regional collaboration model between Lawrence University, Ripon College and St. Norbert College has been awarded a five-year, $1.1 million grant from the U.S. Department of Education TRIO to support the schools’ Ronald E. McNair Post-baccalaureate Achievement Program.

The grant will support the McNair Achievement Program beginning in the fall of 2013 and running through Spring 2018. The program focuses on preparing first-generation, low-income and racially underrepresented students for graduate school and the completion of doctorate degrees.

“The McNair program helps level the playing field for students from less privileged backgrounds by providing exposure to, experience …

Commonwealth Times 2012-09-17

Commonwealth Times, 1969-

No abstract provided.

The Statesman, V. 56, I. 03, Stony Brook University

Stony Brook Statesman-Sucolian

v. 56, i. 03

Current, September 17, 2012, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

September 17, 2012, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Structure And Composition Of Leachfield Bacterial Communities: Role Of Soil Texture, Depth And Septic Tank Effluent Inputs, José A. Amador, Janet A. Atoyan

Natural Resources Science Faculty Publications

Although groundwater quality depends on microbial processes in the soil treatment area (STA) of onsite wastewater treatment systems (OWTS), our understanding of the development of these microbial communities is limited. We examined the bacterial communities of sand, sandy loam, and clay STAs at different depths in response to septic tank effluent (STE) addition using mesocosms. Terminal restriction fragment length polymorphism (TRFLP) analysis was used to compare the bacterial community structure and composition of STE, native soil prior to STE addition (UNX) and soil exposed to STE (EXP). Principal component analysis separated communities with depth in sand but not in sandy …

Columbia Chronicle (09/17/2012), Columbia College Chicago

Columbia Chronicle

Student newspaper from September 17, 2012 entitled The Columbia Chronicle. This issue is 44 pages and is listed as Volume 48, Number 3. Cover story: "Fall enrollment slips to four-year low" Editor-in-Chief: Heather Schröering

Perceptions Of Catholic Identity: Views Of Catholic School Administrators And Teachers, John J. Convey

Journal of Catholic Education

This article presents the results of a survey conducted in 2010 of over 3,300 administrators and teachers in Catholic elementary and secondary schools nationally about their understanding of the meaning of the term “Catholic identity.” The survey was conducted in the fall of 2010 in anticipation of a national conference on the Catholic identity of Catholic elementary and secondary schools at The Catholic University of America, October 2-4, 2011. The vast majority of respondents viewed the school’s culture or faith community as the most important component of its Catholic identity. The longer the teacher or administrator worked in Catholic schools, …

Teaching A Catholic Philosophy Of Interpersonal Communication: The Case For “Soul Friendship”, Kathleen Glenister Roberts

Journal of Catholic Education

While social justice education has a rich and ancient history within the Catholic Church, academic disciplines have only recently begun to make the idea of social justice relevant within courses for undergraduates. In the communication discipline, debate about social justice has been lively and varied over the last two decades, and has provided rich entry points for philosophical interpretation. This paper considers interpersonal communication from the vantage point of social justice in the Catholic intellectual tradition. While the importance of friendship for society is nothing new (Aristotle addressed this issue in the Nicomachean Ethics), contemporary cultural hindrances to a just …

The Collegian (2012-09-17), Joe Molina

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 65, No. 4

Serotonin And Synaptic Transmission At Invertebrate Neuromuscular Junctions, Wen-Hui Wu, Robin L. Cooper

Biology Faculty Publications

The serotonergic system in vertebrates and invertebrates has been a focus for over 50 years and will likely continue in the future. Recently, genomic analysis and discovery of alternative splicing and differential expression in tissues have increased the knowledge of serotonin (5-HT) receptor types. Comparative studies can provide useful insights to the wide variety of mechanistic actions of 5-HT responsible for behaviors regulated or modified by 5-HT. To determine cellular responses and influences on neural systems as well as the efferent control of behaviors by the motor units, preparations amenable to detailed studies of synapses are beneficial as working models. …

Daily Eastern News: September 17, 2012, Eastern Illinois University

September

No abstract provided.

Grand Valley Forum, Volume 037, Number 04, September 17, 2012, Grand Valley State University

2012-2013, Volume 37

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Chancellor's Report 2012-09, John Pugh

Chancellor's Report

No abstract provided.

Perlecan Domain V Induces Vegf Secretion In Brain Endothelial Cells Through Integrin Α5Β1 And Erk-Dependent Signaling Pathways, Douglas N. Clarke, Abraham Al Ahmad, Boyeon Lee, Christi Parham, Lisa Auckland, Andrezj Fertala, Michael Kahle, Courtney S. Shaw, Jill Roberts, Gregory J. Bix

Sanders-Brown Center on Aging Faculty Publications

Perlecan Domain V (DV) promotes brain angiogenesis by inducing VEGF release from brain endothelial cells (BECs) following stroke. In this study, we define the specific mechanism of DV interaction with the α(5)β(1) integrin, identify the downstream signal transduction pathway, and further investigate the functional significance of resultant VEGF release. Interestingly, we found that the LG3 portion of DV, which has been suggested to possess most of DV's angio-modulatory activity outside of the brain, binds poorly to α(5)β(1) and induces less BEC proliferation compared to full length DV. Additionally, we implicate DV's DGR sequence as an important element for the interaction …

N-Terminal Domain Of Vacuolar Snare Vam7p Promotes Trans-Snare Complex Assembly, Hao Xu, William T. Wickner

Dartmouth Scholarship

SNARE-dependent membrane fusion in eukaryotic cells requires that the heptad-repeat SNARE domains from R- and Q-SNAREs, anchored to apposed membranes, assemble into four-helix coiled-coil bundles. In addition to their SNARE and transmembrane domains, most SNAREs have N-terminal domains (N-domains), although their functions are unclear. The N-domain of the yeast vacuolar Qc-SNARE Vam7p is a binding partner for the homotypic fusion and vacuole protein sorting complex (a master regulator of vacuole fusion) and has Phox homology, providing a phosphatidylinositol 3-phosphate (PI3P)-specific membrane anchor. We now report that this Vam7p N-domain has yet another role, one that does not depend on its …

What Is The Predictive Power Of The Colobine Protein-To-Fiber Model And Its Conservation Value?, Jan F. Gogarten, Melissa Guzman, Colin A. Chapman, Aerin L. Jacob, Patrick A. Omeja, Jessica Rothman

Publications and Research

Predicting variation in animal abundance across time and space has proven very difficult; however, a model exists to predict the biomass of small folivorous primates that has considerable correlative support. This model suggests that the protein-to-fiber ratio of leaves in a habitat can predict folivore biomass. Here we present an experimental test of this protein-to-fiber model to assess if the number of infant monkeys per female and group size can be predicted based on the leaf chemistry of a habitat. We expected regenerating forest in Kibale National Park, Uganda to have leaves with higher concentrations of crude protein and lower …

Taxonomic Identity Of The Invasive Fruit Fly Pest, Bactrocera Invadens: Concordance In Morphometry And Dna Barcoding, Fathiya M. Khamis, Daniel K. Masiga, Samira A. Mohamed, Daisy Salifu, Marc De Meyer, Sunday Ekesi

All Peer-Reviewed Publications

In 2003, a new fruit fly pest species was recorded for the first time in Kenya and has subsequently been found in 28 countries across tropical Africa. The insect was described as Bactrocera invadens, due to its rapid invasion of the African continent. In this study, the morphometry and DNA Barcoding of different populations of B. invadens distributed across the species range of tropical Africa and a sample from the pest's putative aboriginal home of Sri Lanka was investigated. Morphometry using wing veins and tibia length was used to separate B. invadens populations from other closely related Bactrocera species. The …

Why Do Women Have More Children Than They Want? Understanding Differences In Women's Ideal And Actual Family Size In A Natural Fertility Population, Lisa Mcallister, Michael Gurven, Hillard Kaplan, Jonathan Stieglitz

ESI Publications

Objectives—We develop and test a conceptual model of factors influencing women’s ideal family size (IFS) in a natural fertility population, the Tsimane of Bolivia. The model posits affects of socioecology, reproductive history, maternal condition, and men’s IFS. We test three hypotheses for why women may exceed their IFS despite experiencing socioeconomic development: (H1) limited autonomy; (H2) improved maternal condition; and (H3) low returns on investments in embodied capital.

Methods—Women’s reproductive histories and prospective fertility data were collected from 2002 to 2008 (n = 305 women). Semistructured interviews were conducted with Tsimane women to study the perceived value of …

September 17, 2012 Aasu Faculty Senate Agenda, Armstrong State University

Armstrong Faculty Senate: Armstrong Faculty Senate Agenda (Archived)

September 17, 2012 AASU Faculty Senate Agenda

Perlecan Domain V Induces Vegf Secretion In Brain Endothelial Cells Through Integrin Α5Β1 And Erk-Dependent Signaling Pathways., Douglas N Clarke, Abraham Al Ahmad, Boyeon Lee, Christi Parham, Lisa Auckland, Andrezj Fertala, Michael Kahle, Courtney S Shaw, Jill Roberts, Gregory J Bix

Department of Dermatology and Cutaneous Biology Faculty Papers

Perlecan Domain V (DV) promotes brain angiogenesis by inducing VEGF release from brain endothelial cells (BECs) following stroke. In this study, we define the specific mechanism of DV interaction with the α(5)β(1) integrin, identify the downstream signal transduction pathway, and further investigate the functional significance of resultant VEGF release. Interestingly, we found that the LG3 portion of DV, which has been suggested to possess most of DV's angio-modulatory activity outside of the brain, binds poorly to α(5)β(1) and induces less BEC proliferation compared to full length DV. Additionally, we implicate DV's DGR sequence as an important element for the interaction …

Transcriptional Cross Talk Within The Mar-Sox-Rob Regulon In Escherichia Coli Is Limited To The Rob And Marrab Operons, Lon Chubiz, George Glekas, Christopher Rao

Biology Department Faculty Works

Bacteria possess multiple mechanisms to survive exposure to various chemical stresses and antimicrobial compounds. In the enteric bacterium Escherichia coli, three homologous transcription factors—MarA, SoxS, and Rob—play a central role in coordinating this response. Three separate systems are known to regulate the expression and activities of MarA, SoxS, and Rob. However, a number of studies have shown that the three do not function in isolation but rather are coregulated through transcriptional cross talk. In this work, we systematically investigated the extent of transcriptional cross talk in the mar-sox-rob regulon. While the three transcription factors were found to have the potential …

Metabolic Remodeling Of The Tumor Microenvironment: Migration Stimulating Factor (Msf) Reprograms Myofibroblasts Toward Lactate Production, Fueling Anabolic Tumor Growth., Valentina Carito, Gloria Bonuccelli, Ubaldo E Martinez-Outschoorn, Diana Whitaker-Menezes, Maria Cristina Caroleo, Erika Cione, Anthony Howell, Richard G Pestell, Michael P. Lisanti, Federica Sotgia

Department of Stem Cell Biology and Regenerative Medicine Faculty Papers & Presentations

Migration stimulating factor (MSF) is a genetically truncated N-terminal isoform of fibronectin that is highly expressed during mammalian development in fetal fibroblasts, and during tumor formation in human cancer-associated myofibroblasts. However, its potential functional role in regulating tumor metabolism remains unexplored. Here, we generated an immortalized fibroblast cell line that recombinantly overexpresses MSF and studied their properties relative to vector-alone control fibroblasts. Our results indicate that overexpression of MSF is sufficient to confer myofibroblastic differentiation, likely via increased TGF-b signaling. In addition, MSF activates the inflammation-associated transcription factor NFκB, resulting in the onset of autophagy/mitophagy, thereby driving glycolytic metabolism (L-lactate …

The International Review | 2012 Fall/Winter, Michael Rhee

The International Review Newsletter

Should nations regulate digital photo editing?

Protecting the privacy of biometric data: National and international efforts

How do nations and international law address bribery?

Cop1 Mediates The Coordination Of Root And Shoot Growth By Light Through Modulation Of Pin1- And Pin2-Dependent Auxin Transport In Arabidopsis, Massimiliano Sassi, Yanfen Lu, Yonghong Zhang, Juan Wang, Pankaj Dhonukshe, Ikram Blilou, Minqiu Dai, Juan Li, Ximing Gong, Yvon Jaillais, Xuhong Yu, Jan Traas, Ida Ruberti, Haiyang Wang, Ben Scheres, Teva Vernoux, Jian Xu

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

When a plant germinates in the soil, elongation of stem-like organs is enhanced whereas leaf and root growth is inhibited. How these differential growth responses are orchestrated by light and integrated at the organismal level to shape the plant remains to be elucidated. Here, we show that light signals through the master photomorphogenesis repressor COP1 to coordinate root and shoot growth in Arabidopsis. In the shoot, COP1 regulates shoot-to-root auxin transport by controlling the transcription of the auxin efflux carrier gene PIN-FORMED1 (PIN1), thus appropriately tuning shoot-derived auxin levels in the root. This in turn directly influences root elongation and …